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4642293 Novel hybridoma cell line producing monoclonal antibodies against laminin and a process for the production thereof  
The invention relates to a novel hybridoma continuous cell line that produces a monoclonal antibody of the IgG type to the glycoprotein GP-2, a subunit of the basement membrane component laminin....
4637984 Monoclonal anti-ornithine decarboxylase antibody and method of producing same  
Monoclonal anti-ornithine decarboxylase antibody is produced by cell hybrids between hypoxanithine phosphoriboxyltransferase deficient myeloma cells and spleen cells derived from an animal...
4634664 Process for the production of human mono-clonal antibodies  
Hybridoma cell line made by fusing a xenogeneic hybridoma cell to a genetically compatible substance producing cell. Such hybridomas can be used i.a. for the production of antibodies.
4634666 Human-murine hybridoma fusion partner  
By careful screening and mutation, a human-murine hybridoma suitable as a fusion partner for immortalizing an antibody-secreting B cell has been generated. The trioma fusion products of this...
4632909 Monoclonal antibodies which block infectivity of malarial parasites to mosquitoes  
Monoclonal antibodies have been developed that bind with one or more proteins located on the surface of gametes or zygotes of malaria parasites. These antibodies are specific for antigens on...
4628027 Vitro diagnostic methods using monoclonal antibodies against connective tissue proteins  
Collagen profiles of human body tissues and fluids, i.e., the types of distinct connective tissue proteins present, their distribution in human body tissues and fluids, and the concentration...
4626507 Hybridomas producing monoclonal antibodies specific for a human cell surface glycoprotein  
Monoclonal antibodies are produced for a glycoprotein which is selectively expressed on the surface of human proliferating and immature hematopoietic cells but which is absent from normal...
4619895 Lipoprotein marker for hypertriglyceridemia  
Methods and compositions are provided for the detection of a particular low density lipoprotein which has been found to be a marker for patients suffering from type IV hypertriglyceridemia. A...
4618577 Human-human hybridoma, CLNH5  
Novel hybridomas, human monoclonal antibodies, and their uses are provided. Specifically CLNH5 is a human-human hybridoma which secretes IgM monoclonal antibodies specific for cervical of...
4618585 Hybridoma cell lines producing monoclonal antibodies directed against cervical cancer cells  
Continuous hybrid cell lines for producing monoclonal antibodies, the antibodies specific for an antigenic determinant unique to cervical cancer cells, have been developed. The hybrid cell lines...
4618589 Immunoprecipitation assay of immunoglobulins using monoclonal antibodies  
An antigen/antibody precipitate is obtained, using monoclonal antibodies, the monoclonal antibodies (samples I or II or III or IV) being selected so as to be specific to two distinct antigenic...
4613576 Human monoclonal antibodies to cancer cells  
Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a...
4612282 Monoclonal antibodies reactive with human breast cancer  
Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of...
4610960 Monoclonal antibody to thrombospondin and method for assaying for and isolating thrombospondin  
A monoclonal antibody produced by a hybridoma formed by the fusion of cells from a mouse myeloma line and spleen cells from a mouse previously immunized with thrombospondin. The monoclonal...
4608337 Human hybridomas and the production of human monoclonal antibodies by human hybridomas  
The present invention provides a stable, continuous human myeloma cell line which is capable of hybridization with antibody-producing cells of humans and other animals, the cell line being a...
4604235 Purification of monoclonal antibodies  
A method of chromatographically separating monoclonal antibody type IgM from mouse ascites fluid utilizing a particular chromatographic packing of silica gel bearing bound polyethylenimine functions.
4599306 Monoclonal antibodies which specifically bind to human immune interferon  
Disclosed are monoclonal antibody substances specifically immunologically reactive with native and recombinant human immune interferon ("IFN-γ") and with polypeptides having amino acid sequences...
4596771 Monoclonal antibodies to vitamin B-6 and immunossay method  
A continuous hybridoma cell line which secretes recoverable quantities of monoclonal antibodies having specificity against Vitamin B6, which antibodies are useful in a method for detecting the...
4596774 Method of preparing murine monoclonal antibodies against cell-free products of activated human T-lymphocytes  
A method of preparing simultaneously monoclonal antibodies specific for different cell-free products of activated human T lymphocytes is disclosed. Human T cells are activated in a medium...
4596769 Monoclonal antibodies to peptidoglycan and methods of preparing same  
Several novel hybridoma cell lines, ATCC #HB-8510, 8511, 8512, 8513, 8514, 8515, 8516, and 8517 produce monoclonal antibody to an antigen, peptidoglycan, which is a normal structural component of...
4595654 Method for detecting immune complexes in serum  
Method and test kit for detecting Clq-containing complexes in human serum containing native serum Cl. The method uses a monoclonal antibody which selectively reacts with human Clq in the presence...
4585742 Monoclonal antibody with specificity to human small cell carcinoma and use thereof  
Monoclonal antibody reactive with SCC cells and unreactive with human neuroblastoma cells, human squamous cell carcinoma cells, and human large-cell undifferentiated lung carcinoma cells.
4585741 Method of assay for vitamin D metabolites  
The vitamin D metabolite, calcitriol, is determined in blood serum by radioimmunoassay employing monoclonal antibodies in which calcitroic acid serves as the immunogen.
4582797 Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins  
Monoclonal antibodies are produced for a family of glycoproteins which are selectively expressed on the surface of nucleated human hematopoietic cells but which are absent from other normal human...
4582790 Monoclonal antibody to angiotension-converting enzyme and methods of preparing and using same  
A method for preparing a monoclonal antibody of improved cross-species specificity. The method includes the steps of preparing an inoculum antigen from a first species of animal producing the...
4579827 Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies  
A panel of monoclonal antibodies produced from human gastrointestinal tumors as immunogen is used to diagnose the presence of colon cancer. The antibody panel subsets the human gastrointestinal...
4574116 Methods and cell lines for immortalization and monoclonal antibody production by antigen-stimulated B-lymphocytes  
Methods are provided for producing fusion partners which involve employing an immortalized human myeloma cell line sensitive to HAT and having an additional dominant selectable resistance marker...
4572896 Monoclonal antibodies to herpes simplex virus type I polypeptides  
A method for producing monoclonal antibody reagents against novel proteins induced by herpes simplex virus type 1 (HSV-1). The method consists of preparing HSV-1 antigen populations by infecting...
4571381 Hybrid cell lines producing monoclonal antibodies directed against neurotransmitter degrading enzymes  
A continuous hybrid cell line which produces monoclonal antibody directed against the neurotransmitter degrading enzyme, monoamine oxidase B (MAO B), has been developed. The hybrid cell line was...
4565687 Monoclonal antibodies specific for the unbound β subunit of human chorionic gonadotropin  
Hybrid-myeloma cells which produce monoclonal antibody specific to the β subunit of human chorionic gonadotropin and methods of use of the monoclonal antibody.
4564597 Anti-Sm hybridoma  
Anti-Sm antibodies are produced by the hybridoma technique and employed to test for lupus erythematosus in humans.
4558005 Monoclonal anti-erythropoietin  
Hybridoma tumor cell line (ATCC Number CRL 8164). A monoclonal anti-erythropoietin antibody substance, Epoclonalan, produced by said cell line. Use of Epoclonalan in immonological methods for...
4558006 A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin  
Disclosed is a new mouse-mouse hybridoma tumor cell line A.T.C.C. No. HB8209. A monoclonal antibody produced by said cell line is specifically immunologically reactive with erythropoietin and with...
4550086 Monoclonal antibodies that recognize human T cells  
A monoclonal antibody which specifically binds to the surface recognition structure of a predetermined mature human T cell clone, which recognition structure renders the clone capable of acting as...
4543439 Production and use of monoclonal antibodies to phosphotyrosine-containing proteins  
A hybridoma cell line is disclosed that secretes monoclonal antibodies which serve as a high titer, reproducible, biological reagent useful in biological/medical research for isolating and...
4541953 Preparation of anti-T-lymphocyte globulin  
Anti-T-lymphocyte globulin is prepared from the serum of immunized animals. Cells of the cell line JM are used for immunization. Anti-T-lymphocyte globulin is prepared by means of hybrid cells,...
4533496 Method of isolating monoclonal antibodies from hybridoma cultures  
Monoclonal antibodies are isolated from spent culture medium of the in vitro growth of hybridoma cells by treating said spent cell culture medium or a concentrate thereof with a water-insoluble,...
4530908 Diagnosis and treatment of fluke infections with monoclonal antibodies  
Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded...
4529694 Cell fusion  
Human hybridomas producing a preselected human monoclonal antibody are prepared by fusing human lymphocytes with a hybrid fusion partner. The hybrid fusion partner is the result of fusing human...
4522918 Process for producing monoclonal antibodies reactive with human breast cancer  
Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of...
4521510 Hybridoma cell lines and monoclonal antibodies to theophylline  
Monoclonal antibodies to theophylline having 5% or less cross-reactivity with caffeine and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are...
4514507 Assay for interferon  
An assay for interferon comprises two antibodies to interferon, one labelled and at least one being a monoclonal antibody. The non-labelled antibody is suitably attached to a solid support such as...
4511661 ATCC HB8116 And its monoclonal anti-H-Y antibody, Hyclonalan  
Hybridoma tumor cell line A.T.C.C. No. HB8116. An anti-H-Y antigen monoclonal antibody substance, "Hyclonalan," produced by said cell line. Use of Hyclonalan in immunoselection methodology.
4510244 Cell labeling with antigen-coupled microspheres  
Method for isolating specific antibody hybridomas from a hybridoma cell mixture employing antigen-conjugated labeled microspheres and a label activated cell sorter. By selecting for labeled cells...
4508643 Rat antibody to hCG  
Antibody against human chorionic gonadotropin is raised in rats, preferably Lewis Strain Inbred rats, using either whole hormone or the β-subunit as the antigen, and displays low cross-reactivity...
4504586 Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1  
Murine-derived hybridoma tumor cell lines and monoclonal anti-Colony Stimulating Factor Subclass Number 1 antibody substances produced by these cell lines. Use of said monoclonal antibody...
4487833 Method of preparing hybridomas and of purifying immunogenic materials  
In a method for preparing a monoclonal hybridoma which secretes antibodies against an immunogenic material, comprising sensitizing an appropriate source with an immunizing amount of a preparation...
4487829 Production and use of monoclonal antibodies against adenoviruses  
Monoclonal antibodies, and a cell line characterized by its production of such monoclonal antibodies, demonstrating specific reactivity to an antigenic determinant possessed by a plurality of...
4474893 Recombinant monoclonal antibodies  
Antibodies having binding affinity for two desired antigens, hereinafter "recombinant monoclonal antibodies"; recombinant monoclonal antibodies produced by a quadroma cell or a trioma cell; and...
4472500 Rat myeloma cell lines  
A rat myeloma cell line which does not express an immunoglobulin chain, YB2/3.0.Ag.20, is prepared from the cell line Y3-Ag 1.2.3 via a hybrid myeloma cell line. This cell line, and variants...