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7087727 Periostin-based diagnostic assays  
The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast...
7087396 Monoclonal antibody and method and kit for immunoassay of soluble human ST2  
A method for determining a soluble human ST2 in a sample conveniently at a high sensitivity and an assay kit are provided. By an immunological method comprising a step for bringing a sample into...
7074903 Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof  
Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to...
7071311 Antibodies having specificity for 2′-C-allyl nucleic acids  
The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of...
7070960 Method of increasing product expression through solute stress  
A method of determining the optimal level of product expression and cell growth of animal cell culture is described. The method generally comprises culturing cells under conditions of solute...
7067268 Antibodies and utilization thereof  
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2...
7056702 Detecting lipocalin  
The invention provides antibodies reactive with distinct lipocalin epitopes that are useful for detecting inflammation and bacterial infections in mammals.
7045605 Modified antibodies to prostate-specific membrane antigen and uses thereof  
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
7041293 HIV env antibodies  
The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in...
7038021 Anti-dioxins monoclonal antibody suitable for assaying dioxins in environment and hybridoma producing the same  
The object of present invention is to provide an immunoassay for dioxins which can rapidly and simply afford measured values having a good correlation with analytical values of dioxins by the...
7033774 Determination of recombinant glycosylated proteins and peptides in biological fluids  
Polyclonal antibodies can be produced that reacts with recombinant EPO and its degradation products but not with native EPO. This antibody precipitation can be used to identify those glycopeptides...
7026140 Serum paraoxonase  
Human serum paraoxonase enzyme and DNA (RNA) encoding such serum paraoxonase enzymes are disclosed. Also provided is the procedure for producing such polypeptides by recombinant techniques. Uses of...
7018809 Expression of functional antibody fragments  
Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab′ and F(ab′)2 antibody fragments are provided. Expression of heavy and light chain Fv in a microbial sec...
7005503 Human monoclonal antibody against coreceptors for human immunodeficiency virus  
Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are...
6992177 Saquinavir derivatives useful in immunoassay  
Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring...
6967081 Method for prediction of bone fractures by osteocalcin measurements  
This invention concerns a method for the assessment of bone fragility and fracture risk, or osteoporosis, in a person. In said method, the concentration of gamma-carboxylated osteocalcin (COC) and...
6965018 Antibodies directed to B7-related polypeptide, BSL-2  
The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors...
6964854 Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis  
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of...
6951645 Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy  
A “cocktail” combination of two monoclonal antibodies respectively acting on different sites of the platelet GPIIb-IIIa complex has been disclosed. This “cocktail” combination can complet...
6946255 Monoclonal antibody reacting specifically reacting with Fas ligand and production process thereof  
The invention provides monoclonal antibodies, which specifically react with a Fas ligand, or active fragments thereof, a production process of the monoclonal antibodies, which specifically react...
6929924 C-peptide specific assay procedure  
The present invention relates to a specific C-peptide assay method which can eliminate all interference due to proinsulin and its intermediates, in particular des-31,32-proinsulin and/or...
6927035 Antiuracil monoclonal antibody  
A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying ...
6916628 Method for the measurement of soluble CD14 proteins separately  
The present invention provides a method for qualitative determination of low molecular weight soluble CD14 proteins separately. The present invention also provides antibodies specific to high...
6913756 Monoclonal antibodies specific for anthrax and peptides derived from the antibodies thereof  
The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and...
6913894 Antibodies directed against signal regulator proteins  
Monoclonal antibodies which bind specifically to the extracellular domain of the SIRP cell surface glycoproteins, and which, in some cases, block the interaction of SIRP with the surface molecule...
6875580 Antibodies specific for plasmacytoid dendritic cells  
The invention provides immunological reagents (antibodies) capable of binding to plasmacytoid dendritic cells (pDC), to cell lines which express such antibodies and to a process for identifying and...
6863892 Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers  
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
6849720 Monoclonal antibodies to the human LDL receptor, their production and use  
There are provided monoclonal antibodies to the LDL receptor which are useful for the identification and purification of LDL and in treatment of e.g. hepatitis C infection.
6838250 Immunoassay for C-reactive protein  
The present invention relates to new CRP immunoassay compositions. The compositions include a low affinity anti-human CRP monoclonal antibody, and an antiidiotypic antibody raised against it. The...
6830896 Process for analyzing annexin-V in urine, and application thereof  
The present invention provides a process and regent for analyzing annexin-V, wherein the measurement of a concentration of annexin-V can be easily carried out without need for addition of chemicals...
6812024 Anti-paratopic antibody as an immunogen  
The present invention provides a method of manufacture of an anti-paratopic antibody comprising the steps of: (1) selecting from a pool of antibodies occurring in one species a prototypic set the...
6806053 Cell-signaling assays  
Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of...
6803209 Preparation for use in cell culture in which an interfering compound is absent or depleted  
A cell culture preparation and methods are provided which are suitable for production in cells of a first protein in a class of proteins where the medium is deficient in a second protein in a...
6800462 Production of recombinant proteins in vivo and use for generating antibodies  
The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the...
6780412 Protein and monoclonal antibody specific thereto  
A novel protein which is useful as diagnostic means for the studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and in other...
6750325 CD3 specific recombinant antibody  
The invention provides recombinant antibody molecules comprising antigen binding regions derived from the heavy and/or light chain variable regions of a donor anti-CD3 antibody, e.g. OKT3, and...
6733981 Antibodies to interleukin-1 β converting enzyme like apoptosis protease-3 and 4  
Disclosed are human interlude-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by ...
6722062 Capsular polysaccharides from enterococci  
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
6719975 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin  
A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
6720165 Methods for making antibody fragments and compositions resulting therefrom  
Improved methods for making antibody fragments, preferably F(ab′)2 fragments from various classes and subclasses of antibodies is described. Pretreatment of antibodies with deglycosylases or c...
6716594 Monoclonal antibody  
The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to...
6713609 Monoclonal antibodies to type I interferon receptor  
Anti-IFNAR1 monoclonal antibodies with neutralizing activities against the anti-viral cytopathic effects of various type I interferons are provided.
6709811 Versatile reagent for detecting murine leukemia viruses  
A method for detecting broad spectrum of murine leukemia viruses belonging to any or all of the ecotropic, xenotropic, polytropic and amphotropic groups, has been described. The method utilizes a...
6709833 Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate  
A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous...
6709873 Method for production of antibodies to specific sites of rapamycin  
This invention relates to the production of polyclonal and monoclonal antibodies to specific sites of rapamycin (Sirolimus). The reactivity of these poly and monoclonal antibodies make them...
6703019 Cationized antibodies against intracellular proteins  
The subject application discloses methods and compositions for the targeted detection and/or inhibition of an intracellular protein in a cell by contacting the cell with a cationized antibody which...
6689360 Human B-cell translocation genes-2 and 3 antibodies  
The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3)....
6677124 Monoclonal antibody recognizing C-terminus of hBNP  
A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the...
6649421 Antibodies against phoshorylated VASP (vasodilator-stimulated phosphoprotein), hybridoma cells for their preparation, and their use  
The invention relates to antibodies against VASP (vasodilator-stimulated phosphoprotein) which only bind VASP as an antigen when VASP is present in phosphorylated form, to hybridoma cells for their...
6632976 Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene  
A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a...