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6171588 Anti-αvβ3 integrin antibody antagonists  
Monoclonal antibodies that recognize the αv β3 integrin receptor complex, but do not significantly bind to αIIbβIIIa, inhibit αvβ3 integrin-mediated diseases.
6156883 Polyclonal and monoclonal antibodies to Norwalk virus and methods for making them  
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
6146903 Method for determination of water treatment polymers  
A method for determining the presence and/or concentration of a water treatment polymer in an aqueous sample, comprising producing a polyclonal or monoclonal antibody to the water treatment...
6143865 Epstein-Barr virus peptides and antibodies against these peptides  
The invention relates to peptides or fragments thereof which are immunochemically reactive with Epstein-Barr Virus (EBV) antibodies. New antibodies directed to said peptides or fragments thereof...
6143559 Methods for the production of chicken monoclonal antibodies  
The present invention provides methods for producing antibodies against a variety of antigens, including mammalian antigens with highly conserved epitopes. In addition, the present invention...
6133427 Anti-human calcitonin monoclonal antibodies and an immunoassay utilizing said antibodies  
Monoclonal antibodies having a high affinity for human calcitonin, particularly monoclonal antibodies suitable for a sandwich immunoassay are disclosed. Also disclosed are hybridomas producing...
6129914 Bispecific antibody effective to treat B-cell lymphoma and cell line  
The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric...
6124439 OB polypeptide antibodies and method of making  
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight,...
6124132 Use of anti-HIV IGA antibodies for producing immunological protection against the human immunodeficiency virus  
The subject invention concerns the production and novel use of human anti-HIV IgA antibodies to confer passive immunity to HIV when administered in vivo to a subject. The IgA antibodies of the...
RE36866 Anti-aids immunotoxins  
The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptase. Also...
6090923 Murine monoclonal antibody binding TNFα  
A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal...
6087130 Antibody substances that bind to ICAM-related protein  
Antibody substances that bind to a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials producing and...
6084075 Agonist and antagonist antibodies to the chemokine receptor-2 (CCR2)  
The invention relates to antibodies which is capable of binding the monocyte chemoattractant protein 1 (MCP-1) receptor CCR2, especially those which are capable of acting either as an antagonist...
6080405 Foam proteins and use thereof  
Novel foam proteins, monoclonal antibodies specifically recognizing said proteins, a method for determining foam protein contents in beer samples by an immunoassay using said monoclonal...
6080560 Method for producing antibodies in plant cells  
A method for producing antibodies in plant cells including the steps of providing a genetic construct that encodes a secretable mammalian single chain antibody, delivering copies of the construct...
6056957 Humanized monoclonal antibodies against human interleukin-5  
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy...
6057121 Method of catalyzing stereochemical reactions  
A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate...
6054632 Method of making monoclonal antibodies using polymorphic transgenic animals  
The invention relates to a method for making monoclonal antibodies having pre-defined specificity for an epitope characteristic of or unique to a single form of a polymorphic protein. The method...
6043087 Monospecific antibody reactive with matrix metalloproteinase cleavage products of fibrin(ogen)  
The invention provides a monospecific antibody that is specifically reactive with enzymatically mediated degradation products of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances)....
6042828 Humanized antibodies to ganglioside GM2  
Chimeric human antibody expression vectors are constructed by inserting the antibody heavy chain variable region-encoding cDNA and antibody light chain variable region-encoding cDNA isolated from...
6040498 Genetically engineered duckweed  
Methods and compositions for the efficient transformation of duckweed are provided. Preferably, the methods involve transformation by either ballistic bombardment or Agrobacterium. In this manner,...
6033667 Method for detecting the presence of P-selectin  
The present invention relates to compositions and methods for treating inflammation and other pathological conditions using novel blocking P-selectin antibodies that inhibit adhesion of leukocytes...
6030616 Hepatitis B escape mutant specific binding molecules  
Molecules which are capable of specifically binding to a hepatitis B escape mutant antigenic determinant include monoclonal antibodies secreted by the cell line SMH HBs 145/G/R/I (ECACC 92122312)....
6030614 Ameliorating immunological rejection of allograft  
The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a...
6027922 Human foam cells and methods for preparing them, monoclonal antibodies to said foam cells and their pharmaceutical and diagnostic use  
The present invention relates to human foam cells generated in vitro from monocyte/macrophage related cell lines which give rise to an average intracellular cholesterol amount of at least 139+36...
6020170 Method of preparing a monoclonal antibody  
The present invention relates to an efficient method of producing monoclonal antibodies against surface antigens of cells and viruses. The method accommodates for antigens which are present in...
6013519 Monoclonal antibodies to antigens expressed by hematopoietic facilitatory cells  
The present invention relates to monoclonal antibodies (MAb) to hematopoietic facilitatory cells (FC). In particular, it relates to MAb against antigens expressed by murine FC, methods of...
6010903 Anti-human ceruloplasmin monoclonal antibody  
Disclosed is a monoclonal antibody which specifically reacts with active human ceruloplasmin as well as a method for diagnosing Wilson's disease using the same. The monoclonal antibody of the...
6011138 Gamma-1 anti-human CD23 monoclonal antibodies  
Anti-human CD23 monoclonal antibodies containing human gamma 1 constant domains and therapeutic uses are provided. These antibodies inhibit IL-4 induced IgE production by B-cells significantly...
6011139 Hybridomas and monoclonal antibodies that specifically bind to glutamic acid decarboxylase peptides  
Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed. Monoclonal antibodies specific for...
6008024 Monoclonal antibodies specific for PHF-tau, hybridomas secreting them, antigen recognition by these antibodies and their applications  
Monoclonal antibody AT180 secreted by the hybridoma deposited at ECACC on Dec. 22, 1992 under No. 92122204, and monoclonal antibody AT270 secreted by the hybridoma deposited at ECACC on Jul. 7,...
6004765 Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin  
A method for the assessment of bone fragility and osteoporosis fracture risk characterized by: measuring in vitro the concentration of under-carboxylated osteocalcin in a biological fluid sample...
5998172 Anti-CD6 ligand antibodies  
The present invention relates, in general, to CD6 and, in particular, to a CD6 ligand present on the surface of thymic epithelial cells, monocytes, activated T cells and a variety of other cell...
5994524 Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same  
The present invention discloses a reshaped human antibody against human IL-8 comprising: (A) L chains each comprising: (1) a human L chain C region; and, (2) an L chain V region comprising a human...
5985278 Anti-αV-integrin monoclonal antibody  
The invention relates to a novel monoclonal antibody, a hybridoma cell line producing said antibody, DNA sequences coding for said antibody, and amino acid sequences. The monoclonal antibody, a...
5980893 Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis  
A class of murine monoclonal antibodies that is capable of stimulating megakaryocytopoiesis in vitro has been raised against human megakaryocytic cells. The monoclonal antibody BAH-1 specifically...
5977323 Method of purifying Gro β or Gro α protein using antibodies  
Two novel cytokines which are involved in an inflammatory response (inflammatory cytokines) are disclosed. The inflammatory cytokines have been isolated from activated peripheral blood, preferably...
5961974 Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same  
There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human...
5962269 Methods for producing antibodies which specifically bind to interleukin-9 receptor  
The invention describes nucleic acid sequences which code for the interleukin 9 receptor (IL9-R) molecule. These sequences may be used as probes to identify cells expressing the molecule, and as...
5959083 Tetravalent bispecific receptors, the preparation and use thereof  
The invention relates to bispecific tetravalent receptors of the formula I ##STR1## or formula II ##STR2## against a tumor-associated antigen and against an agent active against tumors.
5959086 Antibodies specific for human pancreatitis associated protein  
The invention relates to the family of the protein (PAP) associated with acute pancreatitis in man and in the rat. It also relates to the nucleotide fragments coding for the above proteins. Also...
5955358 Optimization of binding proteins  
The invention relates to methods for manipulating nucleic acids so as to optimize the binding characteristics of an encoded binding protein by providing two or more nucleic acids encoding binding...
5955293 Assays for shiga toxin and shiga-like toxins  
The present invention relates to a substantially pure antigenic peptide or protein related to Shiga toxin, Shiga-like toxin I, Shiga-like toxin II or a variant of Shiga-like toxin II, and to a...
5955317 Antibodies to β-amyloids or their derivatives and use thereof  
According to this invention, antibodies which are useful and novel in that they have binding specificity to β-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or...
5951983 Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies  
The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response...
5948647 Nucleic acids encoding antigen-binding sites specific for cancer antigens  
Novel compositions are provided that are derived from antigen-binding sites of immunoglobulins having affinity for cancer antigens. The compositions exhibit immunological binding properties of...
5945311 Method for producing heterologous bi-specific antibodies  
In a method for producing heterologous bi-specific antibodies, a quadroma is provided which is fused from hybridromas one of which generates antibodies that have an affinity to the binding site of...
5939280 Immunological assay for quantifying peg-modified human granulocyte colony stimulating factor and monoclonal antibodies used in the assay  
An immunological assay for quantifying PEG-modified human granulocyte colony stimulating factor or derivatives thereof in a sample comprising bringing into contact with said sample an antibody...
5932448 Bispecific antibody heterodimers  
Methods for producing and using bispecific antibodies formed by leucine zippers are provided. Leucine zippers capable of preferentially forming heterodimers are respectively linked to epitope...
5928893 Monoclonal antibody specific for human 4-1BB and cell line producing same  
A monoclonal antibody specific for human 4-1BB, accessory molecule, selectively expressed on activated T cells; polynucleotides encoding the variable regions of the monoclonal antibody and amino...