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4746612 Aotus interspecies hybridomas and monoclonal receptors produced thereby  
Aotus trivirgatus interspecies hybridomas, their monoclonal receptors and methods of preparation and use are disclosed. The hybridomas are prepared by fusion of Aotus antibody-producing cells with...
4745182 Herpes virus specific immunological materials and methods  
Disclosed are antibody substances displaying unique, multi-specific immunoreactivities with respect to glycoprotein D of Herpes Simplex Virus types 1 and 2 (HSV gD-1 and gD-2) and structurally...
4743543 Method for enhancing and/or accelerating immunoassay detection of human carcinoma tumor associated antigen in a pathology sample  
Detection of an identified human carcinoma tumor antigen in a pathological sample by means of a labelled monoclonal antibody specific to the determinant site on the antigen is enhanced and/or...
4743538 Test for rheumatic fever and monoclonal antibodies useful therefor  
Monoclonal antibodies which react specifically with a complementary rheumatic fever associated antigen on human B-lymphocytes derived from hybridoma cell line HB8783, process for preparing such...
4742000 Antibody to human progesterone receptor and diagnostic materials and methods  
Methods and procedures are described for the isolation of human progestin receptors and for the use of human progestin receptors as immunogens in producing both monoclonal and polyclonal...
4737579 Monoclonal antibodies for human non-small cell lung carinomas  
The present invention is concerned with novel monoclonal antibodies which define antigens associated with human non-small cell lung carcinomas ("NSCLC"). The antibodies bind to normal human cells...
4735898 Monoclonal antibodies and method of identifying species using the same  
The new method an products recognize human serum albumin, differentiating blood and tissue from human sources from blood and tissue of other animals. The method and products are particularly...
4724206 Protein production using hypertonic media  
Disclosed is a method of improving protein production in protein-producing cell cultures. The method comprises the steps of culturing protein-producing cells in a medium comprising essential...
4722899 Producing highly specific, low cross-reactive antibody by immunizing with copolymer of D-glutamic acid and lysine  
A process for producing an antibody having a high specificity to a first antigen and a low cross-reactivity with at least one second antigen, said first antigen comprising a desired antigenic...
4722896 Method for affinity purification of hybridoma antibodies  
An efficient process design for purifying large quantities of specific antibodies by affinity chromatography is disclosed. By utilizing the process strategy described, large scale production of...
4716111 Process for producing human antibodies  
Human antibodies are provided by collecting the mononuclear cells from human blood, removing suppressor T-cells and exposing the remaining lymphocyte cells to an antigen, autologous serum of the...
4716117 Monoclonal antibodies to factor VIIIC  
Hybridomas producing monoclonal antibodies specific for polypeptide fragments derived from human Factor VIIIC are provided. Class I hybridomas produce monoclonal antibodies reactive with a 80/77...
4714681 Quadroma cells and trioma cells and methods for the production of same  
Antibodies having binding affinity for two desired antigens, hereinafter "recombinant monoclonal antibodies"; recombinant monoclonal antibodies produced by a quadroma cell or a trioma cell; and...
4713325 Hybridomas producing monoclonal antibodies specific for FeLV p27  
Compositions and method are described for the detection of feline leukemia virus. Hybridomas are prepared producing monoclonal antibodies specific for at least one determinant site for the protein...
4710377 Antigens and monoclonal antibodies reactive against sporozoites of Eimeria spp.  
Monoclonal antibodies against sporozites of the Eimeria spp. are obtained by use of hybridoma technology. Specific sporozoite antigens for use as vaccines in the prevention and treatment of...
4709015 Monoclonal antibody to human suppressor T cells  
Hybrid cell line for production of monoclonal antibody to an antigen found on normal human suppressor T cells. The hybrid is formed by fusing splenocytes from immunized CAF1 mice with P3X63Ag8Ul...
4708862 Radioimmuno detection of human cancers using anti-tumor monoclonal antibody  
The present invention relates to the radioimmuno detection of cancers by detecting tumor associated antigens and comprising the following steps: (i) preparing samples of hybridoma XMMCO-791 as...
4707443 Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same  
The present invention discloses a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample. The method comprises determining reactivity of said sample with a plurality of...
4703003 Monoclonal antibody with a high affinity for digoxin  
A hybridoma which produces monoclonal antibodies having a high affinity and selectivity for digoxin is produced by immunizing mice with digoxin, fusing the spleen cells from the treated mice with...
4699880 Method of producing monoclonal anti-idiotype antibody  
A method for determining the presence of an antigen in a liquid sample. The method includes incubating the sample with an antibody which specifically binds an epitope on the antigen in the...
4696895 Monoclonal anti-protein C antibody, its preparation and use thereof  
Monoclonal anti-human protein C antibodies which bind to the heavy chain of protein C are disclosed.
4695538 Human monoclonal antibodies to cell surface antigens  
Human monoclonal antibodies (HmAbs) capable of reacting with cell surface antigens and intracellular components are disclosed. It has been found that HmAbs Ev248, Ch-5, Ch-13, Te-39, Hu44, Ge-1,...
4693966 Human monoclonal antibodies from lymphocytes of patients with malignant melanoma  
Human monoclonal antibodies which specifically bind to antigens found on cell surfaces of renal, lung, and breast cancer cells, intracellular cytoskeletal antigens, nuclear antigens, and...
4692405 Monoclonal antibodies to antigen on activated human B-cells and assay therefor, protein antigenic determinant therefor and method of making same  
A monoclonal antibody recognizing an antigenic determinant on activated human B-cells, the antigenic determinant being characteized in that it is a protein distinct from B-LAST-1 and BB-1, the...
4690893 Hybridoma cell lines producing monoclonal antibodies which specifically bind to mouse interleukin-2  
A hybridoma for production of monoclonal antibodies specific for mouse interleukin-2, but which antibodies do not significantly cross-react with human or rat interleukin-2. The hybridoma is a...
4687733 Early cancer detection method  
The invention relates to a method of testing for the presence of cancer. An antibody is produced which contains antibodies specific to a modified nucleoside component. The antibody is admixed with...
4686180 Onco-fetal specific monoclonal antibodies, methods of preparation and use  
A process of preparing a hybridoma secreting oncofetal-specific monoclonal antibodies, which comprises: (a) immunizing an animal with immunizing amounts of a non-proliferating syngeneic...
4683200 Monoclonal antibody to human cancer antigen and method for producing same  
Disclosed herein is a monoclonal antibody of the IgM class which reacts with a glycoprotein antigen having a molecular weight by gel filtration of 1,000,000 or higher, the antigenic determinant to...
4681848 Novel peptide and use thereof  
The invention relates to novel polypeptide of the formula ##STR1## wherein X is a bond, or a peptide or amino acid residue 1 to 16 amino acids counting from the C terminus of the peptide chain of...
4680174 Induction of immune response by immunization with encapsulated antigen-producing cells  
Cells such as genetically modified cells, e.g., hybridoma, which secrete an antigenic substance are encapsulated within capsule membranes having pores of dimensions sufficient to permit efflux of...
4678746 Monoclonal antibodies to epizootic hemorrhagic disease virus antigen  
A method for preparing hybrid cell lines (hybridomas) which secrete monoclonal antibody which is group-specific to epizootic hemorrhagic disease virus antigen and which does not react to...
4678747 Monoclonal antibodies for detection of an H (O) blood group antigen  
Monoclonal antibodies recognizing the difucosyl-type-2-H antigen on human cells and a method of producing said antibodies are disclosed. The monoclonal antibodies are useful in blood typing and in...
4677070 Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use  
Anti-Pseudomonas antibodies which bind to exotoxin A from P. aeruginosa are prepared from hybrid cell lines. The antibodies may be of any isotype. These antibodies may be used to treat infections...
4676981 Monoclonal antibodies against GnRH  
A monoclonal antibody against GnRH and particularly designated USASK/DSIL-GnRH is produced by a hybrid formed by fusion of cells from a myeloma line and antibody producing cells of the immune...
4677056 Monoclonal antibody subsetting human helper and killer T-cells and method  
A monoclonal antibody 4A produced by a human-mouse hybridoma cell line is described. In the presence of complement, 4A subsets both cytotoxic and helper T cells creating a diagnostic tool in blood...
4675386 Monoclonal antibody methods and compositions specific for single antigens in antigen aggregates  
Methods and compositions are provided for producing monoclonal antibodies capable of distinguishing between antigenic aggregates, which are differentiated by one or a small number of antigenic...
4675287 Monoclonal antibody directed to human ganglioside GD2  
A non-human, mammalian monoclonal receptor produced and secreted by a hybridoma having the ATCC accession number HB 8568 and methods of preparing and using same, as well as diagnostics utilizing...
4672044 Murine monoclonal antibody combining site to human C3b receptor (CR1)  
A murine monoclonal antibody combining site produced by a hybridoma formed by fusion of cells from a myeloma cell line and lymphocytes that produce antibodies that react (1) with isolated human...
4670382 Monoclonal antibody to Candida albicans cytoplasmic antigens and methods of preparing same  
Two novel hybridoma cell lines, ATCC #HB-8397 and ATCC #HB-8398 produce monoclonal antibody monospecific to a single determinant shared by a set of three closely related cytoplasmic antigens of...
4668771 Method for separating bovine lactoferrin from cow's milk and purifying same  
This invention discloses a method for separating a highly pure form of bovine lactoferrin from cow's milk and purifying same which comprises preparing an affinity-chromatographic column by fixing...
4666845 Monoclonal antibodies to ovarian, cervical and uterine human cancers and method of diagnosis  
Mouse monoclonal antibodies to several cell antigens of human ovarian, cervical and endometrial carcinomas have been produced and characterized. The distribution of the antigens was determined by...
4665018 Methods and test kit for diagnosing/monitoring cancer in humans  
Human cancer is diagnosed/monitored by measuring the levels of certain modified nucleosides, such as N-[(β-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, in the urine of a subject by a...
4661446 Monoclonal antibodies and method of immunizing therewith  
A method of distinguishing subsets within a plurality of human cells including producing a monoclonal antibody to a non-human primate cell, contacting the monoclonal antibody with the human cells,...
4659663 Methods for isolating cell fusion products  
A method for isolating the fusion product of two cell populations is disclosed. The method involves the introduction of a specific antitoxin into cells of one population while introducing a second...
4656253 Monoclonal antibodies against alveolar surfactant protein  
Monoclonal antibodies specific for a protein associated with a lung surfactant complex, decreased levels of which are related to respiratory distress syndrome, are disclosed. The antibodies are...
4650676 Antigens and monoclonal antibodies reactive against merozoites of Eimeria spp.  
Monoclonal antibodies against merozoites and sporozoites of Eimeria tenella are obtained by use of hybridoma technology. Specific antigens for use as vaccines in the prevention and treatment of...
4649106 Distinguishing subsets of human cells  
A method of distinguishing subsets within a plurality of human cells including producing a monoclonal antibody to a non-human primate cell, contacting the monoclonal antibody with the human cells,...
4649115 Monoclonal antibodies to skin cells  
Successive layers of guinea pig epidermis display discrete antigenic markers that are recognized by a selected panel of five monoclonal antibodies produced by hybridomas resulting from...
4647535 Human nonsecretory plasmacytoid cell line  
A human non-secretory plasmacytoid HPRT- mutant continuous cell line, can be used for the preparation of human-human hybridomas with human B-lymphocytes and separation of the resulting hybridomas...
4642291 Cell surface antigens of human astrocytoma  
Method of forming an antibody producing hybridoma cell line by fusing a myeloma cell line with splenocytes derived from BALB/c mice immunized with human astrocytoma tumor cells, the hybridoma cell...