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6407213 |
Method for making humanized antibodies
Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are...
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6406701 |
Method and compositions for preventing or reducing HIV infection
In spite of having achieved an in depth and comprehensive genetic structure of the human immunodeficiency virus (HIV) and of that of its several structural and geographical clusters, a very limited...
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6358711 |
Antibody to human testin and methods of making and using
The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists....
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6342221 |
Antibody conjugate compositions for selectively inhibiting VEGF
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
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6335163 |
Polyclonal antibody libraries
The invention is directed to methods for the creation and use of libraries of proteins which comprise polyclonal antibodies to a common antigen or group of antigens, receptor proteins with related...
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6331415 |
Methods of producing immunoglobulins, vectors and transformed host cells for use therein
The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and...
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6328963 |
Anti-human MP52 monoclonal antibody
A mouse anti-human MP52 monoclonal antibody which binds to dimeric human MP52 but not to monomeric human MP52. This mouse monoclonal antibody comprising IgG and having a high specificity can be...
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6316600 |
Methods for the production of chicken monoclonial antibodies
The present invention provides methods for producing antibodies against a variety of antigens, including mammalian antigens with highly conserved epitopes. In addition, the present invention...
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6309637 |
Human microfibril-associated glycoprotein 4 splice variant
The invention provides a human microfibril-associated glycoprotein 4 splice variant (MAG4V) and polynucleotides which identify and encode MAG4V. The invention also provides expression vectors, host...
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6309863 |
Methods for generating phosphorylation site-specific immunological reagents
The present invention provides methods for generating phosphorylation site-specific immunological reagents. More specifically, a phosphopeptide mimetic is incorporated into a polypeptide in place...
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6306626 |
Anti-IgM monoclonal antibodies and methods of their use
The present invention provides an anti-IgM antibody conjugate comprising: a monoclonal antibody which binds selectively to IgM antibody, does not bind to IgG1 or IgG2 antibody, and has a G isotype;...
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6300104 |
Secretory immunoglobulin produced by single cells and methods for making and using same
Disclosed is a method of producing secretory Ig molecules. The method comprises transfecting a cell producing an Ig with a polynucleotide encoding an SC to fonn SC transfected Ig producing cells....
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6291649 |
Anti-bodies binding adhesin-derived antigens
An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible...
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6287793 |
Diagnostic methods for alzheimer's disease
Methods are disclosed for the identification of key diagnostic antibodies and antigens characteristic of a disease state of interest. Key diagnostic antibodies and antigens, diagnostic kits, and...
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6284471 |
Anti-TNFa antibodies and assays employing anti-TNFa antibodies
Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as...
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6274334 |
Monoclonal antibody, cell line and immunoassay for ractopamine
A hybridoma cell line has been produced for secreting a monoclonal antibody that binds ractopamine and is effective to detect ractopamine levels of about 1 ng/mL or lower. This monoclonal antibody...
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6274347 |
Method of producing a cell surface bound lam-1 specific antibody
A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis...
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6274324 |
Specific binding reagent comprising a variable domain protein linked to a support or tracer
Small specific binding molecules, such as single variable domain antibodies (Dabs) and Fv fragments, can be coupled to solid plastics surfaces or to tracers such as enzymes by means of linkers...
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6270978 |
Immunomethods for isolating and indentifying human influx peptide transporter
Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide...
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6261790 |
Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs) are described. In one aspect, the invention is directed to monoclonal antibodies that...
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6258564 |
Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method the hybirdomas and antigen proteins recognized by the antibodies
The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a...
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6248546 |
Assay of IGFBP complex
A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be...
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6245897 |
Monoclonal antibody recognizing cell surface antigen CD14
A monoclonal antibody which recognizes lipopolysaccharide binding site of macrophage cell surface receptor CD14 and has binding activity to monocyte or macrophage cells. The monoclonal antibody...
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6232123 |
Monoclonal antibodies against leucocyte-specific G protein-coupled receptors
The invention relates to monoclonal antibodies against leucocyte-specific G protein-coupled receptors (L-GCR). These antibodies are obtainable by the following steps: (a) introduction of an...
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6232447 |
Antibody immunoreactive with a human cytokine designated LERK-6
The invention is directed to antibodies immunoreactive with a Human LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.
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6228618 |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
Methods for enhancing the production of tissue plasminogen activator (tPA) in cell culture are disclosed. The methods involve culturing tPA-producing cells in growth media supplemented with an...
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6214568 |
Monoclonal antibodies of isotype IgG which bind specifically to glutamate decarboxylase, and uses thereof
The invention concerns human monoclonal antibodies of the IgG isotype against human pancreatic islet cells which can be obtained by immortalizing human lymphocytes of prediabetics or diabetics,...
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6210670 |
Cross-reacting monoclonal antibodies specific for E-selectin and P-selectin
This invention provides monoclonal antibodies that bind to both E-selectin and to P-selectin, and inhibit the binding of these proteins to counterreceptors. The invention also provides nucleic...
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6207815 |
Family of high affinity, modified antibodies for cancer treatment
This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies...
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6194385 |
Calcium-binding protein
The present invention provides a human calcium-binding protein (HCBP) and polynucleotides which identify and encode HCBP. The invention also provides expression vectors and host cells, agonists,...
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6183971 |
Human betacellulin-specific antibodies and uses thereof
Disclosed are an antibody which have a binding activity to human betacellulin protein or a mutein thereof with specificity; especially a monoclonal antibody which does not have cross reactitivity...
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6180102 |
Monoclonal antibody to human Mx protein MxA
This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of...
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6171782 |
Antibody compositions to HCV and uses thereof
A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B...
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6171588 |
Anti-αvβ3 integrin antibody antagonists
Monoclonal antibodies that recognize the αv β3 integrin receptor complex, but do not significantly bind to αIIbβIIIa, inhibit αvβ3 integrin-mediated diseases.
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6156883 |
Polyclonal and monoclonal antibodies to Norwalk virus and methods for making them
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
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6146903 |
Method for determination of water treatment polymers
A method for determining the presence and/or concentration of a water treatment polymer in an aqueous sample, comprising producing a polyclonal or monoclonal antibody to the water treatment...
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6143865 |
Epstein-Barr virus peptides and antibodies against these peptides
The invention relates to peptides or fragments thereof which are immunochemically reactive with Epstein-Barr Virus (EBV) antibodies. New antibodies directed to said peptides or fragments thereof...
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6143559 |
Methods for the production of chicken monoclonal antibodies
The present invention provides methods for producing antibodies against a variety of antigens, including mammalian antigens with highly conserved epitopes. In addition, the present invention...
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6133427 |
Anti-human calcitonin monoclonal antibodies and an immunoassay utilizing said antibodies
Monoclonal antibodies having a high affinity for human calcitonin, particularly monoclonal antibodies suitable for a sandwich immunoassay are disclosed. Also disclosed are hybridomas producing said...
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6129914 |
Bispecific antibody effective to treat B-cell lymphoma and cell line
The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric...
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6124439 |
OB polypeptide antibodies and method of making
The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and...
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6124132 |
Use of anti-HIV IGA antibodies for producing immunological protection against the human immunodeficiency virus
The subject invention concerns the production and novel use of human anti-HIV IgA antibodies to confer passive immunity to HIV when administered in vivo to a subject. The IgA antibodies of the...
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RE36866 |
Anti-aids immunotoxins
The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptase. Also...
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6090923 |
Murine monoclonal antibody binding TNFα
A cytotoxic protein expressed by human peripheral blood mononuclear cells is isolated in essentially homogenous form. This protein may be used to elicit production of polyclonal or monoclonal...
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6087130 |
Antibody substances that bind to ICAM-related protein
Antibody substances that bind to a novel human intercellular adhesion molecule polypeptide (designated "ICAM-R") and variants thereof are disclosed along with methods and materials producing and...
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6084075 |
Agonist and antagonist antibodies to the chemokine receptor-2 (CCR2)
The invention relates to antibodies which is capable of binding the monocyte chemoattractant protein 1 (MCP-1) receptor CCR2, especially those which are capable of acting either as an antagonist or...
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6080405 |
Foam proteins and use thereof
Novel foam proteins, monoclonal antibodies specifically recognizing said proteins, a method for determining foam protein contents in beer samples by an immunoassay using said monoclonal antibodies,...
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6080560 |
Method for producing antibodies in plant cells
A method for producing antibodies in plant cells including the steps of providing a genetic construct that encodes a secretable mammalian single chain antibody, delivering copies of the construct...
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6056957 |
Humanized monoclonal antibodies against human interleukin-5
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy...
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6057121 |
Method of catalyzing stereochemical reactions
A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate...
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