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6806053 Cell-signaling assays  
Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of...
6803209 Preparation for use in cell culture in which an interfering compound is absent or depleted  
A cell culture preparation and methods are provided which are suitable for production in cells of a first protein in a class of proteins where the medium is deficient in a second protein in a...
6800462 Production of recombinant proteins in vivo and use for generating antibodies  
The invention is directed to methods of producing a protein by administering a nucleic acid encoding the protein to an animal. Following the administration of the nucleic acid to the animal, the...
6780412 Protein and monoclonal antibody specific thereto  
A novel protein which is useful as diagnostic means for the studies relating to the diagnosis and treatment of cancer (detection of cancer cells, estimation of the malignity, etc.) and in other...
6750325 CD3 specific recombinant antibody  
The invention provides recombinant antibody molecules comprising antigen binding regions derived from the heavy and/or light chain variable regions of a donor anti-CD3 antibody, e.g. OKT3, and...
6733981 Antibodies to interleukin-1 β converting enzyme like apoptosis protease-3 and 4  
Disclosed are human interlude-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by ...
6722062 Capsular polysaccharides from enterococci  
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
6719975 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin  
A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
6720165 Methods for making antibody fragments and compositions resulting therefrom  
Improved methods for making antibody fragments, preferably F(ab′)2 fragments from various classes and subclasses of antibodies is described. Pretreatment of antibodies with deglycosylases or c...
6716594 Monoclonal antibody  
The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to...
6713609 Monoclonal antibodies to type I interferon receptor  
Anti-IFNAR1 monoclonal antibodies with neutralizing activities against the anti-viral cytopathic effects of various type I interferons are provided.
6709811 Versatile reagent for detecting murine leukemia viruses  
A method for detecting broad spectrum of murine leukemia viruses belonging to any or all of the ecotropic, xenotropic, polytropic and amphotropic groups, has been described. The method utilizes a...
6709833 Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate  
A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous...
6709873 Method for production of antibodies to specific sites of rapamycin  
This invention relates to the production of polyclonal and monoclonal antibodies to specific sites of rapamycin (Sirolimus). The reactivity of these poly and monoclonal antibodies make them...
6703019 Cationized antibodies against intracellular proteins  
The subject application discloses methods and compositions for the targeted detection and/or inhibition of an intracellular protein in a cell by contacting the cell with a cationized antibody which...
6689360 Human B-cell translocation genes-2 and 3 antibodies  
The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3)....
6677124 Monoclonal antibody recognizing C-terminus of hBNP  
A hybridoma producing a monoclonal antibody recognizing the C-terminus of human brain natriuretic peptide (hBNP) was cultivated in a medium or the abdominal cavity of a mouse to recover the...
6649421 Antibodies against phoshorylated VASP (vasodilator-stimulated phosphoprotein), hybridoma cells for their preparation, and their use  
The invention relates to antibodies against VASP (vasodilator-stimulated phosphoprotein) which only bind VASP as an antigen when VASP is present in phosphorylated form, to hybridoma cells for their...
6632976 Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene  
A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a...
6613538 Detection of HLA-G  
The present invention relates to the detection of HLA-G. Antibodies to both soluble and membrane bound HLA-G are disclosed. Exemplary antibodies include 2C/C8, 3C/G4, and 4H84. 2C/C8 and 4H84...
6605705 Prostaglandin D synthase-specific monoclonal antibody  
The invention relates to a monoclonal antibody specifically recognizing lipocalin-type prostaglandin D synthase (L-PGDS), a hybridoma producing the monoclonal antibody, methods for detection of...
6593137 Antibodies specific for fullerenes  
This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number...
6551599 Monoclonal antibodies against campylobacter jejuni and campylobacter coli outer membrane antigens  
The present invention is directed to a method of producing monoclonal antibodies that are highly specific for (1) unique epitopes of Campylobacter jejuni (Cj) only and (2) epitopes conserved...
6548640 Altered antibodies  
The invention relates to altered antibodies that have a heavy or light chain variable domain in which the framework regions differ from the framework regions naturally associated with the...
6537762 Peptide mimotope to mycotoxin deoxynivalenol and uses thereof  
The present invention provides a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody...
6528625 Anti-CCR5 antibodies and kits comprising same  
The present invention relates to an antibody or functional portion thereof which binds to a mammalian (e.g., human) chemokine receptor 5 protein (CKR-5 or CCR5) or portion of the receptor. The...
6528061 Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions  
A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a...
6506882 Antibodies that bind tumor necrosis factor delta  
The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the...
6503509 Method for receptor desensitization  
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell...
6503736 Antibodies to crosslinkers and methods for using the same  
The present invention is directed to the discovery of antibodies that will react to proteins or nucleic acids bound to particular crosslinkers, but not to the free crosslinkers or free proteins or...
6482599 Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such  
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid...
6482648 Stable troponin preparation and the use thereof as a calibrator/control in immunoassays  
The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian,...
6471962 Monoclonal antibodies for infectious bursal disease, vaccines and assays for use therewith  
Two monoclonal antibodies which neutralize all infectious bursal disease viruses are employed in the preparation of infectious bursal disease vaccines. A panel of monoclonal antibodies can be used...
6451599 Monoclonal antibodies reactive with fibrin (ogen) degradation products generated by matrix metalloproteinases  
The invention provides monoclonal antibodies which are reactive with fibrin(ogen) degradation products (FDPS) generated by matrix metalloproteinases (MMPs), such as MMP-3, MMP-7, and membrane-type...
6451311 Anti-procalcitonin antibodies and the preparation and use thereof  
The invention relates to anti-procalcitonin antibodies, their preparation and use, in particular in therapy and diagnostics. The antibodies comprise binding to procalcitonin but not to free...
6416758 Antibody conjugate kits for selectively inhibiting VEGF  
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
6407213 Method for making humanized antibodies  
Variant immunoglobulins, particularly humanized antibody polypeptides are provided, along with methods for their preparation and use. Consensus immunoglobulin sequences and structural models are...
6406701 Method and compositions for preventing or reducing HIV infection  
In spite of having achieved an in depth and comprehensive genetic structure of the human immunodeficiency virus (HIV) and of that of its several structural and geographical clusters, a very limited...
6358711 Antibody to human testin and methods of making and using  
The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists....
6342221 Antibody conjugate compositions for selectively inhibiting VEGF  
Disclosed are antibodies that specifically inhibit VEGF binding to only one (VEGFR2) of the two VEGF receptors. The antibodies effectively inhibit angiogenesis and induce tumor regression, and yet...
6335163 Polyclonal antibody libraries  
The invention is directed to methods for the creation and use of libraries of proteins which comprise polyclonal antibodies to a common antigen or group of antigens, receptor proteins with related...
6331415 Methods of producing immunoglobulins, vectors and transformed host cells for use therein  
The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and...
6328963 Anti-human MP52 monoclonal antibody  
A mouse anti-human MP52 monoclonal antibody which binds to dimeric human MP52 but not to monomeric human MP52. This mouse monoclonal antibody comprising IgG and having a high specificity can be...
6316600 Methods for the production of chicken monoclonial antibodies  
The present invention provides methods for producing antibodies against a variety of antigens, including mammalian antigens with highly conserved epitopes. In addition, the present invention...
6309637 Human microfibril-associated glycoprotein 4 splice variant  
The invention provides a human microfibril-associated glycoprotein 4 splice variant (MAG4V) and polynucleotides which identify and encode MAG4V. The invention also provides expression vectors, host...
6309863 Methods for generating phosphorylation site-specific immunological reagents  
The present invention provides methods for generating phosphorylation site-specific immunological reagents. More specifically, a phosphopeptide mimetic is incorporated into a polypeptide in place...
6306626 Anti-IgM monoclonal antibodies and methods of their use  
The present invention provides an anti-IgM antibody conjugate comprising: a monoclonal antibody which binds selectively to IgM antibody, does not bind to IgG1 or IgG2 antibody, and has a G isotype;...
6300104 Secretory immunoglobulin produced by single cells and methods for making and using same  
Disclosed is a method of producing secretory Ig molecules. The method comprises transfecting a cell producing an Ig with a polynucleotide encoding an SC to fonn SC transfected Ig producing cells....
6291649 Anti-bodies binding adhesin-derived antigens  
An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible...
6287793 Diagnostic methods for alzheimer's disease  
Methods are disclosed for the identification of key diagnostic antibodies and antigens characteristic of a disease state of interest. Key diagnostic antibodies and antigens, diagnostic kits, and...