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5101024 Human immunoglobulin and enhancer gene fragments  
The present invention provides an enhancer DNA segment, a gene fragment having (a) the enhancer DNA segment and (b) a structural gene such as human D, V and J gene, and a promoter. A hybrid DNA...
5101017 Antibodies for providing protection against P. vivax malaria infection  
A monoclonal antibody which identifies the human blood group Duffy (ab) is provided. Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by...
5100783 Weighted microsponge for immobilizing bioactive material  
Weighted microsponges formed of a porous, biostable matrix of a biocompatible polymer containing an inert weighing material are prepared suitable for use in culturing organisms in motive reactor...
5096816 In vitro management of ammonia's effect on glycosylation of cell products through pH control  
This invention relates generally to the field of cell culture. The invention presents pH based methods for controlling the glycosylation patterns of cell products, particularly proteins produced...
5093261 Cancer-related antigen-specific human immunoglobulins and human/human hybridomas having the ability to produce said human immunoglobulins  
A new human/human fused cell clone derived from human B cells having the ability to produce immunoglobulins and human B cells substantially lacking the ability to produce immunoglobulins,...
5091313 Antigenic epitopes of IgE present on B cell but not basophil surface  
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B...
5087557 Human monoclonal antibody to lymphadenopathy-associated virus  
Human monoclonal antibodies capable of specifically reacting with an antigenic determinant of LAV/HTLV-III and cell lines producing those monoclonal antibodies are disclosed. The human monoclonal...
5084396 Enhanced production of antibodies utilizing insolubilized immune complexes  
A method for enhancing production of antibodies through immunization with insolubilized immune complexes is disclosed. Purified antigen or heterogeneous antigen mixtures may be combined with...
5084391 Monoclonal antibody to the interleukin-2-receptor and its use  
New monoclonal murine-IgG1 antibody obtainable from a new hybridoma-cell line, binding to an epitope of the human interleukin-2 receptor that differs from Tac, inhibiting the binding of human...
5084561 Method for the purification of a 168 kD protein from mycoplasma pneumoniae  
A new method for the purification of a 168 kD protein from Mycoplasma pneumoniae using zwitterionic and non-ionic detergents.
5081032 Anti-human pulmonary adenocarcinoma monoclonal antibody  
Anti-human pulmonary adenocarcinoma monoclonal antibody ALC-864 which belongs to the class IgG1, reacts with human pulmonary adenocarcinoma cells but not with normal human cells, recognizes...
5077216 Monoclonal antibodies specific for a human mononculear phagocyte-specific antigen  
A 155 kDa phagocyte-specific antigen which is expressed on human monocytes, monocyte-derived macrophages and peritoneal macrophages, but is not expressed on human granulocytes, lymphocytes and...
5073493 Monoclonal antibody NKY13  
Monoclonal antibody NKY13 recognizing sugar chains of mucin-type glycoproteins secreted by cancer cells, for example, the following sugar chains, and hydridoma producing it: ##STR1## The...
5071759 Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B  
Monoclonal antibodies produced by a family of murine hybrid cell lines are cross-reactive with both toxin A and toxin B of Clostridium difficile. The monoclonal antibodies are useful in an...
5066579 HTLV-I peptide antigen and assay  
A recombinant peptide antigen is provided which is derived from HTLV-I envelope protein gp46 and immunoreactive with anti-HTLV-I antibody present in a individuals with HTLV-I related T-cell...
5064942 Protein isolated from blood, process for preparing said protein, antibodies against said new protein, and pharmaceutical compositions containing said protein or said antibodies  
The invention relates to Tetranectin, a new protein isolated from blood. Its structure comprises four polypeptide chains having the formula shown in the attached drawing.Tetranectin plays a role...
5059521 Monoclonal antibodies against prosumal proteins  
The invention relates to monoclonal antibodies against prosomal proteins of a prosome, said prosome having a sedimentation coefficient of approximately 19S, and to a method for detecting cancer...
5057598 Monoclonal antibodies reactive with endotoxin core  
Novel monoclonal antibodies are disclosed, the production of which is specified by particular genes contained, conveniently, in biologically pure cultures of self-reproducing carrier cells, such...
5055404 Monoclonal antibody specifically reactive to surface of human prostatic epithelial cells  
Monoclonal antibodies Pes-1, Pes-2, Pes-3 and Pes-4 which are respectively produced by hybridomas hPro-1.10G (FERM BP-1986), hPro-4.10H (FERM BP-2634), hPro-5.10F and hPro-1.5F specifically bind...
5055560 L60: a novel monoclonal antibody  
L60 is a novel monoclonal antibody that will react with Leu 22. It is equally reactive in formalin, ZnSO4 or Bouin's fixed, paraffin-embedded tissues as well as in frozen tissues.
5053491 Monoclonal antibodies and cell lines for parathyroid tissue-specific antigen  
Monoclonal antibodies specific for an antigen present on the surface of parathyroid tissue are useful in imaging such tissue when conjugated to suitable label. The antibodies of the invention bind...
5053492 Immunopurification using monoclonal antibodies to Mojave toxin  
Monoclonal antibodies to Mojave toxin and use for isolation of cross-reacting proteins in Crotalus venoms are disclosed. Hybridomas secreting monoclonal antibodies against Mojave toxin were...
5051364 Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies  
The present invention provides monoclonal antibodies which are specific for one but not both of human lipocortin-I and human lipocortin-II, as well as cultures of hybridomas and other types of...
5047507 Monoclonal antibodies with specificity affinity for human carcinoembryonic antigen  
The invention concerns novel monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these...
5045466 Purified mammalian cell binding receptor for bacterial lipopolysaccharide endotoxin and monoclonal antibody  
The invention is directed to hydridoma cell lines and the monoclonal antibodies produced by the cell lines, where the monoclonal antibodies specifically bind to the lipopolysaccharide endotoxin...
5043263 Monoclonal antibodies against potyvirus-associated antigens, hybrid cell lines producing these antibodies, and use therefore  
The present invention is directed to monoclonal antibodies, and hybridomas which produce them, which are reactive with a highly conserved epitope present on potyviruses and insignificantly...
5043281 Human monoclonal antibodies against cytomegalovirus and process for producing same  
Human monoclonal antibodies against cytomegalovirus. These antibodies can be advantageously used as a diagnostic, or preventive and remedy for cytomegalovirus infectious diseases.
5039793 Cytoplasmic protein of suprabasal epidermal cells, antibodies capable of recognizing said protein, and hybrid cellular stocks capable of secreting such antibodies  
A protein characterized by the fact that it is a nonkeratinic protein present in the cytoplasm of suprabasal epidermal cells, in particular in man, and absent in basocellular carcinoma, melanoma...
5037750 Method for producing antibodies which catalyze chemical reactions  
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal...
5037755 Monoclonal antibody and method for diagnosing grape disease employing same  
A monoclonal antibody specific to Agrobacterium tumefaciens biovar 3. A method of diagnosing Agrobacterium tumefaciens biovar 3 associated grapevine disease comprising: (1) culturing bacteria from...
5036003 Antibodies to VPF  
A method of producing antibodies against vascular permeability factor (VPF) is disclosed which comprises immunizing a host animal with a peptide having an amino acid sequence as follows: ##STR1##...
5032521 Monoclonal antibody specific for a mammary tumor cell surface antigen  
Hybridomas are provided which secrete an IgG1 or IgG2 monoclonal antibody which binds to an epitope on an antigen, which occurs in the plasma membrane of MCF-7 cells and has a molecular weight of...
5030564 Monoclonal antibody specific to the lymphokine LK 2 and its method of production  
A monoclonal antibody specific to the lymphokine LK 2, and its production is disclosed. The novel lymphokine LK 2 is a glycoprotein with a molecular weight of 20,000±2,000 daltons; isoelectric...
5030717 Antibodies which catalyze hydrolysis of ester bonds  
An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor...
5024946 Human monoclonal antibody to antigen of gastric cancer and B-cell line for producing this antibody, method for preparing this B-cell line and antibody, antigen and method of preparation of this antigen  
The present invention relates to a human B-cell line capable of producing a human monoclonal antibody against an antigen found on gastric cancer cell lines or tissues. The B-cell line is formed by...
5021553 Anti-human adenocarcinoma antigen specific monoclonal antibody  
A monoclonal antibody against human cancer, characterized in that the monoclonal antibody is produced by a hybridoma cell line obtained from the fusion of B-lymphocyte immunized with cells of...
5019648 Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein  
A hybrid cell line is developed which produces a monoclonal antibody which binds to a unique antigenic site expressed on the surface of phagocytic cells. The monoclonal antibody binds to and...
5015576 Macroporous particles for cell cultivation or chromatography  
Particles which enclose cavities can be produced by adding a water-insoluble solid, liquid or gaseous cavity generating compound to an aqueous solution of matrix material. Subsequent to forming...
5013664 Common protein of Haemophilus influenzae type b identified by a monoclonal antibody  
Monoclonal antibodies, and cell lines producing them, which show specificity for surface components of Haemophilus influenzae type b have been developed. These monoclonal antibodies may be used in...
5011778 Monoclonal antibodies directed to IL-1 activated endothelial cells and medicaments employing the monoclonal antibodies  
Hybridoma cell lines are made that produce monoclonal antibodies having, among others, the following identifying characteristics: (1) bind to IL-1 activated endothelial cells; (2) do not bind...
5011912 Hybridoma and monoclonal antibody for use in an immunoaffinity purification system  
A particular calcium-dependent monoclonal antibody, 4E11, is produced from a murine hybridoma cell line and is useful for purifying a recombinant fusion protein having an N-terminal identification...
5009995 Monoclonal antibodies to melanoma cells  
This invention relates to monoclonal antibodies recognizing the gp130 antigen of human cells. Monoclonal antibodies which recognize distinct determinants on this antigen and methods of detecting...
5006470 Human monoclonal antibodies to cell surface antigens of melanoma  
This invention provides a monoclonal antibody, produced by the hybridoma cell line designated GXM1, which specifically binds to a human class 1tumor antigen. This invention also provides a human...
5004694 Complement-dependent cytolytic anti-Trichomonas vaginalis monoclonal antibodies  
Novel monoclonal antibodies specific to Trichomonas vaginalis, having complement--fixing ability and lysing Trichomonas vaginalis in the presence of complement are disclosed and may be used in...
5003046 Monoclonal antibody producing hybridoma and corresponding antibody specific for human breast fibroblast tumor antigen  
The invention concerns a novel lymphocyte hybridoma and an antibody which may be generated from the hybridoma. The hybridoma and antibody have the internal designation LICR-LON-Fib 75. The origin,...
5001225 Monoclonal antibodies to a pan-malarial antigen  
A continuous hybridoma cell line, designated 7H8, which secretes a monoclonal antibody (MAb 7H8) of the IgM class and which binds to a protein present in species of the genus Plasmodium. MAb 7H8...
5001056 Preparation of monoclonal antibodies  
A process for selectively producing monoclonal antibodies which comprises selectively bringing together proliferating cells and the appropriate B-cells by means of ligand recognition of respective...
4997764 Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors  
Disclosed herein is a method for transforming human B-cells by infecting them with Epstein Barr virus and transfecting the Epstein Barr virus infected cells with an activated human c-myc gene. The...
4997753 Weighted collagen microsponge for immobilizing bioactive material  
Weighted collagen microsponges having a highly crosslinked collagen matrix are described suitable for use in culturing organisms in motive reactor systems. The microsponges have an open to the...
4977081 Stable rabbit-mouse hybridomas and secretion products thereof  
Rabbit-mouse hybridomas are cultured immediately after fusion in a suspension medium supplemented with normal rabbit serum. This results in stable hybridomas and provides a source of intact rabbit...