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6841360 |
Nucleotide sequences coding for the export of branched-chain amino acids, process for the isolation thereof and use thereof
This invention relates to isolated polynucleotides containing at least one of the polynucleotide sequences selected from the group
a) polynucleotide which is at least 70% identical to a...
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6838554 |
Nucleic acids encoding proteins that stimulate the proliferation of t-lymphocytes
The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer, and...
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6838555 |
Hansenula polymorpha mutants and process for the preparation of recombinant proteins using the same
Disclosed are Hansenula polymorpha mutants useful as host cells through which various proteins can be produced as being intact at high yield and a process for preparing recombinant proteins using...
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6838290 |
Methods for screening compounds that affect IL-1 epsilon activity
The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such...
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6828121 |
Bacterial host strains
An E. coli strain is described that is deficient in chromosomal degP and prc encoding protease DegP and Prc, respectively, and harbors a mutant spr gene that encodes a protein that suppresses...
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6825004 |
Nucleic acids encoding human TBC-1 protein and polymorphic markers thereof
The invention concerns genomic and cDNA sequences of the human TBC-1 Gene. The invention also concerns polypeptides encoded by the TBC-1 gene. The invention also deals with antibodies directed...
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6815183 |
Plasmodium sp. chitinase
The present invention is directed to isolated nucleic acid molecules encoding Plasmodium sp. chitinases . Expression vectors and host cells comprising the nucleic acid molecules are also...
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6815190 |
Cutinase variants
The present invention relates to cutinase variants having improved thermostability. The variants have one or more amino acid substitutions within the vicinity of the N-terminal amino acid.
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6812004 |
Mammalian dendritic cell chemokine reagents
A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. Methods of using said reagents and...
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6812330 |
Isolation of neurotrophins from a mixture containing other proteins and neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6811773 |
Human monocyte colony inhibitory factor (M-CIF) polypeptides
There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ chemokine β1(CKβ1 or ckb-1)), as well as...
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6808896 |
Method for stable chromosomal multi-copy integration of genes
The present invention solves the problem of integrating multiple copies of a gene of interest by homologous recombination into well defined positions adjacent to conditionally essential genes in a...
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6808895 |
DNA encoding oxidoreductase and polypeptide encoded thereby
The invention provides human oxidoreductase molecules (OXRE) and polynucleotides which identify and encode OXRE. The invention also provides expression vectors, host cells, antibodies, agonists,...
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6806351 |
Secreted protein HBJFE12
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells,...
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6803192 |
B7-H1, a novel immunoregulatory molecule
The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the...
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6803035 |
Anti-diarrheal and method for using the same
A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal...
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6803043 |
Basbo27 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6793917 |
Type CC chemokine-like protein
An isolated novel type CC chemokine-like protein which is expressed from peripheral blood mononuclear cells under an immunological stimulus and has a cell migration activity; a DNA encoding the...
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6794171 |
D-pantolactone hydrolase and gene encoding the same
A novel enzyme which is useful in the optical resolution of D,L-pantolactone via D-selective asymmetric hydrolysis and a gene encoding the the same are provided. The invention discloses the gene...
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6790607 |
Adjustable sensitivity, genetic molecular interaction systems, including protein-protein interaction systems for detection and analysis
A method for detecting interactions between first and second interacting molecules at variable sensitivity. This variable sensitivity may be obtained by providing for the overexpression of either a...
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6790644 |
1,3-dicarbonyl-dioxygenase—a new c-c-bond cleaving enzyme
An enzyme that cleaves 1,3-dicarbonyl compounds by incorporating molecular oxygen into the substrate in amounts equimolar to the amount of substrate cleaved. The enzyme from Acinetobacter...
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6787337 |
Recording of DNA sequences to enable them to be expressed in yeasts, and the transformed yeasts obtained
The present invention relates to a recombinant non-yeast DNA, which encodes a protein of interest, wherein an unmodified DNA corresponding to the recombinant non-yeast DNA contains a region having...
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6787336 |
DNA encoding growth hormone antagonists
The present invention relates to DNA molecules which encode antagonists of vertebrate growth hormones obtained by mutation of at least the amino acid corresponding to Glu-119 in bovine growth...
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6784203 |
Cytokine production inhibitors
A 5,6-dihydro-α-pyrone of formula (I) wherein R is CO 2 H or CH 3 and, when R is CO 2 H, a pharmaceutically or veterinarily acceptable salt thereof. Processes for producing compounds of...
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6780986 |
RIP60 nucleic acid and polypeptide sequences and uses therefor
The invention relates to nucleic acids and encoded polypeptides from the human zinc finger protein RIP60. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors...
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6780973 |
Eotaxin: an eosinophil chemoattractant
Disclosed is substantially pure eotaxin DNA sequence and eotaxin polypeptide, and methods of using such DNA and polypeptide to direct chemotaxis of eosinophils. Methods are provided for the...
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6780419 |
Basb029 polynucleotide(s) and polypeptides from neisseria meningitidis
The invention provides BASB029 polypeptides and polynucleotides encoding BASB029 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6780627 |
22438, 23553, 25278, and 26212 novel human sulfatases
The present invention relates to newly identified human sulfatases. In particular, the invention relates to sulfatase polypeptides and polynucleotides, methods of detecting the sulfatase...
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6777202 |
Recombinant expression of S-layer proteins
The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the...
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6777592 |
Arthropod defensins of Scolopendra canidens, Vaejovis carolinianus, and Argiope spp.
This invention relates to an isolated nucleic acid fragment encoding a defensin which shares a high degree of sequence identity with the disclosed sequences from Scolopendra canidens, Vaejovis...
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6770458 |
Purified and isolated serine-threonine kinase receptors associated protein and use of same in the modulation of the biological activity of TGF-β
Isolated and purified proteins and nucleic acids which modulate TGF-β biological activity, including TGF-β signal transduction. Particularly, a novel serine-threonine kinase receptors associated...
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6770275 |
Live attenuated RTC-producing bacteria of the family
The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a...
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6770459 |
Immunogenic compounds
The invention provides BASB081 polypeptides and polynucleotides encoding BASB081 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6768001 |
Xylanase from trichoderma reesei, method for production thereof, and methods employing this enzyme
The present invention is directed to novel xylanases (referred to as XYL-IV) and to nucleic acid molecules encoding those xylanases. Also provided herein are vectors and host cells including those...
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6764834 |
BASB019 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6762040 |
Method for increasing gene copy number in a host cell and resulting host cell
The invention relates to a method for increasing the copy number of a chromosomally integrated expression cassette in a microbial strain without leaving antibiotic resistance markers behind in the...
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6762044 |
Mammalian adhesion protease peptides
The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides...
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6759219 |
Methods for the biosynthesis of polyesters
Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids,...
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6756222 |
Escherichia coli having accession No. PTA 1579 and its use to produce polyhydroxybutyrate
The present invention provides a novel genetically modified Escherichia coli JM109 bearing accession number PTA 1579, containing the gene coding for poly-beta-hydroxybutyrate synthesis and a...
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6756483 |
Method and substances for diagnosis and therapy of sepsis and sepsis-like systemic infections
Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in...
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6756493 |
Nucleic acid sequence and uses thereof
The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that...
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6753164 |
Nucleic acids encoding human serpin polypeptide HMCIS41
The present invention relates to novel human Serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host...
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6749847 |
Hybrid cytokine of IL-7 and β-chain of hepatocyte growth factor
A hybrid cytokine comprising the B-chain of hepatocyte growth factor and IL-7, linked by a linker molecule, having pre-pro-B growth stimulating activity.
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6740504 |
Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically...
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6737252 |
7 transmembrane receptor family member BLRX
Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are...
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6734000 |
Nanoporous silicon support containing macropores for use as a bioreactor
A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of...
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6733989 |
Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof
Structural phosphoprotein (pp28) of human cytomegalovirus (HCMV), the preparation and use thereof Expression of an SmaI fragment, which is about 1.0 kb in size, on the left-hand end of the HindIII...
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6733998 |
Micromonospora echinospora genes coding for biosynthesis of calicheamicin and self-resistance thereto
An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding proteins and enzymes used in the...
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6733990 |
Nucleic acid encoding 15571, a GPCR-like molecule of the secretin-like family
Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion...
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6730504 |
Bacillus natto culture extract
A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μg or...
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