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6727353 |
Nucleic acid encoding Kv10.1, a voltage-gated potassium channel from human brain
The invention provides isolated nucleic acid and amino acid sequences of Slo potassium family members such as, antibodies to Kv10 subfamily members such as Kv10.1, methods of detecting Kv10,...
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6720166 |
Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV...
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6716613 |
Metalloprotease having aggrecanase activity
This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method...
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6716603 |
Nucleic acids encoding a chloride channel protein
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy,...
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6713618 |
DNA which encodes trehalase and uses thereof
Disclosed are a DNA which encodes murine trehalase, a polypeptide expressed by the DNA, and a transgenic- and knockout- animals which have been genetically engineered with the DNA. The DNA...
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6709842 |
DNA encoding a growth factor specific for epithelial cells
Disccoveries are disclosed that show particular aspects of recombinant DNA technology can be used sucessfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of...
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6703495 |
Polynucleotides encoding human transporter protein
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6699482 |
Leptospira rare outer membrane proteins
The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa....
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6699678 |
Chlamydia trachomatis specific peptides and their use in diagnostic assays
Disclosed are peptides or a mixture of peptides, or analogs thereof, derived from the variable domains of the Chlamydia trachomatis ( C. trachomatis ) immunodominant major outer membrane protein...
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6693186 |
Neisseria meningitidis polypeptide, nucleic acid sequence and uses thereof
The invention discloses the Neisseria meningitidis NMASP polypeptide, polypeptides derived therefrom (NMASP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies...
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6692735 |
Variant of C6 β-chemokine leukotactin-1(shLkn-1) with enhanced biological activity
The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing...
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6689601 |
High growth methanotropic bacterial strain
A high growth methanotrophic bacterial strain capable of growth on a C1 carbon substrate has been isolated and characterized. The strain has the unique ability to utilize both methane and methanol...
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6689877 |
Methods and compositions for the treatment of human immunodeficiency virus infection
Materials and methods are provided to inhibit HIV replication in targeted host cells.
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6689360 |
Human B-cell translocation genes-2 and 3 antibodies
The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3)....
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6689876 |
Cloning and sequencing of allergens of dermatophagoides
Isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus , which are protein allergens or...
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6689750 |
Bactericide compositions prepared and obtained from microccus varians
A bacteriocin is obtained by culturing cells of a strain of Micrococcus varians which, upon culturing in a culture medium, produces a bacteriocin which has agar well incubation inhibition test...
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6683232 |
Production of &ggr linolenic acid by a &Dgr 6-desaturase
Linoleic acid is converted into γ-linolenic acid by the enzyme Δ6-desaturase. The present invention is directed to isolated nucleic acids comprising the Δ6-desaturase gene. More particularly,...
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6682908 |
Mouse growth hormone secretagogue receptor
A mouse growth hormone secretagogue receptor has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Mouse growth hormone secretagogue...
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6680186 |
Nucleotide sequences which encode plsC gene
The present invention relates to polynucleotides corresponding to the plsC gene and which encode 1-acyl-SN-glycerol-3-phosphate acyltransferase, methods of producing L-amino acids, and methods of...
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6680380 |
Nucleic acids encoding mammalian interleukin-1&zgr , related reagents and methods
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided....
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6680185 |
Plant polyphenol oxidase homologs
This invention relates to an isolated nucleic acid fragment encoding a polyphenol oxidase enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6680181 |
Production of peptides
The invention relates to a method for the production of recombinant peptides by fed-batch cultivation of a microorganism in a bioreactor containing a medium comprising organic carbon source,...
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6677442 |
Nucleic acid encoding human REV1 protein
The present invention relates to a human cDNA homologous to the yeast REV1 gene. The sequence of human REV1 (hREV1) gene is described.
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6677125 |
Assay for disease related conformation of a protein and isolating same
An assay method is disclosed which isolates and detects the presence of a disease related conformation of a protein (e.g., PrP Sc ) present in a sample also containing the non-disease related...
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6673575 |
Method for preparing polypeptides with appropriate glycosilation
The invention concerns a process for the production of a polypeptide with suitable glycosylation by culturing eukaryotic cells and isolating the polypeptide from the culture medium or/and the...
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6673915 |
Nucleic acid encoding monocyte chemotactic protein 4
Substantially pure nucleic acid molecules encoding the monocyte chemotactic proteins MCP-4 and MCP-5. These molecules and the polypeptides they encode are useful in treating diseases or conditions...
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6670148 |
Compositions comprising bioactive peptides prepared without formation of native disulfide bonds
A method of preparing a bioactive polypeptide in a stable, inactivated form, the method comprising the step of treating the polypeptide with ozonated water in order to oxidize and/or stabilize the...
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6664089 |
38692 and 21117, novel dual specificity phosphatase molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 38692 or 21117 nucleic acid molecules, which encode novel dual specificity phosphatase family members. The invention also...
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6664386 |
System for efficient secretion of recombinant proteins
Provided is a signal peptide comprising an amino acid sequence at least 90% homologous to the amino acid sequence as shown in SEQ ID NO:1. Further provided is a fusion protein comprising the signal...
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6653135 |
Dynamic protein signature assay
An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a...
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6653068 |
Generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs
The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion...
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6653076 |
Stable isotope metabolic labeling for analysis of biopolymers
Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which as been labeled with a stable isotope are...
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6649374 |
Recombinant Chlamydia trachomatis PGP3 antigen
A new recombinant form of the plasmid-encoded protein pgp3 from C. trachomatis , serotype D, to be used in immunogenic compositions and in the preparation of immunogenic compositions was purified...
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6645738 |
DNA molecules encoding the melanocortin 5 receptor protein from rhesus monkey
The present invention relates to rhesus monkey DNA molecules encoding the melanocortin-5 receptor protein, recombinant vectors comprising DNA molecules encoding rhesus MC-5R, recombinant host cells...
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6646110 |
G-CSF polypeptides and conjugates
The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at...
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6645745 |
Identification of a new member of the cytochrome P450 3A (CYP3A) gene family: CYP3AX
The present invention relates to polynucleotides encoding the CYP3AX protein and variants thereof. Further, the present invention also provides vectors comprising said polynucleotides, in...
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6645739 |
Yeast expression systems, methods of producing polypeptides in yeast, and compositions relating to same
The present invention provides novel expression systems for producing desired polypeptides in certain strains of yeast. The present invention further provides methods for producing polypeptide...
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6642031 |
Microorganisms with ability to degrade indole and enzymes therefrom
There is provided novel indole oxidase activity isolated from P. putida , such indole oxidase activity is believed to be useful in the biosynthetic production of indigo from its precursor indole....
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6642030 |
Nucleic acid compositions encoding modified Bacillus thuringiensis coleopteran-toxic crystal proteins
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic B. thuringiensis δ-endotoxins. Also disclosed are methods of using these genes for the...
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6638733 |
G-protein coupled receptors amplified in breast cancer
The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of...
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6638503 |
STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME
The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The...
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6639064 |
NRIF3, novel co-activator for nuclear hormone receptors
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is...
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6635741 |
G-protein coupled receptor BCA-GPCR-3
The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of...
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6632636 |
Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis
The present invention provides the genomic sequences of a library of purified nucleic acid molecules, or their complements, comprising the genome of Moraxella catarrhalis . The invention also...
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6632640 |
Vaccine against Staphylococcus intoxication
Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus , compositions and methods for use in inducing an immune response which is protective against staphylococcal...
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6632638 |
Enhanced solubility of recombinant proteins using Uracil DNA glycosylase inhibitor
Disclosed are methods for improving the solubility of a protein of interest produced recombinantly by expressing the protein of interest as a fusion protein with Uracil DNA glycosylase inhibitor...
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6630619 |
Toxin genes from the bacteria Xenorhabdus nematophilus and photorhabdus luminescens
The invention relates to the identification and isolation of polynucleotide molecules encoding a new class of protein insecticidal toxins which are produced by bacteria from the genera Xenorhabdus...
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6630328 |
Increasing production of proteins in gram-positive microorganisms
The present invention relates to secretion in Gram-positive microorganisms. The present invention provides the nucleic acid amino acid sequences for the Bacillus subtilis secretion factors SecDF....
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6627604 |
Memno peptides, process for their preparation and use thereof
The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and (A)n have the meaning herein, obtainable...
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6627423 |
21481, a novel dehydrogenase molecule and uses therefor
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
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