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8129196 |
Parallel loading of arrays
The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray...
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7943184 |
Process for preparing an extract from ivy leaves
The present invention relates to a process for preparing an extract from ivy leaves which includes the active ingredient hederacoside C and α-hederin, and to extracts prepared by this process. ...
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7910334 |
Biotransformation of colchicinoid compounds
The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.
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7816079 |
Method of DNA sequencing using cleavable tags
The present invention provides novel systems for sequencing nucleic acid molecules using dNTPs that are 3′ end labeled with cleavable tags that block further extension and uniquely identify the b...
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7759101 |
Ginsenoside glycosidases hydrolyzing ginsenoside sugar moieties and uses thereof
The invention relates to ginsenoside glycosidases which hydrolyzes ginsenosides having higher contents in ginsengs so as to prepare rare ginsenosides with high physioloigical activity. Said...
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7419751 |
Titanylphthalocyanine crystal and method of producing the titanylphthalocyanine crystal, and electrophotographic photoreceptor, method, apparatus and process cartridge using the titanylphthalocyanine crystal
A titanylphthalocyanine crystal having an X-ray diffraction spectrum having plural diffraction peaks and a primary particle diameter not greater than 0.2 μm, wherein a maximum diffraction peak is ...
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7208294 |
Display device and display panel driving method
A display device and a display panel driving method, in which a matrix panel includes pixel portions each have a series circuit of a bistable element and a light emitting element, every time one...
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6613523 |
Method of DNA sequencing using cleavable tags
The present invention provides novel systems for sequencing nucleic acid molecules using dNTPs that are 3′ end labeled with cleavable tags that block further extension and uniquely identify the b...
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6562569 |
Arrays with modified oligonucleotide and polynucleotide compositions
The present invention provides arrays having associated modified oligonucleotides that selectively bind to DNA or RNA, methods of making such arrays, assays for using such arrays, and the like. In...
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6410265 |
Gene encoding a putive efflux protein for solvents/antibiotics in Pseudomonas mendocina
This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an...
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6399583 |
Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof
The present invention relates to novel hybrid anthracyclines generated by cloning of fused genes in a mutated Streptomyces galilaeus strain DSM 11638. Said strain was obtained by mutagenization of...
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6210930 |
Process for preparing doxorubicin
The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated....
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6187758 |
Anthracycline glycosides
An anthracycline glycoside of formula I ##STR1##wherein R is one of the two following residues: ##STR2##or a pharmaceutically acceptable salt thereof.
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6080561 |
Variety of Stevia Rebaudiana Bertoni
The present invention provides seeds for cultivation of a new variety of Stevia rebaudiana Bertoni, the new variety, a sweetening obtained from dried leaves of the new variety and a process for...
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6048712 |
Process for producing α-monoglucosyl hesperidin-rich substance
The present process for producing a high α-monoglucosyl hesperidin content product is characterized in that it comprises the steps of contacting glucoamylase and α-L-rhamnosidase simultaneously o...
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5989869 |
Process for preparing daunorubicin and doxorubicin
The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in...
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5976830 |
Methods of producing doxorubicin
The present invention provides novel methods for producing doxorubicin using daunomycin as a substrate. One method employs a genetically engineered host microorganism which is transformed with a...
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H001817 |
Enzymatic methods for the preparation of pradimicins
Enzymatic hydrolysis and glycosidation methods for the preparation of pradimicin compounds, especially the compound BMY-28960: ##STR1## and salts thereof.
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5965407 |
Anthracycline compound 0624
The present invention relates to compound 0624 having excellent antitumor activity and antimicrobial activity, which is represented by the general formula (1), and a pharmaceutically acceptable...
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5932555 |
Terpenoid compound 0406TP-1
The present invention relates to compound 0406TP-1 represented by the general formula (I): ##STR1## wherein Ac represents an acetyl group and Me represents a methyl group, or a pharmaceutically...
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5869298 |
Stable mutants of D-N-α-carbamoylase and process for preparing D-α-amino acids
The present invention relates to mutants of D-N-α-carbamylase wherein at least one of the cysteines in position 243, 250 and 279 of the amino acid sequence of the wild type enzyme is substituted ...
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5843735 |
Aklavinone C-11 hydroxylase, gene coding for same, expression vector therefor, and process for preparing hybrid antibiotics by using said vector
Aklavinone C-11 hydroxylase separated from Streptomyces sp.; a gene encoding same; an expression vector comprising said gene; a microorganism transformed with said vector; and a process for...
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5821098 |
Glycosyltransferase gene gtfD from amycolatopsis orientalis
The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed...
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5756335 |
CDC25A and CDC25B proteins, fusion proteins thereof, and antibodies thereto
Two previously undescribed human cdc25 genes, designated cdc25 A and cdc25 B, which have been shown to have an endogenous tyrosine phosphatase activity that can be specifically activated by B-type...
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5747312 |
Human AlkB polypeptide
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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5702924 |
Process for preparing antiparasitic agents
Compounds of the formula: ##STR1## wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2...
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5698528 |
Substance IT-62-B and medicinal composition containing the same
A substance IT-62-B represented by the following formula (1): ##STR1## a production process thereof, a medicinal composition comprising the compound as an active component, and methods of treating...
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5695966 |
DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can...
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5691169 |
Process for preparing a desired protein
A desired protein having the formula: A-B-C-Pwherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is...
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5681725 |
Process for producing heme proteins
Process for producing an extracellular heme protein in increased yields, the process comprising culturing an apoprotein producing microorganism in a fermentation medium containing heme or a...
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5665564 |
Isolation and characterisation of genes resistant to anthracycline antibiotics
Doxorubicin resistance can be conferred on a host by transforming the host with a recombinant vector comprising a DNA having the configuration of restriction sites shown in FIGS. 1 or 2 of the...
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5652125 |
Process for preparing daunorubicin
The ability to improve the conversion of ε-rhodomycinone to daunorubicin can be conferred on a bacterial host transformed with a recombinant vector comprising a DNA coding for an appropriate ...
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5652124 |
α-glycosyl hesperidin, and its preparation and uses
α-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the α-bond, is formed by a saccharide-transferring enzyme in a liquid c...
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5650283 |
Biological assay for detecting agonists to the Ah receptor
Murine and human Ah receptor cDNAs are provided. These molecules can be used to generate large quantities of Ah-receptor protein. The Ah receptor can be inserted into cell systems such as yeast or...
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5639735 |
Antitumor antibiotic compounds: hayumicins and analogs thereof
Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic,...
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5597806 |
Antifungal agents
There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
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5484712 |
Method for producing aclacinomycins A, B, Y using Strepomyces lavendofoliae DKRS
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS(KCTC...
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5468637 |
S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins A, B, Y and aglycones
Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC...
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5374552 |
Production of pradimicin antibiotics
The present invention relates to a fermentation process for producing BMY-28960 and desxylosyl BMY-28960, and to a novel BMY-28960-producing organism belonging to the genus Actinomadura and...
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5147860 |
TAN-1120, its derivatives, production and use thereof
The present invention relates to a compound of the formula: ##STR1## wherein X is hydroxyl group or hydrogenatom, or a salt thereof. The compound (I) has an acitivity to inhibit angiogenesis, which...
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5066585 |
Method of inhibiting fungus using novel antifungal compounds
A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production,...
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5013549 |
Production, isolation, and identification of novel antifungal compounds
A new species of Micromonospora, in particular Micromonospora spartanea ATCC 53803, is described. The species produces antifungal compounds spartanamicins A and B. Methods for the production,...
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4954438 |
Process for preparing antibiotics D788-7
This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while...
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4950612 |
Peroxy acid pretreatment in vitamin B12 assay
Serum samples for vitamin B12 analysis can be pretreated using a combination of peroxy acid and dithiothreitol. The pretreatment makes vitamin B12 bound to serum binding proteins available for...
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4939125 |
Acyl derivatives of urdamycin A, their preparation and their use
The O-acyl derivatives of urdamycin A exhibit an antibiotic or antitumoral activity.
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4927754 |
Method for selectively increasing the ratio of single major components of teicoplanin A2 complex
The object of this invention is to provide a method for selectively increasing the ratio of the single T-A2 major components in the T-A2 complex. More particularly, the object of this invention is...
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4895933 |
New antitumor agent obtained by microbial stereoselective reduction of 4'-deoxy-4'-iododoxorubicin
4'-Deoxy-13(S)-dihydro-4'-iododoxorubicin having the formula (II): ##STR1## and pharmaceutically acceptable salts thereof are anti-tumor agents.
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4859655 |
Urdamycin G and derivatives thereof, a process for their preparation and their use
A new substance, urdamycin G, has been found which, like its O-acyl derivatives, exhibits an antibiotic or antitumoral activity.
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4649058 |
Gluco-oligosaccharide mixture and a process for its manufacture
A gluco-oligosaccharide mixture having up to 30, in particular from 10 to 20, anhydroglucose units is prepared by reacting an aqueous solution of a mono-or disaccharide composed of glucose units...
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4647529 |
Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
Improved hybridization probe compositions and method for detecting nucleic acids are provided. A hybridization probe constructed to contain thionucleotides is hybridized to a nucleotide sequence of...
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