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7390628 |
Microparticle-based diagnostic methods
The present invention concerns novel materials and methods to detect low frequency surface changes utilizing modified microspheres. Upon exposing the surface to the modified microspheres of the...
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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7374950 |
Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7374891 |
Methods to identify compounds that modulate rage
Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE...
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7368543 |
Diagnosis and treatment of hepatic disorders
The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration...
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7368277 |
Method for assay of antibodies and antibody assay device
The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the...
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7361481 |
Diagnosis of lysosomal storage disorders using saposins and other markers
Methods for assaying a lysosomal enzyme activity present in a blood sample obtained from a patient. The method combines the blood or plasma sample in a buffer with at least one binding reagent...
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7335477 |
Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been...
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7332343 |
Determining enantiomeric excess using indicator-displacement assays
The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of...
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7326578 |
Urine assay for ovarian reserve
It has been found that a urine test for ovarian reserve can be provided which is equivalent in sensitivity to current laboratory methods which determine ovarian reserve based on FSH levels in...
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7319041 |
Applications of acridinium compounds and derivatives in homogeneous assays
Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent...
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7312319 |
Neurotrophic factor (NT-4) immunoassay systems
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and...
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7312089 |
Detection of erythropoietin and erythropoietin receptor
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents...
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7303884 |
Method for indirectly determining the blood-clotting status
The invention relates to a method for indirectly determining the blood-clotting status. The inventive method comprises the following steps: a) collecting body fluids which contain a protein that...
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7300761 |
Methods and device for detecting prostate specific antigen (PSA)
An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed...
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7297554 |
Immunoassay system
A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay...
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7279288 |
I kappa B kinase complex as a target for the treatment of Huntington's disease
The present invention provides methods and compositions for protecting cells from the toxicity of mutant huntingtin (Htt) protein and for treatment of Huntington's disease (HD). The methods...
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7276347 |
Cytoxan antibodies and immunoassay
Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and...
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7271007 |
Microscale diffusion immunoassay
Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding...
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7270995 |
Analyzing device
The present invention is an analytical device which comprises a porous piece assembly consisting of a liquid reagent-receiving porous piece ( 1 ), a labeled substance-retaining piece ( 2 ), a test...
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7270965 |
Assays to screen for compounds that bind the dorsal root receptor
The present invention is directed to assays that can be used to screen for compounds that act as agonists or antagonists or inverse agonists of bovine adrenal medulla docosapeptide (BAM-22P). The...
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7264939 |
Method of detecting native proBNP
The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the...
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RE39816 |
Conjunctive analysis of biological marker expression for predicting cardiac mortality
A diagnostic tool is disclosed for accurately and rapidly diagnosing the condition of an ailing organ. Although applicable to numerous organ and organ systems, this application particularly...
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7259846 |
Lab in a cuvette
The present disclosure provides an apparatus for handling a liquid sample, wherein the apparatus includes integrated sample processing and sample evaluating components. The sample processing and...
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7258994 |
Saliva immunoassay for detection of antibodies for cardiovascular disease
A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin,...
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7256008 |
Determination of concentration of FK778 by competitive immunoassay
Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use...
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7252961 |
Competitive immunoassay using complexed analyte derivatives
The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for...
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7252951 |
Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates...
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7244582 |
Immobilized carbohydrate biosensor
A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.
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7241626 |
Isolation and confirmation of analytes from test devices
Methods, articles, and kits for obtaining elevated concentrations of a substance from a sample that has become bound, for example by providing a positive test result in an immunoassay or other...
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7235370 |
Site-specific aminoglycoside derivatives for use in immunodiagnostic assays
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group...
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7229842 |
Metal chelate containing compositions for use in chemiluminescent assays
Compositions are disclosed comprising (a) a metal chelate wherein the metal is selected from the group consisting of europium, terbium, dysprosium, samarium osmium and ruthenium in at least a...
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7229782 |
Antibodies specific to multiple beta blockers and methods for their use
The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies.
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7226753 |
Displacement assay for selective biological material detection
The present invention relates to displacement assay type bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products,...
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7226752 |
Methods for detecting an analyte in a sample
Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label...
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7226746 |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7223553 |
Immunoassays for everolimus
Immunoassays for the detection of everolimus are provided. Compounds for producing antibodies for everolimus, as well as antibodies produced therefrom, are also provided.
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7220597 |
Assay test device and method of making same
In accordance with certain disclosed embodiments of the present invention, there is provided an assay test device for determining whether a fluid under test contains a certain substance, wherein...
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7211409 |
Standard compound for immunoassay for dioxin and method of immunoassay for dioxin
A compound of formula (1) and an immunoassay method for quantitative determination of dioxins in a sample using as a standard the compound of the following formula (1):
wherein R 1 , R 2 , R 3 ...
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7211405 |
Placental protein 13
The full amino acid and DNA sequences of placental protein 13 (PP13) are disclosed. Also described are various PP13 derived peptide fragments, and a recombinant method for the production of PP13....
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7205116 |
5-Fluoro-uracil immunoassay
Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and...
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7202040 |
Method for screening compounds which change the binding properties of a protein with a ligand
The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the...
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7198904 |
Immunoassay method employing monoclonal antibody reactive to human iNOS
A panel of monoclonal antibodies recognizing and binding to human inducible nitric oxide synthase (iNOS or type II iNOS) enzyme have been developed. The monoclonal antibodies may also be employed...
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7195882 |
Monoclonal antibodies specific for buprenorphine and metabolites thereof
The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine...
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7192784 |
Method of measurement in chromatography
A substantial amount of a marker reagent associated with a measurement is measured in a marker reagent measurement area, and the substantial amount of the marker reagent is reflected by a result...
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7192722 |
Phenethanolamine-derived haptens, immunogens, antibodies and conjugates
The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays...
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7189582 |
Compositions and methods for detection of sirolimus
Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at...
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7189520 |
Compositions and methods for detecting animal byproduct in feed
Analytes and ligands for detecting animal byproduct in agricultural samples such as animal feed to minimize the transmission of prion pathogens into food products consumed by humans. The analyte is...
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