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6030614 Ameliorating immunological rejection of allograft  
The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a...
6027922 Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use  
The present invention relates to human foam cells generated in vitro from monocyte/macrophage related cell lines which give rise to an average intracellular cholesterol amount of at least 139+36...
6020170 Method of preparing a monoclonal antibody  
The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in only...
6013519 Monoclonal antibodies to antigens expressed by hematopoietic facilitatory cells  
The present invention relates to monoclonal antibodies (MAb) to hematopoietic facilitatory cells (FC). In particular, it relates to MAb against antigens expressed by murine FC, methods of...
6010903 Anti-human ceruloplasmin monoclonal antibody  
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the...
6011138 Gamma-1 anti-human CD23 monoclonal antibodies  
Anti-human CD23 monoclonal antibodies containing human gamma 1 constant domains and therapeutic uses are provided. These antibodies inhibit IL-4 induced IgE production by B-cells significantly...
6011139 Hybridomas and monoclonal antibodies that specifically bind to glutamic acid decarboxylase peptides  
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed. Monoclonal antibodies specific for...
6008024 Monoclonal antibodies specific for PHF-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications  
Monoclonal antibody AT180 secreted by the hybridoma deposited at ECACC on Dec. 22, 1992 under No. 92122204, and monoclonal antibody AT270 secreted by the hybridoma deposited at ECACC on Jul. 7,...
6004765 Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin  
A method for the assessment of bone fragility and osteoporosis fracture risk characterized by: measuring in vitro the concentration of under-carboxylated osteocalcin in a biological fluid sample...
5998172 Anti-CD6 ligand antibodies  
The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell...
5994524 Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same  
The present invention discloses a reshaped human antibody against human IL-8 comprising: (A) L chains each comprising: (1) a human L chain C region; and, (2) an L chain V region comprising a human...
5985278 Anti-αV-integrin monoclonal antibody  
The invention relates to a novel monoclonal antibody, a hybridoma cell line producing said antibody, DNA sequences coding for said antibody, and amino acid sequences. The monoclonal antibody, a...
5980893 Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis  
A class of murine monoclonal antibodies that is capable of stimulating megakaryocytopoiesis in vitro has been raised against human megakaryocytic cells. The monoclonal antibody BAH-1 specifically...
5977323 Method of purifying Gro β or Gro α protein using antibodies  
Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably...
5961974 Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same  
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
5962269 Methods for producing antibodies which specifically bind to interleukin-9 receptor  
The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as...
5959083 Tetravalent bispecific receptors, the preparation and use thereof  
The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.
5959086 Antibodies specific for human pancreatitis associated protein  
The invention relates to the family of the protein (PAP) associated with acute pancreatitis in man and in the rat. It also relates to the nucleotide fragments coding for the above proteins. Also...
5955358 Optimization of binding proteins  
The invention relates to methods for manipulating nucleic acids so as to optimize the binding characteristics of an encoded binding protein by providing two or more nucleic acids encoding binding...
5955293 Assays for shiga toxin and shiga-like toxins  
The present invention relates to a substantially pure antigenic peptide or protein related to Shiga toxin, Shiga-like toxin I, Shiga-like toxin II or a variant of Shiga-like toxin II, and to a...
5955317 Antibodies to β-amyloids or their derivatives and use thereof  
According to this invention, antibodies which are useful and novel in that they have binding specificity to β-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or ...
5951983 Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies  
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
5948647 Nucleic acids encoding antigen-binding sites specific for cancer antigens  
Novel compositions are provided that are derived from antigen-binding sites of immunoglobulins having affinity for cancer antigens. The compositions exhibit immunological binding properties of...
5945311 Method for producing heterologous bi-specific antibodies  
In a method for producing heterologous bi-specific antibodies, a quadroma is provided which is fused from hybridromas one of which generates antibodies that have an affinity to the binding site of...
5939280 Immunological assay for quantifying peg-modified human granulocyte colony stimulating factor and monoclonal antibodies used in the assay  
An immunological assay for quantifying PEG-modified human granulocyte colony stimulating factor or derivatives thereof in a sample comprising bringing into contact with said sample an antibody...
5932448 Bispecific antibody heterodimers  
Methods for producing and using bispecific antibodies formed by leucine zippers are provided. Leucine zippers capable of preferentially forming heterodimers are respectively linked to epitope...
5928893 Monoclonal antibody specific for human 4-1BB and cell line producing same  
A monoclonal antibody specific for human 4-1BB, accessory molecule, selectively expressed on activated T cells; polynucleotides encoding the variable regions of the monoclonal antibody and amino...
5928904 DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders  
Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
5922325 Synergistic neutralization of HIV-1 by human monoclonal antibodies and other antibodies directed against the v3 loop and the CD-4 binding site of GP-120,and the use for immunotherapy of HIV-1 infection  
A synergistic combination of antibodies specific for HIV envelope glycoprotein gp120 is described. One of the antibodies specific for the V3 loop and the other is specific for the CD-4 binding site...
5919457 TXU-5/B53-PAP antiviral biotherapeutic agent for the treatment of AIDS  
Immunoconjugates comprising the monoclonal antibody TXU-5/B53 linked to pokeweed antiviral protein or bioactive subunits thereof are provided which are effective for the treatment of mammalian HIV...
5914110 Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders  
Chimeric and humanized IL4 MAbs derived from high affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
5914109 Heterohybridomas producing human monoclonal antibodies to HIV-1  
Heterohybridomas producing human monoclonal antibodies against a neutralizing epitope of HIV-1 are prepared by transforming peripheral blood lymphocytes by Epstein-Barr virus, selecting cells...
5891434 Monoclonal antibodies to the APO-1 antigen  
The APO-1 cellular membrane antigen, an about 50 kDa antigen associated with cellular apoptosis, and purified cDNA encoding same is described. The antigen is expressed by numerous normal and...
5891722 Antibodies to free IGFBP-1  
Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and...
5891647 Method for the immunoassay of antithrombin III activated by a glycosaminoglycan, corresponding monoclonal antibodies and method for obtaining them  
A method that assays activated antithrombin III (AT III) is useful for monitoring the effect in vivo of an agent that activates AT III. It involves the steps of contacting AT III with a solution...
5885575 Antibodies that react with variant CD44 surface proteins  
The inventon relates to antibodies that react with a variant epilope in the extracellular region of a variant CD44 polypeptide, wherein the variant epitope has the amino acid sequence:I S S T I S T...
5879898 Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors  
There is marked over-expression of multiple spliced variants of the CD44 gene in tumor compared to counterpart normal tissue. This observation forms the basis of a method of diagnosing neoplasia by...
5876973 Method for making antibodies which specifically bind to glial growth factors  
Disclosed is the characterization and purification of DNA encoding numerous polypeptides factors useful for the inhibition of cell (particularly, Schwann cell) proliferation. These factors are...
5876716 Method of using an antibody to the TN antigen for the inhibition of HIV infection  
A monoclonal or other antibody to the carbohydrate antigen Tn can be used to inhibit or slow the progression of AIDS or ARC. The antigen can be used in a vaccine, for immunisation.
5876947 Monospecific antibody reactive with Fibrinogen and fibrinopeptide B  
The invention provides monospecific antibodies that are specifically reactive with fibrinopeptide B (FPB) and with fibrinogen and fragments thereof containing the amino acid sequence defined by SEQ...
5874255 DNA encoding humanized antibodies specific for the ganglioside GM2  
Chimeric human antibody expression vectors are constructed by inserting the antibody heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from...
5866416 Cell line for propagating receptor binding site-deleted FMDV  
A method of making a genetically-engineered cell line which is susceptible to infection by foot-and-mouth disease virus and allows the virus to replicate is disclosed. The method involves fusing...
5863742 Inhibition of protease activity of human whole blood cell lysates  
A method of inhibiting proteolytic degradation of a thermally-stable intracellular protein is described. The method involves adding 1 or more denaturing agents to a sample which contains the...
5858728 Monoclonal antibody against LPS core  
The invention provides monoclonal antibodies (Mabs) which are cross-protective against endotoxemia caused by at least two different Gram-negative bacterial strains having different core structures;...
5858725 Preparation of chimaeric antibodies using the recombinant PCR strategy  
The invention relates to a method of producing a chimaeric antibody in which the CDR of a first antibody is spliced between the framework regions of a second antibody. The method is performed using...
5852186 Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof  
The present invention is directed to a recombinant human monoclonal antibody which binds to a discontinuous epitope on the HIV gp120 envelope glycoprotien, blocks the binding of gp120 to the CD4...
5852176 Antibodies to receptors for human interleukin-12  
Antibodies to human IL-12 beta 2 receptor protein or an IL-12 receptor complex, the complex comprising the beta1 receptor protein complexed with a beta2 receptor protein, which complex is capable...
5849288 Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells  
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and in which xenogeneic hematopoietic...
5849876 Hybridomas producing monoclonal antibodies to new mucin epitopes  
Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor...
5849539 Thymidine kinase-lacking ouabain-resistant chicken hybridoma  
The thymidine kinase-lacking hybridoma of the invention has resistance to oaubain and an Ig-producing ability and is formed by fusing a chicken B lymphoblast cell with an immunized chicken spleen...