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7488592 |
Human protein acyl transferases and methods of uses therefor
The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefore. In addition, methods of screening for modulators of human...
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7488608 |
Reduction of non-specific binding in assays
Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding...
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7485430 |
Methods and compositions for evaluation of fertility
The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In...
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7482010 |
Non-anaphylactic forms of grass pollen Phl p 6 allergen and their use
The invention relates to a hypoallergenic immunogenic molecule derived from the Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule...
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7482174 |
Disease markers for early stage atherosclerosis
The invention relates to methods of diagnosing early stages of atherosclerosis.
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7482128 |
Anti-feline albumin antibodies
The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in...
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7482162 |
Determination of vitamin D metabolite and displacement from plasma or serum binding proteins
We disclose methods for measuring vitamin D metabolite in plasma or serum samples. The methods comprise a step of adding to the plasma or serum samples a non-competitive displacement agent...
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7479372 |
Beta-secretase substrates and uses thereof
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of...
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7476551 |
Diagnosing atherosclerosis risk by measuring carbamylated low density lipoprotein levels
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of: measuring the level of carbamylated LDL in a sample obtained...
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7476545 |
Method of quickly detecting and/or assaying antigen by fluorescence correlation spectrometry
The present invention provides a method of quickly and accurately detecting and/or assaying an antigen using fluorescence correlation spectroscopy (FCS), which involves a fluorescence-labeled...
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7473549 |
Target recognition element and biosensor including the same
The present invention provides a target recognizing element wherein a receptor is fixed to an inclusion complex containing a mediator. The target recognizing element includes a first host molecule...
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7470783 |
Photocleavable protecting groups and methods for their use
Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
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7465556 |
Method of immunoassay tartrate resistant acid phosphatase 5b and kit to be used therein
Specific and accurate immunoassay of tartrate resistant acid phosphatase 5b (TRACP 5b) in a specimen may be carried out by bonding TRACP 5b in the specimen to an antibody, subjecting the TRACP 5b...
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7465555 |
Early detection of sepsis
Diagnostic methods, systems, and kits for identifying patients with systemic inflammatory response syndrome who are likely to progress to sepsis.
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7462495 |
Methods and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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7459317 |
Method for detecting an analyte in a sample
Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label...
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7459276 |
Methods and controls for monitoring assay quality and accuracy in parathyroid hormone measurement
The present invention relates to the use of control compositions and kits comprising such to evaluate and monitor the consistency of assays utilized to determine parathyroid hormone levels.
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7459269 |
Detection of bovine viral diarrhea virus in hair samples
The present invention relates to a method of detecting whether a target animal is Bovine Viral Diarrhea Virus (BVDV) positive or negative by determining whether a gp48 protein-specific reagent...
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7455985 |
Detection and quantification of intracellular pathogens
The present invention provides methods and compositions for detecting bacteria of the Chlamydiaceae family in a biological sample. Methods include, for example, contacting a biological sample with...
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7455980 |
Method for characterizing autoimmune disorders
The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is...
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7455976 |
Method of measuring oxidized LDL/β2-glycoprotein I complex occurring in the living body
A complex having oxLDL bound covalently to β2-GPI can be used as a standard for measuring a β2-GPI/oxLDL complex in the living body thereby measuring the β2-GPI/oxLDL complex in the living body...
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7452678 |
Identification of biomarkers for liver toxicity
The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other...
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7452565 |
Immobilization of bead-displayed ligands on substrate surfaces
Disclosed are two different approaches for immobilization of beads on a substrate, one of which involves forming a bead-nanoparticle composite by cross-linking of the bead mixture with...
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7445889 |
Methods for detecting parvovirus infections
The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19...
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7446180 |
Conformationally abnormal forms of tau proteins and specific antibodies thereto
Invention relates to antibodies with a specificity to an abnormally truncated form of tau protein which is conformationally different from normal tau and does not bind to normal tau protein,...
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7442558 |
Phthalamide-lanthanide complexes for use as luminescent markers
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also...
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7442514 |
Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at...
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7442516 |
Antibody specific to central nervous system tau protein
The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable...
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7438917 |
Peptide sequences specific for the hepatic stages of P. falciparum bearing epitopes capable of stimulating the T lymphocytes
The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or...
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7439025 |
Antibodies binding a gamma carboxyglutamic acid displaying epitope
Antibodies are described, which are suitable for identification of γ-carboxyglutamic acid (Gla), said antibodies having an ability of identifying Gla residues in proteins and/or peptides, while...
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7439026 |
Methods and kits for detecting ITA in a biological sample
Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7432067 |
Methods of detection of MATER protein autoantibodies
Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for...
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7429466 |
Methods and arrays for detecting biological molecules
Arrays and methods for detecting one or more biological molecules, where the methods generally comprise the steps of: providing a first support immobilized with one or more reagents; providing a...
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7429458 |
Methods of using bioelastomers
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of...
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7427490 |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount...
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7427486 |
Mullerian inhibiting substance levels and ovarian response
Methods and kits are provided for assessing the ovarian reserve and predicting the ovarian response to fertility treatments in a female subject. The serum levels of MIS are shown to be positively...
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7423131 |
Busulfan immunoassay
Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in...
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7422864 |
Method for measuring oxidized LDL-CRP complex and measurement kit
The present invention provides a method for measuring a “complex of oxidized LDL and CRP” which comprises using an “anti-CRP antibody”. An “anti-apoB antibody and/or anti-β2-GPI...
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7419796 |
Method of making a test device
The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including...
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7419788 |
Method for screening anti-bacterial agents
The invention provides a method of screening for potential anti-bacterial agents being antagonists of the transpeptidase enzyme involved in peptidoglycan biosynthesis in bacteria. The method is...
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7416855 |
Immunoassay methods for detecting interleukin-1 β converting enzyme like apoptosis protease-3
Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by...
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7416850 |
Cytochrome c and leucine-rich alpha-2-glycoprotein-1 assays, methods and antibodies
The present invention relates generally to assays and methods involving Cytochrome c (Cyt c) and leucine-rich alpha-2-glycoprotein-1 (LRG), and related antibodies. In an embodiment, the invention...
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7413868 |
Use of particulate labels in bioanalyte detection methods
New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular...
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7413884 |
Immunological control of β-amyloid levels in vivo
Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using...
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7410771 |
Reagent and method for detecting a Cryptosporidium parvum sporozoite antigen
A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay...
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7407743 |
Kit and method of screening wilson's disease
The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard...
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7407764 |
Plasma C5A levels as an indicator of asthma severity
This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient...
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7405054 |
Signal amplification method for surface plasmon resonance-based chemical detection
The present invention provides methods and compositions for amplifying the detection signal in surface plasmon resonance (SPR)-based flow systems. The signal amplification methods comprise the use...
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7405084 |
Analytical method using particles and test kit for performing the method
A method for use in a flow matrix, which utilizes biospecific affinity reactions to detect an analyte in the sample, and which comprises allowing the sample comprising the analyte and an...
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