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8623353 TLR2 antagonistic antibody and use thereof  
The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further...
8609820 Humanized antibodies that recognize alpha-synuclein  
The present application discloses humanized 9E4 antibodies. The antibodies bind to human alpha synuclein and can be used for immunotherapy of Lewy body disease.
8598408 Method of producing an antibody using a cancer cell  
The present invention aims to provide a method for antibody preparation. The present invention is directed to a method for preparing an antibody-producing cell, which comprises the following...
8598322 Anti CEACAM1 antibodies and methods of using same  
A hybridoma cell which has been deposited under ATCC Accession Number PTA-9974 is disclosed. Also provided are Antibodies and methods of using same.
8586042 Hybridomas producing monoclonal anti-mortalin peptide antibodies  
The present invention provides anti-mortalin peptide antibodies having stronger anticancer effects than known anti-mortalin antibodies, hybridomas producing such antibodies, and anticancer agents...
8574580 Monoclonal antibodies that recognize neurospheres or neural progenitor cells  
Method for generating monoclonal antibodies that recognize progenitor cells. Said method comprises immunization of an Armenian hamster with neurospheres obtained from olfactory bulb cells from a...
8518653 Detection of cannabis use  
A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding...
8513397 DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants  
Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes,...
8506960 Antibody molecule for human GM-CSF receptor alpha  
Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFRα), especially antibody molecules. Use of the binding members in treating inflammatory and...
8501427 Factor H polymorphisms in the diagnosis and therapy of inflammatory diseases such as age-related macular degeneration  
The invention relates to antibodies, including monoclonal and polyclonal, or fragments thereof, which discriminate between the histidine and tyrosine isoforms of Complement Factor H and to their...
8486663 Compositions and methods for generating antibodies  
The compositions and methods of the present invention comprise the efficient and effective presentation of antigens to the appropriate components of the immune system resulting in the production...
8486401 Monoclonal antibodies binding to TrkA and acting as NGF-antagonist molecules and their use for treating pain induced by NGF  
Monoclonal antibodies, synthetic and biotechnological derivatives thereof (ScFv or others) are able to recognise the NGF high affinity receptor, TrkA, and act as NGF-antagonist molecules....
8481290 Antibody specific for a chondroitin sulphate epitope  
An antibody specific for a chondroitin sulphate epitope is described, as is a hybridoma cell line which produces such an antibody. The antibody is useful in the diagnosis and treatment of...
8476027 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Detection of cannabis use
 
A binding partner, especially an antibody fragment that specifically recognizes an antigen-antibody immune complex between anti-THC and THC (tetrahydrocannabinol), is disclosed. The binding...
8465737 Three-dimensional structure of complement receptor type 2 and uses thereof  
Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly...
8455629 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors  
Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically...
8455626 Aβ conformer selective anti-aβ globulomer monoclonal antibodies  
The subject invention relates to monoclonal antibodies that may be used in the treatment and diagnosis of Alzheimer's Disease. In particular, the present invention relates to monoclonal antibodies...
8445229 Methods of generating high-production of antibodies from hybridomas created by in vitro immunization  
The invention provides methods for generating high titers of high-affinity antibodies from hybridoma cells produced by fusing myeloma cells with in vitro immunized donor cells. The hybridoma cells...
8420085 Anti-IGF-IR antibodies and uses thereof  
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine...
8420353 Humanized antibody and process for preparing same  
A humanized antibody is produced by process comprising the steps of: (a) selecting a specificity determining residue (SDR) of the complementarity determining region (CDR) of murine monoclonal...
8420348 Antibodies for the detection of integrin complexes in FFPE material  
The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in...
8415113 Diagnostic method for detecting disturbances of the pancreas  
A procedure for the identification of a functional disorder of the pancreas by the use of parts of all iso-enzymes of the pancreas elastase and of synthetic amino-acid sequences as antigens for...
8399202 Peptides for development of diagnostic and therapeutic agents and methods of using same  
Novel immuno-interactive fragments of the αC portion of a mammalian inhibin α subunit, together with their variants and derivatives, produce antigen-binding molecules that are interactive with the...
8399207 Monoclonal antibodies against osteopontin  
The present invention relates to reagents and methods for the detection of osteopontin fragments and distinguishing them from each other and from the full-length osteopontin protein. The present...
8367356 Gelsolin binding agent compositions and uses of same  
The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination,...
8367374 Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function  
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having...
8361461 Anti-IGF-IR antibodies and uses thereof  
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR). The invention likewise comprises the use of these...
8349569 Anti-fibronectin fragment monoclonal antibody  
A method for measuring a fibronectin fragment which is easy to handle and has excellent measuring accuracy, specificity and reproducibility is provided. An anti-fibronectin fragment monoclonal...
8337861 Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector  
The present invention comprises methods for enhancing the immunogenicity of a bacterial vaccine vector and an antigen by passaging the bacterial vaccine vector through an animal.
8329886 Nucleic acid molecules encoding anti-amyloid beta antibodies  
The present invention relates to antibody molecules capable of specifically recognizing two regions of the β-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as...
RE43823 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Human monoclonal antibody against coreceptors for human immunodeficiency virus
 
Compositions are provided that comprise antibody against coreceptors for human immunodeficiency virus such as CCR5 and CXCR4. In particular, monoclonal human antibodies against human CCR5 are...
8309315 Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods  
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are...
8298836 Isolated Polynucleotide encoding modified fab' antibody, expression vector, and transformed host cell  
Disclosed is an isolated polynucleotide encoding a modified Fab' antibody, which includes an Fd chain and an L chain with the Fd chain including a CH1 region and the L chain including a CL region,...
8278424 Antibodies that bind to PSCA proteins for diagnosis of cancer  
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is...
8268592 Anti-system ASC amino acid transporter 2 (ASCT2) antibody  
An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (hereinafter, referred...
8268617 Anti-IGF-I receptor antibodies, DNAs, vectors, host cells and genetic constructs  
DNAs, vectors, host cells and genetic constructs of antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with...
8268973 Anti-amyloid antibodies  
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a...
8268593 Polynucleotides encoding antibodies directed against amyloid-beta peptide  
Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide...
8247188 FAS binding antibodies  
The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices...
8236530 Method for preparing monoclonal antibody  
A significantly increased amount of a monoclonal antibody is obtained from the culture medium of recombinant hybridoma prepared by introducing genes encoding a protein identical to the...
8216807 Antibodies to lymphotoxin-α  
The invention provides various antibodies that bind to lymphotoxin-α, methods for making such antibodies, compositions and articles incorporating such antibodies, and their uses in treating, for...
8206951 Stabilized liquid anti-RSV antibody formulations  
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which...
8187602 Anti-histone H1 monoclonal antibody and hybridoma for the production thereof  
The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing...
8187884 Method of enhancing homologous recombination of somatic cells and method of constructing specific antibody  
The present invention provides a novel method for obtaining diverse antibodies as a result of markedly enhancing the somatic homologous recombination at an antibody locus in immunocytes. By...
8168409 Compositions and methods relating to anti-IGF-1 receptor antibodies  
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
8163886 Purification of proteins  
The present invention relates to a selectively soluble polymer capable of binding to one or more constituents in a mixture containing various biological materials and the methods of using such a...
8163288 S. aureus polypeptides and antibodies  
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to...
8163285 Nogo-A binding molecules and pharmaceutical use thereof  
The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such...
8158365 Anti-2-O-desulfated acharan sulfate antibody and its application  
An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The...
8158386 Method for producing human antibodies with properties of agonist, antagonist, or inverse agonist  
A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are...