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7628823 |
Method of testing for ATP load in commercial laundry and for data tracking the results
A method of testing for sanitization of textiles comprises the steps of cleaning textiles in a water solution and testing the water solution for the presence of contaminants such as adenosine...
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7612251 |
Nucleotide sequences mediating male fertility and method of using same
Nucleotide sequences mediating male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are also identified. The...
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7605144 |
Enzyme catalyzed therapeutic compounds
This invention provides novel compounds selected from the group consisting of a 1,5-substituted pyrimidine derivative or analog and substituted furano-pyrimidone analogs. The compounds are useful...
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7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
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7582417 |
Sequential reporter enzyme luminescence (SRL) methods and compositions for practicing the same
Sequential reporter enzyme luminescence (SRL) methods are provided. In the subject methods, the activity of a reporter enzyme is evaluated using a secondary reporter system that employs a product...
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7579161 |
Assay methods for suppressor of fused modulation of hedgehog signaling
The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those...
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7575881 |
Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent...
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7563574 |
Methods, systems and compositions for monitoring enzyme activity and applications thereof
Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems...
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7560245 |
Luciferase and methods for measuring intracellular ATP using the same
The present invention relates to luciferase having resistance to a surfactant and a method for measuring intracellular ATP which is characterized in that the luciferase having resistance to a...
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7556933 |
Reagent system and process for adenosine triphosphate monitoring
A reagent system comprises a first reagent which includes a high pH phosphate buffer, and a second reagent which includes luciferase, luciferin, a magnesium salt and an enzyme stabilizer. The...
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7547543 |
Method for identifying substances useful for treating inflammation using the response element to the ikbalpha ROR receptor
The present invention concerns a method for identifying substances useful for treating inflammation, characterized in that it comprises the following steps: (a) placing said substance in contact...
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7537912 |
Methods of measuring luminogenic activity with a protected coelenterazine
A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light...
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7521199 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the...
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7517647 |
Genetic screen for bioactive peptides
A method of screening for a protein involved in the extracellular regulation of latent TGFβ activation by transducing a cell line with a retroviral cDNA library to create a reporter cell line that...
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7494781 |
Sensitive method for detecting low levels of ATP
Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting...
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7476514 |
Method for monitoring the immune response and predicting clinical outcomes in transplant recipients
Methods for monitoring the immune response and predicting clinical outcomes for patients on immunosuppressive drugs (such as transplant patients) are provided. The methods are based on the...
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7459282 |
Use of c-Jun or c-Jun activating agents such as UV or c-Jun N-terminal kinases (JNKs) for treating cancer
The invention concerns the increased stabilization and activation of p73, a homologue of p53. Specifically, the inventors have determined that c-Jun, a component of the AP-1 family of transcription...
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7452663 |
Kits for detection of ATP
Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase...
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7442518 |
Imaging regulated protein-protein interactions in cells and living animals by enhanced luciferase protein fragment complementation
An enhanced firefly luciferase protein fragment complementation assay method is described that produces a robust and broadly applicable bioluminescence signal and demonstrates both...
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7439015 |
Methods for detecting DNA viruses
A DNA virus in a sample is detected by contacting the sample with host cells that have been transiently transfected with a reporter sequence under the control of a virus-specific promoter, and then...
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7435546 |
System to detect inducible translocation
The present invention relates to a novel method for screening to identify/detect polypeptides capable of translocating into or out of the nucleus of a cell in response to induction by an external...
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7425422 |
Luciferase detection assay system
The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and...
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7416854 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
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7396655 |
Method for enhancing activity of luciferase with fluorescence activity
Methods for enhancing luminescence of a luciferase (BFP-aq) with fluorescence activity derived from a calcium-binding photoprotein are provided. To a luciferase solution with fluorescence activity...
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7384758 |
Bioluminescent protease assay with modified aminoluciferin or derivatives thereof
A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay...
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7384751 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7364843 |
Method of identifying target cell using target cell-specific virus
Provided is a method of identifying a target cell using a virus. The method includes infecting the target cell with the virus by contacting the virus to the target cell and culturing the target...
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7354729 |
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to...
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7354730 |
High-throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7348159 |
Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors.
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7329486 |
High-throughput assay for virus entry and drug screening
The present invention provides a rapid virus entry/binding detection assay. An enzyme such as luciferase was incorporated at the C-terminal end of viral envelope proteins that would deliver the...
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7326536 |
Agents for treatment of HCV and methods of use
An amphipathic helix at the approximate N-terminus of Hepatitis C virus (HCV) nonstructural proteins mediates the association of these proteins with cytoplasmic membranes in infected cells. This...
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7323305 |
Methods of amplifying and sequencing nucleic acids
An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing,...
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7316905 |
Method for measurement of hepatitis C virus
A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a...
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7309579 |
Method for screening for activators of soluble guanylate cyclase having oxidized heme iron
The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the...
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7303894 |
Detection of phenols using engineered bacteria
Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate...
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7300766 |
Polymeric ammonium and or phosphonium salts having added π-electrons and higher molecular weight as enhancers for chemiluminescent systems
A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker...
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7297503 |
Methods of identifying reduced internalization transmembrane receptor agonists
Described herein are methods of identifying a transmembrane receptor (TMR) agonist and compounds identified by this method. The TMR agonist (TMRA) is capable of activating TMR signaling while...
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7276373 |
Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease
The present invention concerns the development of a cell-based assay system having improved sensitivity to HCV NS3 protease activity when compared to known assays, which is useful for screening...
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7262306 |
Chemiluminescent compounds and their use
The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these...
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7256009 |
Luminous bacteria and methods for the isolation, identification and quantitation of toxicants
Methods for the isolation and identification of a toxicant in a sample are disclosed. Luminescent biological agents (i.e., bacteria) having sensitivity to a toxicant or an isolatable component in a...
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7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
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7252943 |
In Vitro sorting method
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: compartmentalizing genetic elements into...
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7241584 |
Thermostable luciferases and methods of production
Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases,...
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7217527 |
Assay for phosphodiesterase function
The present invention provides filter-based assays for measuring binding of compounds to phosphodiesterases (PDEs). The assay permits stoichiometric binding of compounds to PDEs, thereby providing...
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7211399 |
Method for detecting leptin receptor ligands
The present invention relates to a method for detecting leptin receptor ligands using resonance energy transfer between fusion proteins comprising a leptin receptor and energy donor protein and a...
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7205120 |
Substrates and assays for β-secretase activity
The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage...
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7205108 |
Trp8, Trp9 and Trp10, novel markers for cancer
The present invention relates to gene expression in normal cells and cells of malignant tumors and particularly to novel markers associated with cancer, Trp8, Trp9 and Trp10, and the genes encoding...
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7172750 |
Compositions and methods for the treatment and diagnosis of immune disorders
The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are...
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7166447 |
Probe for analyzing protein—protein interaction and method of analyzing protein—protein interactions with the use of the same
A probe for protein—protein interaction analysis suitable for analyzing protein—protein interactions of various proteins with high accuracy and in a simple manner and a method for analyzing...
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