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7572597 |
Diagnostics method
Method of diagnosing in an individual recent exposure to an agent which is a pathogen, vaccine or any other moiety which induces a cellular response, said method comprising determining in vitro...
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7572596 |
Modulation of the neuroendoctrine system as a therapy for motor neuron disease
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
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7569396 |
Caffeine detection using internally referenced competitive assays
Methods, compositions, and apparatus for detecting the presence of caffeine in a liquid sample are provided. In certain embodiments, an internally referenced competitive assay allows a very precise...
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7569355 |
Homogeneous luminescence energy transfer bioassay
A homogeneous bioassay including a first group labelled with an energy donor and a second group labelled with an energy acceptor, where the donor is a luminescent lanthanide label capable of...
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7569353 |
Myeloperoxidase detection in diagnosis and prognosis of hematopoietic disorders
The present invention relates to the diagnosis of hematopoietic disorders and to determining the prognosis of patients affected by such disorders. The methods generally comprise determining a level...
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7566542 |
Use of protein ASC as a marker for breast cancer
The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a...
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7566541 |
Diagnostic method for screening complement regulatory protein levels to predict spontaneous abortion
The invention provides a method for the early detection of pregnancy failure, spontaneous abortion or premature birth by determinations of complement regulatory protein levels. A kit for use in...
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7566545 |
Method for producing a nucleosome preparation and use thereof in in vitro diagnosis of disseminated lupus erythematosus (DLE)
Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or delaying the onset of a rise in blood glucose levels in an animal, comprising...
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7560244 |
Method of evaluating a subject for risk or predisposition of reduced renal function over time
The invention includes diagnostic, predictive, prognostic and monitoring methods and reagents for loss of renal function, e.g., diabetic nephropathy and end stage renal disease (ESRD).
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7560240 |
Method for monitoring gastrointestinal inflammation in persons with inflammatory bowel disease(IBD)
A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces,...
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7560238 |
Immunological latex turbidimetry method and reagent therefor
An immunological latex turbidimetry method for analyzing an antigen or antibody in a sample is disclosed, comprising steps of (1) bringing a sample which may contain the antigen or antibody to be...
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7560239 |
Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly...
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7556932 |
Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF)...
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7556927 |
Methods for diagnosing, imaging and treating atherosclerotic disease
The invention provides a novel human Mab Fab, cloned by phage display, and its use in diagnostic and therapeutic methods. In particular the invention provides a method for analyzing the OxLDL...
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7553630 |
Methods for detecting metalloproteinase inhibitors
A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders...
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7550270 |
Ileitis diagnostic assay
Improved immunoassays for the protection of antibodies against Lawsonia intracellularis are provided which permit rapid, easy detection of low concentrations of anti- Lawsonia antibodies in...
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7550269 |
PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies
A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the...
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7547518 |
Method of screening endothelial cells for angiogenic capability
Provided is a method of screening a primary endothelial cell population for angiogenesis capability comprising: (a) measuring the percentage of cells that are positive for VEGF R2 and CD34, the...
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7547519 |
Methods of diagnosing multidrug resistant tuberculosis
The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis with no previously identified function is responsible for the ability of the bacterium to activate...
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7544513 |
Hemoglobin assay for neonatal screening
The present invention provides an assay, suitable for neonatal screening of hemoglobinopathies by quantitatively determining the presence of at least one pair of hemoglobin (Hb) variants,...
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7541160 |
ELISA for VEGF
The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions,...
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7537704 |
Method for determining the concentration of asymmetric dimethylarginine (ADMA)
The invention relates to a method for determining the concentration of asymmetric dimethylarginine (ADMA) simultaneously with arginine and with symmetric dimethylarginine (SDMA) in biological...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7534580 |
PSP94 diagnostic reagents and assays
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
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7534579 |
14273 receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
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7534574 |
Epitope-captured antibody display
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is...
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7531315 |
Method for detecting a host receptor for pathogenic bacteria
A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli ....
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7527924 |
Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation
A rapid method for the quantitation of various live cell types is described. The method may include a variety of steps including: 1) suspending the cells in a detergent-like compound, 2) isolating...
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7527939 |
Polyclonal-monoclonal ELISA assay for detecting N-terminus proBNP
A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are...
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7524642 |
Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents
Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying...
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7524639 |
Assay for screening antipsychotic drugs
A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal...
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7521196 |
Prewetting lateral flow test strip
A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer...
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7517699 |
Positive detection lateral-flow apparatus and method for small and large analytes
Methods and devices for the detection and/or quantification of an analyte in a sample are provided. These are positive detection methods and devices, in that the more analyte is present in the...
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7517663 |
Rabbit monoclonal antibody against Id1 protein
The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant,...
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7514226 |
Antibody pair screening methods
The invention provides methods for identifying antibody preparations that can form a pair of antibodies that optimally detect a target antigen, for example, in a sandwich immunoassay. These methods...
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7514223 |
Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
The invention is directed to a cross-screening system and methods of the invention utilizing a combination of an immunoassay (IA) and electrochemiluminescence assay (ECLA) to identify molecules...
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7510881 |
Method and kit for the quantitative and/or qualitative detection of components in a sample
A method and kit for quantitatively and/or qualitatively detecting one or more components in samples, including the use of metal-particle labelled reagents and an antibody conjugate are disclosed....
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7507550 |
Analytical sandwich test for determining NT-proBNP
The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal...
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7504228 |
Integrin linked kinase modulation of monocyte activation
Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the...
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7501287 |
Transcobalamin II assay method
An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin...
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7498145 |
Concentration measuring method, concentration measuring kit, and sensor chip for use in the method
The method for measuring the concentration of the measuring object uses a sensor chip comprising an optical waveguide layer and an antibody immobilized layer formed on the surface of the optical...
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7498144 |
Elisa method for the detection of guanylate binding protein 1 (gbp-1)
A method for the identification and/or quantification of GBP-1 or fragments of this protein in the culture supernatant of a tissue sample, a body fluid sample or a sample from a cell culture...
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7494820 |
Electrochemiluminescence of rare earth metal chelates
Luminescent chemical reagents that include complexes of rare earth metals with ligands such as aromatic heterocyclic nitrogen-containing compounds and semi-aromatic oxygen-containing compounds are...
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7494647 |
Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
A humanized antibody against tissue factor (TF), comprising: A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the...
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7494780 |
Epididymis-specific defensin for evaluating and regulating male fertility
The present invention relates to the discovery that an epididymis-specific defensin, EP2D, plays an important role in regulating sperm motility and therefore male fertility. Provided are methods...
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7494824 |
Interactive system for presenting and eliminating substances
An interactive system is provided with at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance...
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7494782 |
Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing...
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7491551 |
Quantitative lateral flow assays and devices
This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention...
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7491499 |
Method for diagnosing or predicting susceptibility to psychiatric disorders
The present invention provides a method for diagnosing or predicting susceptibility to a psychiatric disorder in an individual, which comprises confirming molecular diversity and/or subcellular...
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7491553 |
Homogeneous immunoassays for multiple allergens
A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling...
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