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5770361 Protein conferring an inducible resistance to glycopeptides, particularly in gram-positive bacteria  
The invention relates to a protein VanB involved, in Gram-positive bacteria, in resistance to glycopeptides, particularly to vancomycine, said resistance being of the type inducible by the...
5770403 Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4  
Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal...
5766946 Monoclonal antibodies to glycoprotein P  
A monoclonal antibody that recognises a structurally continuous and extracellularly-located epitope of human P-glycoprotein is described. The monoclonal antibody has a continuous amino acid...
5763202 Methods of detecting prostate carcinoma using a monoclonal antibody to a new antigenic marker in epithelial prostatic cells alone or with a monoclonal antibody to an antigen of LNCaP cells  
Monoclonal antibodies to prostatic cells, are produced by a hybridoma formed by fusing mouse lymphocytes and mouse myeloma cells. The monoclonal antibodies show specificity for a non-soluble,...
5756301 Endogenous taxol-like substance in human serum, monoclonal antibodies directed thereto and methods of assaying therefor  
The present invention provides two monoclonal antibodies capable of binding to taxol and taxol-like substances which are produced by hybridomas designated 69E4A8E, having ATCC Accession No....
5756095 Antibodies with specificity for a common epitope on E-selectin and L-selectin  
The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking...
5753229 Monoclonal antibodies reactive with tumor proliferating cells  
This invention concerns monoclonal antibodies directed against breast carcinoma cells. Immunoglobulin secreting hybridoma cultures are produced by hybridoma technology using undifferentiated...
5747037 Anti-GP39 antibodies  
Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred...
5747034 Methods and materials for the induction of T cell anergy  
Anti-B7-1 antibodies or other B7-1 ligands may be used to prevent or treat a T-cell-mediated immune system disease in a patient or to induce antigen-specific tolerance.The anti-B7-1 antibodies may...
5738847 Anti-VH3-15 reagents and methods for their use  
Anti-VH3-15 idiotypic antibody materials, hybridomas producing this antibody material and methods for using these to detect, isolate and purify VH3-15 polypeptides. Also provided in the present...
5736138 Monoclonal antibodies with specific binding against membrane proteins on human cells, and pharmaceutical compositions containing them  
A monoclonal antibody, or fragments thereof, against human TNF receptor protein which antibody neutralizes the known actions of TNFα and/or TNFβ is disclosed. The antibody may be chimeric or...
5736344 Serum pyridinium crosslinks assay  
A method of assaying bone collagen breakdown levels in a human subject useful to screen for the presence of bone resorption disorders. Also disclosed is a method for monitoring the progression...
5730981 Monoclonal anti-ganglioside antibody and its preparation  
The invention relates to monoclonal antibodies of high avidity, which react specifically with the gangliosides GD3 and GQ1b, and to their use for detecting melanomas and other tumors or tissues...
5728537 Methods of producing antibodies against cytokeraton fragments and test kits containing such fragments  
Provided is a method for reproducible production of cytokeratin antigen immunogen. Cytokeratins from whole carcinoma cells are purified by preparative SDS-PAGE. Bands corresponding to cytokeratins...
5721122 Method comprising immunization of antigen-free mice  
A method of obtaining lymphocytes making a highly specific antibody by immunizing an antigen-free mouse and removing the blood, lymph nodes or spleen from the immunized mouse. Alternatively, a...
5721130 Antibodies and fragments thereof which bind the carboxyl-terminus of an amino-terminal fragment of βAPP  
Processing of β-amyloid precursor protein (βAPP) is monitored by detecting the secretion of a soluble βAPP fragment resulting from cleavage of βAPP at the amino-terminus of β-amyloid peptide. In...
5719050 Animal cell culturing media containing N-acetyl-L-glutamic acid  
The present invention relates to a medium composition for culturing animal cells which is obtained by combining at least one component selected from the group of substances mentioned below with a...
5717072 Antibodies that are immunoreactive with interleukin-4 receptors  
Mammalian antibodies that are immunoreactive with Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4...
5712120 Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them  
Modified chimaeric antibodies, and antibody heavy and light chains, which comprise variable domains derived from a first mammalian species, usually mouse, and constant domains from a second...
5702904 Immunoassay for identifying alcoholics and monitoring alcohol consumption  
The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and...
5703213 Monoclonal antibodies which recognize an adenocarcinoma cell antigen  
The present invention is directed to antibodies, and fragments thereof, which specifically bind the AF-20 and the XF-8 epitopes of adenocarcinoma cell antigen(s).
5702905 Monoclonal antibody to human ventricular myosin light chains  
A monoclonal antibody having high affinity to the cardiac isoform of human myosin light chains is described. The monoclonal antibody is prepared against a synthetic peptide from the amino terminal...
5698419 Monoclonal antibodies to cachectin/tumor necrosis factor and methods for preparing same  
The present invention pertains to the novel hybridoma SDW18.1.1, hybridomas obtained from SDW18.1.1, monoclonal antibodies obtained from such hybridomas and derivatives of such monoclonal...
5686073 Polyclonal and monoclonal antibodies against a 43 KDA dystrophin associated protein  
Disclosed are methods for the preparation of polyclonal and monoclonal antibodies which bind specifically to a 43 kDa dystrophin-associated. The molecular weight of the 43 kDa protein is...
5683892 DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders  
DNA encoding chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
5684133 Neurite growth regulatory factors, antibodies thereto, and pharmaceutical compositions  
The CNS myelin associated proteins inhibit neurite outgrowth in nerve cells and neuroblastoma cells, and can also inhibit fibroblast spreading. Such inhibitory proteins include a 35,000 dalton and...
5679548 Methods for producing polypeptide metal binding sites and compositions thereof  
The present invention describes methods for producing metal binding sites on polypeptides, and particularly for producing metal binding sites within the CDR regions of immunoglobulin heavy or...
5677150 Antibodies produced from lipopolysaccharide-stimulated monocyte/macprophage cell lines  
Lipopolysaccharide-stimulated monocyte/macrophage cell lines are used as antigens to obtain antibodies. Antibodies which inhibit intercellular adhesion of cells stimulated by a differentiation...
5677165 Anti-CD40 monoclonal antibodies capable of blocking B-cell activation  
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen...
5674719 Method for producing monoclonal antibodies specific to hair follicles  
This invention provides a method for preparing hybridomas, which include the steps of: quickly and deeply freezing hair-bulbs of follicle isolated from a human or an animal of species A;...
5672502 Animal cell culture  
Process for the fed-batch culture of animal cells comprises culturing the cells in nutrient medium characterized in that during the culture the medium is supplemented with a combined feed of one...
5672692 Purification of human myelomonocyte interferon gamma with an immobilized antibody  
A human myelomonocyte interferon-gamma having a novel polypeptide and carbohydrate chain structure is produced by propagation of an established human myelomonocyte in vitro or after being...
5670373 Antibody to human interleukin-6 receptor  
Antibodies, polyclonal and monoclonal, which are capable of specifically binding to a human interleukin-6 receptor. Also included are monoclonal antibodies which competitively and...
5667781 Enhanced inhibition of tumor cell proliferation using a combination of two monoclonal antibodies to the human transferrin receptor  
Combinations of monoclonal antibodies which are highly effective for inhibiting cell growth and methods for inhibiting cell growth employing novel combinations of monoclonal antibodies are...
5661010 Process to obtain monoclonal and polyclonal antibodies to identify pathogenic amebiasis and pathogenic Entamoeba histolytica trophozoites  
The present invention is a process to obtain polyclonal and monoclonal antibodies useful to identify symptomatic or asymptomatic amebiasis. This invention includes the following steps: 1) Antigen...
5658803 Monoclonal antibodies reactive with cachectin  
Cell lines are provided that produce improved neutralizing monoclonal antibodies reactive with human cachectin. The antibodies have various therapeutic and diagnostic uses.
5656435 Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof  
Disclosed are (A) an antibody to a peptide including at least 8 successive amino acids of an amino acid sequence represented by formula TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys...
5654178 Immunoassay for tetrachloroisophthalonitrile (chlorothalonil), its derivatives and breakdown products  
Novel derivatives of chlorothalanil® (tetrachloroisophthalonitrile, TCPN), permit conjugation of the TCPN derivative to a carrier useful as an immunogen to induce antibodies specific for TCPN or a...
5650300 Method of producing monoclonal antibodies to oncofetal protein  
The present invention provides a low cost, less toxic, anti-cancer immunotherapy which enhances the host's immune system ability to destroy or contain cancers, and also provides a diagnostic test...
5650291 Monoclonal antibodies against an antigen associated with ovarian cervical and other tumors  
Monoclonal antibodies immunoreactive with tumor-associated antigen, CA 215 which is present on an ovarian tumor cell line, fragments of those antibodies (either radiolabeled, bound to a toxin, or...
5648469 Monoclonal antibodies reactive with transferrin receptor cytoplasmic domain  
Monoclonal antibodies have been produced which specifically bind to epitopes found in the cytoplasmic domain of the transferrin receptor (TR). The antibodies are useful for isolating sequences in...
5646041 Monoclonal antibody to herpes simplex virus and cell line producing same  
Human Monoclonal antibodies effective for the diagnosis and treatment of Herpes Simplex Virus 1 and 2 have been prepared from a cell line obtained by fusing a xenogeneic hybridoma designated SPAZ...
5643759 Method for preparing bispecific monoclonal antibodies  
The present invention relates to a method for the selective preparation of hybridoma cell lines which produce a murine monoclonal antibody (MAK) of the IgGl class with a high capacity for...
5641638 Monoclonal antibodies against Mycoplasma pneumoniae, hybridomas producing these, methods for the preparation thereof, and the use thereof  
The invention relates to monoclonal antibodies and fragments thereof which are specific for Mycoplasma pneumoniae P2 protein and have a cross-reactivity of 1% or less with five other species of...
5639621 Monoclonal antibodies against tumor-associated antigens  
The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as...
5635601 Beta-8 integrin subunit antibodies  
The cDNA encoding a novel beta integrin subunit, called the beta-8 integrin subunit, has been isolated from rabbit and human tissue and sequenced. Provided herein is nucleic acid sequence of the...
5631351 Antibodies to MDC proteins  
The present invention provides an antibody encoded by a gene which is present in a commonly deleted region of a chromosome in breast and ovarian cancers. A monoclonal antibody was prepared by...
5629197 Monoclonal anti-human breast cancer antibodies  
Murine monoclonal antibodies are prepared and characterized which bind selectively to high molecular weight mucins by immunoprecipitation test and are IgGs or IgMs. Immunotoxins comprising the...
5627073 Hybridomas producing antibodies to cardiac hypertrophy factor  
Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic...
5622836 Monoclonal antibodies which recognize malignant cells from bladder carcinomas  
The present invention relates to a family of novel antigens associated with malignant cells of bladder carcinomas, and to antibodies, portions or fragments thereof, or single domain antibodies...