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6967088 |
Soluble recombinant botulinum toxin proteins
The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A, type B and type E toxin proteins...
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6958223 |
Methods for producing extracellular matrix proteins
Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the...
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6958235 |
Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19)...
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6955807 |
IL-2 selective agonists and antagonists
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
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6955904 |
Gene coding for quinone oxidoreductase of kluyveromyces marxianus and protein expressed therefrom
The invention is a gene coding for a quinone oxidoreductase from Kluyveromyces marxianus and a protein having an amino acid sequence expressed therefrom, which can be advantageously used in a...
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6953844 |
Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6951747 |
Polyhydroxyalkanoate synthase and gene encoding the same
The present invention provides a PHA (polyhydroxyalkanoate) synthase useful in a process for preparing a PHA, a gene encoding the enzyme, a recombinant vector comprising the gene, a transformant...
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6951734 |
Methods for producing proteins by using cell-free protein synthesis systems
A method for producing a protein suitable for X-ray crystallographic analysis, in a cell-free protein synthesis system comprising a cell-free extract, a nucleic acid coding for said protein, and...
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6949363 |
Polynucleotides encoding novel human leucine-rich repeat containing protein expressed predominately in bone marrow, HLRRBM1
The present invention provides novel polynucleotides encoding HLRRBM1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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6949366 |
Cytokines that bind the cell surface receptor hek
Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek)...
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6936440 |
Selecting ligand agonists and antagonists
We have discovered that growth hormones from ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to...
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6936451 |
Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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6936453 |
Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention...
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6936256 |
Sub-unit vaccine for infectious pancreatic necrosis virus
The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty...
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6936259 |
CAMP factor of Streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs,...
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6933130 |
Recombinants process for preparing a complete malaria antigen, gp190/MSP1
The present invention relates to a method for producing recombinants intended for use in the complete cell-surface protein gp190/MSP1 from plasmodium, especially plasmodium falciparum, as well as...
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6929917 |
Method for cloning of a rare, specifically mutated cell
The invention concerns a new method of detecting a rare product of a directed genetic alteration of a cultured cell. The method is applicable to any method of making the alteration provided that a...
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6929935 |
Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof
This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase...
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6924125 |
Expression of heterologous multi-domain proteins in yeast
This invention demonstrates the utility of a yeast expression system for the expression of functional heterologous multi-domain proteins in yeast. The yeast expression system allows for the...
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6924124 |
Feeding strategies for cell culture
The invention is in the field of cell culture, particularly recombinant cell culture. More specifically, the invention relates to methods of fed batch CHO cell culture.
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6916641 |
(R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid...
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6913886 |
Fast and exhaustive method for selecting a prey polypeptide interacting with a bait polypeptide of interest: application to the construction of maps of interactors polypeptides
The present invention is directed to a method for selecting a prey polypeptide that is able to interact with a bait polypeptide of interest, to a prey polynucleotide encoding the prey polypeptide...
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6911204 |
Method and composition for altering a B cell mediated pathology
The present invention provides methods and compositions for altering a B cell mediated malignancy in a patient. These methods comprise administering a composition comprising at least one or two...
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6908619 |
Camp factor of streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
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6905865 |
Detection of a gene, vatE, encoding an acetyltransferase inactivating streptogramin
A gene encoding an acetyltransferase inactivating streptogramin A was isolated from an Enterococcus faecium strain and sequenced. The gene, designated vatE, encodes a 23.775 kDa protein...
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6902912 |
Process for producing glutathione
There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione...
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6900036 |
Prion isomers, methods of making, methods of using, and compositions and products comprising prion isomers
Prion peptides exhibiting structural isomerism to wild-type prion peptide are disclosed. The invention further discloses methods of making prion isomers, compositions comprising prion isomers, and...
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6897056 |
32544, a novel human phospholipase C and uses thereof
The invention provides isolated nucleic acids molecules, designated 32544 nucleic acid molecules, which encode novel phospholipase family members. The invention also provides antisense nucleic acid...
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6893642 |
Algae protein polysaccharide extraction and use thereof
The present invention provides a pharmaceutical composition containing proteoglycan extracts of algae and a process for preparing proteoglycan extracts from the algae.
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6893843 |
Nucleic acids
Polypeptides, in particular the polypeptide of formula I:
Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-...
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6893839 |
Methods for producing polypeptides in cyclohexadepsipeptide-deficient cells
The present invention relates to methods for producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the...
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6893841 |
Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof
The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to...
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6890734 |
Nucleic acids encoding a cytokine receptor complex
Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
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6890542 |
Leishmania vaccine
The present invention relates to the use of a live mutant Leishmania in the preparation of a vaccine and to vaccine formulations for use in immunizing mammals, such as dogs and/or humans. The...
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6887683 |
Human G-protein coupled receptors
Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also...
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6887686 |
Cloning and expression of Haemophilus somnus transferrin-binding proteins
Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and...
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6884609 |
Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6875590 |
Leader peptides for enhancing secretion of recombinant protein from a host cell
Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides...
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6872550 |
Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B. burgdorferi are...
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6867024 |
Ubiquinone composition and methods related thereto
A composition is provided that includes an ubiquinone, such as CoQ 10 , bound by a glycoprotein matrix. A method is also provided for the manufacture of a composition of the invention. The...
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6858714 |
Cyclic GMP phosphodiesterase
The invention provides a human cyclic GMP phosphodiesterase (PDE9A) and polynucleotides which identify and encode PDE9A. The invention also provides expression vectors, host cells, antibodies,...
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6858397 |
Antibodies specific for native PrPsc
Antibodies are disclosed which specifically bind to native PrP Sc in situ. Preferred antibodies bind only to the native PrP Sc of a particular species e.g., human, cow, sheep, pig, etc....
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6858410 |
Process for making antifusogenic fusion peptides that form inclusion bodies
A process is provided for producing an antifusogenic peptide by producing a fusion peptide of from about 14 amino acids up to 70 amino acids in a prokaryotic host cell under conditions in which...
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6855319 |
Gene encoding merozoite protein of Babesia caballi, recombinant protein obtained therefrom and utilization thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
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6852511 |
Heat-inducible promoter
The invention relates to nucleic acid molecules comprising a heat-inducible promoter and to expression vectors and host cells containing at least one nucleic acid molecule according to the...
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6849716 |
Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases
The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases....
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6849427 |
Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid...
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6849728 |
GLUT10: a glucose transporter in the type 2 diabetes linked region of chromosome 20Q12-13.1
GLUT 10 is an insulin-responsive glucose transporter gene located in the type 2 diabetes linked region of chromosome 20Q12-13.3. Isolated nucleic acids encoding the GLUT 10 glucose transporter, the...
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6844169 |
Constructs for controlled expression of recombinant proteins in prokaryotic cells
The invention concerns a novel construct for expressing a gene coding for a recombinant protein of interest placed under the control of the Ptrp tryptophan operon promoter in a procaryotic host...
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6841165 |
Insecticidal agents
Disclosed are novel strains of Xenorhabdus bovienii deposited with NCIMB under accession numbers NCIMB 40985 and NCIMB 40986 which are a source of orally acting pesticides. Also disclosed are...
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