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7605000 |
Cold shock inducible expression and production of heterologous polypeptides
The present invention relates to a DNA molecule or vector and a host cell containing this DNA molecule or vector which can be used to produce a heterologous polypeptide under conditions that elicit...
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7597904 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7588929 |
Production of bacteriophage compositions for use in phage therapy
The present invention relates to the use of bacteriophages to treat infectious diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage...
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7547529 |
Methods for reducing the formation of by-products in the production of recombinant polypeptides
A method for reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the...
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7544493 |
Method for the purification of an N-terminal fragment of hepatocyte growth factor
A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell,...
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7534586 |
Method for producing biomass
The invention relates to a method for producing biomass from halophilic organisms, in which the halophilic organisms are fermented in a hollow space in a salt dome and said halophilic organisms or...
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7498155 |
Microbial nanowires, related systems and methods of fabrication
Conductive nanowires, as are available from a range of bacteria species, methods of use and related device structures.
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7491528 |
Method for extracellular production of target proteins employing OmpF in E. coli
The present invention provides an expression vector comprising genes encoding OmpF of E. coli and a desired protein, E.coli transformed with the expression vector, and a method for...
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7465443 |
Acellular antibordetella vaccine
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of ...
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7459161 |
Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins
The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export...
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7456272 |
Neurotoxins with enhanced target specificity
Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle...
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7449311 |
Method of producing macedocin by culturing Streptococcus macedonicus
The invention relates to the field of bacteriocin producing microorganisms. The invention more specifically relates to the characterization of a novel food grade bacteriocin, namely a lantibiotic,...
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7422863 |
Molting hormone receptor and method for screening ligand to the receptor
The present invention provides a completely novel molting hormone receptor, which is used for efficiently screening a substance that can be applied to a disinfestant or the like. An insect molting...
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7419804 |
CASH (Caspase Homologue) with death effector domain, modulators of the function of FAS
Proteins capable of modulating or mediating the function of MORT-1 are disclosed. Also disclosed are DNA sequences encoding these proteins, the recombinant production of these proteins as well as...
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7396665 |
Method of producing FR901228
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for...
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7374874 |
Bacteriophages that infect Bacillus bacteria (Anthrax)
The invention provides bacteriophages that infect Bacillus bacteria, including Bacillus anthracis , and compositions containing the bacteriophages. The invention also provides methods for using...
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7368547 |
Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of Listeria monocytogenes
A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are...
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7341852 |
Methods of decoupling reaction scale and protein synthesis yield in batch mode
Biological macromolecules are synthesized in vitro in a thin film that provides for high surface area/volume ratio, allowing improved yield in scaled up reactions.
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7338789 |
Methods of in vitro protein synthesis
Biological macromolecules are synthesized in vitro under conditions and in a reaction composition wherein oxidative phosphorylation is activated and protein folding is improved.
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7329513 |
High level constitutive production of anthrax protective antigen
The present invention relates to a process for preparing anthrax protective antigen protein from E. coli using fed batch culture. This process creates a constitutively expressing system for...
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7300790 |
Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins
The present invention relates to non-vaccinal and non-pharmacologic compositions and methods for controlling complex retroviral infections. In particular, the present invention provides transgenic...
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7297514 |
Method for preventing superoxide damage to cells and oxygen-labile proteins
A method of reducing superoxide damage to a cell is disclosed. In one embodiment, this method comprises the step of engineering the cell to produce more than a native amount of the YggX protein or...
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7282354 |
Method for producing fermented milk product
There is provided a fermented milk product that contains lactic acid bacteria capable of producing a large amount of lactotripeptide and a large amount of active ingredient having hypotensive...
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7264949 |
Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
The promoter region associated with the Yarrowia lipolytica glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes...
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7258996 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7256018 |
Microorganism producing L-threonine having inactivated tyrR gene, method of producing the same and method of producing L-threonine using the microorganism
Provided are a microorganism capable of producing L-threonine and having an inactivated tyrR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The...
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7247453 |
Calcium binding recombinant antibody against protein C
A Ca 2+ dependent recombinant antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C has been constructed. The...
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7241590 |
Identification and cloning of a full-length human Clnk-related gene, MIST (mast cell immunoreceptor signal transducer)
The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human...
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7241614 |
Methods for producing polypeptides in Aspergillus mutant cells
The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid...
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7229794 |
Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
Provided are a microorganism capable of producing L-threonine and having an inactivated galR gene, a method of producing the same and a method of producing L-threonine using the microorganism. The...
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7227010 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain...
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7223567 |
Mutant E. coli strain with increased succinic acid production
The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic...
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7214787 |
Recombinant vaccine against botulinum neurotoxin
This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to...
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7202059 |
Fusion proteins capable of being secreted into a fermentation medium
Fusion protein including a fusion part and a protein of interest, the combination of the two proteins leading to the fusion protein being secreted into a supernatant of a bacterial host with the...
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7198918 |
Nucleic acid encoding a human serrate-1 polypeptide
A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in...
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7192742 |
FO-6979 substances and process for producing the same
( Beauveria ) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby...
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7189550 |
β1,3-galactosyltransferase and DNA encoding the same
The present invention provides a protein having β1,3-galactosyltransferase activity, a DNA encoding the protein, a transformant comprising the DNA, a process for producing the protein using the...
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7179622 |
Method of suppressing differentiation by administering a human serrate-1 polypeptide
A polypeptide which contains the amino acid sequence described in SEQ ID NO: 1 in the Sequence Listing encoded by a gene originating in human being. Because of serving as a chemical efficacious in...
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7169912 |
PRO1017 nucleic acids
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7125690 |
Promoters showing stationary phase-specific activity in gram-positive bacteria
Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS: 1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in...
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7125679 |
Methods to screen peptide libraries using minicell display
A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process....
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7122352 |
Polynucleotide encoding mammalian cytokine-like polypeptide-10
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
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7115725 |
Multi-mutant diphtheria toxin vaccines
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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7105317 |
Immunogenic compositions comprising vrg-gene products from Bordetella extracts
This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B....
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7105653 |
IL-2 selective agonists and antagonists
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
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7094579 |
Eukaryotic signal sequences for prokaryotic expression
The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
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7078027 |
Human endokine alpha
The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha...
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7078193 |
Pathogenic Escherichia coli associated protein espA
The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli , such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli . The invention also...
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7070944 |
System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a...
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7063950 |
Nucleic acids encoding human calcium channel and methods of use thereof
Isolated DNA encoding each of human calcium channel α 1 -, α 2 -, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors...
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