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6720166 |
Non-a, non-b, non-c, non-c, non-d, non-e hepatitis reagents and methods for their use
Hepatitis GB Virus (HGBV) nucleic acid and amino acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGBV nucleic acid or amino acid sequences, HGBV...
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6716600 |
Persephin and related growth factors
A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and...
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6713618 |
DNA which encodes trehalase and uses thereof
Disclosed are a DNA which encodes murine trehalase, a polypeptide expressed by the DNA, and a transgenic- and knockout- animals which have been genetically engineered with the DNA. The DNA...
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6709873 |
Method for production of antibodies to specific sites of rapamycin
This invention relates to the production of polyclonal and monoclonal antibodies to specific sites of rapamycin (Sirolimus). The reactivity of these poly and monoclonal antibodies make them...
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6692938 |
Nucleic acids encoding active and inactive CCR5 chemokine receptors
A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic...
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6692943 |
Persephin and related growth factors
A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The mouse and rat amino acid sequences have been identified. Mouse and rat persephin...
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6692696 |
Biosensor
Apparatus comprising G-protein coupled receptor (GPCR) for detecting ligands or substances in liquid or vapor media. The GPCR is based on in a cell or in a synthetic membrane or polymer system, and...
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6693181 |
Protein secretion
DNA constructs, host cells and production methods are disclosed for the expression and recovery of polypeptides, especially those altered to have one or more glycosylation sites added or deleted....
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6689579 |
Polynucleotides encoding neutrokine-α
The present invention relates to a novel Neutrokine-α protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human...
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6689877 |
Methods and compositions for the treatment of human immunodeficiency virus infection
Materials and methods are provided to inhibit HIV replication in targeted host cells.
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6685911 |
Sensitization process for antigen-presenting cells and means for implementing the process
The object of the invention is a novel sensitization process for antigen-presenting cells, novel means for implementing the process and novel membrane vesicles possessing immunogenic potency. The...
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6686178 |
Cytokine zalpha11 ligand polynucleotides
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the...
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6683161 |
Human ependymin
The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin...
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6682911 |
Laminins and uses thereof
The present invention is based on the discovery of a novel member of the laminin family, laminin 12. Accordingly, the present invention features a purified or isolated preparation or a recombinant...
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6680180 |
Kv6.2, a voltage-gated potassium channel subunit
The invention provides isolated nucleic acid and amino acid sequences of Kv6.2, antibodies to Kv6.2, methods of detecting Kv6.2, methods of screening for voltage-gated potassium channel activators...
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6680427 |
Corn cDNAs encoding corn Mlo proteins
This invention relates to an isolated nucleic acid fragment encoding an Mlo-like polypeptide. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6677505 |
Promoter inductible in plants, sequence incorporating same and resulting product
The invention concerns a set of plant promoters inductible by biotic or abiotic stresses, in particular by pathogens, their use, expression vectors comprising said promoters and a gene of interest,...
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6673623 |
Methods and compositions that control lipid production
The present invention relates generally to the use of lipogenins, proteins, e.g. human extra-cellular matrix protein 1 (ECM-1), human glia-derived nexin I alpha protein (NP-I), human tissue...
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6670147 |
Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use
The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following...
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6670178 |
In Vivo production and delivery of insulinotropin for gene therapy
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) that encodes...
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6667163 |
Polynucleotide sequences encoding mouse sphingosine-1-phosphate phosphatase
The present invention provides polynucleotides and polypeptides of a murine sphingosine-1-phosphate phosphatase, referred to herein as mSPP1. The polynucleotides and polypeptides are used to...
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6664098 |
Differentiation inhibitory agent
Amino acids constituting a physiologically active molecule human delta 2; a gene arrangement thereof; and an antibody thereto. The human delta 2 molecule, at least the amino acid sequence described...
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6664077 |
DNA encoding ACPL
The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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6660846 |
Vesicular amino acid transporter composition and method
Disclosed are invertebrate and vertebrate synaptic vesicle amino acid transporter compositions which define a novel family of transporter proteins, recombinant vectors and cells comprising nucleic...
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6653135 |
Dynamic protein signature assay
An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a...
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6653460 |
Voltage-gated calcium channel antagonist and method
A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the...
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6653076 |
Stable isotope metabolic labeling for analysis of biopolymers
Methods for the determination of the rate of synthesis of biopolymer synthesis and degradation in cells, tissues, or cell-free systems using monomer which as been labeled with a stable isotope are...
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6653086 |
Endogenous constitutively activated G protein-coupled orphan receptors
Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan...
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6653105 |
Clonal cells and cell lines derived from C3A cells and methods of making and using them
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from...
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6649377 |
Human aggrecanase and nucleic acid compositions encoding the same
Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a...
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6646110 |
G-CSF polypeptides and conjugates
The invention relates to polypeptide conjugates comprising a polypeptide exhibiting G-CSF activity and having an amino acid sequence that differs from the amino acid sequence of human G-CSF in at...
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6642030 |
Nucleic acid compositions encoding modified Bacillus thuringiensis coleopteran-toxic crystal proteins
Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic B. thuringiensis δ-endotoxins. Also disclosed are methods of using these genes for the...
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6642022 |
Platelet-derived growth factor receptors
DNA sequences encoding human platelet-derived growth factor receptors (hPDGF-R), and expression constructs comprising sequences which encode a receptor that can be secreted or incorporated into the...
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6641820 |
Clostridial toxin derivatives and methods to treat pain
Methods for treating a bone tumor, in particular pain associated with bone tumor, by administration to a patient of a therapeutically effective amount of an agent are disclosed. The agent may...
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6642434 |
Transgenic plants with &ggr -tocopherol methyltransferase
Disclosed is are gene sequences encoding γ-tocopherol methyltransferases from photosynthetic organisms. The enzyme γ-tocopherol methyltransferase catalyzes the methylation of γ-tocopherol to...
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6635445 |
Nucleic acid molecules encoding human luteinizing hormone-human chorionic gonadotropin receptor protein and transformants thereof
Disclosed are (1) a human luteinizing hormone-human chorionic gonadotropin receptor protein, (2) a DNA comprising a CDNA segment coding for a human luteinizing hormone-human chorionic gonadotropin...
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6632636 |
Nucleic acids encoding 3-ketoacyl-ACP reductase from Moraxella catarrahalis
The present invention provides the genomic sequences of a library of purified nucleic acid molecules, or their complements, comprising the genome of Moraxella catarrhalis . The invention also...
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6632976 |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a...
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6630443 |
Human amine transporter antibodies
A Human amine transporter polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also provided are methods for...
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6623957 |
Secretion of T cell receptor fragments from recombinant host cells
Variable domain murine T-cell receptor genes have been isolated and used to construct cloning and expression vectors. V α , V β , and single chain V α -V β fragments have been expressed as...
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6620595 |
Retroviral vectors comprising an enhanced 3′ transcription termination structure
The invention provides novel retroviral vectors that have enhanced transcription termination structures. The termination structures comprise one or several heterologous upstream transcription...
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6617131 |
Nucleic acid molecule encoding the potassium channel protein, KCNQ5
KCNQ5, DNA encoding KCNQ5 or a polypeptide having KCNQ5 activity, related vectors, host cells and methods and a screening assay for identification of compounds which modify activity of a potassium...
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6610517 |
Compartmentalization of recombinant polypeptides in host cells
The present invention relates to host cells which contain at least two functional recombinant polypeptides, at least one of which is bound to a support, preferably in each case in different cell...
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6610516 |
Cell culture process
A glycoprotein is produced by a process comprising culturing mammalian host cells expressing nucleic acid encoding a glycoprotein in the presence of (a) a factor that modifies growth state in a...
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6610843 |
Modified starch from plants, plants synthesizing the same, as well as process for their production
The present invention describes transgenic plant cells and plants which due to a reduced activity of a disproportionating enzyme (D enzyme) synthesize a modified starch. Furthermore, the starch...
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6602710 |
Screening method for SREBP pathway-specific inhibitors
This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for...
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6600089 |
Carotenoid biosynthesis enzymes
This invention relates to an isolated nucleic acid fragment encoding a carotenoid biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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6600030 |
Delayed progression to aids by a missense allele of the CCR2 gene
The present invention relates to a CCR2 deletion mutant, designated “CCR2-64I.” CCR2 is a C—C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered...
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6599744 |
Viral expression vectors comprising a ribosomal promoter sequence
The present invention provides improved vectors, including viral vectors such as adenovirus vectors. The vectors comprise ribosomal promoters in operable combination with a gene of interest. The...
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6596509 |
Recombinant constructs and systems for secretion of proteins via type III secretion systems
One aspect of the present invention relates to a DNA construct that contains a first DNA molecule encoding a functional type III secretion system, a promoter, and a second DNA molecule encoding a...
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