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7125679 |
Methods to screen peptide libraries using minicell display
A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process....
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7122352 |
Polynucleotide encoding mammalian cytokine-like polypeptide-10
A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and...
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7122341 |
Engineering of metabolic control
The invention features a method of producing heterologous molecules in cells under the regulatory control of a metabolite and metabolic flux. The method can enhance the synthesis of heterologous...
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7122369 |
Bacterial strains, methods of preparing the same and use thereof in fermentation processes for L-lysine production
The invention provides novel microorganisms, methods for the production thereof and novel processes for the production of amino acids. Mutagenesis of parental bacterial strains and selection of an...
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7122346 |
Process for the recombinant production of ribonucleoproteins
A process is described for the recombinant production of ribonucleoproteins in prokaryotic cells.
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7118891 |
Crystal harvest from fermentation broth
A method for producing a crystalline and/or amorphous metabolite suspension from a fermentation broth comprising treating the fermentation broth with one or more coagulants and/or one or more...
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7115269 |
Attenuated Salmonella strain used as a vehicle for oral immunization
The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to...
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7115725 |
Multi-mutant diphtheria toxin vaccines
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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7115403 |
Directed evolution of galactose oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantageously produced...
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7109010 |
Methods and materials for the synthesis of organic products
This invention provides biocatalysts that are recombinant yeast cells comprising recombinant expression vectors encoding heterologous lactate dehydrogenase genes for producing lactate.
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7109009 |
Regulatory region of the CYP52A2A gene from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7109008 |
L-glutamate oxidase
The present invention provides a novel L-glutamate oxidase, a gene encoding the enzyme, and a method for producing the enzyme. By use of a gene encoding the enzyme, L-glutamate oxidase can be...
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7105296 |
Genes encoding Baeyer-Villiger monooxygenases
Genes have been isolated from a variety of bacteria encoding Baeyer-Villiger monooxygenase activity. The genes and their products are useful for the conversion of ketones to the corresponding...
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7105316 |
Neisseria lactoferrin binding protein
LbpB polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing LbpB polypeptides and...
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7105317 |
Immunogenic compositions comprising vrg-gene products from Bordetella extracts
This invention relates to an immunogenic composition comprising a bacterial extract containing at least one expression products of the vrg genes of a strain of Bordetella chosen from B....
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7105653 |
IL-2 selective agonists and antagonists
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
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7101989 |
DsrA protein and polynucleotides encoding the same
DsrA is an outer membrane protein of H. ducreyi that confers serum resistance to the bacteria. Isolated polynucleotides encoding the protein, end expression vectors and host cells encoding the...
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7101696 |
Polyhydroxyalkanoate synthase and gene encoding the same enzyme
A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase...
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7098010 |
Directed evolution of oxidase enzymes
This invention relates to the expression of improved polynucleotide and polypeptide sequences encoding for eukaryotic enzymes, particularly oxidase enzymes. The enzymes are advantagoeusly produced...
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7098002 |
Preparation of biologically active molecules
Biologically active molecules are produced from their biologically inactive precursors by mutation of their native cleavage site to a site which is capable of being cleaved by a protease, and...
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7094589 |
53010, A novel human carboxylesterase family member and uses thereof
The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid...
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7094569 |
Hair follicle growth factor proteins
The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF...
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7091000 |
Bacterial strains which overproduce riboflavin and methods of use thereof
Vectors and recombinant bacteria for overproducing riboflavin, in which nucleic acid overproducing riboflavin biosynthetic proteins is introduced in the chromosome of the host organism, e.g. at...
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7087418 |
Pichia pastoris formate dehydrogenase and uses therefor
This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide...
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7087412 |
Methods for large scale protein production in prokaryotes
The invention belongs to the field of protein production in prokaryotic cells. The invention relates to methods for the production of recombinant DNA-derived heterologous protein in prokaryotic...
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7083942 |
Alleles of the aceA gene from coryneform bacteria
The invention relates to alleles of the aceA gene from coryneform bacteria coding for isocitrate lyases and processes for the fermentative production of L-lysine using bacteria that contain these...
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7083960 |
Production of a highly active, soluble form of the cytochrome P450 reductase (CPR A) from Candida tropicalis
The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal...
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7078027 |
Human endokine alpha
The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha...
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7078204 |
Glucose-6-phosphate dehydrogenase
The present invention relates to a novel glucose-6-phosphate dehydrogenase (hereinafter referred to as “G6PD”) derived from a bacterium belonging to the genus Corynebacterium , a DNA encoding...
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7078193 |
Pathogenic Escherichia coli associated protein espA
The present invention provides a polypeptide, called EspA, which is secreted by pathogenic E. coli , such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli . The invention also...
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7074592 |
Secreted and transmembrane polypeptides nucleic acid encoding
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7074913 |
Receptor for B anthracis toxin
The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the...
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7074571 |
Serine carboxypeptidase hx (SCPhx) and compositions thereof
The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers,...
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7070989 |
Escherichia coli strain secreting human granulocyte colony stimulating factor (G-CSF)
The present invention provides a recombinant plasmid vector comprising a kanamycin resistance gene, a promoter, an endoxylanase signal sequence, a nucleotide sequence coding for an oligopeptide...
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7070791 |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunoassay
A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis , serotype D, was purified by ion exchange column chromatography and shown to be suitable for quantitative immunoassy...
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7071313 |
Methods of purifying authentic IGF from yeast hosts
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a...
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7070944 |
System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a...
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7070793 |
Antigen protein and nucleic acid coding for said protein
To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida...
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7070974 |
Metalloproteases of the neprilysin family
In this paper, we describe RT-PCR strategies that allowed us to identify and clone members of the NEP-like family. Degenerate oligoncleotide primers corresponding to consensus sequences located on...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7067285 |
Desaturase genes and uses thereof
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e.,...
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7063950 |
Nucleic acids encoding human calcium channel and methods of use thereof
Isolated DNA encoding each of human calcium channel α 1 -, α 2 -, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors...
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7063972 |
Cytochrome P450 monooxygenase CYP52A2A from Candida tropicalis
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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7060669 |
Process for partitioning of proteins
The present invention relates to isolation and purification of proteins in aqueous two-phase systems (ATPS). Specifically the invention provides processes for partitioning of proteins of interest...
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7060462 |
AopB gene, protein,homologs, fragments and variants thereof, and their use for cell surface display
The present invention provides an Agrobacterium tumefaciens outer membrane protein designated aopB, its variants, homologs and fragments and corresponding DNA molecules. The invention also...
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7060480 |
MRE11 orthologue and uses thereof
The invention provides isolated Mre11 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Mre11 levels in plants. The invention...
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7060261 |
Chemokine α-5
The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5...
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7060481 |
Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention...
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7056672 |
Method of identifying an open reading frame using a nucleic acid molecule encoding multiple start codons and histidine tags
Compositions and methods for identifying nucleotide fragments that contain an open reading frame are provided. Compositions comprise a nucleotide sequence that encodes, in each of the three...
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7056717 |
Genes involved in isoprenoid compound production
Genes have been isolated from Methylomonas 16a sp. encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Methylomonas strain that is capable of...
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