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9034591 Immunoassay for quantification of an unstable antigen selected from BNP and proBNP  
The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a...
9034592 Immunoassay for quantification of an unstable antigen selected from BNP and proBNP  
The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a...
9029093 Methods and compositions for diagnosis and prognosis of renal injury and renal failure  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal...
9017958 Method of simultaneous detection of heparin-induced immunoglobulins types G, A, and M  
The invention provides a method for detecting heparin-induced antibodies comprising a) binding a PF4-heparin antigen to a solid surface; b) incubating the bound PF4-heparin with a sample...
9017959 5.9 kDa peptide immunoassay method  
Disclosed is an immunoassay method whereby a 5.9 kDa peptide which results from the degradation of the α-E chain and α chain of human fibrinogens and which is used as a peptide marker for...
9012155 Oncofetal antigen/immature laminin receptor antibodies for diagnostic and clinical applications  
The present invention relates to antibodies against Oncofetal Antigen/immature Laminin receptor protein (OFA/iLRP) that can be used singly or in conjunction to detect or treat OFA/iLRP-related...
9005984 Determining feline proBNP  
Methods and compositions are disclosed for determining feline proBNP or fragments thereof in a sample. In one method, feline proBNP or fragments thereof are determined by providing a feline...
9005993 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Analyte detection
 
The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid...
8975087 Longitudinal assay  
Embodiments of the invention include methods for detecting and determining the concentrations of macro and small molecules, including bio-molecules, in a liquid or gaseous sample.
8969099 Microanalysis methods and systems using field effect transistor  
Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle...
8969024 Compositions and methods comprising binding proteins for adalimumab  
Compositions and methods comprising proteins that bind specifically to adalimumab are disclosed herein. Adalimumab is a monoclonal antibody specific for the cytokine TNF-α and was developed to...
8962264 Non-heating detection method for dermatophyte  
The present invention provides a method of detecting dermatophyte, which does not require a complicated operation such as an enzyme treatment and a heat treatment. The present invention provides a...
8962257 Methods for diagnosing heart failure and other cardiac diseases  
The invention relates to methods of diagnosing the severity of heart failure or a cardiac dysfunction in a subject. The invention further relates to monitoring the severity of heart failure in a...
8956823 Anti-antibody reagent  
An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in...
8956877 Separation-free assay method  
A separation-free assay including a binding partner, a binding partner labeled with a directly luminescent label, and a nonspecifically binding label able to affect the signal of the unbound...
8951743 Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways  
The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method...
8951519 Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins  
The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated...
8927225 Human catechol-O-methyltransferase (COMT) assay  
Disclosed is an assay (method) to quantify the amounts of catecholamine-O-methyltransferase (COMT) protein in samples, such as extracts from cell cultures, body fluids, tissues, and environmental...
8911731 Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof  
The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide...
8883428 Methods to determine atherosclerosis regression, plaque stabilization and cardiovascular risk  
Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD).
8852956 Method for diagnosing primary biliary cirrhosis (PBC) using novel autoantigens  
Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
8852879 Materials and methods for the detection of nitrated fibrinogen  
Compositions are disclosed comprising an effective amount of nitrated fibrinogen and a pharmaceutically acceptable carrier for detecting a patient's risk for coronary artery disease. The...
8841080 System for determining unprocessed and partially processed neurotoxin type A  
The present invention is concerned with tools for the quality control and safety during manufacture of neurotoxins. In particular, it relates to a method for the determination of the amount of...
8835125 Methods and compositions for selective labeling of different biotinylated targets within multicolor or multilabel assays  
Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within...
8834878 Antigen-antibody cancer recognition system  
A method for the treatment of cancer is provided wherein a cancer recognition (CARE) antigen or CARE antibody is administered to a patient. Administration of the CARE antigen or antibody will...
8828671 Simultaneous assay of target and target-drug binding  
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
8828738 Amelioration of heterophile antibody immunosensor interference  
The invention is directed to methods and devices for reducing interference from heterophile antibodies in an analyte immunoassay. In one embodiment, the invention is to a method comprising the...
8828667 Methods and compositions relating to isocyanate conjugates  
Compositions are provided according to embodiments of the present invention which include an isolated antibody or antigen binding antibody fragment characterized by binding specificity for a...
8822229 Method for assaying keratan sulfate, assay kit therefor and method for detecting joint disease by using the same  
The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological...
8809005 Conjugate and its use as a standard in an immunoassay  
A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G,...
8778699 Detection of degradation products of canine NT-proBNP  
A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits...
8765393 Endotoxin-binding ligands and their use  
An affinity ligand-matrix conjugate of the structure Z-Spacer-[NX-A]m-NY-A-NK2 is useful for the isolation, separation, purification, characterization, identification or quantification of...
8753823 Immunoassay method for detecting the presence of antibodies to intravenously injected oral medications  
The steps of the method are preparing a specific antigen; intravenously injecting prescription medication initially intended for oral consumption into the blood stream of the patient, the...
8753831 Methods for detection of botulinum neurotoxin  
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin. This assay is designed to capture a...
8748115 PCSK9 immunoassay  
Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay The immunoassay used can be a solid phase...
8748118 Urinary biomarkers for cancer diagnosis  
The present invention is directed to the field of cancer diagnosis, specifically to the diagnosis of bladder cancer (BC) and prostate cancer (CaP). More specifically, the invention provides...
8722342 Method for enhancing sensitivity or method for avoiding influence of hemoglobin in immunological measurement  
A method for enhancing measurement sensitivity or avoiding hemoglobin influence in a latex agglutination or metal agglutination immunoassay method of a target antigen in a biological sample that...
8715951 Highly sensitive immunoassays and antibodies for detection of blood factor VIII  
Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about...
8716031 Method for quantification of antigen-specific canine IgE  
Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which...
8697368 Diagnostic marker for lung cancer comprising HPαR as active ingredient  
Disclosed is a diagnostic marker for lung cancer comprising HpαR as an active ingredient. Because blood, which is relatively easy to sample, is employed as a specimen, the diagnostic kit and...
8691585 Methods for predicting pregnancy outcome in a subject by hCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8685753 Highly multiplexed particle-based assays  
Methods are provided for detecting and optionally quantitating multiple analytes, including nucleic acid and/or polypeptide analytes, in particle-based assays that can be highly multiplexed....
8685662 Use of the α chain of brain spectrin and fragments thereof, for diagnosing cerebral diseases  
The present invention pertains to a method for in vitro prognosticating and/or diagnosing cerebral cerebral malaria, wherein said method comprises a step of detecting non-erythroid spectrin or...
8679827 Apparatus and methods for analyte measurement and immunoassay  
The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a...
8679768 Diagnosis of alzheimer's disease using Aβ22(pE)-42 peptide  
The present inventors screened peptides having a specific sequence specifically binding to amyloid-beta antibody and accordingly confirmed that Aβ22(pE)-42 peptide showed higher reactivity to...
8673585 Biochemical serum marker  
The present invention relates to a method for detecting the presence and/or concentration of the soluble BAG3 protein in an unknown biological sample and the assay is preferably carried by ELISA...
8673583 Monoclonal antibodies and detection methods for enzymes that confer resistance to 2,4-dichlorophenoxyacetic acid  
Described herein are monoclonal antibodies and methods useful for determining and quantitating the presence of AAD-1 (aryloxyalkanoate dioxygenase) enzyme. These monoclonal antibodies are...
8652421 Immunoassay product and process  
The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the...
8652422 Immunoassay product and process  
The invention is directed to an apparatus useful in conducting detection of compounds on blotting membranes. The device is comprised of several layers including a porous support layer below the...
8652409 Photoelectrocatalytic fluid analyte sensors including reference electrodes  
Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the...