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6600089 |
Carotenoid biosynthesis enzymes
This invention relates to an isolated nucleic acid fragment encoding a carotenoid biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6600030 |
Delayed progression to aids by a missense allele of the CCR2 gene
The present invention relates to a CCR2 deletion mutant, designated “CCR2-64I.” CCR2 is a C—C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered...
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6599744 |
Viral expression vectors comprising a ribosomal promoter sequence
The present invention provides improved vectors, including viral vectors such as adenovirus vectors. The vectors comprise ribosomal promoters in operable combination with a gene of interest. The...
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6596509 |
Recombinant constructs and systems for secretion of proteins via type III secretion systems
One aspect of the present invention relates to a DNA construct that contains a first DNA molecule encoding a functional type III secretion system, a promoter, and a second DNA molecule encoding a...
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6593461 |
Adherence gene from Helicobacter pylori and polypeptide coded thereby
The present invention concerns an adherence gene from Helicobacter pylori , a polypeptide coded thereby and antibodies against the polypeptide.
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6593108 |
Nucleic acid molecule encoding a melanin-concentrating hormone receptor 2 polypeptide
The present invention features HG67 nucleic acids and HG67 polypeptides. HG67, also referred to herein as “MCH-R2”, is a G-protein coupled receptor having a high degree of sequence identity...
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6589936 |
Pharmaceutical compositions comprising recombinant troponin subunits
The present invention relates to pharmaceutical compositions comprising therapeutically effective amounts of recombinant troponin C, I or T subunits for the treatment of diseases or disorders...
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6590072 |
Method for extractive refolding of scrambled single-chain polypeptides
The present invention relates to a method for extractive refolding of scrambled and/or polymerised single-chain polypeptides or proteins into their native conformation directly from a microbial...
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6590089 |
RVP-1 variant differentially expressed in Crohn's disease
The invention provides a mammalian cDNA which encodes a mammalian an RVP-1 variant. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded...
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6582961 |
Methods of protecting plants from pathogens
This invention provides novel methods for improving plant quality and yield in the presence of pathogens. The method increases the levels of pathogenesis-related proteins, such as PR1,...
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6576751 |
FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same
Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic...
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6573081 |
Method for growing circoviruses
Methods for growing circoviruses, in particular porcine circoviruses, which are obtained from an infected cell culture after one or more passages in cultures of porcine, bovine or human cells are...
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6573432 |
Regulation of anthocyanin pigment production
A method for determining gene expression in transgenic plants is disclosed. This method includes providing expression vectors having the PAP1 or PAP2 gene linked to an expressed gene of interest....
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6570062 |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
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6566512 |
ARV1, a protein involved in sterol uptake and sterol homeostasis in the budding yeast, S-cerevisiae, and a functional human ARV1
This invention provides an isolated nucleic acid which encodes mammalian ACAT-Related Enzyme 2 Required for Viability protein (ARV1p), wherein the encoded ARV1p protein has the amino acid sequence...
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6559298 |
Polypeptides that bind interleukin-18 (IL-18)
Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including...
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6558919 |
AmpS from Streptococus pneumoniae
The invention provides ampS polypeptides and DNA (RNA) encoding ampS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ampS...
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6559294 |
Chlamydia pneumoniae polynucleotides and uses thereof
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or...
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6558948 |
Permanent amniocytic cell line, its production and use for the production of gene transfer vectors
The invention relates to a permanent amniocytic cell line comprising at least one nucleic acid which brings about expression of the gene products of the adenovirus E1A and E1B regions. The present...
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6555346 |
Protein expression in baculovirus vector expression systems
The invention relates to a method to increase protein expression in baculo vector virus expression systems. The invention provides a method to produce a recombinant protein in insect-cell culture...
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6555373 |
Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of...
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6555347 |
Human minor vault protein p193
A polynucleotide molecule encoding human minor vault protein p193, or its complementary strands. A purified and isolated polynucleotide molecule consisting essentially of a nucleotide sequence...
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6555338 |
NrdF from Staphylococcus aureus
The invention provides nrdF polynucleotides encoding nrdF polypeptides from Staphylococcus aureus and methods for producing such polypeptides by recombinant techniques. The invention also...
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6548653 |
Erythropoietin analog-human serum albumin fusion
Erythropoietin analog-human serum albumin (EPOa-hSA) fusion protein and methods of making and using the fusion protein.
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6548276 |
Enhanced in vitro synthesis of active proteins containing disulfide bonds
Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions,...
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6544785 |
Helper-free rescue of recombinant negative strand RNA viruses
The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present...
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6541619 |
Fusion protein of hEGF and human angiogenin and process for preparing the same
The present invention provides a genetically engineered fusion protein consisting of hEGF that is internalized inside of the cells after tracing down the cancer cells expressing hEGF receptors and...
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6541224 |
Tumor necrosis factor delta polypeptides
The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the...
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6537548 |
Antibodies specific for ungulate PrP
The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrP C and/or a denatured ungulate PrP Sc , but not to a native ungulate...
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6537754 |
Association of kinesin with sensitivity to chemotherapeutic drugs
The invention provides diagnostic assays for assessing the sensitivity or resistance to DNA damaging agents and microtubule-directed chemotherapeutic drugs of malignant cells in a tumor or tissue....
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6537769 |
Purified and recombinant antigenic protein associated with abdominal aortic aneurysm (AAA) disease, and diagnostic and therapeutic use thereof
This invention provides an isolated protein of approximately 40 kDa which is purified from human aortic tissue and immunoreactive with AAA-associated immunoglobulin. Also provided are a method of...
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6537760 |
Receptor binding assay for detecting TSH-receptor auto-antibodies
In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or...
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6537782 |
Media for culturing animal cells and process for producing protein by using the same
A culture medium for culture of an animal cell, characterized by containing an enzymatic degradation product of fish meat or a fish meat extract, and a method for producing a desired protein with...
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6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6537777 |
Human porphobilinogen deaminase sequences
A method for treatment or prophylaxis of disease caused by deficiency, in a subject, of an enzyme belonging to the heme biosynthetic pathway, the method comprising administering, to the subject, an...
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6534284 |
MurD protein and gene of Staphylococcus aureus
This invention provides the murD gene of Staphylococcus aureas. Purified and isolated MurD recombinant proteins are also provided. Nucleic acid sequences which encode functionally active MurD...
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6528702 |
Plant genes and uses thereof
Homologues of the Arabidopsis NIM1 gene, which is involved in the signal transduction cascade leading to systemic acquired resistance (SAR), are isolated from Nicotiana tabacum (tobacco), ...
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6528283 |
Members of the D52 Gene family
The present invention relates to a murine homolog and a novel isoform of hD53, and a novel member of the D52 gene family, hD54. The genes and gene fragments of the present invention are themselves...
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6528635 |
Tumor antigen protein, gene thereof, and utilization thereof
A DNA consisting of the base sequence represented by SEQ ID NO: 1 or a DNA hybridizing with a DNA consisting of the base sequence represented by SEQ ID NO: 1 under stringent conditions and encoding...
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6528286 |
Mammalian cell culture process for producing glycoproteins
The present invention relates to novel process for the preparation of glycoproteins by mammalian cell culture wherein the sialic acid content of the glycoprotein recovered is optimized by...
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6525173 |
Process for expression and production of recombinant protein hybrid protein (p24/p17) derived from human immunodeficiency viruses (HIV-1)
The present invention describes recombinant p24/p17 hybrid protein derived from the human immunodeficiency virus, their corresponding encoding recombinant DNA molecule and the process of production...
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6525244 |
Plant histidinol-phosphate aminotransferase homologs
This invention relates to an isolated nucleic acid fragment encoding a histidine biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6521426 |
Preparation of recombinant adenovirus carrying a rep gene of adeno-associated virus
Adenoviral particles are produced by incubating cells containing a helper adenovirus vector and a helper-dependent adenoviral vector including an Adeno-Associated Virus (AAV) rep gene, such as rep...
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6521423 |
Intracellular production of Hepatitis C E2 polypeptides
Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved...
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6518011 |
Method for screening compounds to identify beta-amyloid production modulators
The present invention is directed generally to methods and composition for monitoring the processing of epitope-tagged beta-APP. More specifically, the present invention relates to the use of such...
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6509163 |
Methods of screening modulators of mammalian P2X7 purinergic receptors
The present invention relates, in general, to a purinergic receptor and, particular, to a P2X 7 (also designated P2Z) receptor. The invention further relates to a nucleic acid encoding the P2X 7 ...
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6509447 |
G protein chimeras and methods of screening compounds
A chimeric G α protein having yeast G α (Gpa1p) amino acid sequences modified by a minimum of 3 amino acids positions within the C-terminal 10 amino acids by substitution by alternative amino...
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6500642 |
Molecule associated with apoptosis
The invention provides a mammalian cDNA which encodes a mammalian MAPOP-3. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein,...
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6491921 |
Avian polyomavirus vaccines in psittacine birds
The invention provides a nucleic acid vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order comprising a...
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6492507 |
Polynucleotides encoding human eosinophil-derived basic protein
The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression...
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