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7872102 Anti-IL-23 antibodies  
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind to the p19 subunit of IL-23. These antibodies, or antigen-binding portions...
7867725 Monoclonal antibodies against osteopontin  
The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present...
7863019 Interleukin-15 receptors  
There are disclosed Interleukin-15 Receptor (IL-15R) proteins, DNAs and expression vectors encoding IL-15R, and processes for producing IL-15R as products of recombinant cell cultures.
7858091 Antibodies to insulin-like growth factor binding protein and uses thereof  
Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor...
7854930 Anti-igf-ir antibodies and uses thereof  
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine...
7850963 Vascular endothelial growth factor 2  
Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions...
7851601 Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor  
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell...
7846435 Humanized antibodies that recognize Verotoxin II and cell line producing same  
The invention provides humanized antibodies that specifically bind to, and preferably, neutralize, verotoxin II (VT2). The antibodies are useful for treating patients suffering from, or at risk of...
7846692 HE4 monoclonal antibodies and methods for their use  
Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel...
7842500 Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate  
An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine...
7842513 Pregnancy detection  
This invention provides methods and compositions for testing for pregnancy and non-pregnancy in ungulates and non-hoofed ruminates. The tests provided by this invention are useful during a time...
7838247 Antibody specific for mutant presenilin 2 and method of use thereof  
The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on...
7834155 CA6 antigen-specific cytotoxic conjugate and methods of using the same  
Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and...
7829294 Anti-human soluble fibrin monoclonal antibody and immunological assay method using the antibody  
The present invention is directed to a monoclonal antibody against a soluble fibrin, which specifically recognizes a conformation-changed site newly occurred in a C-terminal region of an Aα-chain...
7820410 Proteins with high immunoreactivity and method for their production  
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced using a...
7811770 Method of detecting a subfraction of proBNP  
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
7807415 Methods of producing stable B-lymphocytes  
The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.
7807380 Method of detecting a subfraction of proBNP  
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
7807416 Antibodies and methods for generating genetically altered antibodies with enhanced effector function  
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and...
7803915 Antibody compositions for the diagnosis and treatment of tumor  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
7799327 Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment  
This invention describes a method whereby human autoimmune antibodies are used as carrier compounds to deliver imaging agents and pharmaceutical drugs to the tumor in the human patient. These...
7794981 Prosuction of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae  
A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an example DNA sequence encoding the...
7790163 Antibodies that bind both IL-17A and IL-17F and methods of using the same  
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory...
7790863 Angiogenesis inhibiting molecules and their use in the treatment and diagnosis of cancer  
The present invention relates to angiogenesis inhibiting molecules that are the monoclonal antibody H33 or fragments or derivatives thereof, to their use in the treatment of cancer, in particular...
7777017 Nucleic acids encoding opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria  
The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and...
7776330 Humanized anti-CEA T84.66 antibody and uses thereof  
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes...
7771969 Methods for obtaining antibodies  
The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is...
7754450 Methods of generating high-production of antibodies from hybridomas created by in vitro immunization  
The invention provides methods for generating high titers of high-affinity antibodies from hybridoma cells produced by fusing myeloma cells with in vitro immunized donor cells. The hybridoma cells...
7750125 Antibodies that bind to the C35 polypeptide  
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human...
7749504 Anti-TAT188 antibodies  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
7750124 Anti-human DLL4 antibodies and compositions  
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of...
7744886 Methods for interfering with rank signaling  
Disclosed herein are methods for interfering with RANK signaling by administering blocking antibodies that bind a RANKL polypeptide and inhibit the binding of the RANKL polypeptide to a RANK...
7741114 Antibodies for identifying and/or isolating at least one cell population  
Monoclonal antibodies, or fragments thereof, are used for isolating and/or identifying at least one cell population. The cell population can include any of the following types of cells:...
7736644 Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof  
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant,...
7731965 Human ring specific BNP antibodies  
The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.
7732168 Fusion partner for production of monoclonal rabbit antibodies  
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not...
7728115 Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis  
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis...
7722871 Immunoglobulins devoid of light chains  
The invention relates to an immunoglobulin having determined antigen specificity, and having a variable fragment which is obtainable from a camelid heavy-chain immunoglobulin having two heavy...
7718779 Prophylactic and therapeutic monoclonal antibodies  
In this application are described monoclonal antibodies which specifically recognize V antigen of Y. pestis and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of...
7718776 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors  
Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically...
7713712 Antibodies active against a fusion polypeptide comprising a histidine portion  
The present invention relates to an antibody active against a fusion polypeptide comprising a histidine portion, a process for the preparation thereof and its use.
7704501 Antibodies binding to human ataxin-1-like polypeptide  
This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat...
7700321 Antibody-based therapeutics with enhanced ADCC activity  
Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion...
7696322 Fusion antibodies  
The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further...
7695940 Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics  
Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The...
7670805 Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84  
Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the...
7667006 Anti-HIV antibody  
The present invention aims at providing a high affinity anti-HIV antibody. According to the present invention, there are provided an antibody or a fragment thereof that binds to the gp12...
7666414 Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen  
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or...
7662928 Anti-FcRn antibodies for treatment of auto/allo immune conditions  
Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or...
7659083 Device for detecting molecules, method for detecting molecules  
A construct is provided that is capable of binding a plurality of molecules, the construct comprising a first moiety with a first molecule binding region and a first molecule non-binding region;...