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5858725 |
Preparation of chimaeric antibodies using the recombinant PCR strategy
The invention relates to a method of producing a chimaeric antibody in which the CDR of a first antibody is spliced between the framework regions of a second antibody. The method is performed using...
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5852186 |
Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof
The present invention is directed to a recombinant human monoclonal antibody which binds to a discontinuous epitope on the HIV gp120 envelope glycoprotien, blocks the binding of gp120 to the CD4...
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5852176 |
Antibodies to receptors for human interleukin-12
Antibodies to human IL-12 beta 2 receptor protein or an IL-12 receptor complex, the complex comprising the beta1 receptor protein complexed with a beta2 receptor protein, which complex is capable...
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5849288 |
Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and in which xenogeneic hematopoietic...
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5849876 |
Hybridomas producing monoclonal antibodies to new mucin epitopes
Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor...
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5849539 |
Thymidine kinase-lacking ouabain-resistant chicken hybridoma
The thymidine kinase-lacking hybridoma of the invention has resistance to oaubain and an Ig-producing ability and is formed by fusing a chicken B lymphoblast cell with an immunized chicken spleen...
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5847088 |
Antibodies specific for platelet-activating factor acetylhydrolase
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the...
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5846746 |
Antibody to ocular and vaginal surface epithelium
A monoclonal antibody has been produced that binds to apical cells of human ocular surface and vaginal epithelia. The antigen recognized by this monoclonal antibody is a mucin-like cell surface...
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5846732 |
Peptides of caseinomacropeptide, antibodies against the said peptides, and uses
The present invention presents an antigenic peptide whose amino acid sequence comprises a fragment of the caseinomacropeptide (CMP) sequence, which peptide is characterized in that it carries at...
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5843674 |
Anti-human tyrosinase monoclonal antibody
A mammal is immunized by using an antigen of a peptide having an amino acid sequence existing in a region having low homology to amino acid sequences of tyrosinase-related proteins but included in...
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5840856 |
Antibodies to a human PF4 superfamily receptor
cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue Recombinantly produced PF4ARs are used in the preparation and purification of antibodies...
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5834212 |
Anti-human stromelysin monoclonal antibody and method for diagnosis of rheumatoid arthritis by enzyme immunoassay
Anti-human stromelysin monoclonal antibodies reactive with latent and active forms of stromelysin without discrimination between the two, each being immunoreactive with only one of the antigenic...
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5830636 |
HEV orf-2 monoclonal antibodies and methods for using same
Monoclonal antibodies are described which specifically bind to Hepatitis E Virus (HEV), and more particularly to HEV orf-2 antigen. Also provided are hybridoma cell lines which secrete these...
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5830681 |
Immunoassays for and monoclonal antibodies to prothrombin activation peptide F1.2
Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of prothrombin activation peptide F1.2, which can be used in immunoassays to predict...
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5830688 |
DNA sequences, vectors, recombinant viruses and method which employs recombinant vaccinia viruses capable of muliplying in CHO cells
The DNA sequence of this invention, isolated from cowpox virus, participates in the multiplication of this virus in CHO cells. This DNA may be incorporated into vectors and recombinant viruses...
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5824510 |
Monoclonal antibodies to human influx peptide transporter
Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide...
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5817514 |
O6 -Methylguanine-DNA-methyltransferase (MGMT) specific antibodies
The present invention provides antibodies capable of discriminating between native human MGMT and an active site alkylated form of this enzyme in an immunoprecipitation procedure.Monoclonal...
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5817515 |
Human B2 integrin alpha subunit antibodies
Monoclonal antibodies, and hybridomas that express the antibodies, which are immunospecific for a novel human β2 integrin alpha subunit polypeptide are disclosed.
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5811310 |
The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
The invention relates to an antigen associated with Alzheimer's disease and to antibodies specific for said antigen. This invention further relates to methods for diagnosing Alzheimer's disease...
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5811267 |
Isolated nucleic acid molecules encoding antigen binding sites of antibody molecules specific for cancer antigens
Novel compositions are provided that are derived from antigen-binding sites of immunoglobulins having affinity for cancer antigens. The compositions exhibit immunological binding properties of...
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5807734 |
Monoclonal antibodies and FV specific for CD2 antigen
An anti-CD2 monoclonal antibody according to the present invention can be: (1) a chimeric monoclonal antibody CD2 SFv-Ig produced by expression of the construct cloned in recombinant Escherichia...
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5808033 |
Family of anti-carcinoembryonic antigen chimeric antibodies
The present invention discloses novel chimeric monoclonal antibodies directed against human carcinoembryonic antigen, having antigen-specific variable regions. DNA constructs for the light and...
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5807741 |
Neutralizing monoclonal antibody against botulinum neurotoxin serotype F
Antibodies which neutralize botulinum neurotoxin serotype F are produced using biologically active botulinum neurotoxin instead of toxoid for immunization and exploiting the importance of cross...
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5800815 |
Antibodies to P-selectin and their uses
The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes...
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5799190 |
Communications coprocessor for realizing bidirectional isochronous communications link with host computer
An intelligent communications coprocessor connects computer workstations to moderate-bandwidth (up to 2 megabits/second) digital communications services. In particular, such communications services...
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5798274 |
Method for selecting monoclonal antibodies for human G-CSF permitting low-level detection in human fluids
The present invention relates to a high affinity monoclonal antibody for human G-CSF and to an enzyme immunoassay using said antibody. Specifically, the practice of the invention permits one...
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5798230 |
Process for the preparation of human monoclonal antibodies and their use
The present invention provides a process for the preparation of human monoclonal antibodies from human B cells. According to this process, human antibody-producing B cells are immortalized by...
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5798229 |
Bispecific molecules recognizing lymphocyte antigen CD2 and tumor antigens
The present invention relates to novel and highly effective bispecific antibody fragments which recognize lymphocyte CD2 antigen and any variable tumor antigen. Moreover, the invention relates to...
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5789183 |
Serological detection and identification of rice blast
Monoclonal antibodies (MAbs) useful in the serological detection and identification of rice blast were produced by hybridoma cells formed from fusions of myeloma cells with splenocytes from BALB/c...
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5786159 |
Method of producing antibodies to a restricted population of T lymphocytes antibodies produced therefrom and methods of use thereof
Antibodies to specific subsets of T cells can be obtained by incubating a polyclonal population of T cells with a microbial superantigen, and injecting of the incubated T cells into a host animal....
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5786180 |
Monoclonal antibody 369.2B specific for β A4 peptide
The instant invention provides for monoclonal antibody which is specific for the βA4 peptide, and in particular the free C-terminus of βA4 "1-42" but not "1-43", and stains diffuse and fibrillar a...
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5780030 |
Passive vaccine against Lyme disease
The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of...
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5773293 |
Anti-ICAM-4 antibodies and hybridomas
DNA sequences encoding a novel intercellular adhesion molecule polypeptide (designated "ICAM-4") and variants thereof are disclosed along with methods and materials for production of the same by...
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5770361 |
Protein conferring an inducible resistance to glycopeptides, particularly in gram-positive bacteria
The invention relates to a protein VanB involved, in Gram-positive bacteria, in resistance to glycopeptides, particularly to vancomycine, said resistance being of the type inducible by the...
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5770403 |
Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4
Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal...
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5766946 |
Monoclonal antibodies to glycoprotein P
A monoclonal antibody that recognises a structurally continuous and extracellularly-located epitope of human P-glycoprotein is described. The monoclonal antibody has a continuous amino acid...
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5763202 |
Methods of detecting prostate carcinoma using a monoclonal antibody to a new antigenic marker in epithelial prostatic cells alone or with a monoclonal antibody to an antigen of LNCaP cells
Monoclonal antibodies to prostatic cells, are produced by a hybridoma formed by fusing mouse lymphocytes and mouse myeloma cells. The monoclonal antibodies show specificity for a non-soluble,...
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5756301 |
Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor
The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No. HB11281...
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5756095 |
Antibodies with specificity for a common epitope on E-selectin and L-selectin
The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular...
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5753229 |
Monoclonal antibodies reactive with tumor proliferating cells
This invention concerns monoclonal antibodies directed against breast carcinoma cells. Immunoglobulin secreting hybridoma cultures are produced by hybridoma technology using undifferentiated breast...
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5747037 |
Anti-GP39 antibodies
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred...
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5747034 |
Methods and materials for the induction of T cell anergy
Anti-B7-1 antibodies or other B7-1 ligands may be used to prevent or treat a T-cell-mediated immune system disease in a patient or to induce antigen-specific tolerance.The anti-B7-1 antibodies may...
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5738847 |
Anti-VH3-15 reagents and methods for their use
Anti-VH3-15 idiotypic antibody materials, hybridomas producing this antibody material and methods for using these to detect, isolate and purify VH3-15 polypeptides. Also provided in the present...
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5736138 |
Monoclonal antibodies with specific binding against membrane proteins on human cells, and pharmaceutical compositions containing them
A monoclonal antibody, or fragments thereof, against human TNF receptor protein which antibody neutralizes the known actions of TNFα and/or TNFβ is disclosed. The antibody may be chimeric or h...
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5736344 |
Serum pyridinium crosslinks assay
A method of assaying bone collagen breakdown levels in a human subject useful to screen for the presence of bone resorption disorders. Also disclosed is a method for monitoring the progression...
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5730981 |
Monoclonal anti-ganglioside antibody and its preparation
The invention relates to monoclonal antibodies of high avidity, which react specifically with the gangliosides GD3 and GQ1b, and to their use for detecting melanomas and other tumors or tissues...
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5728537 |
Methods of producing antibodies against cytokeraton fragments and test kits containing such fragments
Provided is a method for reproducible production of cytokeratin antigen immunogen. Cytokeratins from whole carcinoma cells are purified by preparative SDS-PAGE. Bands corresponding to cytokeratins...
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5721130 |
Antibodies and fragments thereof which bind the carboxyl-terminus of an amino-terminal fragment of βAPP
Processing of β-amyloid precursor protein (βAPP) is monitored by detecting the secretion of a soluble βAPP fragment resulting from cleavage of βAPP at the amino-terminus of β-amyloid peptide. In v...
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5721122 |
Method comprising immunization of antigen-free mice
A method of obtaining lymphocytes making a highly specific antibody by immunizing an antigen-free mouse and removing the blood, lymph nodes or spleen from the immunized mouse. Alternatively, a...
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5719050 |
Animal cell culturing media containing N-acetyl-L-glutamic acid
The present invention relates to a medium composition for culturing animal cells which is obtained by combining at least one component selected from the group of substances mentioned below with a...
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