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5506344 Antibodies specific for BCL-2 gene product  
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms...
5503981 Isolation of fetal cells from maternal blood to enable prenatal diagnosis  
This invention relates to a method for the isolation of trophoblast (placental) cells from the blood of a pregnant mammal so as to provide the essential starting material, namely cells derived...
5503984 Hybridoma producing monoclonal antibody F4 which specifically binds to multidrug resistant P-glycoprotein and assays for detection of P-glycoprotein  
A unique monoclonal antibody against P-glycoprotein. The monoclonal antibody is different than those previously described and has the surprising property of reacting to a soluble form of...
5502168 Monoclonal antibodies to a continuous and cross-reactive epitope and an isolated protein of a sexual stage of P. falciparum  
Monoclonal antibodies which recognize a continuous epitope in the sexual stages of P. falciparum. The epitope so recognized has the following amino acid sequence: ##STR1## Malaria vaccines based...
5501988 Anti hCG-β core monoclonal antibody, its production and use  
A hybridoma capable of producing monoclonal antibody for recognizing hCG-β core region and hCG-β subunit, which is obtained by cell fusion of an antibody producing cell of a mammal immunized with...
5500345 Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein  
Monoclonal antibodies specifically reacting with the side face of a C-reactive protein (CRP), i.e., monoclonal antibodies specifically reacting with the side face of a disk-like subunit of a...
5500349 Blood-coagulation factor XIIA β monoclonal antibody and immunoassay  
A monoclonal antibody which binds to Factor βXII and which shows substantially no binding to Factor XII. This antibody may be used in immunoassays to measure Factor βXIIa levels in blood, for...
5496548 Human anti-RH(D) monoclonal antibodies, cell lines and methods of use of antibodies in immunoassays  
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system;...
5493009 Antiidiotypic monoclonal antibodies MK2-23 anti-melanomal antibody 763.74  
The invention concerns murine antiidiotypic monoclonal antibodies which are the internal image of determinants recognized by a monoclonal antibody on high molecular weight-melanoma associated...
5491088 Monoclonal antibody BR 96 and chimeric monoclonal antibodies having the variable region of MAB BR96, which bind to a variant of ley antigen on human carcimona cells  
The present invention relates to novel antibodies reactive with human carcinoma cells. More particularly, the antibodies of the invention include: a murine monoclonal antibody, BR96; a...
5491065 Monoclonal antibodies that bind to and neutralize dimeric but not monomeric human M-CSF and methods of use thereof for detection of dimeric M-CSF  
Monoclonal antibodies that bind to an apparent conformational epitope associated with recombinant or native dimeric M-CSF with concomitant neutralization of biological activity, which monoclonal...
5487890 Mammalian primate erythrocyte bound heteropolymerized monoclonal antibodies and methods of use thereof  
Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a...
5487891 Human anti-RH(D) monoclonal antibodies reagents and hybridomas and methods of RH typing using anti-RH(D) monoclonal antibodies and reagents  
The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system;...
5486361 Hybridomas and monoclonal antibodies that speifically bind to GPIB on platelets and inhibit the binding of thrombin to platelets  
Monoclonal antibodies which specifically bind to glycoprotein Ib are described. These antibodies completely inhibit the binding of thrombin to platelets, thereby totally inhibiting the activation...
5484892 Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells  
The present invention is concerned with a series of novel monoclonal antibodies directed against CD22, a B lineage-restricted member of the Ig-superfamily which serves as an adhesion receptor...
5484735 Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids  
An immunoassay for a protein that is non-enzymatically glycosylated on the alpha amino group of its N-terminal amino acid, the immunoassay comprising: providing a sample containing the...
5478741 Antibodies to the HRPII protein of plasmodium falciparum  
Antibodies which recognize and bind to histidine rich protein II of Plasmodium falciparum. These antibodies exhibit improved specificity and affinity for the antigen which provides enhanced...
5476921 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Antiparathyroid antibodies which specifically bind to cell surface molecules on parathyroid, renal and cytotrophoblast cells which are involved in calcium sensing
 
Antibody preparations are useful in the prognosis of parathyroid and renal disorders. The antibody preparation includes antibodies which bind specifically to a surface antigen, Ca2+ sensing...
5474771 Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same  
This invention provides a monoclonal antibody which specifically recognizes and forms a complex with a protein located on the surface of activated T cells and thereby inhibits T cell activation of...
5459044 High affinity monoclonal antibodies to Bowman-Birk inhibitor and immunoassay methods  
Hybrid cell lines (hybridomas) which produce and secrete high affinity monoclonal antibodies specific for Bowman-Birk inhibitor (BBI) are described. High affinity antibodies to BBI are described...
5459061 Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor  
Hybridomas producing monoclonal antibodies that specifically bind to the human EGF receptor and compete with EGF for binding to the EGF receptor are described. The subject monoclonal antibodies...
5459048 DNA encoding 85kd polypeptide useful in diagnosis of Mycoplasma infections in animals  
A class of polypeptides useful in an in vitro diagnosis of Mycoplasma infection in animals is disclosed. These polypeptides are also capable of inducing an immune response in swine which were...
5455030 Immunotheraphy using single chain polypeptide binding molecules  
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and...
5453269 Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use  
Heterobifunctional antibodies having dual specificities, one specificity directed against a thrombus, and the other specificity directed against a thrombolytic agent are disclosed. The invention...
5449610 Monoclonal antibodies against chicken T-lymphocytes  
Seven murine hybridoma cell lines capable of secreting monoclonal antibodies that can identify subpopulations of chicken lymphocytes have been developed. Precursor cytotoxic and suppressor T...
5447853 Method of producing useful high-molecular-weight substances by culturing proliferous animal cells, and culture system therefor  
A method of producing a useful high-molecular-weight substance by culturing animal cells capable of proliferation, which comprises (A) a culturing step of culturing said animal cells in suspension...
5443957 Anti-asialo-GM1 monoclonal antibodies and method of use  
A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal...
5444156 Monoclonal antibodies to human plasma prekallikrein  
Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein,...
5439795 Monoclonal antibodies that specifically bind somatotropin binding proteins but not to corresponding somatotropin receptors and methods of use in immunoassays  
The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding...
5434076 Tumor-specific, cell surface-binding monoclonal antibodies  
Disclosed is a process for the preparation and use of gynecological tumor diagnostic and antitumor reagents. The process involves the pre-treatment of a patient with a viral oncolysate and the...
5427931 Monoclonal antibody produced against native βamyloid precursor protein  
Monoclonal antibody and the hybridoma producing the antibody are disclosed. The antibody is produced against an epitope on native secreted forms of βAPP. A characteristic of the antibody is that...
5428133 Chimeric anti-human IgE-monoclonal antibody which binds to secreted IgE and membrane-bound IgE expressed by IgE-expressing B cells but notto IgE bound to FC receptors on basophils  
Chimeric antibodies which bind to unique antigenic epitopes of IgE (designated ige.b1) which are present on IgE-bearing B lymphocytes but not basophils are described.
5426037 Production of monoclonal antibodies  
Apparatus and method for the production of monoclonal antibodies, wherein a sealed dialysis tube (18) is fixed within a roller bottle (10) to be immersed in a growth medium (24) contained within...
5422258 Methods for producing high affinity anti-human IgE-monoclonal antibodies which binds to IgE on IgEabearing B cells but not basophils  
Methods of producing monoclonal antibodies that bind to unique antigenic epitopes of IgE (designated ige.bl) which are present on IgE-bearing B cells but not basophils are described. The...
5422239 Immunoassay utilizing monoclonal high affinity IgM antibodies  
Hybridomally produced monoclonal IgM antibodies having high affinity are useful for the immunoassay and purification of vital antigens.
5418129 Blood treatment method  
A method of producing monoclonal antibodies that bind to tumor-associated gangliosides, the method comprising: (1) immunizing a host with tumor cells; (2) boosting the host with a suspension...
5414072 Anti-octopus rhodopsin monoclonal antibody  
The invention relates to a monoclonal antibody which binds to octopus rhodopsin and octopus metarhodopsin wherein said monoclonal antibody binds with higher affinity to metarhodopsin than to...
5411884 Monoclonal antibody L53 which recognizes a human tumor-associated antigen  
The present invention is concerned with novel monoclonal antibody L53 which binds strongly to a glycoprotein antigen associated with human tumors, including carcinomas of the colon, breast, and...
5407811 Monoclonal antibodies to GP110 of HIV and hybridomas secreting these antibodies  
This invention is directed to an isolated antibody specific for gp110 glycoprotein of a human immunodeficiency virus type 1 (HIV-1), and a hybridoma which produces such an antibody. HIV-1 is the...
5407804 Assays for O6 -methylguanine-DNA methyltransferase  
Assays for the DNA repair protein O6 -methylguanine-DNA methyltransferase (MGMT) are provided which employ monoclonal antibodies prepared using MGMT having transferase activity, as opposed to...
5389518 Monoclonal antibodies directed against vitronectin and fibronectin, and uses thereof  
The present invention provides monoclonal antibodies directed against specific domains of fibronectin and vitronectin. These monoclonals may be used in the production of the biomaterial and...
5384263 Method to produce immunodiagnostic reagents  
Screening methods to obtain suitable antibodies for use in immunoassays for analytes not ordinarily susceptible to detection by this means involves in vitro, screening of panels of cells secreting...
5374529 Methods of and compositions for diagnosis, monitoring and treating the early stages of osteoarthritis  
Methods of and compositions for early diagnosis, monitoring and treatment of osteoarthritis using monoclonal antibodies which specifically recognize antigenic determinants on atypical chondroitin...
5362643 Antibodies to epitopes present on membrane-bound but not secreted IGA  
The invention relates to antibodies which immunologically bind epitopes present on B cell-bound but not secreted IgA. This is accomplished by targeting extracellular epitopes on the membrane...
5360716 Human tumor necrosis factor αspecific monoclonal antibody and method for detecting human tumor necrosis factor α  
Monoclonal antibodies exhibiting specificity for human TNF-α are disclosed. The antibodies are useful for immunological purification and for measurement of said human TNF-α in immunoassays.
5358849 Monoclonal antibody recognizing membrane phospholipase A2 and immunoassay of membrane phospholipase A2  
The present invention first provides monoclonal antibodies recognizing membrane phospholipase A2, namely, monoclonal antibodies PL-49, PL-71, PL-76, and PL-78, hybridomas producing them, methods...
5352772 75 Kilodalton interleukin-2 receptor proteins and their uses  
A new cellular protein produced by activated T cells and involved in the high affinity binding of interleukin-2 has been discovered. This protein has a molecular weight of about 75,000 (Mr) and is...
5348858 Monoclonal antibody specific for human interleukin-1β and method for detection of biologically active human interleukin-1β  
The present invention provides a monoclonal antibody characterized in that the antibody has specific reactivity on human IL-1β, and a process for producing the antibody. The invention also...
5342924 Extracellular segments of human ε immunoglobulin anchoring peptides and antibodies specific therefor  
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B...
5336610 Method for purification of the zymogen of protein C or the heavy chain thereof using monoclonal antibody HPC-4  
A Ca2+ dependent monoclonal antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C. The antibody does not bind...