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7595156 |
Genes for synthesis of FR-008 polyketides
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes...
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7560252 |
Borrelidin-producing polyketide synthase and its use
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis...
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7521414 |
Polyol macrolide antitumor-antibiotics from the marine actinomycete strain CNQ140
A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population...
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7459294 |
Method of producing a compound by fermentation
During the production of a product compound by fermentation, the concentration of a precursor compound is maintained within a pre-selected concentration range by having an adsorbent resin in...
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7413878 |
Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
Host cells, such as E. coli , are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway.
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7291486 |
Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA
Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces...
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7285653 |
Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis
The present invention relates to nucleic acid coding for enzyme activities of spinosyn biosynthesis and to the relevant enzymes per se. Furthermore, the invention relates to methods for preparing...
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7220560 |
Secondary metabolite congener distribution modulation
The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various...
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7208294 |
Display device and display panel driving method
A display device and a display panel driving method, in which a matrix panel includes pixel portions each have a series circuit of a bistable element and a light emitting element, every time one...
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7067286 |
Cystobacterineae host cells containing heterologous PKS genes for the synthesis of polykedtides
Recombinant host cells of the suborder Cystobacterineae, genus Stizmatella , containing recombinant expression vectors that encode heterologous epothilone polyketide synthase (PKS) genes and can...
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7049100 |
Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal...
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7033621 |
Isoflavone compositions produced from legumes
Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to...
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7018814 |
Process of purifying vancomycin hydrochloride
Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin...
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7011959 |
Heterologous production of polyketides
Recombinant E. coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis...
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7001748 |
Methods of making polyketides using hybrid polyketide synthases
Linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the...
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7001747 |
Nucleic acid molecules encoding modified polyketide synthases containing polylinkers and uses thereof
Nucleic acid molecules encoding at least part of a Type I polyketide synthase, and having a polylinker with multiple restriction enzyme sites in place of one or more PKS genes encoding enzymes...
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6998256 |
Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example, Sorangium cellulosum and Myxococcus xanthus (recombinant)....
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6984515 |
Macrolide analogs
A polyketide or glycosylated polyketide which has the formula:
wherein R* is methyl or ethyl;
each of R 1 -R 6 is methyl;
X 1 is OH or H; and/or
X 2 is=O, OH or H;
X 3 is OH or H;
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6960453 |
Hybrid polyketide synthases combining heterologous loading and extender modules
A hybrid type I polyketide synthase gene typically containing a starter module and a plurality of heterologous extender modules is used to synthesize novel polyketides. It is preferably under the...
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6939691 |
E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
The use of enzymes that catalyze the production of starter and extender units for polyketides in E. coli and Streptomyces is described; these enzymes include malonyl CoA decarboxylase (MatA),...
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6902925 |
Selection media for beauveriolide I or beauveriolide III and process for selectively producing these substances
The present invention is a process for selective production of beauveriolide I substance or beauveriolide III substance, in which a beauveriolide producing microorganism strain FO-6979 or mutant...
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6902913 |
Recombinant narbonolide polyketide synthase
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of...
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6884604 |
Glycorandomization and the production of novel erythronolide and coumarin analogs
The present invention provides combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in...
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6858404 |
Genes for the biosynthesis of epothilones
Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in...
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6846654 |
Catalytic antibodies as chemical sensors
A system for detecting physical or chemical changes in an environment is disclosed. The system comprises means for conducting a chemical reaction; an active biological molecule whose physiological...
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6838265 |
Overproduction hosts for biosynthesis of polyketides
Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement.
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6828126 |
Methods for introducing hydroxyl or epoxide groups into polyketides using OleP
The heterologous expression of the oleandomycin polyketide synthase (OlePKS) in Streptomyces lividans , produces 8,8 a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression...
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6808903 |
Preparation of a macrocyclic lactone
Subject of the invention is a process for the preparation of a compound of formula (I) in which R 1 -R 9 represent, independently of each other hydrogen a substituent; m is 0, 1 or 2; n is 0, 1, 2...
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6689611 |
Modified Streptomyces host cells for increased avermectin production and methods of making the same
The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and...
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6558942 |
Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The...
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6551802 |
Methods for making polyketides
The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT...
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6503737 |
Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster
Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising...
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6495348 |
Mitomycin biosynthetic gene cluster
The invention provides a biosynthetic gene cluster for mitomycin, for example, a mitomycin biosynthetic cluster from organisms such as Streptomyces, for instance, S. lavendulae , as well as...
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6395743 |
HIV integrase inhibitors
Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts,...
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6395711 |
Macrolides with antitumor activity
The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can...
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6303342 |
Recombinant methods and materials for producing epothilones C and D
Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones,...
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6274350 |
Biosynthetic genes for spinosyn insecticide production
Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal...
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6251636 |
Recombinant oleandolide polyketide synthase
Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of...
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6197591 |
Streptomyces avermitilis regulatory genes for increased avermectin production
The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and...
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6177262 |
Recombinant host cells for the production of polyketides
Yields of polyketides produced in host cells such as Streptomyces can be increased by coexpression of the ptpA gene. The introduction of recombinant vectors encoding ptpA and polyketide synthase...
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6146668 |
Preparation of isoflavones from legumes
Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the...
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6132993 |
Process for the production of amphotericin-B inhibiting production of amphotericin-A
Methods are provided for improving the microbial production of amphotericin B by the selective inhibition of amphotericin A by means of protein synthesis inhibitors.
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5925550 |
Method for selectively increasing the ratio of single major components of antibiotic A/16686 complex
The present invention relates to a method for selectively enhancing the production of factors A 2 and/or A 3 of antibiotic A/16686 either to isolate these single components or to enrich the...
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5908764 |
Methods and compositions for increasing production of erythromycin
Methods and compositions for increasing the production of erythromycins are provided. In particular, the invention relates to the engineering of erythromycin-producing organisms to express a...
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5905034 |
Method for precipitating natural avermectins
A process for separating a natural B avermectin from a natural avermectin containing fermentation broth by using an aqueous precipitation. The process comprises extracting natural avermectins from...
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5879913 |
Process for the production of sophorolipids by cyclic fermentation with feed of fatty acid esters or oils
A process for the production of sophorolipids by a stock of Candida bombicola or apicola in a medium that contains a source of nitrogen and a substrate is described. The process includes a first...
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5851792 |
Aglucone isoflavone enriched vegetable protein whey whey protein material aglucone isoflavone material high genistein content material and high daidzein content material and process for producing the same from a vegetable protein whey
An aglucone isoflavone enriched vegetable protein whey, whey protein material, high genistein material, high daidzein material, and aglucone isoflavone material are provided, as well as a process...
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5843679 |
Method for selectively enhancing the production of factors A or B.sub.0 of antibiotic A 40926 complex
The present invention is directed to a method for selectively enhancing the production of factors A, and/or B 0 of antibiotic A 40926 either to isolate these single components in better yields or...
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5840861 |
A83543 compounds and process for production thereof
New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of...
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5824513 |
Recombinant DNA method for producing erythromycin analogs
A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific...
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