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7625718 |
SVCT2 transporters expressed in blood brain barrier cells
SVCT2 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is...
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7622100 |
Rapid multiple panel of biomarkers in laboratory blood tests for TIA/stroke
A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor...
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7622114 |
Assay methods for immediate diagnosis of cause of stroke
A methods, kits and compositions for diagnosing a central nervous system disorder, particularly transient ischemic attack or stroke, comprising measuring the level of NR2A and/or NR2B NMDA receptor...
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7611853 |
Assay to screen for anti-malarials
Malarial parasite Plasmodium falciparum is responsible for the most severe form of malaria in humans, causing about 2 million deaths every year. Lack of effective vaccines and emergence of...
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7611858 |
Detection of cannabinoid receptor biomarkers and uses thereof
Traumatic insult to the brain leads to a degradation of low molecular weight of cannabinoid type 1 receptor (CB1) and generation of high molecular weight complexes in the cortex and hippocampus, as...
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7611855 |
Immunoassay method and kit to be used therein
Using two types of antibodies, i.e., a first antibody having a higher affinity for a target substance than for a competitive substance and a second antibody having a higher affinity for the...
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7608414 |
Method for diagnosing and prognosing inflammatory bowel disease and crohn's disease
Disclosed are methods for diagnosing and prognosing Inflammatory Bowel disease or Crohn's disease (CD) by measuring levels of antibodies to glycans in a biological sample.
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7604946 |
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in...
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7604952 |
Detection and determination of the stages of coronary artery disease
A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing...
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7598351 |
Antibody and use thereof
The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2...
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7592150 |
Method for diagnosing diseases based on levels of anti-glycan antibodies
Disclosed are methods for diagnosing Crohn's disease (CD) or anti-phospholipid syndrome by measuring levels of antibodies to glycans in a biological sample.
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7582443 |
Method for the detection and measurement of Hapten-conjugated biological binding entities by western and dot-blot using anti-hapten antibodies
The invention is a procedure for measuring the binding of an entity (ligand) to a surface by using a hapten-conjugated version of the ligand (hapten-ligand). An excess of the hapten-ligand is...
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7582441 |
Methods and compositions for treating and diagnosing disease
Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy...
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7575881 |
Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent...
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7569675 |
High affinity monoclonal antibody for recognizing the progesterone receptor (PR) and method for creating the antibody
A lagomorph derived monoclonal antibody for recognizing the progesterone receptor (PR) (clone SP2) with immunohistochemistry and methods for creating such an antibody are disclosed. No need of...
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7566542 |
Use of protein ASC as a marker for breast cancer
The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a...
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7563587 |
Method and kit for cell analyte assay
The present invention relates to a method for analysing a cell sample for cell surface-bound or intracellularly bound analytes by providing an array of immobilised specific binding agents for a set...
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RE40835 |
Enhancement of immunochemical staining in aldehyde-fixed tissue
A method for restoring immunoreactivity of a tissue, particularly decalcified tissue, fixed width an aldehyde fixative agent and embedded in an embedding medium, usually comprising celloidin, the...
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7537908 |
Methods of diagnosing sepsis by measuring HMG1
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7537938 |
Biomarker detection in circulating cells
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having...
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7524642 |
Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7507550 |
Analytical sandwich test for determining NT-proBNP
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
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7494820 |
Electrochemiluminescence of rare earth metal chelates
Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are...
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RE40596 |
Rapamycin assay
Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with novel haptens, immunogenic conjugates, and processes for making them and assay kits for...
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7452731 |
Assay
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of...
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7449340 |
Method for the early diagnosis of cancer
The present invention relates to a method for the early diagnosis of cancer in a subject, which is based on determination of the relative fraction of microorganisms derived from the feces of the...
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7442514 |
Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
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7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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RE40535 |
Anti-KC4 humanized monoclonal antibody and cells that express the antibody
An anti-KC-4 humanized monoclonal antibody that comprises the variable regions of the light and heavy chains of the anti-KC-4 murine antibody, wherein the light chain has 7 amino acids and the...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7416855 |
Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3
Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by...
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7410771 |
Reagent and method for detecting a Cryptosporidium parvum sporozoite antigen
A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay...
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7393647 |
Methods for detecting B. anthracis infection
This invention pertains to methods for detecting B. anthracis and antibodies to B. anthracis , the causative agent of anthrax, in a subject.
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7393653 |
Methods of modulating cell death based on the Bit1/AES regulatory pathway
The present invention provides a method of identifying an effective agent that alters the association of a Bit1 polypeptide with an AES polypeptide. The method is practiced by contacting a Bit1...
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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7368277 |
Method for assay of antibodies and antibody assay device
The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the...
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7361480 |
Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies...
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7358052 |
Catalytic amplification of multiplexed assay signals
Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a...
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7344848 |
Methods for determining adequacy of heat processing of a cooked meat sample
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7335477 |
Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been...
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7335724 |
Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis
The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The...
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7312089 |
Detection of erythropoietin and erythropoietin receptor
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents...
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7297551 |
Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
Recombinant fragments of Factor C are disclosed. These proteins and peptides show great potency in recognizing, binding to, neutralizing and removing endotoxin. These molecules can thus be used for...
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7279295 |
Allergen
The present invention relates to a novel allergen from timothy grass ( Phleum pretense ) pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well...
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7270964 |
Detection of antibodies to squalene in serum
The invention is a method for detecting squalene in sera.
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7264939 |
Method of detecting native proBNP
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
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