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6548260 |
Detection of PSA-α2-macroglobulin complex in a biological fluid
The present invention provides methods for detecting and quantitating PSA-α2-macroglobulin complexes in the sera of patients at risk for prostate cancer. Methods for detecting and monitoring...
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6544728 |
Methods and kits for diagnosing human immunodeficiency virus type 2 (HIV-2), proteins of HIV-2, and vaccinating agents for HIV-2
A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a...
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6541214 |
N-terminally truncated HER-2/neu protein as a cancer prognostic indicator
There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western...
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6537762 |
Peptide mimotope to mycotoxin deoxynivalenol and uses thereof
The present invention provides a peptide mimotope of the non-peptide mycotoxin deoxynivalenol. In particular, the peptide mimotope competes with deoxynivalenol for binding to a monoclonal antibody...
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6537760 |
Receptor binding assay for detecting TSH-receptor auto-antibodies
In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or...
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6537766 |
Ikaros isoforms and mutants
Specific Ikaros mutations, as well as the correlation of the presence of the specific Ikaros mutations and other wild-type non-DNA binding Ikaros isoforms with lymphoid cell abnormality is provided...
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6534281 |
Immunoassay for measuring human C-peptide and kit therefor
An immunoassay for selectively measuring human C-peptide as well as a kit therefor is disclosed. In the method, human C-peptide contained in a sample, a first anti-human C-peptide antibody, and a...
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6534282 |
Detection of hypertension using immunoreactive metabolic products
A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETs) and metabolites of DHETs, which are metabolites of arachidonic acid (AA)...
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6534323 |
Compositions and methods for early detection of heart disease
The invention relates to methods, compositions, kits, and devices for detecting cardiac ischemia, hypoxia, or other causes of heart failure in a mammal by obtaining a test sample from a mammal,...
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6534322 |
Kits for early detection of heart disease
The invention relates to methods, compositions, kits, and devices for detecting cardiac ischemia, hypoxia, or other causes of heart failure in a mammal by obtaining a test sample from a mammal,...
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6534270 |
Biochip and method for fabricating the same
Disclosed are biochips having a high detecting sensitivity with readiness in fabrication of microarray, and a method for fabricating the same, in which a solid support wound with fibers is immersed...
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6531278 |
Ligand-DNA composition for capture and detection of contaminants on a solid surface
Compositions and methods of use thereof for capture and detection of selected molecules are described. In one embodiment, a first composition includes a ligand component, such as an antibody...
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6528272 |
Receptor-based assays for pathogens
A rapid, simple, and inexpensive sandwich enzyme-linked receptor based immunodot assay detects pathogens or pathogenic products in test samples using receptors for a characteristic component of the...
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6524866 |
Capillary electrophoretic method to detect target-binding ligands and to determine their relative affinities
The invention relates to capillary electrophoretic methods for detecting ligands or hit compounds that can bind to a selected target at or above a selected binding strength. The method allows one...
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6521416 |
Determination of the amount of hLHβ core fragment in a sample from a subject and uses thereof
The present invention provides a method for predicting the likely timing of the onset of menopause for a perimenopausal female subject by determining the amount of hLHβcf in a sample from the...
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6521465 |
Parallel production of high density arrays
An array bundle is provided for creating multiple arrays for testing. The array bundle is adapted to be cut transversely to form a series of identical arrays of cells. In one embodiment, the array...
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6521414 |
Methods for identifying a modulator of the interaction of NMDA receptor with protein tyrosine phosphatase L1
The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and a protein tyrosine phosphatase (PTP), e.g., PTPL1. The present invention provides...
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6518033 |
Method of detecting the presence of CD155 for diagnosis of cancer and to determine treatment
The present invention relates to a method of diagnosing, classifying and grading of tumor growths and to determine whether the use of chimeric polioviruses is a proper course for the treatment of...
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6514716 |
Detection of the end-position sialic acid groups of the human transferrin molecule
The subject matter of this invention is a method of determining terminal sialic acid residues in human transferrin according to a sandwich principle, which is characterized in that the sample fluid...
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6514768 |
Replicable probe array
A system for producing substantially identical specific binding ligand (e.g., nucleic acid) probe arrays, for instance, by preparing and replicating an original master array and/or by providing a...
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6514707 |
Methods for detection of prion protein as an indication of transmissible spongiform encephalophathies
Methods to detect prion or PrP-Sc protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals, and postmortem detection...
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6514714 |
Method for immunobead flow cytometric detection of anti-HLA panel reactive antibody
The present invention provides an improved method for detection of panel reactive antibodies in serum of a subject against HLA class I antigens, which comprises the steps of adding serum from a...
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6511812 |
Method and test kit for use in improving immunoassay specificity
An improved method for detecting antibodies is disclosed. The method employs a recombinant denatured bacterial enzyme. The invention also relates to a test kit useful for performing an immunoassay...
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6511798 |
Methods for the preparation of cell monolayers
Cell based screens for studying drug transport are described and improved methods for the preparation of cell monolayers for use in such screens are disclosed.
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6511801 |
HIV-1 group O antigens and uses thereof
The claimed invention relates to an HIV-1 group O envelope antigen comprising SEQ ID NO: 100, and the use of said antigen as a reagent in the diagnosis of HIV-1 group O infection, and a kit therefore.
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6509148 |
Method for fabricating biosensors using hydrophilic polyurethane
Disclosed is a method for fabricating biosensors, using hydrophilic polyurethane. Bio-active reagents, including enzymes, antibodies, antigens, cells and receptors, are mixed with hydrophilic...
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6506570 |
Method of sorting birds in ovo
A method of determining the gender of a bird in ovo comprises detecting the presence or absence of an elevated level of a sex-related hormone in the extra-embryonic fluid of the bird egg, and then...
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6506885 |
Monoclonal antibodies to the drug tilmicosin and a method for detecting the same
Hybridoma cell lines have been generated which produce and secrete monoclonal antibodies which selectively bind to tilmicosin. These hybridomas may be obtained by using as an immunization agent or...
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6503722 |
Diagnostic tests and kits for Clostridium difficile
This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile ...
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6503702 |
Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction
The present invention is drawn to an immunoassay capable of the rapid detection of a variety of test substances that may be present in a test sample. One feature of the invention is that extraction...
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6500674 |
Method for the diagnosis of brain/neurological disease using monoclonal antibodies specific for PHF-tau, hybridomas secreting them, and antigen recognition by these antibodies and their applications
A method for the diagnosis of brain/neurological disease involving abnormally phosphorylated tau protein using at least one antibody chosen from the group consisting of monoclonal antibody AT180...
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6500628 |
Nucleic acid molecules encoding human kinase and phosphatase homologues and uses therefor
The invention provides isolated nucleic acids molecules, designated Kinase and Phosphatase nucleic acid molecules, which encode novel protein kinase and protein Phosphatase polypeptides. The...
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6500625 |
Methods for diagnosing cancer or precancer based upon hnRNP protein expression
The present invention is a purified and isolated epithelial protein, peptide and variants thereof whose increased presence in an epithelial cell is indicative of precancer. One epithelial protein...
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6498016 |
Rapid method for enzyme-linked immunosorbent assay
This invention relates to a rapid and efficient method for carrying out enzyme-linked immunosorbent assay for detection of minute quantities of biomolecules such as antigen, antibody etc. This...
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6498008 |
Method for detecting swine infertility and respiratory virus
The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery...
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6498038 |
Loss of sialic acid from apolipoprotein j as an indicator of alcohol intake and/or alcohol related liver damage
Disclosed is a method for determining alcohol intake or alcohol induced liver damage in a subject by quantifying the content of sialic acid in apolipoprotein J (Apo J). In particular the present...
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6492185 |
Immunoassay for detection of very low density lipoprotein and antibodies useful therefor
The present invention provides a method for directly measuring apolipoprotein B-100 (apoB) or cholesterol associated with very low density lipoprotein (VLDL) in a fluid sample. In one embodiment...
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6492125 |
Method to assess library X library interactions
Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal-generating moieties, such as fluorophores emitting at...
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6492113 |
Detection of Mycoplasma genus and species in patients with chronic fatigue syndrome and fibromyalgia
Methods for detecting chronic fatigue syndrome and/or fibromyalgia in an individual, comprising isolating peripheral blood mononuclear cells (PBMC) and: 1) determining the amounts of Mycoplasma...
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6492127 |
Lateral flow testing device with on-board chemical reactant
A lateral flow testing device is provided for testing a biological fluid for the presence of methamphetamines. The device includes a substrate element such as a nitrocellulose strip, including an...
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6489131 |
Interference reduction by rheumatoid factors
The invention concerns a method for the determination of an analyte in which rheumatoid factors or rheumatoid-factor-like substances are added as an interference reducing reagent to reduce of avoid...
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6489129 |
Antigen-specific IgM detection
The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in...
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6489132 |
Methods and apparatus for determining specific analytes in foods and other complex matrices
Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte...
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6485982 |
Test device and method for colored particle immunoassay
Disclosed is a test cell and a method for detection of a preselected ligand in a liquid sample such as a body fluid. The test cell includes an elongate outer casing which houses an interior...
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6482596 |
Method for measuring antigen concentration
This invention provides a method for measuring an antigen concentration in a sample, which comprises: preparing VH-domain polypeptide and VL-domain polypeptide of an antibody specific to the...
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6482600 |
Breast cancer associated nucleic acid sequences and their associated proteins
This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments...
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6482599 |
Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such
A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid...
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6479248 |
Process and agent for detecting antibodies against Treponema pallidum
A method and agent for antibodies against Treponema pallidum are provided. The method involves gene-amplifying and cloning a selection of recombinant antigens. The selection of recombinant...
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6479302 |
Method for the immunological determination of an analyte
The invention concerns a method for the immunological determination of an analyte in a sample using magnetic particles coated with the analyte to be determined or analyte-specific bonding partners...
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6475747 |
Method for detecting Cryptosporidium parvum oocysts
Methods for detecting parasites, such as Cryptosporidium parvum , in turbid and non-turbid samples by solubilizing molecular markers or antigens of the parasite. The molecular markers are...
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