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8143013 |
Visible to near-infrared light probe using energy transfer between luciferase and an organic dye via a sugar chain
An object of the present invention is to produce a luminescent probe that has less biological effects, efficiently emits visible to near-infrared light, which is excellent for the imaging of...
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8137904 |
Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent...
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8124349 |
Toll-like receptor assays
Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR...
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8124330 |
Screening methods for cognitive enhancers
The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in...
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8124424 |
Single molecule-format bioluminescent probe
The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which...
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8114622 |
Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface
Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in...
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8097431 |
Methods and compositions for detecting steroids
The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof....
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8076159 |
Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists
Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable...
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8071328 |
Bioluminescent protease assay
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
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8043827 |
Single molecule-format real-time bioluminescence imaging probe
The present invention provides an “in vivo and in vitro real-time bioluminescence imaging means,” which can transmit a detection signal promptly in response to an external signal, while taking adv...
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8043826 |
Device for monitoring inhibition of platelet function response
The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX 1...
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8039228 |
Signal amplification using a synthetic zymogen
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a...
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8029980 |
Identification and use of agents that modulate oncogenic transcription agent activity
Embodiments of the invention provides, among other things, methods for identifying agents that inhibit oncogenic transcription factors, induce apoptosis, inhibit the growth of transformed cells and...
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8030017 |
Thermostable luciferases and methods of production
Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, ...
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8021662 |
Microorganisms for therapy
Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and...
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8008002 |
Nucleic acid sequencing
A method is disclosed for determining a target nucleic acid sequence, where the target nucleic acid sequence is comprised in a preparation comprising a non-target nucleic acid sequence, the target...
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8008006 |
Synthetic nucleic acid molecule compositions and methods of preparation
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
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7994396 |
Transgenic bioluminescent plants
Transgenic plants, and a method for making the same, wherein genes encoding the enzyme luciferase and its corresponding substrate luciferin are incorporated into a native plant genome. Once...
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7989178 |
Colony assay miniaturization with enumeration output
A system combining a clonogenic differentiation assay with an instrument-based ATP bioluminescence proliferation assay to produce a standardized colony-forming stem and progenitor cell potency...
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7968286 |
Settings for recombinant adenoviral-based vaccines
Described are of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, described are assays to...
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7955602 |
Annexin proteins and autoantibodies as serum markers for cancer
The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin...
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7951551 |
Kits and reagents for luciferase detection assay system
The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and...
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7951532 |
Method of screening a midkine modulating agent
This invention relates to the discovery that midkine modulates pulmonary vasculature development and smooth muscle cell development. Modulation of midkine activity thus alters pulmonary vasculature...
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7951550 |
Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
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7943300 |
Method for improved protein expression in bacteria by monitoring and modulating protein folding
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced...
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7943296 |
Methods of screening using a natriuretic peptide receptor
This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein...
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7939286 |
Enhancing a luminescent signal
Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of...
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7919248 |
Methods for the modulation of IL-13
The present invention is drawn to methods for modulating IL-13 expression and/or activity in a mammal comprising administering an effective amount of an agent which modulates the expression and/or...
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7915478 |
Msca1 nucleotide sequences impacting plant male fertility and method of using same
Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are...
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7915021 |
Mutant firefly luciferase
This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate...
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7910320 |
Methods compositions and compound assays for inhibiting amyloid-beta protein production
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring...
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7910087 |
Luciferins
Novel luciferins, methods of making luciferins, and uses of the same are disclosed.
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7906298 |
Thermostable Photinus pyralis luciferase mutant
A protein having luciferase activity and at least 60% similarity to luciferase from Photinus pyralis, Luciola mingrelica, Luciola cruciata or Luciola lateralis. Hotaria paroula, Pyrophorus...
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7892733 |
Response element regions
Response element regions, DNA constructs comprising response element regions, host cells comprising response element regions, and methods of using response element regions are provided.
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7883861 |
High throughput assay of hematopoietic stem and progenitor cell proliferation
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
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7879575 |
Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence
The present invention relates to nanostructures for use in luminescent assays as well as methods for the production of nano-sized tube and rods, including arrays of nanotubes and nanorods from a...
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7879540 |
Synthetic nucleic acid molecule compositions and methods of preparation
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
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7871803 |
Gene encoding novel luciferase
The present invention provides genes encoding novel luciferases having at least the properties of: being capable of using coelenterazine as their luminescent substrates; and being capable of being...
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7871444 |
Method of testing for ATP load in commercial laundry and for data tracking the results
A method of testing for sanitization of textiles comprises the steps of cleaning textiles in a water solution and testing the water solution for the presence of contaminants such as adenosine...
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7858394 |
Test methods for determining the intracellular concentration of cyclic nucleotides
The invention relates to methods for the quantitative optical analysis of the intracellular concentration of the cyclic nucleotides cGMP and cAMP, said methods using cell lines which express a...
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7833793 |
Method and device for monitoring inhibition of platelet function
The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX1...
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7829066 |
Assay for anti-metastatic agents
This invention relates, e.g., to a method for identifying an agent that inhibits a metastatic cell (e.g. that inhibits cancer metastasis), comprising measuring the amount of seeding of a tumor by a...
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7824878 |
Sensitive method for detecting low levels of ATP
Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to...
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7820374 |
Detection methods based on HR23 protein binding molecules
A method is provided for determining whether an agent is capable of inducing a DNA lesion in a eukaryotic cell, including exposing the eukaryotic cell to the agent and determining whether an HR23...
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7820184 |
Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and...
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7811760 |
Vector and method for detecting the change in transcription amount
A vector includes an enhancer region derived from a transcriptional regulatory region of tyrosine hydroxylase gene wherein the enhancer region enhances transcription amount of a downstream gene in...
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7807417 |
Ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
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7794966 |
Method of measuring glycated amine
The present invention aims to enable highly reliable measurement of a glycated amine. A fructosyl amino acid oxidase (FAOD) is added to a sample to remove a non-analyte glycated amine that is...
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7785792 |
Targeted modification of chromatin structure
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating...
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7763420 |
Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
Described herein are methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using...
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