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5212085 SF-25 Colon adenocarcinoma antigen, and antibodies with recognize this antigen  
The present invention pertains to the SF-25 antigen of colon adenocarcinoma cells, to functional derivatives of this antigen, and to antibodies and antibody fragments capable of binding this...
5204095 Monoclonal antibodies against hepatitis B virus  
The new hybridoma cell lines RF-HBs-1, RF-HBs-2 and RF-HBs-4 each secrete a nonoclonal antibody to hepatitis B surface antigen. The production of the antibodies may be carried out in vitro by...
5202422 Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use  
The present invention contemplates glycopolypeptide multimers having a polypeptide that contain an immunoglobulin amino acid residue sequence and an oligosaccharide that comprises a core...
5202251 Monocot-specific monoclonal antibodies against acetohydroxyacid synthase  
This invention is directed to the generation of hybridomas and the monocot-specific monoclonal antibodies prepared from those hybridomas against the acetohydroxyacid synthase enzyme. The...
5202253 Monoclonal antibody specific for protein C and antibody purification method  
A Ca2+ dependent monoclonal antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C. The antibody does not bind...
5196337 Human monoclonal antibody, and its production and use  
A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Committee's...
5194592 Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor  
Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least...
5194385 Hybridoma and monoclonal antibody MLS102 which recognizes a NeuAcα2➝6GalNAc sugar chain present on human intestinal cancer cells  
The present invention relates to a monoclonal antibody MLS 102 recognizing human intestinal cancer cells, especially their sugar chain of glycoprotein, and more specifically NeuAc α2➝6GalNAc. The...
5192664 Parathyroid hypertensive factor, antibodies and uses thereof  
A new circulating factor from the parathyroid gland of some hypertensive mammals have been isolated and characterized. Polyclonal and monoclonal antibodies raised against this factor are usable as...
5192683 Monoclonal antibodies to cruciform DNA structure  
The present invention relates to monoclonal antibodies of class IgG1 and IgM possessing among others the property to bind to stable heteroduplex cruciform DNA structures constructed from two DNA...
5192684 Human IgG1 monoclonal antibody specific for the nicotinic acetylcholine receptor and hybridoma producing the antibody  
A human IgG1 type monoclonal antibody which possesses a molecular weight in the range of 180,000±20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of...
5190858 Monoclonal antibodies directed to epitopes of human transforming growth factor--α and uses thereof  
The present invention provides a monoclonal antibody which specifically forms a complex with TGFα in formalin-fixed, paraffin-embedded tissue sections which has an affinity of a least 107, and...
5183756 Monoclonal antibody (D612) having selective reactivity for gastrointestinal caricinomas and method for employing the same  
The present invention relates to the monoclonal antibody (termed D612) having selective reactivity for gastrointestinal carcinoma and methods for employing the same. A hybridoma producing such...
5183739 Monoclonal antibodies specific for non-A1C glycated hemoglobin and immunoassay methods  
Monoclonal antibodies specific for an epitope found on hemoglobin glycated both in vivo and in vitro but not found on hemoglobin Ao or hemoglobin A1c are provided. Use of these antibodies to...
5183755 Anti-human papillomavirus monoclonal antibody, hybridoma producing the same and process for preparing the same  
An anti-human papillomavirus (HPV) monoclonal antibody reactive with various types of HPVs, which is produced by a hybridoma comprising a fused cell of a mouse spleen cell from a mouse immunized...
5180663 Immunochemical assays for human amylase isoenzymes and related monoclonal antibodies, hydridoma cell lines and production thereof  
Immunochemical assays for human amylase isoenzymes are disclosed. These assays utilize monoclonal antibodies which are produced from hybridoma cell lines and are specific for human salivary...
5180813 Early envelope glycoprotein of human cytomegalovirus (HMCV) and monoclonal antibodies to the glycoproteins  
The present invention provides an envelope glycoprotein which is encoded by an early structural gene of human cytomegalovirus, and polyclonal and monoclonal antibodies to the early envelope...
5179008 Hybridoma and monoclonal antibody to FHAP  
Antibodies, hybridomas, and immunoassays relating to a fast homoargenine-sensitive alkaline phosphatase cancer complex in serum ("FHAP") are disclosed. FHAP is a disease (e.g. cancer) marker. One...
5177000 Monoclonal antibodies selective for prostate cancer and diagnostic immunoassay for prostate cancer  
Four monoclonal antibodies are found which selectively identify prostate cancer. These monoclonals are therefore useful in diagnosis and differential diagnosis of prostate cancer.
5173420 Monoclonal antibody recognizing un-natural ganglioside GD3  
A monoclonal antibody A exhibits specificity to the sialic acid glycolipid containing the epitope NeuAcα2➝9NeuAc terminal. A monoclonal antibody B exhibits specificity to the sialic acid...
5171666 Monoclonal antibodies reactive with a cell-surface gylcoprotein expressed on human carcinomas  
The present invention relates to a novel tumor-associated antigen that is a cell-surface glycoprotein having a molecular weight in the range of 110,000-140,000 daltons that is present in a variety...
5171667 Hybridomas producing monoclonal antibodies to mono-, di- and trifucosylated type 2 chain  
Hybridoma cell lines that produce monoclonal antibodies that differentially recognize glycolipids with mono-, di-, and trifucosylated type 2 chain structures are disclosed. The monoclonal...
5169773 Monoclonal antibodies to cyclosporins  
Novel monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18, are produced, e.g. starting from novel cyclosporins...
5166050 Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections  
Methods and composition for HIV diagnosis and treatment using monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, using the peptides or homologs thereof from that...
5165922 Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy  
The present invention relates to the use of combinations of antibody therapy and chemotherapy in the treatment of malignant disease. More particularly, the invention relates to novel methods of...
5164293 Monoclonal antibody for detecting HTLV-I, HTLV-II and STLV-I viruses  
A hybrid cell line is provided which is capable of producing monoclonal antibodies which binds to HTLV-I and HTLV-II core antigens p24 and p53; but does not bind the p19 core antigen. The antibody...
5162504 Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients  
Monoclonal antibodies to prostatic cells, are produced by a hybridoma formed by fusing mouse lymphocytes and mouse myeloma cells. The monoclonal antibodies show specificity for a non-soluble,...
5158886 Monoclonal antibodies specific for free N-acetylfuraminic acid and beta-glycosides and beta-glycoconjugates thereof  
A hybridoma producing a monoclonal antibody specific for free N-acetylneuraminic acid or beta glycoconjugates thereof, is herein disclosed. The hybridoma can be generated by fusing (i) B cells of...
5157112 Antibodies immunoreactive with the T-cell growth factor, P40  
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports...
5155036 Serum-free medium containing retinoic acid useful for cultivating human/human hybridomas  
A serum-free medium for cultivating a human monoclonal antibody-producing human/human hybridoma, said medium comprising a serum-free complete medium and at least 10-12 M but not more than 10-6 M...
5155038 Use of thrombospondin to promote wound healing  
Pharmaceutical compositions and dressings useful in wound healing are provided. The pharmaceutical compositions comprise thrombospondin as the active ingredient.
5143843 Method for production of monoclonal antibodies for cancer diagnosis and therapy  
Monoclonal antibodies to human antigens present on a majority of human cells are described. These mAbs have use in a method for isolating mAb for less expressive antigens, such as cancer antigens,...
5141736 Bispecific monoclonal antibody, its production and use  
The present invention discloses, a bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, which can carry an anasamitocin...
5141865 Monoclonal antibodies which bind thromboxane A2 receptor antagonists and diagnostic methods based thereon  
Monoclonal antibodies which bind thromboxane A2 receptor antagonists, hybrid cell lines which produce these monoclonal antibodies, and immunoassay methods for detecting thromboxane A2 receptor...
5141864 Monoclonal antibody recognizing alpha 2➝3 bonds  
A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2➝3 linkage is herein disclosed. The...
5134076 Monoclonal antibodies specific for protease nexin-1 and puriciation of protease nexin-1 using monoclonal antibodies  
Monoclonal antibodies having a specificity for protease nexin-1 are described. Preferably an antibody has specificity to the reactive protease-binding site. The antibody is used in the affinity...
5126262 Monoclonal antibody  
Specific antibody of the invention is capable of differentiating between malignant and benign tumors, and is obtained by culturing hybridoma cells prepared from tumor cells treated with a certain...
5126253 Cell lines for use in the preparation of hybridoma cells  
A novel cell line for use as a parent for hybridoma preparation is provided. This cell line is derived from tumor cells, in particular human tumor cells, other than those originating from bone...
5126434 Monoclonal antibody specific for a human macrophage chemotactic factor  
The present invention relates to a monoclonal antibody which specifically binds to a peptide having amino acid sequence (I) described below or having in part at least continuous 4 amino acid...
5124248 Monoclonal antibody recognizing gamma atrial natriuretic polypeptide  
A monoclonal antibody which recognizes the N-terminal of gamma-atrial natriuretic polypeptide (γ-ANP). A hybridoma producing said monoclonal antibody and a process for immunoassay of γ-ANP are...
5120834 Fibrin-specific monoclonal antibody  
The subject invention relates to a fibrin-specific monoclonal antibody wherein said monoclonal antibody does not crossreact with: (a) fibrinogen, (b) plasmin derived fibrinogen degradation...
5118618 Dimethylglycine enhancement of antibody production  
N,N-dimethylglycine, along or in combination with mitogen, increases the antibody productivity of antibody-producing cell cultures.
5116613 Antibody-thrombolytic agent product and method of use  
A thrombolytic product comprising a fibrin-specific antibody substantially devoid of fibrinogen cross-reactivity coupled to a thrombolytic agent.
5116747 Immobilization of biologically active material in capsules prepared from a water-soluble polymer and chitosan acetate  
Biologically-active material, particularly hybridoma cells, is immobilized for mass culture in bioreactors to produce biological products, particularly monoclonal antibodies, by...
5114712 Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for protecting Pseudomonas aeruginosa infection  
PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A...
5114863 Immunosorbant assay for α-1-antitrypsin, kit employing said assay, monoclonal antibody to α-1-antitrypsin, and hybridoma for producing said monoclonal antibody  
A double antibody sandwich immunosorbent assay for detecting alpha-1-antitrypsin (α1 AT) comprising the steps of: (1) reacting (a) a first-species-of-animal antibody to α1 AT with (b) a solid...
5112737 Monoclonal antibodies against activated ras proteins with amino acid mutations at position 13 of the protein  
Monoclonal antibodies reactive with oncogenic and activated ras p21 proteins containing aspartic acid or valine at position 13 and unreactive with normal ras p21 proteins containing glycine at...
5109115 Monoclonal antibody specific for bombesin  
The present invention discloses anti-bombesin monoclonal antibody and a method of detecting autocrine growth factor. A method and kit for screening and controlling growth of human SCLC has also...
5106760 ATCC HB8209, its monoclonal antibody to erythropoietin and assay using same  
Disclosed is a new mouse-mouse hybridoma tumor cell line A.T.C.C. No. HB8209. A monoclonal antibody produced by said cell line is specifically immunologically reactive with erythropoietin and with...
5104789 Monoclonal antibodies which discriminate between strains of citrus tristeza virus  
Monoclonal cell lines producing antibodies to severe citrus tristeza virus have been developed. The antibodies react with crude plant extracts infected with severe isolates, but not with crude...