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7390637 |
Keratinocyte derived interferon
The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide,...
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7390633 |
Methods for preparing low molecular weight heparin with modified heparinase III
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of...
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7388076 |
Human immunosuppressive protein
A method for purifying an immunosuppressant protein (HISP) has the steps of obtaining supernatant from hNT cells; exposing the supernatant to preparative polyacrylamide gel electrophoresis to...
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7384771 |
Beta 1,4-N-acetylgalactosaminyltransferases from C. jejuni
This invention provides prokaryotic β1,4-N-acetylgucosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). The β1,4-GalNAc transferases can be obtained from, for...
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7375205 |
Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these...
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7364842 |
Methods of identifying modulators of human retrovirus replication
This invention relates to the discovery that the transcription factors Pbx1 and HMG I are involved in retrovirus, e.g., HIV, replication. Thus, the invention provides methods of identifying...
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7351816 |
Nucleic acid encoding anti-IgE antibodies
The present invention describes IgE antagonists (including variant anti-IgE antibodies) and their use in diagnosis, therapy or prophylaxis of allergic and other IgE-mediated disorders, including...
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7348407 |
Stress-responsive activator of p300 (strap) protein
The invention provides a protein which is a stress-responsive activator of the p300 protein, and nucleic acid sequences encoding the protein. The protein performs a key role in facilitating...
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7348162 |
Nucleic acids encoding fibroblast growth factor receptor-like proteins and uses thereof
The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents,...
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7344863 |
Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides...
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7344860 |
Polynucleotide encoding a novel human P2X7 splice variant, HBMYP2X7v
The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and...
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7344856 |
Method of controlling cleavage by OmpT protease
Methods of using OmpT protease are provided. In particular, the invention provides for a method of controlling cleavage of a polypeptide by OmpT protease comprising, converting a sequence site...
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7338788 |
Interferon-β variants and conjugates
The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use of such conjugates in therapy, in particular for the treatment of multiple sclerosis.
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7338759 |
HCV variants
HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive...
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7335504 |
Engineered enzymes and uses thereof
The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for...
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7335491 |
Production of anti-abeta
An improved system for large scale production of proteins and/or polypeptides in cell culture, particularly in media characterized by one or more of: i) a cumulative amino acid concentration...
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7323558 |
Nucleic acids encoding dendritic cell transmembrane serine protease
Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can...
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7320870 |
Ocular tear growth factor-like protein
The present invention relates to a novel lacrimal gland protein (designated lacritin) and the nucleic acid sequences encoding that protein. Lacritin has activity as a growth factor on both human...
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7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
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7300790 |
Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins
The present invention relates to non-vaccinal and non-pharmacologic compositions and methods for controlling complex retroviral infections. In particular, the present invention provides transgenic...
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7297515 |
Zinc finger proteins
Novel zinc finger proteins and nucleic acids encoding the proteins are provided. The zinc finger proteins interact with ZNF202, a zinc finger protein that regulates the expression of a variety of...
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7294505 |
Stable episomal vectors
The present invention provides a vector system which can be stably translocated from the cytoplasm of a cell to the nucleus where it is a stable nuclear episomal vector. A basic vector system...
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7294481 |
Method for producing recombinant proteins
A method for producing recombinant proteins, preferably fusion proteins comprising an Fc portion of an immunoglobulin molecule, more preferably fusion proteins comprising an extracellular domain of...
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7291495 |
β-Secretase variant
The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to...
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7288701 |
Inbred maize line PH77P
An inbred maize line, designated PH77P, the seeds and plants of inbred maize line PH77P, methods for producing a maize plant, either inbred or hybrid, produced by crossing the inbred maize line...
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7285400 |
High bone mass gene of 11q13.3
The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates...
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7285390 |
Screening methods for identifying compounds which decrease HIV entry into a cell
A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic...
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7279560 |
Antibody fragments to JTT-1 protein and cells secreting such antibody fragments
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have...
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7279464 |
DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof
A DNA vaccine effective for eliciting an immune response against cells that present a carcinoembryonic antigen (CEA) comprises a DNA operably encoding a CEA and a DNA operably encoding a CD40...
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7273725 |
Human and mammalian stem cell-derived neuron survival factors
The present invention relates to human, rat and mouse stem cell-derived neuron survival factor polypeptides (SDNSF), a process for producing them, cDNA encoding SDNSF, a vector comprising the cDNA,...
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7268275 |
tcdB2 protein from Photorhabdus luminescens W-14
TcdB2, a protein from Photorhabdus luminescens W-14, and nucleotide sequences encoding TcdB2, are useful for enhancing expression of orally active Photorhabdus luminescens insecticidal toxins...
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7267965 |
Means and methods for regulating gene expression
The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell...
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7259146 |
Neuroprotective peptides
Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include...
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7258998 |
Cell culture medium
A method for culturing cells in the presence of an alcanoic acid for enhancing protein production.
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7256279 |
Protein having ribonucleotide reductase activity and DNA thereof
A protein having ribonucleotide reductase activity, DNA encoding the protein, antibodies to these and the like are disclosed. The protein, DNA and antibodies are useful in the prevention, treatment...
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7252973 |
Protein and processes for producing the same
A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a...
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7252824 |
Anti-neovasculature preparations for cancer
Disclosed herein are immunogenic compositions, methods of designing immunogenic compositions, methods of treatment using immunogenic compositions, methods of evaluating cell-mediated immunity...
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7250503 |
Nucleic acid molecules encoding clot-specific streptokinase fusion proteins possessing altered plasminogen activation characteristics
The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of...
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7247453 |
Calcium binding recombinant antibody against protein C
A Ca 2+ dependent recombinant antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C has been constructed. The...
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7244588 |
Cold-induced expression vector
A vector having a region encoding a cold shock protein gene mRNA-origin 5′-nontranslated region, characterized in that the 5′-nontranslated region has a mutation having been transferred therein...
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7244586 |
DNA molecules encoding ligand-gated ion channels from Drosophila melanogaster
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Drosophila melanogaster ligand-gated ion channel proteins. The present invention also...
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7244578 |
Methods for modeling infectious disease and chemosensitivity in cultured cells and tissues
The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided...
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7241860 |
Transcription factor polypeptide that regulates Chondromodulin-I expression
The polypeptide of the present invention has an activity of binding specifically to the cis-element of Chondromodulin-I (ChM-I) gene promoter and promoting the transcription of the ChM-I gene. The...
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7241598 |
Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
A method for preparing an antigen-specific antibody by constructing a library of phage-displayed single chain variable fragment of an antibody with a novel frame-shifting PCR is disclosed. Also...
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7238356 |
Core-glycosylated HCV envelope proteins
The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in...
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7235724 |
Plants and seeds of corn variety I900105
According to the invention, there is provided seed and plants of the corn variety designated I900105. The invention thus relates to the plants, seeds and tissue cultures of the variety I900105, and...
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7235394 |
Functional DNA clone for hepatitis C virus (HCV) and uses thereof
The present invention relates to the determination of an authentic HCV genome RNA sequences, to construction of infectious HCV DNA clones, and to use of the clones, or their derivatives, in...
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7232946 |
Hybrid maize plant and seed 33T56
A novel hybrid maize variety designated 33T56 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
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7232893 |
Method of manufacturing a stellate cell death factor
The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury....
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7227065 |
Hybrid maize plant and seed X4M830
A novel hybrid maize variety designated X4M830 and seed, plants and plant parts thereof, produced by crossing Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. Methods for...
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