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5622835 WT1 monoclonal antibodies  
Three unique monoclonal antibodies, each having an epitope located in amino acids 1-181 of the WT1 tumor protein, and the hybridomas which secrete them have been constructed. These monoclonal...
5620861 Method and kit for pyridinium crosslink assay  
A method of assaying bone collagen degradation activity in a human subject. In the method, a human urine sample is reacted with an antibody which (i) is capable of reacting immunospecifically with...
5620686 Antigen-antibody conjugates  
Diseases attribute to a predominantly cell-mediated immune response, notably autoimmune diseases, can be suppressed by administering a novel conjugate of an appropriate antigen, notably an...
5618700 IL-6 specific monoclonal antibodies, hybridomas therefor and methods of making and using same  
The hybridoma 34-1 (CNCM I-813) which produces anti-human IL-6 monoclonal antibody 34-1 is disclosed. Methods of producing the monoclonal antibody and methods for affinity purification of human...
5614394 Method and monoclonal antibodies for vitamin B12 determination  
A method for making an monoclonal antibody specific for vitamin B12 by immunizing mice with vitamin B12-b-acid and isolating hybridomas that produce monoclonal antibodies which have an affinity...
5612030 Anti-idiotype monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma  
The present invention relates isolation of anti-idiotypic antibody 1A7 raised against anti-GD2 mAb 14G2a and its use for the treatment of melanoma and small cell carcinoma. The antibody may be...
5610035 Methods for the preparation of hybridomas producing lymphadenopathy-associated virus (LAV) GP110-specific monoclonal antibodies and methods for the purification of GP110 employing said monoclonal antibodies  
A novel human retrovirus which is the aetiological agent of acquired immune deficiency syndrome (AIDS), designated lymphadenopathy-associated virus (LAV), was isolated from the lymph nodes of a...
5610280 Monoclonal antibodies against melanoma  
The present invention provides a human monoclonal antibody against melanoma, characterized in that it binds to the gangliosides GM3 and GD3 but essentially does not bind to the gangliosides GM1,...
5607862 Assay for N-terminal type I collagen telopeptide that survives bone resorption in vivo  
A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method...
5603931 Method for delivering a bioactive molecule to a cellular target  
Hybrid reagents comprising a first portion having an affinity for a cellular target and a second portion having an affinity for a bioactive molecule are described, said hybrid reagents being...
5601987 Immunodiagnosis of parasitoses due to a protozoon in mollusks  
This invention relates to a monoclonal antibody which specifically recognises an antigen of a protozoon parasitizing a mollusk.Application: immunodiagnosis of parasitoses due to a protozoon in...
5597726 Monoclonal antibodies reactive with a human atheroma associated antigen  
The present invention relates to a naturally occurring, minimally modified LDL antigen which is present in human atherosclerotic lesions as well as in the serum of a high percentage of patients...
5597896 Retrovirus human immunodeficiency virus type 2(HIV2), capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes  
The invention relates to a new variety of retroviruses designated Human Immunodeficiency Virus Type 2 (HIV-2), samples of which have been deposited at CNCM and having Accession Numbers I-502 and...
5597725 Cadherin-specific antibodies and hybridoma cell lines  
DNA sequences encoding novel cadherins, desginated cadherins-4 through -12, are disclosed along with methods and materials for the recombinant production of the same. Antibody substances specific...
5595868 Monoclonal antibodies to hepatitis C virus  
The invention concerns a hybridoma cell line that produces a monoclonal antibody having binding specificity for epitopes on Hepatitis C virus (HCV) core protein and a monoclonal antibody produced...
5593822 IgG depleted serum preparations and methods for antibody production  
A method for preparing serum depleted of IgG to be used in the production of IgG monoclonal antibodies is disclosed. Animal serum is contacted with protein G or protein A prior to addition to base...
5591628 Method of determining the presence of endotoxin in a sample  
There is disclosed a method for determining the presence of endotoxin or an endotoxin like substance in a sample, as well as a monoclonal antibody and test kit useful in the method.
5591629 Monoclonal antibodies which promote central nervous system remyelination  
Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ...
5587291 Method for the determination of plasmin α2 -antiplasmin complexes and the use of this method as a mean of determining changes in the fibrinolytic system  
Method for the quantitative determination of plasmin-α2-antiplasmin complexes, using a specific monoclonal antibody directed against the neoantigene in the plasmin-α2-antiplasmin complex, and use...
5582998 Monoclonal antibodies against human TNF-binding protein I (TNF-BP I) and immunoassays therefor  
The invention concerns monoclonal antibodies, designated tbp-1, tbp-2 and tbp-6, against the extracellular part of the human 60 kD TN tumour necrosis factor receptor (TNF-BP I). These antibodies...
5580740 Antihuman pulmonary adenocarcinoma monoclonal antibody  
An antihuman pulmonary adenocarcinoma monoclonal antibody ALC-390 and a process for producing thereof are disclosed. This monoclonal antibody, which belongs to IgG class and is reactive with human...
5580780 Vascular adhesion protein-(VAP-1) and VAP-1-specific antibodies  
A novel endothelial cell molecule, VAP-1, is described that mediates lymphocyte binding in man. Further described are anti-VAP-1 monoclonal antibodies and methods for the diagnosis and treatment...
5578484 Hybridoma and monoclonal antibody 9H10-A4 specific to an antigen of LNCaP cells  
Monoclonal antibodies, specifically 9H10-A4 monoclonal antibodies, specific to an epitope present on the surface of LNCaP cells, are produced by hybridoma cell line 9H10-A4 formed by fusing mouse...
5578704 Antibody to osteoclast alphavbeta3 ntegrin  
Hybridoma cell line, ATCC HB 11029, which produces murine monoclonal antibody, 10C4.1.3 which specifically binds to alphavbeta3 integrin on human osteoclasts, and is capable of blocking binding of...
5576423 Antibodies to the slam protein expressed on activated T cells  
Purified genes which encode a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of...
5576182 Anti-mucus glycoprotein monoclonal antibody  
An IgM class monoclonal antibody which specifically reacts with mucus glycoproteins produced by human gastric gland-type mucous cells is provided. By performing immunohistochemical staining using...
5573918 Process and reagent for specific determination of pancreatic alpha amylase  
The present invention provides a process for the specific determination of pancreatic alpha-amylase in the presence of salivary alpha-amylase in body fluids, especially in serum, plasma, duodenal...
5573762 Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy  
A leukemia inhibitory factor antagonist, alone or in combination with an endothelin antagonist, may be used for treatment of heart failure. The antagonist(s) are administered in a chronic fashion,...
5571714 Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use  
Monoclonal antibodies have been produced which bind to Transforming Growth Factors β1 (TGF-β1) and β2 (TGF-β2). The monoclonal antibody produced by the hybridoma designated 1D11.16 deposited as...
5571513 Anti-gp130 monoclonal antibodies  
Anti-gp130 monoclonal antibodies (Mabs) obtained from hybridomas designated 4B11 and 2H4 are effective in the inhibition of the acute phase response on hepatoma cells and prevent the IL-6-induced...
5571720 Integrated cell culture protein purification system for the automated production and purification of proteins  
An integrated cell culture-protein purification system has been developed for the continuous, automated production of pure cell culture protein products. The instrument comprises a bioreactor...
5565354 Production of human monoclonal antibodies specific for hepatitis B surface antigen  
Monoclonal antibodies effective for the diagnosis and treatment of diseases caused by infection with hepatitis B have been prepared from a cell line obtained by fusing a xenogeneic hybridoma...
5565337 Hybridoma-producing NSO myeloma cell line  
This invention relates to an NSO myeloma cell line which has increased fusion frequency, and to a method of producing said cell line. The NSO cell line of the invention, when fused with B cells,...
5565356 Hybridoma cell lines which produce monoclonal antibodies having the properties of monoclonal antibody 100-310 and the monoclonal antibodies produced by these hybridoma cell lines  
Monoclonal antibody 100-310 is found to be reactive against colon cancer cells and would therefore be useful for diagnostic imaging and treatment of colon cancer.
5563074 Immunological detection methods  
The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards triasulfurone and that are therefore outstandingly suitable for...
5563247 Monoclonal antibodies to oncoproteins and methods of making monoclonal antibodies  
Monoclonal receptors raised to immunogenic polypeptides whose amino acid residue sequences correspond to sequences of oncoprotein ligands are disclosed, as are methods for the production of those...
5559012 Therapeutic, IL-6 antibody kits, and process for their preparation  
A therapeutic kit which includes at least three unlinked monoclonal antibodies for neutralizing a short life IL-6 cytokine and a method for preparing said kit.
5558997 Monoclonal antibodies to mycosphaerella species  
The invention relates to monoclonal antibodies that react specifically with members of the genus Mycosphaerella and hybridomas that produce such antibodies. The invention is further directed to a...
5554515 Preparation of a monoclonal antibody specific to human myelomonocyte interferon-gamma  
A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being...
5552286 Hybridoma cell lines and their monoclonal antibodies to human pluripotent granulocyte colony stimulating factor  
Murine-derived hybridoma tumor cell lines and monoclonal anti-human pluripotent Granulocyte Colony Stimulating Factor antibody substances produced by these cell lines. Use of said monoclonal...
5547668 Conjugates of folate anti-effector cell antibodies  
The present invention provides a process of targeting folate-receptor-positive tumor cells for lysis by binding a conjugate of folate and an anti-T-cell-receptor antibody or an anti-Fc receptor...
5545533 Monoclonal antibodies against c-kit and method of detecting a malignancy using c-kit specific antibodies  
The invention concerns monoclonal antibodies against the human c-kit receptor which are obtainable from the cell lines DSM ACC 2007, DSM ACC 2008 and DSM ACC 2009 or are capable of binding to the...
5541295 Detection of type II collagen and its peptides  
The invention discloses monoclonal antibodies which bind specifically to Type II collagen, but not to its peptides, or vice versa. Also disclosed are the methods of preparing hybridomas for...
5541101 Anti-oxytocin receptor antibodies  
Anti-oxytocin receptor antibodies, which specifically bind to the extracellular or intracellular region of an oxytocin receptor, hybridomas which produce said antibodies, and methods for the...
5536641 Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells  
An antigen which is specific to vascular endothelium is described. Described is a cell surface antigen which consists of four subunits, of 190, 145, 125 and 110 kd as determined by SDS-PAGE under...
5534431 Hybridomas and monoclonal antibodies specific for unique determinants of nephropathy-related immunoglobulin G and complexes thereof  
A novel immunoglobulin-like glycoprotein is described which has been found to occur in high concentrations in the urine of patients with glomerulosclerosis of end-stage renal disease. This...
5534621 Immunoaffinity purification methods using single polypeptide chain binding molecules  
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and...
5534411 Monoclonal IgA antibody specific for respiratory syncytial virus, a hybridoma cell line that produces this antibody amd methods of using the antibody to diagnose RSV infection  
A new hybridoma cell line HNK20 which secretes a monoclonal IgA antibody to respiratory syncytial virus is disclosed. The antibody has diagnostic uses in respect of Respiratory Syncytial Virus.
5534255 Monoclonal antibody specific to human α2 -plasmin inhibitor  
This invention provides a monoclonal antibody or its fragment specific to a human α2 -plasmin inhibitor, said antibody having the function of specifically blocking that site of the human α2...
5532137 Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method  
Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 isa compound having pharmacological...