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6893843 |
Nucleic acids
Polypeptides, in particular the polypeptide of formula I:
Ala-Gln-Glu-Pro-Val-Lys-Gly-Pro-Val-Ser-Thr-Lys- Pro-Gly-Ser-Cys-Pro-Ile-Ile-Leu-Ile-Arg-Cys-Ala-...
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6894022 |
Growth factor modified protein matrices for tissue engineering
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling, and/or drug delivery. The proteins can be incorporated so that they are...
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6890528 |
Cells for the production of helper dependent adenoviral vectors
The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective...
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6891084 |
DNA encoding raffinose synthase from soybean
The present invention provides a DNA encoding a raffinose synthase from soybean and vectors containing the same. Also provided are plants and host cells transformed with the DNA sequence and...
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6890713 |
Multidrug resistance-associated polypeptide
Compositions and methods are disclosed for improving the effectiveness of a chemotherapeutic regimen to eradicate multidrug-resistant transformed cells from the body of a mammal, preferably from...
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6887663 |
Streptococcus pneumoniae SP036 polynucleotides
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae . The invention further relates to isolated nucleic acid molecules...
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6869779 |
Nucleic acid sequence for potentiating the expression of useful gene and method therefor
Nucleic acid sequences for enhancing expression of a useful gene, which car increase the production of the gene product by enhancing gene expression, comprising a 5′-untranslated region of a...
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6866998 |
Cellular assays for identifying signaling peptides
The invention includes a DNA encoding a known translocatable protein, for example, human mpl, lacking secretory ability due to deletion of its secretory signal and the major part of the...
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6863892 |
Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers
A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers...
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6864089 |
Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
This invention related to methods useful in the labeling of multiple polypeptide samples and subsequent analysis of these samples by mass spectrometry, particularly in the high throughput proteomic...
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6858397 |
Antibodies specific for native PrPsc
Antibodies are disclosed which specifically bind to native PrP Sc in situ. Preferred antibodies bind only to the native PrP Sc of a particular species e.g., human, cow, sheep, pig, etc....
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6855495 |
Toso as a target for drug screening
The present invention is directed to methods for identifying novel compositions which modulate the activity of Toso, and the use of such compositions in diagnosis and treatment of disease.
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6852511 |
Heat-inducible promoter
The invention relates to nucleic acid molecules comprising a heat-inducible promoter and to expression vectors and host cells containing at least one nucleic acid molecule according to the...
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6849401 |
Methods for determining coat color genotypes in pigs
Methods for determining coat color genotypes in pigs are provided. In particular, these methods are based on determining whether a mutation is/is not present at one or more exon/intron splice sites...
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6849427 |
Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid...
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6844189 |
Chromosome 17P-linked prostate cancer susceptibility gene
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human prostate cancer...
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6841362 |
Melanoma differentiation associated gene-7 promoter and uses thereof
The present invention provides for an isolated Mda-7 promoter capable of directing transcription of a heterologous coding sequence positioned downstream therefrom, wherein the promoter is selected...
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6838254 |
Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae
A process is provided for the production of an antibody or a fragment or functionalized fragment thereof using a transformed lower eukaryotic host containing an expressible DNA sequence encoding...
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6835879 |
Inbred corn line WICY418C
An inbred corn line, designated WICY418C, is disclosed. The invention relates to the seeds of inbred corn line WICY418C, to the plants of inbred corn line WICY418C and to methods for producing a...
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6835568 |
Regulated nucleic acid expression system
The present invention provides nucleic acid constructs, expression systems, and methods relating to the regulation of gene expression. The invention may be applied to regulate the expression of any...
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6828101 |
Methods of screening for modifiers of potassium channel protein activity
The present invention relates to a novel potassium channel protein expressed exclusively in the brain, a gene encoding this protein, a vector containing this gene, a host cell containing this...
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6821753 |
Replication incompetent herpes viruses for use in gene therapy
Use of a replication incompetent herpes virus capable of delivering a gene to multiple connected sites within the nervous system, which virus comprises: (a) a mutation which prevents or reduces the...
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6818803 |
Transgenic plants as an alternative source of lignocellulosic-degrading enzymes
Transgenic plants which express cellulose-degrading enzymes, methods to make the transgenic plants, and methods to use the cellulose-degrading enzymes produced by the transgenic plants are disclosed.
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6815183 |
Plasmodium sp. chitinase
The present invention is directed to isolated nucleic acid molecules encoding Plasmodium sp. chitinases . Expression vectors and host cells comprising the nucleic acid molecules are also...
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6812330 |
Isolation of neurotrophins from a mixture containing other proteins and neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6812337 |
Presenilin associated membrane protein and uses thereof
Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and...
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6812024 |
Anti-paratopic antibody as an immunogen
The present invention provides a method of manufacture of an anti-paratopic antibody comprising the steps of: (1) selecting from a pool of antibodies occurring in one species a prototypic set the...
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6806045 |
Method for the identification of a receptor
A method for the identification and characterization of a receptor in target tissue for which a selected vector has affinity, wherein a transfected cell line expressing the receptor is added to a...
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6803209 |
Preparation for use in cell culture in which an interfering compound is absent or depleted
A cell culture preparation and methods are provided which are suitable for production in cells of a first protein in a class of proteins where the medium is deficient in a second protein in a...
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6800454 |
Nucleic acid molecule encoding chemokine-like factor 1 (CKLF1)
The present invention provides chemokine-like factor (CKLF) polypeptides with chemotactic and hematopoietic stimulating activities and polynucleotides encoding such polypeptides. Additionally, a...
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6800447 |
Methods for identifying compounds which bind the active CCR5 chemokine receptor
A peptide has an amino acid sequence having more than 80% homology with the amino acid sequence listed as SEQ ID NO:4. A nucleic acid molecule has more than 80% homology with one of the nucleic...
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6800442 |
Methods of selecting polynucleotides encoding antigens
The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
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6797494 |
Self-replicating episomal expression vectors conferring tissue-specific gene expression
Selph-replicating, locus control region (LCR)-containing, episomal expression vectors for tissue-specific gene expression for long-term persistent, tissue-specific expression of a gene of interest...
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6797515 |
Regulated autocrine growth of mammalian cells
Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilize mammalian host cells engineered for autonomous and regulated growth in low cost...
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6787684 |
Lipoxygenase genes from Vitis vinifera
Lipoxygenase genes from Vitis vinifera and polypeptides encoded thereby are provided.
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6787336 |
DNA encoding growth hormone antagonists
The present invention relates to DNA molecules which encode antagonists of vertebrate growth hormones obtained by mutation of at least the amino acid corresponding to Glu-119 in bovine growth...
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6780615 |
Production of recombinant monellin using methylotrophic yeast expression system
The present invention relates to a single-chain monellin-like protein which is stable and which is at least 100-fold sweet as compared to sucrose on the weight basis. The present invention also...
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6780607 |
Method for cell-free protein complete post-translational modification
The present invention relates to methods of production of the completely post-translationally modified protein by combination of cell-free protein synthesis and cell-free co- and post-translational...
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6777202 |
Recombinant expression of S-layer proteins
The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the...
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6770458 |
Purified and isolated serine-threonine kinase receptors associated protein and use of same in the modulation of the biological activity of TGF-β
Isolated and purified proteins and nucleic acids which modulate TGF-β biological activity, including TGF-β signal transduction. Particularly, a novel serine-threonine kinase receptors associated...
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6767709 |
Immunoassay of human medullasin and diagnosis of multiple sclerosis using the same
There is provided an immunoassay by which the amount of human medullasin present inside granulocytes, which are one leukocyte component in blood, can be determined with high accuracy and with good...
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6759215 |
Method of preparing human stem cell factor polypeptide
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6740507 |
Engineering of living cells for the expression of holo-phycobiliprotein-based constructs
Recombinant cells which express a fluorescent holo-phycobiliprotein fusion protein and methods of use are described. The cells comprises a bilin, a recombinant bilin reductase, an...
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6740505 |
Production of proteins
A process for the production of a protein by cell culture, said process comprising culturing eukaryotic cells which constitutively produce said protein in a medium which comprises an alkanoic acid...
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6737509 |
Zinsi polypeptide composition stimulating pancreatic islet growth
The present invention provides compositions for stimulating an increase in islet proliferation and β-cell mass using an insulin homolog polypeptide. The present invention also includes methods for...
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6733997 |
Isolated nucleic acids encoding a secretory signal for expression and secretion of heterologous recombinant proteins
A universal secretory signal originally derived from a piscine vitellogenin (Vtg) gene is inserted into various expression vectors for driving the secretion of the recombinant protein into the...
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6730823 |
Plant choline phosphate cytidylyltransferase
This invention relates to an isolated nucleic acid fragment encoding a cholinephosphate cytidylyltransferase. The invention also relates to the construction of a chimeric gene encoding all or a...
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6727078 |
EIAV p26 deletion vaccine and diagnostic
Disclosed herein is a vaccine which provides immunity to mammals from infection and/or disease caused by a lentivirus, such as equine infectious anemia virus, human immunodeficiency virus (HIV),...
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6720182 |
Alternative splice variants of CD40
The invention concerns novel nucleic acid sequences and amino acid sequences obtained by alternative splicing, expression vectors, host cell and pharmaceutical compositions comprising said sequences.
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