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7160691 |
Protein fragment complementation assays for the detection of biological or drug interactions
The present invention describes a method for detecting biomolecular interactions said method comprising: (a) selecting an appropriate reporter molecule selected from the group consisting of a...
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7153665 |
Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
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7148018 |
Protease-activated receptor (par) modulator assays
There is provided a method of identifying a PAR cleaving molecule comprising the steps of: (a) providing an immobilized PAR cleavage peptide linked to a reporter molecule; (b) contacting the...
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7148030 |
Bioluminescent protease assay
A sensitive bioluminescent assay to detect proteases including caspases, trypsin and tryptase is provided.
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7138233 |
IN vitro sorting method
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements...
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7132249 |
Method of determining allergenic food on surfaces
Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. An aspect of the invention includes a low molarity and...
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7118878 |
Method for increasing luminescence assay sensitivity
The invention provides kits and methods for increasing the sensitivity of a bio-luminescent assay, which employ an organic compound that, for instance, reduces luminescence that is not dependent on...
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7108996 |
Method for increasing luminescence assay sensitivity
A method for increasing the sensitivity of a bio-luminescent assay comprising carrying out the assay in the presence of an organic compound that reduces luminescence that is not dependent on the...
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7101677 |
Receptor assay
The present invention relates to receptor/reporter fusion protein based assays for detecting the effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion...
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7094559 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the...
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7090994 |
Methods of screening for introduction of DNA into a target cell
The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important...
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7083911 |
Method for detection of ATP
Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase...
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7081352 |
Chemiluminescent influenza diagnostic kit
A chemiluminescent system for detecting the presence of influenza virus in a biological fluid sample is provided. An influenza diagnostic kit is provided which includes (1) a sampling device for...
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7078181 |
Kits for increasing luminescence assay sensitivity
Assay kits for increasing the sensitivity of luminescent assays are provided that include an organic compound that reduces luminescence that is not dependent on the presence of an analyte by at...
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7056687 |
Methods and compositions for screening for altered cellular phenotypes
The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more...
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7052843 |
Transcription-based assay for identification of post-translational modification and its application in proteomics
The present invention relates to a method for detecting the post-translational modification of a target protein by a post translational modifier polypeptide molecule; a method for screening a...
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7026122 |
Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
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7001733 |
Methods and compositions for screening for modulations of IgE synthesis, secretion and switch rearrangement
The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
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6964856 |
Animal models and methods for sepsis
Methods for selecting a candidate drug for treating sepsis are disclosed. The methods involve labeling a sepsis-causing pathogen with a reporter and monitoring the progress of infection by...
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6949351 |
Cell assay, method and reagents
A method for detecting the presence of a lysed eukaryotic cell in a sample, said method comprising: (i) adding adenosine diphosphate (ADP) to said sample under conditions which allows the...
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6943025 |
Method for identifying genes involved in cell proliferation
The present invention provides fish system as a powerful forward genetic tool to directly identify a number of novel genes involved in cell proliferation in vertebrates without the time consuming...
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6921634 |
Replication competent hepatitus C virus and methods of use
The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide. The invention also includes methods for modifying a hepatitis C virus...
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6913898 |
Luminescent method of detecting soluble guanylate cyclase
The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the...
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6911319 |
Methods and kits for detecting protein kinases
A method for measuring protein kinase activity comprising:
(a) providing a first solution comprising ATP and a protein kinase to be tested, and a second solution comprising ATP in the...
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6911432 |
Drugs, foods or drinks with the use of algae-derived physiologically active substances
Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose are represented by formula (I):
These compositions include foods,...
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6905836 |
Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of iκb
Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6878517 |
Multispecies food testing and characterization organoleptic properties
A testing system useful for food products employs a multispecies testing array to test for presence or amount of a plurality of organisms in a sample by detecting plural characteristic sequences...
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6866995 |
Method to enable assessment of growth and death of micro-organisms
The invention is a method of assessing growth and death rates of micro-organisms within a time period environment of interest. Two reporter genes coding for luminescent and/or fluorescent products...
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6852499 |
Luciferase detection reagent kits and luciferase detection method using the kit
The present invention provides a detection method and a method of manufacturing a detection kit, both characterized by use of an organic sulfur reagent, and which are effective at low concentration...
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6815214 |
Pharmaceutical uses and synthesis of diketopiperazines
The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of...
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6811990 |
Methods and compositions for coupled luminescent assays
The present invention provides a set of methods and compositions for homogeneous coupled luminescent assays of cytotoxicity and/or proliferation of cells, as well as for enzymatic activity. In both...
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6806361 |
Methods of enhancing functional performance of nucleic acid arrays
Methods are provided for preparing nucleic acid arrays on a support. In these methods a plurality of nucleic acids are synthesized on the support and the synthesis steps are followed by drying...
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6787326 |
Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells....
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6787133 |
Using purified telomerase to identify telomerase activators and inhibitors
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
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6787325 |
Complexes containing crosslinked avidin, analytical method with the use of crosslinked avidin and analytical reagents and kits
Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately...
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6787142 |
Mutant human hepatitis B viral strain and uses thereof
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-‘S’-133 Oon Strain (Methionine to Threonine) which constituent viral genome is...
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6781032 |
Homologous recombination in plants
The present invention provides novel methods for modifying target nucleotide sequences in a plant cell through the use of homologous recombination. The plant cell is transformed with a DNA...
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6767705 |
Reagents and methods for identifying and modulating expression of genes regulated by retinoids
This invention identifies growth-inhibitory genes induced by retinoids. The invention provides reagents and methods for identifying compounds other than retinoids that induce expression of these...
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6756198 |
Oligonucleotide for highly sensitive detection of hepatitis C virus and method for detection thereof
An oligonucleotide useful for specific amplification of HCV RNA, or highly sensitive detection and identification of HCV RNA, and a combination thereof. A detection method using RNA amplification...
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6737245 |
Luciferase expression cassettes and methods of use
The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and...
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6730479 |
Detection of nucleic acid hybrids
Processes are disclosed using the depolymerization of a nucleic acid hybrid to qualitatively and quantitatively analyze for the presence of a predetermined nucleic acid. Applications of those...
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6720153 |
Luciferase reporter bioassay of parathyroid hormone compounds
This invention is directed to a bioassay for determining the functionality of parathyroid hormone compounds. More particularly, this invention is directed to a bioassay wherein the compound to be...
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6716595 |
Method for detecting sphingosine-1-phosphate (S1P) for cancer detection
The present invention relates to non-radioactive enzymatic methods for detecting Sphingosine-1-Phosphate (S1P) in biological fluids. The present invention further relates to a method of detecting...
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6703211 |
Cellular detection by providing high energy phosphate donor other than ADP to produce ATP
Processes and materials are disclosed for the detection of cells using endogenous enzymes to catalyze the conversion of AMP and/or ADP to ATP in the presence of a high energy phosphate donor other...
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6699657 |
In vitro system for replication of RNA-dependent RNA polymerase (RDRP) viruses
An in vitro method to conduct genomic replication of the viral genomes of viruses that utilize RNA-dependent RNA polymerase for replication (RDRP viruses), such as HCV. The method employs a...
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6696244 |
G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof
The present invention provides two new HIV/SIV translocation promoting agents, Bonzo and BOB. The present invention also provides the amino acid and DNA sequences of human, African green monkey,...
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6689577 |
Reagent and procedure for the detection of pathogens, especially spirochetes from body fluids
A reagent for microscopy-based detection of pathogens, especially spirochetes, from body fluids characterized by that containing the following ingredients: tetracain (125-200 mg/l), mannit...
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6673596 |
In vivo biosensor apparatus and method of use
Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been...
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