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5332665 Species specific, high affinity monoclonal antibodies  
High affinity species specific monoclonal antibodies are provided. The antibodies are anti-immunoglobulin antibodies which bind the Ig of a particular species but does not cross react with the Ig...
5330909 Monoclonal antibody specifically recognizing N-terminal portion of human calcitonin  
A monoclonal antibody specifically recognizing N-terminal portion of human calcitonin (hCT), a hybridoma producing said monoclonal antibody, a process for preparing said monoclonal antibody, and a...
5328840 Method for preparing targeted carrier erythrocytes  
The present invention provides new compounds and methods for promoting platelet aggregation, and controlling bleeding. The present invention is based on the surprising discovery that erythrocytes...
5326559 Treatment of accelerated atheosclerosis with interleukin-2 receptor targeted molecules  
The invention features a method for treating a patient suffering from accelerated atherosclerosis in a patient suffering from vascular damage, e.g., damage caused by percutaneous transluminal...
5322788 Monoclonal anti-body to cell surface protein of the bacterium Streptococcus pneumoniae  
This invention relates to a monoclonal antibody (MAb) directed against a surface protein of Streptococcus pneumoniae, a hybridoma cell line producing said antibody, and the use of such an antibody...
5314995 Therapeutic interleukin-2-antibody based fusion proteins  
The present invention relates to antibody-based fusion proteins wherein a portion of an immunoglobulin molecule is linked to a biologically active ligand. In particular embodiments of the...
5314996 Isolated nucleotide sequences encoding an: antigen binding site of monoclonal antibody PD41; and antigen associated with prostate adenocarcinomas  
Monoclonal antibodies that bind specifically to prostate carcinoma and do not bind substantially to normal prostate or benign prostatic hyperplasia, as well as hybridoma cell lines producing the...
5312751 Hybridoma producing a monoclonal antibody specific for an antigen of the stratum corneum of human epidermis  
The subject invention relates to monoclonal antibodies which react with antigenic determinants which are present of the stratus corneum of human epidermis. Furthermore, the invention also relates...
5310655 Process for the detection of kidney tubule functioning  
In the case of a process for the detection of the functionability of the kidney tubules, one specifically determines the content of THP in the urine as measure of the function of the kidney...
5302519 Method of producing a Mad polypeptide  
Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 453 of the max cDNAs shown in FIG. 2, or to the nucleotide...
5300631 Antibodies specific for either ras photo-oncogene encoded P21 proteins or ras oncogene encoded P21 proteins but not for both and method of producing same  
Experiments designed to define the differences between the pas p21 oncogene DNA isolated from human bladder cancer cells and its corresponding proto-oncogene are described herein. By a series of...
5298419 Human hybridomas and monoclonal antibodies which bind both gp41 and gp120 envelope proteins of human immunodeficiency virus  
The invention is directed to the human hybridoma designated MCA 86 and having A.T.C.C. Accession No. HB 9669 and human monoclonal antibodies produced by hybridoma MCA 86. Human monoclonal...
5296352 Monoclonal antibodies directed against complexes formed by thrombin and hirudin  
The invention concerns monoclonal antibodies which are directed against the thrombin/hirudin-complex and derivatives thereof, processes for their preparation, hybridoma cell lines secreting said...
5290681 Method of assaying immunization stimulating activity  
A method of assaying immunization stimulating activity comprising (a) immunizing a lymphocyte in vitro by culturing the lymphocyte in contact with an immobilized antigen in a medium containing a...
5290680 Monoclonal antibody, method of production thereof and use thereof  
The present invention relates to a monoclonal antibody which specifically recognizes 6,15-diketo-13,14-dihydro-prostaglandin F1 α with high sensitivity, a hybridoma producing said monoclonal...
5286647 Human-human hybridomas for neoplasms  
Novel hybridomas, human monoclonal antibodies and their uses are provided. The antibodies distinguish a human neoplastic cell from a normal cell of the same tissue type. The monoclonal antibodies...
5283176 Reagents for use in competition assays for progesterone  
A reagent for use in an immunoassay for measuring haptens, antigens or antibodies by means of a competitive binding method, which comprises a combination of an antibody and a labelled hapten or a...
5279956 Activated protein C polypeptides and anti-peptide antibodies, diagnostic methods and systems for inhibiting activated protein C  
The present invention describes APC polypeptides and anti-peptide antibodies capable of inhibiting activated Protein C anticoagulant activity. The polypeptide and antibody are useful in diagnostic...
5279822 Monoclonal antibodies against the 28KD protein of S. mansoni  
A hybridoma is provided which provides a monoclonal antibody of isotope IgG2a, which recognizes a strip corresponding to a peptidic fragment of 8kD, isolated by controlled proteolysis of the 28kD...
5280108 Antibodies to p40  
The present invention relates, in general, to antibodies to p40 (both polyclonal and monoclonal). Additionally, the present invention relates to hybridomas which produce monoclonal antibodies to...
5275935 Amebic glycoconjugate and monoclonal antibody  
An amebic glycoconjugate is disclosed that is recognized by an Entamoeba histolytica specific monoclonal antibody The glycoconjugate is isolated from the lysates of E. histolytica trophozoites, it...
5272059 Monoclonal antibodies specific for hirudin  
The invention concerns a process for the preparation of hybridoma cells which secrete monoclonal antibodies specific for hirudin, the hybridoma cells themselves, the monoclonal antibodies specific...
5266477 Monoclonal antibodies which differentiate between native and modified porcine somatotropins  
Monoclonal antibodies are provided which differentiate between native and modified sequence proteins. Also provided are methods for using monoclonal antibodies to determine the relative amount of...
5264351 Monoclonal antibodies against autoimmune RNA proteins  
Monoclonal antibodies against autoimmune RNA proteins such as La/SSB, Ro/SSA, nNP and Sm. These monoclonal antibodies, which are produced by a continuous hybridoma cell line, may be used in...
5256413 Method and use for site-specific activation of substances  
Disclosed is a method for the in vivo lysis of a thrombus in a host by administration of a conjugate consisting of a monoclonal antibody specific for fibrin coupled to a plasminogen activator such...
5252467 Method of making antibodies to antigenic epitopes of IGE present on B cells but not basophil cell surface or secreted, soluble IGE  
A method for producing antibodies specific for antigenic associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane is disclosed. The epitopes...
5252480 Human monoclonal antibody and hybridoma producing the same  
A human monoclonal antibody, which has prophylactic and therapeutic effect to infections diseases caused by Pseudomonas aeruginosa, and the epitope of which is located in the outer core moiety of...
5248607 Monoclonal antibodies and hybridomas specific for green-oat phytochrome  
The present invention provides a novel method to purify green-plant phytochrome; the production of hybridoma cell lines secreting monoclonal antibodies specific for green-plant phytochrome and...
5248593 Process and reagent for the determination of the luteinizing hormone and monoclonal antibodies suitable thereof  
The present invention provides an immunological process for the determination of the luteinizing hormone (LH), wherein at least one monoclonal antibody is used which is directed against LH and...
5244801 Process for producing monoclonal antibodies which specifically bind to benign colonic adenomatous polyps of human origin and hybridomas and monoclonal antibodies produced by said process  
Monoclonal antibodies manifesting specific reactivity to benign adenomatous polyps of the human colon are produced. Hybridoma technology was utilized to produce immunoglobulin producing cell...
5242813 Mouse monoclonal antibodies specific for normal primate tissue, malignant human cultural cell lines human tumors  
The subject invention relates to monoclonal antibodies and uses thereof. In particular, the invention relates to three monoclonal antibodies, referred to as B1, B3, and B5, which are useful in the...
5240833 Method for the production of monoclonal antibodies directed to tumor-associated gangliosides and fucogangliosides  
A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension...
5238824 Hybridomas and monoclonal antibodies therefrom reactive toward antigens from Edwardsiella ictaluri  
A hybridoma cell line produces an antibody with reactivity directed specifically to immunodominant antigens from the catfish pathogen Edwardsiella ictaluri, the antigens having molecular weights...
5233025 Amphetamine protein complex as immunogen for obtaining antibodies specific to methamphetamine  
A N-(4-aminobutyl)amphetamine-protein complex has been synthesized to be used as an immunogen to prepare an antibody having a higher affinity to methamphetamine that to the hapten...
5232834 Anti-human sperm antibody, and its production and use  
A monoclonal or polyclonal antibody having a specific binding property to an antigenic site on the human sperm acrosome, which is produced by a hybridoma obtained by fusion between an...
5231170 Antibodies to dense microspheres  
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the...
5231024 Monoclonal antibodies against human tumor necrosis factor (TNF), and use thereof  
New hybridoma cell lines which synthesize highly specific monoclonal antibodies (mAb) against human tumor necrosis factor (TNF), monoclonal antibodies against TNF, a process for the preparation of...
5229275 In-vitro method for producing antigen-specific human monoclonal antibodies  
A method of amplifying production of IgG, IgA and IgM antigen specific human monoclonal antibodies from transformed, T-cell depleted, human peripheral blood lymphocytes through the use of an...
5227471 Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma  
Monoclonal antibodies that bind specifically to prostate carcinoma and do not bind substantially to normal prostate or benign prostatic hyperplasia, as well as hybridoma cell lines producing the...
5227159 Anti-idiotype antibodies reactive with shared idiotopes expressed by B cell lymphomas and autoantibodies  
B-cell lymphomas express surface immunoglobulin (immunoglobulin) containing unique idiotypic (idiotype) determinants which may be exploited as tumor specific markers. The inventor has produced...
5225539 Recombinant altered antibodies and methods of making altered antibodies  
An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using...
5225540 Monoclonal antibodies to tissue plasminogen activator (T-PA) which prolong its functional half-life  
High-affinity murine monoclonal antibodies to t-PA were prepared which prolong the in vivo functional half-life of t-PA without decreasing its plasminogen-activator activity.
5225541 Composition containing CEA/NCA-specific monoclonal antibody XMMBR-B14 conjugated to a detectable moiety and a kit containing the antibody  
The present invention provides a composition consisting of a monoclonal antibody that defines an epitope found on an antigen antigen/normal cross-reacting antigen produced by hybridoma XMMBR-B14...
5223417 Method for transforming human B lymphocytes  
Disclosed herein is a method for transforming human B-cells preferably by infecting them with Epstein-Barr virus followed by transforming the Epstein Barr virus infected cells with an activated...
5223410 Method for production of antibodies utilizing an antigen-free animal  
The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized antigen free animal. The invention also provides a method for the use of such...
5219730 Idiotype-anti-idiotype immunoassay  
The present invention provides an immunoassay of general applicability. The assay detects an antigen by its inhibition of the reaction between the combining site of two antibodies. One of the...
5219996 Recombinant antibodies and methods for their production in which surface residues are altered to cysteine residues for attachment of effector or receptor molecules  
The present invention provides an altered antibody molecule wherein a residue in a surface pocket on the molecule has been changed to a cysteine residue to introduce a thiol group in the surface...
5217895 Monoclonal anti-idiotypic antibodies specific for anti-T4 antibodies and cross-reactive with HIV  
Disclosed are immunologically active polypeptides, preferably antibodies or antibody fragments, and most preferably monoclonal antibodies, which are reactive with idiotypes of antibodies to human...
5217896 Monoclonal antibodies recognizing parathyroid hormone-like protein  
This invention provides a monoclonal antibody which specifically forms a complex with amino acids 1-87 of PTHLP which does not form a complex with amino acids 1-34 of PTHLP, and which forms a...
H001198 Pseudomonas aeruginosa type-specific human monoclonal antibodies, their preparation and use  
Serotype-specific human anti-Pseudomonas monoclonal antibodies which bind to determinants of the cell wall lipopolysaccharides of P. aeruginosa are prepared from hybrid cell lines. The antibodies...