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7655783 Methods and compositions for increasing antibody production  
The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and...
7642341 Angiogenesis inhibiting molecules, their selection, production and their use in the treatment of cancer  
The present invention relates to a method for providing molecules that are capable of inhibiting angiogenesis, comprising the steps of providing a range of molecules; testing whether these...
7641904 IL-32 monoclonal antibodies and uses thereof  
The present invention provides monoclonal antibodies specific for interleukin-32 (IL-32, previously referred to as “natural killer cell transcript 4” or “NK4”) and hybridomas secreting monoclonal...
7638605 Fully human antibodies directed against the human insulin-like growth factor-1 receptor  
This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific...
7638604 Monoclonal antibodies against interleukin-22  
Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The...
7635757 B7-4 Antibodies and uses therefor  
The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules,...
7611855 Immunoassay method and kit to be used therein  
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
7612178 Anti-IGF-1R antibodies and uses thereof  
The invention relates to antibodies which bind to insulin like growth factor receptor-1 (IGF-1R) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine...
7608694 Antibody molecules having specificity for human IL-1β  
The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1β, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
7598351 Antibody and use thereof  
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2...
7598030 Antibodies against cancer produced using masked cancer cells as immunogen  
This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for...
7592427 Antibodies to IL-21 receptor  
Monoclonal antibodies to the IL-21 receptor and multimeric complexes comprising the IL-21 receptor; including monoclonal antibodies to the heterodimeric receptor, IL-21/IL-2Rγ; have been prepared....
7589181 Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use  
Humanized anti-TAG-72 CC49 monoclonal antibodies are disclosed herein. The antibodies include a light chain Complementarity Determining Region (L-CDR)1, a L-CDR2, and a L-CDR3; and a heavy chain...
7579170 Method for preparing monoclonal antibodies capable of activating effector cells expressing FCγRIII  
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcγ receptors and having a particular glycan...
7575873 Reagents for diagnosing, imaging and treating atherosclerotic disease  
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
7572895 Transferrin receptor antibodies  
The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the...
7569673 Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors  
The present disclosure provides humanized CC49 monoclonal antibodies that bind TAG-72 with high binding affinity and that are minimally immunogenic. In one embodiment, a humanized CC49 antibody...
7563882 Polynucleotides encoding antibodies that bind to the C35 polypeptide  
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human...
7556804 Anti-HGF-R antibodies and their use  
The present invention relates to monoclonal antibodies which recognize the chain of the HFG receptor with the agonist activity of the natural ligand. The invention also relates to the hybridoma...
7553937 Specific antibodies for diagnosing heart failure  
The invention relates to an in vitro diagnosis of heart failure. More specifically, the invention relates to specific antibodies of a peptide domain which is situated on either side of hinge...
7547768 Anti-TAT 113 antibodies  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
7541027 Use of an epitope of vascular endothelial growth factor receptor KDR/Flk-1  
The present invention relates to the use of the epitope which comprises the tyrosine at position 1214 in the amino acid sequence of the vascular endothelial growth factor receptor, KDR/Flk-1, as a...
7541160 ELISA for VEGF  
The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions,...
7538195 Anti-IGF-I receptor antibody  
Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit...
7534580 PSP94 diagnostic reagents and assays  
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
7527973 Antibodies against West Nile Virus and therapeutic and prophylactic uses thereof  
The present invention relates to compositions comprising antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus...
7527939 Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP  
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
7521542 Humanized FcγRIIB-specific antibodies and methods of use thereof  
The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention...
7517524 Immunointeractive molecules  
The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural...
7517663 Rabbit monoclonal antibody against Id1 protein  
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
7514078 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies  
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
7511123 Immuno-interactive fragments of the alpha-C subunit of inhibin  
Novels immuno-interactive fragments of the (alpha)C portion of a mammalian inhibin alpha subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules...
7507550 Analytical sandwich test for determining NT-proBNP  
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
7504254 Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes  
Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid...
7501264 Methods of producing 7C10 and 16C10 CD80-specific antibodies  
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and...
7495081 Framework patched anti-CD20 antibody  
Framework (FR)-patching is a novel approach to modify immunoglobulin for reducing potential immunogenicity without significant alterations in specificity and affinity. Unlike previous described...
7491514 Reducing the immunogenicity of anti-CD20 antibodies by framework patching  
Framework (FR)-patching is a novel approach to modify immunoglobulin for reducing potential immunogenicity without significant alterations in specificity and affinity. Unlike previous described...
7491516 Dual specificity antibodies and methods of making and using  
Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or...
7488803 Antibodies to the extracellular domain of human Fragilis polypeptide and methods of making said antibodies  
The present invention relates to two primordial germ cell-specific expressed genes, Fragilis and Stella. The sequences and sues of human Stella and Fragilis are disclosed herein, as are several...
7473564 Kit and method for detecting the ESM-1 protein  
The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising: a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between the...
7470775 Anti-CD30 stalk and anti-CD30 antibodies suitable for use in immunotoxins  
CD30 is a receptor expressed on cells of Hodgkin's disease and certain leukemias. The extracellular portion of CD30 is cleaved, releasing a form known as sCD30. The invention relates in part to...
7439025 Antibodies binding a gamma carboxyglutamic acid displaying epitope  
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while...
7435871 Transgenic animals bearing human Igλ light chain genes  
The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have...
7435553 Isolating cells expressing secreted proteins  
A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture...
7431927 TNFα-neutralizing antibodies  
The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from...
7429646 Antibodies to human tumor necrosis factor receptor-like 2  
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice...
7429644 Humanized anti-LT-β-R antibodies  
Humanized antibodies to LT-β-R and methods of use thereof are provided.
7429645 Humanized anti-lymphotoxin beta receptor antibodies  
This invention concerns humanized antibodies specific for the lymphotoxin beta receptor (LT-β-R), cell lines that produce these antibodies, immunochemicals made from the antibodies, and diagnostic...
7427669 ULBP antibodies  
The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
7427495 Methods of using Bcl-2 for the therapeutic treatment and prevention of diseases  
The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the...