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6623957 |
Secretion of T cell receptor fragments from recombinant host cells
Variable domain murine T-cell receptor genes have been isolated and used to construct cloning and expression vectors. V α , V β , and single chain V α -V β fragments have been expressed as...
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6623942 |
Macrophage inflammatory protein-4 (MIP-4) polynucleotides
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3...
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6620987 |
Nucleic acid encoding a starch R1 phosphorylation protein homolog from maize
An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide having starch R1 phosphorylation activity, or the complement of the nucleotide sequence. Plant transformation and...
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6620912 |
Dendritic enriched secreted lymphocyte activation molecule
The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are...
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6617145 |
DNA molecules encoding fibrinolytically active polypeptide
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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6617132 |
Human cystatin E polynucleotides
Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for...
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6610515 |
Feline granulocyte colony-stimulating factor
The present invention provides a medicine which promotes the production of neutrophiles in case the number of the neutrophiles decreases upon treating the tumor of a cat, and does not have...
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6607729 |
Surface antigen
The invention provides a novel surface polypeptide from Neisseria meningitidis as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Pharmaceutical compositions...
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6605592 |
Protein HOFNF53
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. In particular, the present application...
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6605699 |
Galectin-11 polypeptides
The present invention relates to galectin 11 proteins which are members of the galectin superfamily. In particular, the present invention relates to full-length polypeptides, fragments, and...
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6602687 |
DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby
The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the...
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6599718 |
Growth hormone secretagogue related receptors and nucleic acids
This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R)...
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6600030 |
Delayed progression to aids by a missense allele of the CCR2 gene
The present invention relates to a CCR2 deletion mutant, designated “CCR2-64I.” CCR2 is a C—C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered...
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6600020 |
Canine interleukin 18 polypeptide
The present invention relates to canine interleukin 18 and an interleukin 18 production method.
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6596853 |
DNA encoding peptides of IL-2
The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of...
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6596509 |
Recombinant constructs and systems for secretion of proteins via type III secretion systems
One aspect of the present invention relates to a DNA construct that contains a first DNA molecule encoding a functional type III secretion system, a promoter, and a second DNA molecule encoding a...
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6596512 |
Nucleic acid encoding Nematode dopamine transporter and the protein encoded thereby
A nematode dopamine tansporter cDNA has been cloned, sequenced, and expressed, and provides a convenient screening assay for antiparasitics, as well as psychoactive drugs.
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6590073 |
Formation and anion-exchange of crystalline echinocandin ammonium salts
A method is described for forming a crystalline Echinocandin nucleus salt from its mixed broth and/or partially purified process streams by the steps of nanofiltration to form a concentrate,...
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6586210 |
Polynucleotides encoding T1 receptor like ligand II
The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II...
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H002071 |
Streptococcus pneumoniae gene HI0454
The invention provides isolated nucleic acid compounds encoding the 454 gene of Streptococcus pneumoniae . Also provided are vectors and transformed host cells for expressing the encoded protein,...
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6583337 |
Plant glucose-6-phosphate translocator
This invention relates to an isolated nucleic acid fragment encoding a glucose-6-phosphate/phosphate translocator. The invention also relates to the construction of a chimeric gene encoding all or...
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6582935 |
Isolated nucleic acid molecules encoding human aspartate aminotransferase protein and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the aminotransferase peptides of the present invention. The present invention...
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6583270 |
Interleukin-19
The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are...
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6573066 |
FtsH from Staphylococcus aureus
The invention provides ftsH polypeptides, polynucleotides encoding ftsH polypeptides and related polynucleotides and methods for producing such polypeptides by recombinant techniques. Also provided...
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6573074 |
Methods for ansamitocin production
Improved purification methods for ansamitocins are disclosed.
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6573366 |
Process for the purification of human interleukin-1 receptor antagonist from recombinant E. coli
A process for purifying human Interleukin-1 receptor antagonist (IL-1ra), obtained by fermenting a strain of recombinant E. coli , which comprises: a) loading the mixture to be purified, which has...
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6572853 |
Recombinant human beta interferon with enhanced solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15),...
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6570061 |
Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice
Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with...
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6569641 |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein by recombinant DNA technique
The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by...
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6569657 |
32140, a novel human aldehyde dehydrogenase and uses therefor
The invention provides isolated nucleic acids molecules, designated 32140 nucleic acid molecules, which encode novel aldehyde dehydrogenase family members. The invention also provides antisense...
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6569646 |
Process for the production of an enzyme preparation containing xylanase and carboxymethyl cellulase from termitomyces clypeatus having accession no 11CB-411
This invention relates to a process for the production of carboxymethyl cellulase and xylanase which comprises inoculating and growing Termitomyces clypeatus which has been deposited in the...
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6569433 |
Compounds and methods for the diagnosis and treatment of B. microti infection
Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B....
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6566503 |
Mammalian CX3C chemokine
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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6566512 |
ARV1, a protein involved in sterol uptake and sterol homeostasis in the budding yeast, S-cerevisiae, and a functional human ARV1
This invention provides an isolated nucleic acid which encodes mammalian ACAT-Related Enzyme 2 Required for Viability protein (ARV1p), wherein the encoded ARV1p protein has the amino acid sequence...
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6566501 |
Transcription factor regulating TNF-α
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in...
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6558941 |
Delivering lipophilic substances into cells using nanoemulsions
Nanoemulsions are prepared containing oily droplets of a diameter of less than 100 nm in an aqueous phase. The oily droplets contain a lipophilic substance, and have on their surface an amphoteric...
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6558926 |
Method for production of tetanus toxin using media substantially free of animal products
The present invention provides a system for the growth of C. tetani and production of Tetanus Toxin for use in formulating Tetanus Toxoid preparations. The system includes growth media that...
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6558919 |
AmpS from Streptococus pneumoniae
The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS...
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6558921 |
Promoters of the genes glutamate deshydrogenase, β-N-acetylhexosaminidase and &ggr -actin and their use in filamentous fungi expression, secretion and antisense systems
An isolated DNA having the promoter sequence of the hex gene of P. chrysogenum or a DNA fragment that is hybridizable to the complement of the promoter sequence under stringent conditions and is...
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6555346 |
Protein expression in baculovirus vector expression systems
The invention relates to a method to increase protein expression in baculo vector virus expression systems. The invention provides a method to produce a recombinant protein in insect-cell culture...
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6555347 |
Human minor vault protein p193
A polynucleotide molecule encoding human minor vault protein p193, or its complementary strands. A purified and isolated polynucleotide molecule consisting essentially of a nucleotide sequence...
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6555338 |
NrdF from Staphylococcus aureus
The invention provides nrdF polynucleotides encoding nrdF polypeptides from Staphylococcus aureus and methods for producing such polypeptides by recombinant techniques. The invention also...
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6551796 |
Nucleic acid encoding urate transporter and methods of use thereof
The present invention provides an isolated nucleic acid encoding a urate transporter, vectors comprising the nucleic acid, host cells comprising the nucleic acid, and host cells comprising the...
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6551800 |
Recombinant materials for production of a protein toxic to fire ants
A nucleic acid derived from Bacillus thuringiensis contains a nucleotide sequence that encodes a polypeptide demonstrated to be toxic to fire ants.
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6551781 |
Methods of screening for compounds that regulate the level of Nramp
The present invention relates to mouse and human cDNAs for a gene family designated Nramp (natural resistance-associated macrophage protein), involved in macrophage function and responsible for the...
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6548272 |
Gene encoding for a transmembrane protein
A gene for a novel transmembrane protein was isolated and its nucleotide sequence was determined. A protein encoded by this gene (TRPC7) has 7 transmembrane regions, and because there is homology...
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6548271 |
Nucleic acids encoding human transporter proteins
The present invention provides two novel families of novel human transporter proteins (NTPs). The invention additionally provides for agonists, antagonists, antibodies, antisense molecules that are...
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6544764 |
Isolated human dehydrogenase proteins, nucleic acid molecules encoding these human dehydrogenase proteins, and uses thereof
The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the dehydrogenase polypeptides of the present invention. The present invention...
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6541218 |
Acid sphingomyelinase protein and methods of treating type B Niemann-Pick disease
The present invention relates to the acid sphingomyelinase gene and to methods of diagnosing Niemann-Pick disease. It is based, at least in part, on the cloning and expression of the full-length...
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6541622 |
Cloning of a yeast alpha-amylase promoter and its regulated heterologous expression
The present invention provides the promoter clone discovery of an alpha-amylase gene of a starch utilizing yeast strain Schwanniomyces castellii. The isolated alpha-amylase promoter is an...
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