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8148102 |
Sequences for FK228 biosynthesis and methods of synthesizing FK228 and FK228 analogs
Polynucleotides encoding the polypeptides involved in biosynthesis of FK 228 and those involved in synthesis of a novel FK228 analog, thailandepsin are disclosed herein. Also provided are methods...
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8129139 |
Process for obtaining botulinum neurotoxin
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
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8119371 |
Process for the preparation of polymyxin B employing (PAENI) Bacillus polymyxa
The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxin B with yield from 1.8 to 2.8 g/l of filtrate of...
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8110549 |
Alpha-conotoxin peptides
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or ...
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8101573 |
α-conotoxin MII analogs
The invention relates to novel conopeptides and/or novel uses of conopeptides. The conopeptides of the invention are analogs of α-Conotoxin MII that are selective for α6-containing nAChRs as d...
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8021862 |
Process for preparing human G-CSF
The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
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8003348 |
Method for the mass expression of an antimicrobial peptide by co-expression of a basic antimicrobial peptide and an acidic peptide using a translational coupling system
The present invention relates to a gene construct which is capable of achieving efficient production of an antimicrobial peptide in a microorganism, and a method for efficient mass production and...
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7939081 |
Method for producing cercosporamide
The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus Lachnum and/or fungus belonging to the genus Pseudaegerita and recovering...
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7935503 |
Methods for producing and using polymyxins
The present invention provides methods for producing a polymyxin from an isolated Paenibacillus amylolyticus, and methods for using the polymyxin, including methods for producing a recombinant...
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7927836 |
Device and method for the production of biologically active compounds by fermentation
The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is...
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7855059 |
Fermentation with cyclic pulse-pause feeding
A process for the production of a valuable compound, comprising the steps of a) fermentation of a filamentous bacterial or fungal strain (e.g. a Streptomyces strain or an Aspergillus strain) in a...
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7846435 |
Humanized antibodies that recognize Verotoxin II and cell line producing same
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of...
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7833524 |
Method of preparing botulinum neurotoxin type E light chain
The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists...
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7829321 |
Method for the production of bacterial toxins
Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression...
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7820411 |
Escherichia coli-derived vaccine and therapy against botulism
A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an...
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7811598 |
AXMI-028 and AXMI-029, a family of novel delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
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7803391 |
AXMI-028 and AXMI-029, a family of novel delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
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7771972 |
Gene cluster of pederin biosynthesis genes
The present invention relates to the cloning, sequencing and analysing of a gene cluster encoding a modular polyketide synthase enzyme involved in the biosynthesis of the antitumor compound...
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7745175 |
Polynucleotides encoding Clostridium perfringens alpha toxin proteins
This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic...
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7666631 |
Adenosylmethionine synthetase from streptomyces sp., gene sequences coding the same and method for mass production of secondary metabolites including antibiotics thereof
Disclosed is an isolated nucleotide sequence encoding an enzyme catalyzing biosynthesis of SAM (SAM-s) and its amino acid sequence. Also, the present invention provides a method for mass production...
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7582291 |
Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
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7553832 |
Methods and compositions for specific inhibition of protein splicing by small molecules
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the...
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7517667 |
Methods for promoting, inhibiting and detecting toxin entry into cells
In vitro delivery of the diphtheria toxin (DT) catalytic (C) domain from the lumen of purified early endosomes to the external milieu requires the addition of both ATP and a cytosolic translocation...
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7465443 |
Acellular antibordetella vaccine
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of...
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7449311 |
Method of producing macedocin by culturing Streptococcus macedonicus
The invention relates to the field of bacteriocin producing microorganisms. The invention more specifically relates to the characterization of a novel food grade bacteriocin, namely a lantibiotic,...
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7446094 |
Cytotoxic depsipeptides
Compounds of general formula (I) wherein R1, R2, R3 are as defined and R4 groups are each independently selected from NR2, O and S; are of use in treatment of cancers.
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7432080 |
Process for the production of teicoplanin
The present invention provides a newly isolated mutant culture of Actinoplanes teichomyceticus BNG 2315. This culture is capable of producing teicoplanin more than 60 times productivity than those...
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7407654 |
Antibiotics GE 81112 factors A,B,B1, pharmaceutically acceptable salts and compositions, and use thereof
The invention relates to an antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 81112 factor A, factor B1 and factor B, which is produced by fermentation of...
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7396665 |
Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
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7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7335495 |
Process for the isolation of pharmaceutical compound cyclosporin a from fungus fusarium nivale
The present invention describes the development and standardization of a facile method for the isolation and purification of cyclosporin A from a new source, viz., Fusarium nivale and evaluation of...
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7326782 |
Metabolic engineering of viomycin biosynthesis
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
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7326689 |
Pseudomycins useful against plant diseases
Plants and crops subject to attack by fungal related diseases are protected or treated by the application of Pseudomycin compositions which were originally isolated from Pseudomonas syringae.
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7312080 |
Plant resistance to insect pests mediated by viral proteins
The invention involves combining a peptide toxin effective against insects, including but not limited to thrips, leaf hoppers, and beetles, with a transport peptide capable of facilitating transfer...
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7241614 |
Methods for producing polypeptides in Aspergillus mutant cells
The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid...
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7232800 |
Derivatives of magainin and methods of production thereof
The present invention provides a Magainin derivative peptide and method of production thereof. Also provided is a pharmaceutically composition comprising said Magainin derivative peptide and...
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7192743 |
Method of producing teicoplanin
Disclosed is a method of producing teicoplanin. The method includes purifying teicoplanin from a culture broth, obtained by culturing microorganisms capable of producing teicoplanin by a porous...
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7176001 |
Manufacture and purification of cyclosporin A
The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under...
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7169756 |
Streptogramin antibiotics
Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.
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7144858 |
Antibacterial compounds and methods for treating Gram positive bacterial infections
The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject...
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7141395 |
Biological control of crown gall disease
The present invention provides a method for controlling crown gall disease in plants using an effective quantity of α-proteobacteria that produces trifolitoxin (TFX). The present invention also ...
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7118749 |
Transferrin receptor genes
Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic...
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7105317 |
Immunogenic compositions comprising vrg-gene products from Bordetella extracts
This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B. pertussis,...
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7052874 |
Detection of antibacterial activity in excretory secretory product of adult Trichuris suis
The present invention provides a heat-stable and protease-resistant antibacterial activity in excretory-secretory products (ESP) of Trichuris suis. The antibacterial activity is not more than...
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7045314 |
Method for the production of bacterial toxins
Methods and compositions are provided for the enhanced production of bacterial toxins in large-scale cultures. Specifically, methods and compositions for reducing bacterial toxin expression...
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7030085 |
Thiopeptide compounds
A microorganism belonging to the genus Bacillus is cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs...
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7018814 |
Process of purifying vancomycin hydrochloride
Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin...
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6986893 |
Method for treating a mucus secretion
A method and composition for treating a patient suffering from an excessive mucus secretion includes administration to the patient of a therapeutically effective amount of a botulinum toxin type A,...
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6964860 |
Glycopeptide antibiotics
The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
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6896886 |
Use of botulinum toxins for treating various disorders and conditions and associated pain
A method and composition for treating a patient suffering from a disease, disorder or condition and associated pain include the administration to the patient of a therapeutically effective amount...
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