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6316218 |
Intestinal trefoil proteins
Intestinal trefoil factors and nucleic acids encoding intestinal trefoil factors are disclosed. The intestinal trefoil factors disclosed are resistent to destruction in the digestive tract and can...
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6316223 |
Mammalian protein interaction cloning system
The present invention is directed to compositions and methods for a genetic system of detecting protein-protein interactions in a mammalian host cell. Two fusion proteins are made in the host cell....
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6309860 |
Cloning and uses of BCL-8
This invention provides an isolated nucleic acid which encodes bcl-8. This invention also provides an oligonucleotide of at least 15 nucleotides capable of specifically hybridizing with a sequence...
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6309854 |
Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or...
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6309862 |
Methionine containing animal cell culture medium and its use
A nutrient medium for protein producing cells, characterized in that said medium consists essentially of the following components: a physiological saline containing Ca 2 +, K + , Mg 2 + and Na + ,...
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6306600 |
Rapidly degrading GFP-fusion proteins and methods of use
Green fluorescent protein (GFP) is widely used as a reporter in determining gene expression and protein localization. The present invention provides fusion proteins with a half life of ten hours or...
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6300100 |
Process for preparing tissue factor pathway inhibitor
In a process for preparing Tissue Factor Pathway Inhibitor (TFPI) by the genetically engineered technique by the use of a transformed animal cell wherein a DNA encoding human TFPI is introduced,...
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6300104 |
Secretory immunoglobulin produced by single cells and methods for making and using same
Disclosed is a method of producing secretory Ig molecules. The method comprises transfecting a cell producing an Ig with a polynucleotide encoding an SC to fonn SC transfected Ig producing cells....
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6300103 |
Anti-microbial proteins
An anti-microbial protein comprising a peptide having the amino acid sequence: AA 1 -AA 2 -AA 3 -Cys-AA 5 -AA 6 -AA 7 -AA 8 -AA 9 -Cys-AA 11 -AA 12 -AA 13 -AA 14 -Cys-Cys-AA 17 -AA 18 ...
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6300097 |
Signal peptidase polypeptides of Staphylococcus aureus
spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for the...
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6300099 |
Methods for producing secreted ligand-binding fusion proteins
Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers...
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6300096 |
Polynucleotides encoding fatty acid transport proteins
A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among...
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6291212 |
DNA constructs encoding ligand-binding fusion proteins
Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers...
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6284491 |
Biologically active synthetic thyrotropin and cloned gene for producing same
Substantially pure recombinant TSH has been prepared from a clone comprising complete nucleotide sequence for the expression of the TSH. Diagnostic and therapeutic applications of the synthetic TSH...
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6284536 |
Modified immunoglobin molecules and methods for use thereof
Disclosed are modified immunoglobulin (Ig) molecules, a method of producing modified Ig molecules, and methods for treatment and prevention of infectious diseases using modified Ig molecules. In...
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6284488 |
Protein expression system
A method for expressing recombinant molecules in bacterial hosts in a defined medium in the absence of antibiotic selection is disclosed. The method uses an expression vector comprising a...
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6284879 |
Transport associated protein splice variants
Splice variants of known TAP1 and TAP2 proteins, which are involved in translocation of antigen peptides into the endoplasmic reticulum for complexing with MHC class I molecules and eventual...
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6281329 |
Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
The present invention relates to a vector for expression of a heterologous protein by a Gram negative bacteria, wherein the vector includes a nucleic acid such as DNA encoding the following: an...
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6280973 |
Mammalian methadone-specific opioid receptor gene and uses
The present invention relates to a novel-mammalian methadone-specific opioid receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization...
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6277590 |
Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These...
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6274339 |
Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity
The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses...
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6271347 |
Eosinophil eotaxin receptor
The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human β-chemokine receptor and has been designated "CC CKR3". The eosinophil eotaxin receptor may be...
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6271366 |
Polynucleotide encoding secretory membrane protein
Three genes encoding secretory membrane proteins have been successfully isolated from an osteoblast-like cell line by a method for specifically cloning secretory membrane proteins. One of these...
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6268179 |
Spo-rel from streptococcus pneumoniae
The invention provides spo/rel polypeptides and DNA (RNA) encoding spo/rel polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6265556 |
Nucleic acid encoding CD40 associated proteins
The present invention provides a mammalian CD40-associated protein (CAP), a nucleic acid molecule encoding the CAP and antibodies specific for the CAP. The invention further provides a...
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6265189 |
Pox virus containing DNA encoding a cytokine and/or a tumor associated antigen
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6265188 |
aspS
The invention provides aspS polypeptides and DNA (RNA) encoding aspS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aspS...
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6265563 |
Opioid receptor genes
Genes encoding opioid receptors can be retrieved from vertebrate libraries using the murine probe disclosed herein under low-stringency conditions. The DNA sequence shown in FIG. 5 or its...
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6261790 |
Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs) are described. In one aspect, the invention is directed to monoclonal antibodies that...
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6258564 |
Antibodies, production method of the antibodies, hybridomas which produce the antibodies, production method the hybirdomas and antigen proteins recognized by the antibodies
The invention is related to antibodies which specifically react with connective tissue type-human mast cells, a production method of the antibodies, hybridomas which produce the antibodies, a...
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6255079 |
Polynucleotides encoding natural killer cell enhancing factor C
A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are...
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6255114 |
Starch biosynthetic enzymes
This invention relates to isolated nucleic acid fragments encoding all or a substantial portion of a plant glycogenin or water stress protein. The invention also relates to the construction of...
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6251630 |
Rnc from Streptococcus pneumonia
The invention provides rnc polynucleotides which encode rnc polypeptides, polynucleotides related thereto, and methods for producing such polypeptides by recombinant techniques. Also provided are...
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6251617 |
Glycine transporter
Provided are, among other things, nucleic acid sequences encoding the GlyT1d form of glycine transporter, vectors, methods of producing the transporter, and methods for identifying bioactive agents.
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6251629 |
ABC transporter
The invention provides ABC transporter polypeptides and polynucleotides encoding ABC transporter polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided...
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6248559 |
Gene encoding human tau-protein kinase I and use thereof
A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical...
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6245520 |
Methods for introducing nucleic acids into mammalian cells using imidazolium lipids
Methods for introducing nucleic acids into mammalian cells are provided which use imidazolium lipids. The imidazolium lipids have the formula: ##STR1## wherein R 1 and R 2 each independently...
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6245530 |
Receptor ligand
Provided are ligands for the receptor tyrosine kinase, Flt4. Also provided are cDNAs and vectors encoding the ligands, pharmaceutical compositions and diagnostic reagents.
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6245541 |
Isolated spinach ribulose-1,5-bisphosphate carboxylase/oxgenase large subunit ε n-methyltransferase and method of inactivating ribulose-1,5-bishosphatase ε n-methyltransferase activity
The gene sequence for ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) large subunit (LS) ε N-methyltansferase (protein methylase III or Rubisco LSMT) from a plant which has a...
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6242574 |
Antimicrobial proteins
Isolated proteins having anti-fungal activity against at least Cercospora spp. The proteins contain an amino acid sequence which has at least 95% sequence identity to any of the following...
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6242175 |
Methods and means relating to retrotransposon and retroviral integration
Ku(Ku70 and Ku80) of yeast and mammalian cells and other components of the Ku-associated DNA repair pathway are involved in retrotransposon and retroviral integration into cellular nucleic acids....
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6242585 |
Mycobacterium tuberculosis specific DNA fragment
This invention relates to a Mycobacterium tuberculosis specific DNA fragment containing IS like and repetitive sequences, a method of production of such DNA fragment and the use of such DNA...
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6238858 |
Transgenomic viruses
The present invention provides chimeric primary viruses, which are capable of producing secondary viruses in a producer host cell, and methods of making the same.
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6232094 |
DNA encoding human κ casein and process for obtaining the protein
The present invention relates to an expression system comprising a DNA sequence encoding a polypeptide which has a biological activity of human κ-casein, the system comprising a 5'-flanking...
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6228625 |
metK from Streptococcus pneumoniae
The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6225083 |
FtsL from Streptococcus pneumoniae
The invention provides ftsL polypeptides and DNA (RNA) encoding ftsL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are ftsL polynucleotides for...
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6225060 |
Baculovirus expression system and method for high throughput expression of genetic material
The present invention provides novel recombinant baculovirus expression systems for expressing foreign genetic material in a host cell. Such expression systems are readily adapted to an automated...
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6214972 |
DNA encoding prostaglandin receptor DP
A novel human DP prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel...
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6214564 |
Method of identifying modulators of protein tyrosine phosphatase activity
A human protein tyrosine phosphatase (PTP) has been identified and its cDNA has been isolated. This PTP, denoted PTP-OB, has a receptor-like three dimensional structure and is present in...
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6214975 |
Method for evaluating target protein quality from fermenter
A chemiluminescence-based gel assay may be used as an indicator of fermenter health. The assay is performed using a sample of fermentation medium essentially directly from the fermenter (with no...
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