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7390633 |
Methods for preparing low molecular weight heparin with modified heparinase III
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of...
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7384771 |
Beta 1,4-N-acetylgalactosaminyltransferases from C. jejuni
This invention provides prokaryotic β1,4-N-acetylgucosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). The β1,4-GalNAc transferases can be obtained from, for...
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7384767 |
Nucleic acid encoding an interleukin-9 receptor variant
This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One...
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7381545 |
Method for controlling metallophosphate precipitation in high cell density fermentations
The invention relates to the use of a phosphate glass as a phosphorous source in the media of high cell density bacterial fermentation processes in order to reduce metallophosphate precipitation...
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7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7375205 |
Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these...
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7374917 |
Mutant 2.5-diketo-L-gluconic acid reductases
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
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7371838 |
Nucleic acids encoding β 1,4-N-acetylgalactosaminyltransferases from C. jejuni
This invention provides prokaryotic β1,4-N-acetylglucosaminyl (GalNAc) traosferases involved in synthesis of lipooligosaccharide (LOS). The β1,4-GalNAc transferases can be obtained from, for...
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7371824 |
PRO6093 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7371821 |
Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus
The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi , Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa...
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7368547 |
Use of novel virulence-specific genes as targets for diagnosis and potential control of virulent strains of Listeria monocytogenes
A method for identifying virulent strains of L. monocytogenes that includes the use of primers or probes in a PCR assay or hybridization technique that employs primers or probes, which are...
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7368272 |
Expression of proteolytic enzymes in koji mold in the presence of carbon sources
The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the...
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7368261 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7365184 |
B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production
The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2...
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7365157 |
PRO9912 polypeptides
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7364724 |
Recombinant super-compound interferon
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor...
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7361738 |
Megakaryocyte stimulating factors
Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided.
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7361348 |
Immunogenic glycopeptides, screening, preparation and uses
The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or...
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7358355 |
Antibodies against human parathyroid hormone related protein
Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant...
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7358074 |
Human phosphatase RET31, and variants thereof
The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant...
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7354740 |
Animal product free system and process for purifying a botulinum toxin
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
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7351555 |
Mouse cytokine receptor Zcytor16
Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as “mouse...
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7351550 |
Exoenzyme toxin of Aeromonas salmonicida, and uses thereof
A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent...
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7348015 |
Antigen modified cancer cell vaccines for cancer therapy
Disclosed are methods for treating cancers, particularly tumorigenic types. Cancer cells are modified to express highly immunogenic antigens so that the cells will generate a defensive response in...
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7347995 |
Compositions and methods for achieving immune suppression
Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient.
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7344880 |
Nucleic acid encoding PRO9912 polypeptides
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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7344856 |
Method of controlling cleavage by OmpT protease
Methods of using OmpT protease are provided. In particular, the invention provides for a method of controlling cleavage of a polypeptide by OmpT protease comprising, converting a sequence site...
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7339037 |
Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins
The invention provides a method of inhibiting prophylactically or therapeutically an influenza viral infection in a host. The method comprises instilling into or onto a host a cell producing an...
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7335504 |
Engineered enzymes and uses thereof
The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for...
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7335495 |
Process for the isolation of pharmaceutical compound cyclosporin a from fungus fusarium nivale
The present invention describes the development and standardization of a facile method for the isolation and purification of cyclosporin A from a new source, viz., Fusarium nivale and evaluation...
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7332322 |
Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof
The present invention provides a Venezuelan equine encephalitis virus replicon RNA useful in the development of stable lines of mammalian, avian and insect cells in which these replicons will...
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7332316 |
Plant cytokinin oxidase
The present invention relates to methods for stimulating root growth and/or enhancing the formation of lateral or adventitious roots and/or altering root geotropism comprising expression of a plant...
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7329527 |
Serine proteases from gram-positive microorganisms
The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nuclei acid and amino acid sequences for the ...
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7329523 |
Phosphoserine phosphatase of coryneform bacteria and variants thereof
The present invention provides a DNA coding for a protein defined in the following (A) or (B) is obtained from Brevibacterium flavum chromosomal DNA library by cloning a DNA fragment that...
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7329518 |
Enzyme for producing optically active pyridineethanol derivatives
The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic...
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7329513 |
High level constitutive production of anthrax protective antigen
The present invention relates to a process for preparing anthrax protective antigen protein from E. coli using fed batch culture. This process creates a constitutively expressing system for...
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7326782 |
Metabolic engineering of viomycin biosynthesis
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
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7323558 |
Nucleic acids encoding dendritic cell transmembrane serine protease
Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can...
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7320794 |
Transporter protein
A novel protein which has an activity to transport hydantoin compounds is described, as well as a recombinant expressing this transporter protein. From Microbacterium liquefaciens strain AJ3912,...
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7319021 |
Cell lysis composition, methods of use, apparatus and kit
Cell lysis compositions, methods for extracting and isolating proteins and peptides from a host cells using the compositions, kits and apparatus for extracting and isolating protein and peptide...
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7317088 |
PRO5993 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7314737 |
Method of effecting a change in a cell, and a vector
A method of effecting a change in a cell using a transfer system which is contacted with the cell to be changed. The transfer system comprises a fusion protein which is transferred into the cell...
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7312312 |
PRO6242 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7312051 |
Polynucleotides encoding dendritic enriched secreted lymphocyte activation molecule
The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are...
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7304141 |
Human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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7304140 |
PRO4503 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7297514 |
Method for preventing superoxide damage to cells and oxygen-labile proteins
A method of reducing superoxide damage to a cell is disclosed. In one embodiment, this method comprises the step of engineering the cell to produce more than a native amount of the YggX protein or...
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7294482 |
EGF-like nucleic acids
The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1, 2, and 3). ELVIS nucleic acid molecules encode...
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7291495 |
β-Secretase variant
The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to...
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