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7390632 |
Soluble ErbB3 receptor isoforms
The present invention discloses a system and method using the human ErbB3 receptor, p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present...
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7390627 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7390489 |
Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody
The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes , a hybridoma cell producing the monoclonal antibody, a test kit comprising...
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7387897 |
Tetrameric antibody complexes for blocking non-specific labeling of antigens
A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody...
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7384751 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7378285 |
Devices for the detection of multiple analytes in a sample
The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.
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7378270 |
Device for analyte measurement
A biochemical analysis instrument for multiple fluid analyses includes a housing. A sensor for sensing a reaction is disposed in the housing. An aperture is formed in the housing. A test tape...
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7374950 |
Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7374891 |
Methods to identify compounds that modulate rage
Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE...
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7371581 |
Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell
We describe a process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell, wherein at least two different samples taken...
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7371534 |
Sensitive intracellular calcium assay
A sensitive intracellular calcium assay is disclosed comprising conveniently a reagent comprised of a dye precursor capable of entering cells and being hydrolyzed to a dye, whereby the dye...
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7368277 |
Method for assay of antibodies and antibody assay device
The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the...
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7368253 |
Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the...
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7368251 |
MEGSIN protein
A gene expressed specifically in mesangial cells. A DNA expressed specifically in mesangial cells; a protein encoded by this DNA; an antibody binding to this protein, etc. These substances are...
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7368249 |
Methods and compositions for evaluation and modulation of fertility
The present invention concerns compositions and methods for regulating or determining fertility in humans and animals. In various embodiments of the invention, LOX and other related enzymes can be...
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7368247 |
Diagnostic assay for transmissible spongiform encephalopathies
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7361517 |
Real time method of detecting acute inflammatory conditions
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage...
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7361484 |
GSK3 polypeptides
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also...
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7361479 |
Assay
The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts...
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7358096 |
Immobilisation of proteins
The immobilization of proteins at solid surfaces facilitated by incorporation of a polypeptide segment which is capable of adopting a folded structure is described. Materials comprising proteins so...
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7358063 |
Method of detecting PS2V
A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7354725 |
Kinase peptides and antibodies
The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and...
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7354614 |
Diagnostic device
A diagnostic device 1 for performing an immunochromatographic analysis of a sample is disclosed. The diagnostic device 1 comprises a porous substrate 10 for performing the analysis and a...
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7351547 |
Diagnostic test for West Nile virus
The present invention provides a rapid and sensitive method for the detection of a West Nile virus (WNV), Japanese encephalitis virus (JEV), St. Louis encephalitis virus (SLEV) and Dengue virus...
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7348157 |
Immunoassay
A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two...
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7344848 |
Methods for determining adequacy of heat processing of a cooked meat sample
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
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7341844 |
Methods for diagnosing autism
The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including...
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7338809 |
Method for assaying whole blood
In a method for measuring an analyte, which comprises a reaction step of forming a reaction system including a sample containing whole blood, a first substance carried by a solid carrier and...
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7335480 |
Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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7335478 |
Reactivation-based molecular interaction sensors
This invention provides methods and systems for linking the functional activation of a responder molecule to the interaction of two or more binding ensemble members of interest either in vitro or...
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7335477 |
Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
A recombinant, refolded non-fusion polypeptide expressed from a truncated r56 gene of the causative agent of scrub typhus, Orientia tsutsugamushi for the Karp, Kato and Gilliam strains has been...
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7332349 |
Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays
Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be...
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7332344 |
Luminescence assays
A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor...
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7332343 |
Determining enantiomeric excess using indicator-displacement assays
The invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of...
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7332289 |
Method of purifying protein
A method for removing contaminant DNA in a sample containing a physiologically active protein, which comprises the following steps:
1) converting the sample containing a physiologically...
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7332287 |
Methods and compositions for diagnosing breast cancer
Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights...
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7326776 |
Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
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7326578 |
Urine assay for ovarian reserve
It has been found that a urine test for ovarian reserve can be provided which is equivalent in sensitivity to current laboratory methods which determine ovarian reserve based on FSH levels in...
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7326573 |
Assay procedures and apparatus
In cytometry and like procedures, particles containing signal dyes are exposed to a laser, and the resulting fluorescence is assessed in two different wavelength bands. When the particle is a...
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7326535 |
Immunoreactive peptides from Epstein-Barr virus
Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment...
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7320875 |
Hepatitis C virus E2 binding protein
HCV assays are described. The assays utilize a 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), or functionally equivalent variants or fragments of the 24 kd...
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7320867 |
Linker compound, ligand, and producing method thereof
A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or...
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7316905 |
Method for measurement of hepatitis C virus
A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a...
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7314727 |
Methods to facilitate diagnosis of normal pressure hydrocephalus
The present invention relates to methods for differentiating demential diseases comprising measuring the concentration of human lipocalin-type prostaglandin D synthase in a sample of a body fluid...
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7312089 |
Detection of erythropoietin and erythropoietin receptor
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents...
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