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8143013 Visible to near-infrared light probe using energy transfer between luciferase and an organic dye via a sugar chain  
An object of the present invention is to produce a luminescent probe that has less biological effects, efficiently emits visible to near-infrared light, which is excellent for the imaging of...
8137904 Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue  
Described is the use of a microorganism or cell containing a DNA sequence encoding a detectable protein or a protein capable of inducing a detectable signal, e.g., a luminescent or fluorescent...
8124349 Toll-like receptor assays  
Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR...
8124330 Screening methods for cognitive enhancers  
The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in...
8124424 Single molecule-format bioluminescent probe  
The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which...
8114622 Methods for generation of reporter phages and immobilization of active bacteriophages on a polymer surface  
Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of E. coli 0157:H7 to be propagated in...
8097431 Methods and compositions for detecting steroids  
The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof....
8076159 Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists  
Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable...
8071328 Bioluminescent protease assay  
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
8043827 Single molecule-format real-time bioluminescence imaging probe  
The present invention provides an “in vivo and in vitro real-time bioluminescence imaging means,” which can transmit a detection signal promptly in response to an external signal, while taking adv...
8043826 Device for monitoring inhibition of platelet function response  
The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX 1...
8039228 Signal amplification using a synthetic zymogen  
Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a...
8029980 Identification and use of agents that modulate oncogenic transcription agent activity  
Embodiments of the invention provides, among other things, methods for identifying agents that inhibit oncogenic transcription factors, induce apoptosis, inhibit the growth of transformed cells and...
8030017 Thermostable luciferases and methods of production  
Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, ...
8021662 Microorganisms for therapy  
Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and...
8008002 Nucleic acid sequencing  
A method is disclosed for determining a target nucleic acid sequence, where the target nucleic acid sequence is comprised in a preparation comprising a non-target nucleic acid sequence, the target...
8008006 Synthetic nucleic acid molecule compositions and methods of preparation  
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
7994396 Transgenic bioluminescent plants  
Transgenic plants, and a method for making the same, wherein genes encoding the enzyme luciferase and its corresponding substrate luciferin are incorporated into a native plant genome. Once...
7989178 Colony assay miniaturization with enumeration output  
A system combining a clonogenic differentiation assay with an instrument-based ATP bioluminescence proliferation assay to produce a standardized colony-forming stem and progenitor cell potency...
7968286 Settings for recombinant adenoviral-based vaccines  
Described are of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, described are assays to...
7955602 Annexin proteins and autoantibodies as serum markers for cancer  
The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin...
7951551 Kits and reagents for luciferase detection assay system  
The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and...
7951532 Method of screening a midkine modulating agent  
This invention relates to the discovery that midkine modulates pulmonary vasculature development and smooth muscle cell development. Modulation of midkine activity thus alters pulmonary vasculature...
7951550 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions  
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
7943300 Method for improved protein expression in bacteria by monitoring and modulating protein folding  
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced...
7943296 Methods of screening using a natriuretic peptide receptor  
This disclosure provides an intracellular fragment of natriuretic peptide receptor A (NPRA), referred to herein as soluble natriuretic peptide receptor-related fragment (sNRF). It is shown herein...
7939286 Enhancing a luminescent signal  
Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of...
7919248 Methods for the modulation of IL-13  
The present invention is drawn to methods for modulating IL-13 expression and/or activity in a mammal comprising administering an effective amount of an agent which modulates the expression and/or...
7915478 Msca1 nucleotide sequences impacting plant male fertility and method of using same  
Nucleotide sequences of a Msca1 gene, critical to male fertility in plants are described, with DNA molecule and amino acid sequences set forth. Promoter sequences and their essential regions are...
7915021 Mutant firefly luciferase  
This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate...
7910320 Methods compositions and compound assays for inhibiting amyloid-beta protein production  
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring...
7910087 Luciferins  
Novel luciferins, methods of making luciferins, and uses of the same are disclosed.
7906298 Thermostable Photinus pyralis luciferase mutant  
A protein having luciferase activity and at least 60% similarity to luciferase from Photinus pyralis, Luciola mingrelica, Luciola cruciata or Luciola lateralis. Hotaria paroula, Pyrophorus...
7892733 Response element regions  
Response element regions, DNA constructs comprising response element regions, host cells comprising response element regions, and methods of using response element regions are provided.
7883861 High throughput assay of hematopoietic stem and progenitor cell proliferation  
The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status...
7879575 Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence  
The present invention relates to nanostructures for use in luminescent assays as well as methods for the production of nano-sized tube and rods, including arrays of nanotubes and nanorods from a...
7879540 Synthetic nucleic acid molecule compositions and methods of preparation  
A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.
7871803 Gene encoding novel luciferase  
The present invention provides genes encoding novel luciferases having at least the properties of: being capable of using coelenterazine as their luminescent substrates; and being capable of being...
7871444 Method of testing for ATP load in commercial laundry and for data tracking the results  
A method of testing for sanitization of textiles comprises the steps of cleaning textiles in a water solution and testing the water solution for the presence of contaminants such as adenosine...
7858394 Test methods for determining the intracellular concentration of cyclic nucleotides  
The invention relates to methods for the quantitative optical analysis of the intracellular concentration of the cyclic nucleotides cGMP and cAMP, said methods using cell lines which express a...
7833793 Method and device for monitoring inhibition of platelet function  
The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX1...
7829066 Assay for anti-metastatic agents  
This invention relates, e.g., to a method for identifying an agent that inhibits a metastatic cell (e.g. that inhibits cancer metastasis), comprising measuring the amount of seeding of a tumor by a...
7824878 Sensitive method for detecting low levels of ATP  
Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to...
7820374 Detection methods based on HR23 protein binding molecules  
A method is provided for determining whether an agent is capable of inducing a DNA lesion in a eukaryotic cell, including exposing the eukaryotic cell to the agent and determining whether an HR23...
7820184 Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders  
Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and...
7811760 Vector and method for detecting the change in transcription amount  
A vector includes an enhancer region derived from a transcriptional regulatory region of tyrosine hydroxylase gene wherein the enhancer region enhances transcription amount of a downstream gene in...
7807417 Ecdysone receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
7794966 Method of measuring glycated amine  
The present invention aims to enable highly reliable measurement of a glycated amine. A fructosyl amino acid oxidase (FAOD) is added to a sample to remove a non-analyte glycated amine that is...
7785792 Targeted modification of chromatin structure  
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating...
7763420 Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders  
Described herein are methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using...
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