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8183207 |
Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules
Methods of using colony stimulating factor receptor (CSF1R) extracellular domain (ECD) fusion molecules for treating osteolytic bone loss, cancer metastasis, cancer metastasis-induced osteolytic...
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8178107 |
Method of treatment of thrombocytopenia or risk thereof using MPL ligand (thrombopoietin), variants, and fragments thereof
Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication,...
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8173398 |
Humanized anti-IL-6 antibodies
The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host...
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8163886 |
Purification of proteins
The present invention relates to a selectively soluble polymer capable of binding to one or more constituents in a mixture containing various biological materials and the methods of using such a...
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8158766 |
Genes with ES cell-specific expression
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs...
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8153397 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The...
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8148608 |
Systems and methods for clonal expression in plants
The present invention provides systems and methods for generating clonal root lines, clonal root cell lines, clonal plant cell lines, and clonal plants and for expressing gene products in such cell...
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8148507 |
Nucleic acid encoding TNFx protein
Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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8148111 |
Cell culture carrier comprising poly(meth)acrylic (salt) particle and artificial polypeptide
A carrier for cell culture is provided which improves the cell proliferativity in serum-free culture and which is free from risk from infection factor contamination. The gist of the features of the...
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8148502 |
R-ALPHA1 antitrypsin anion exchange chromatography
The present invention relates to a method for obtaining highly purified recombinant alpha1-antitrypsin (rAAT) using anion exchange chromatography, wherein a composition comprising rAAT and at least...
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8147856 |
AXMI-031, AXMI-039, AXMI-040 and AXMI-049, a family of novel delta-endotoxin genes and methods for their use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
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8148109 |
Interferon-like proteins and uses thereof
The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and...
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8147844 |
Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the...
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8143027 |
Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity
The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of...
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8142793 |
Norovirus and Sapovirus antigens
Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid...
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8137933 |
Mammalian expression vector pUHAB
The present invention relates to the construction and utilization of a new mammalian expression vector that contains a unique multiple cloning site (MCS), designated pUHAB. The pUHAB vector...
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8133983 |
Agonistic binding molecules to the human OX40 receptor
The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such...
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8133699 |
Minimal DNA sequence acting as a chromatin insulator and its use in protein expression
The invention relates to expression vectors comprising a DNA sequence of 146 bp capable of acting as chromatin insulator, to host cells containing such vectors, to a method of producing a desired...
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8129594 |
Bacillus thuringiensis gene with lepidopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8124104 |
Norovirus and sapovirus antigens
Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid...
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8124374 |
Method of producing recombinant protein
An object of the present invention is to provide a method of mass-producing recombinant protein by the liquid culture method with koji molds as host. According to the present invention, it is...
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8124377 |
Method of producing TAT-HOXB4H
The present invention relates to a new and nonobvious method of producing the C-terminal histidine tagged TAT-HOXB4 fusion protein (TAT-HOXB4H), providing unexpected benefits of increased yield and...
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8119396 |
Recombinant adenoviral vectors and applications thereof
Recombinant adenoviruses or pseudoviruses having a deletion of all or part of the region of the adenovirus genome corresponding to nucleotides 311 to 499 in canine adenovirus type 2 (GeneBank...
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8119366 |
Antennapedia-dominant negative mastermind-like construct
The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also...
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8119145 |
Methods for producing norovirus VLPS
Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid...
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8114415 |
Method for producing temperature sensitive influenza A viruses
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid...
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8114648 |
In vivo incorporation of unnatural amino acids
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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8115063 |
Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8114630 |
Modified interferon beta polypeptides and their uses
Modified interferon beta polypeptides and uses thereof are provided.
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8110379 |
Targeted integration into the PPP1R12C locus
Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.
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8110376 |
Long-acting EPO polypeptides and derivatives thereof and methods thereof
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to an EPO peptide are disclosed. Pharmaceutical...
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8110378 |
Nucleic acids encoding DCRS5
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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8101716 |
Human interferon-beta mutein
The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared...
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8097435 |
Polynucleotides encoding long-acting growth hormone polypeptides and methods of producing same
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a peptide-of-interest are disclosed. Pharmaceutical...
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8097256 |
Cancer vaccines and vaccination methods
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
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8093052 |
Serum-free culture medium for the production of recombinant gonadotropins
The present invention is in the field of the manufacture of recombinant proteins. More specifically, it relates to the use of a serum-free culture medium comprising an antioxidant for the...
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8092807 |
Modified leukocyte Ig-like receptor family members (LIRs) with increased affinity for class 1 MHC and their uses in modulating T-cell activation
The present invention provides polypeptides having the property of binding to a given Class I pMHC CHARACTERISED IN THAT said polypeptide has a KD for the said given Class I pMHC of less than or...
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8084251 |
Recombinant cell clones having increased stability and methods of making and using the same
Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum-...
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8084228 |
Nogo-B receptor antagonists
Nogo-B receptors bind to Nogo-B and mediate its biological function. We have discovered that Nogo-B receptor is a component of endothelial cells, and is highly expressed in intact blood vessels....
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8084252 |
Recombinant cell clones having increased stability and methods of making and using the same
Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum-...
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8084239 |
Preparation of a therapeutic composition
Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system comprises a unique peptide having 31 amino acids and another unique peptide having 21...
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8080387 |
Method for preparing soluble and active recombinant proteins usins PDI as a fusion partner
The present invention relates to a method for producing a recombinant protein capable of increasing expression rate of a target protein and also improving solubility and folding of the expressed...
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8080414 |
Recombinant cell clones having increased stability and methods of making and using the same
Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum-...
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8071745 |
Polynucleotides encoding rod-derived cone viability factor (rdcvf) and methods of using the same
Disclosed are methods and compositions for early diagnosis, monitoring and treatment of retinal dystrophy, age-related macular degeneration, Bardet-Biedel syndrome, Bassen-kornzweig syndrome, best...
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8071736 |
Nucleic acid molecules encodng a cathepsin L-like cysteine protease
Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic...
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8071748 |
Thermophilic and thermoacidophilic sugar transporter genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across...
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8062867 |
Fusion partner for production of monoclonal rabbit antibodies
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not...
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8062866 |
Humanized anti-IL-6 antibodies
The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host...
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8057806 |
Viruses comprising mutant ion channel protein
A method to prepare viruses lacking ion channel activity is provided.
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8058027 |
Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants
The invention relates to cell culture methods, kits and cell lines for producing recombinant products, e.g. therapeutic proteins and antibodies, in the presence of reduced levels of one or more...
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