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6620590 |
Diagnosis of pre-eclampsia
A method for diagnosis of pre-eclampsia is disclosed, which comprises measuring the hormone inhibin A in a biological sample such as maternal serum. The method allows non-invasive, early diagnosis...
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6613537 |
Pyrrolopyridinium derivatives
The present invention is drawn to pyrrolopyridinium derivatives having a new structural skeleton, preferably containing an intramolecular hemiacetal, which is clearly different from any known...
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6613582 |
Methods for rapid and efficient protein cross-linking
The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including...
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6610487 |
Method of diagnosing gummy stem blight in plants using a polymerase chain reaction assay
The present invention provides a sensitive test for objectively diagnosing the presence of Didymella bryoniae , the causative agent of gummy stem blight, and differentiating it from similar,...
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6610484 |
Identifying material from a breast duct
Methods and systems for identifying material from a breast duct using one or more markers that can be identified in ductal fluid retrieved from the breast are provided.
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6610493 |
Screening compounds for the ability to alter the production of amyloid-β peptide
This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≧41) alone or in combination with Aβ(x≦40). The methods involve administering compounds...
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6607891 |
Method of assaying insulin-like growth factor
A pretreatment method for assaying a substance which comprises mixing a biological specimen with at least one pretreating agent selected from among surfactants and alkali agents, thus releasing...
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6607894 |
Matrix metalloproteinase levels as indicators of endometrial cancer
This invention relates to methods for assaying the presence and/or risk of endometrial cancer by measurement of levels of matrix metalloproteinase-2 and/or matrix metalloproteinase-9 in uterine...
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6605444 |
Method and device for obtaining and detecting immunologically active substances from the gas phase
A method is disclosed for obtaining and/or immunologically detecting an analyte contained in a gas phase by immunologically binding the analyte to a binding partner thereof contained in a gas- and...
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6605445 |
Rapid method of determining clearance of prion protein
Transmissible spongiform encephalopathies (TSEs) are a class of fatal, neurodegenerative diseases found in many mammalian species. Human TSEs include kuru, Creutzfeldt-Jakob disease (CJD), and...
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6605425 |
Immunogenic determinant for use in the diagnosis of Kaposi's sarcoma
The present invention relates to an immunogenic determinant. More particularly, it relates to a protein or a protein fragment for use in the diagnosis of Kaposi's sarcoma or human herpesvirus 8...
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6605255 |
Repinotan kit
The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration...
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6602716 |
Method and device for referencing fluorescence intensity signals
A method and device for fluorimetric determination of a biological, chemical or physical parameter of a sample utilize at least two different luminescent materials, the first of which is sensitive...
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6602987 |
Azobenzene derivatives as labeling agents and intermediates thereof
A compound of the formula I: wherein R is H or —N═N-2-carboxyphenyl; A is (CH 2 ) n or —CH═CH—, wherein n is an integer from 0 to 10, or A may also be —CH(COOH)— when R is...
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6602661 |
Methods and arrays for detecting biomolecules
The present invention is directed to a device and a method for detecting biomolecules in a tissue section or other two-dimensional sample by creating “carbon copies” of the biomolecules eluted...
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6602676 |
Testing method
This invention relates to a method of predicting pregnancy, particularly, in a cow, the method comprising taking a milk sample from the cow in which a milk progesterone concentration of >3 ng ml...
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6599691 |
Rapid immunoassay to detect infection with Mycobacterium tuberculosis
A rapid, non-invasive, semi-quantitative immunoassay of saliva has been developed to aid in the diagnosis of diseases, e.g., using saliva to detect subjects actively or previously infected with ...
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6599709 |
Method for screening for soluble ligands to a receptor-type tyrosine kinase
The present invention relates to a method of screening for ligands to a receptor-type tyrosine kinase. The receptor-type tyrosine, in its naturally occurring form, is characterized by being...
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6596497 |
Screening of antiviral compounds targeted to the HIV-1 gp41 core structure
A method for the screening of antiviral compounds targeted to the HIV gp41 core structure comprising capturing polyclonal antibodies from an animal other than a mouse directed against a trimer of a...
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6593079 |
Method for simultaneous detection of HIV antigens and HIV antibodies
The invention concerns a process for diagnosis of an HIV infection by means of an immunoassay using the specific detection of the p24 antigen of HIV1, HIV1-Sub0 and/or the p26 antigen of HIV2, at...
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6593085 |
Assay method and apparatus
A method of assaying for an analyte including the steps of: (i) passing a sample suspected of containing an analyte and reagents comprising a target ligand-analyte receptor conjugate and a...
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6589755 |
Assay for quantifying arthritic conditions
The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons...
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6589746 |
Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
Patients having several neurological diseases have been shown to have elevated levels of axonally-derived proteins (i.e. tau and neurofilament proteins) in cerebrospinal fluid (CSF) and in brain...
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6589799 |
Supported aldehydic silanes and method of manufacture
A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an...
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6589756 |
Immunoassays using anti-allotypic monoclonal antibodies
The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as...
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6589754 |
Immunoassay element and process for immunoassay
An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an...
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6586259 |
Platelet/leukocyte interaction assay and reagent therefor
A platelet/leukocyte interaction assay method and reagent therefor are provided using the presence of a solid-phase stimulus, such as magnetic or non-magnetic particles or mixtures thereof, having...
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6586194 |
Method for assaying creatine kinase isozyme activity and assay reagent
A method for measuring the activity of creatine kinase MB (CK-MB) isozyme which is accurate, high in specificity, convenient, by inhibiting the activity of a mitochondria localized creatine kinase...
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6582970 |
Simple immunochemical semi-quantitative assay method and apparatus
The present invention relates to a simple immunochemical semi-quantitative assay method according to chromatography, which comprises trapping a certain amount of an analyte in a sample with a...
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6582907 |
Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing...
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6582912 |
Device, method and apparatus for implementing the method, for dosing at least a particular constituent in a product sample
A device for dosing at least a particular constituent in a product sample has a receptacle and a cover assembled to form a closed container having a vertical axis. The receptacle and cover bear...
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6579688 |
Stabilizing diluent for polypeptides and antigens
Compositions for stabilizing polypeptides or antigens are described. These compositions are useful for stabilizing polypeptides or antigens stored in aqueous formulations. Such formulations can be...
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6579684 |
Assay of YKL-40 as a marker for cancer
This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects...
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6579689 |
Modulation of &ggr -secretase activity
The present invention provides cell-free γ-secretase activity. The method of the invention utilizes a membrane source of APP/γ-secretase mixture in the assay to determine factors that may enhance...
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6576431 |
Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
The present invention relates to a treatment for myocardial infarction and blood clots within a patient, and more specifically to a therapy which enhances clot lysis comprising administering to a...
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6576420 |
Method for early diagnosis of, and determination of prognosis in, cancer
The invention provides a method for diagnosis of, and determining a prognosis for, cancer causatively associated with derangements of chromosome 9p21. Underlying the invention is the discovery that...
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6576430 |
Detection of ligands by refractive surface methods
Methods for detection and analysis of allosteric receptor/ligand binding by changes in surface refractive index are provided. When analyzed by surface plasmon resonance, binding of such allosteric...
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6576433 |
Method for identification of cell growth or differentiation factors
The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay...
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6573056 |
Process for purifying factor VII and activated factor VII
The invention relates to a process for purifying factor VII and/or activated factor VIIa (F VII/F VIIa) by means of binding to immobilized soluble thromboplastin.
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6569636 |
Assay for modulators of metallo-enzyme activity
An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of...
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6569632 |
Monoclonal antibody probe for detection of adhesins associated with mature endospores of pasteuria SPP
Disclosed are methods for identifying the presence of Pasteuria endospores in soil and soil extract samples and distinguishing between Pasteuria spp and non-Pasteuria spp in the samples. Also...
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6566085 |
Synthetic peptides, antibodies directed against them, and the use thereof
The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof...
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6558900 |
Regulation of apoptosis and in vitro model for studies thereof
A cell-free system based on the cytosol of normally growing cells, which reproduces measurable aspects of the apoptotic program, is provided. The apoptotic program is initiated by addition of DATP...
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6558911 |
Sperm quality assay
The present invention relates to male infertility, and in particular to assays for predicting fertility in animals including human and bovines. In some embodiments, semen samples are evaluated by...
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6558959 |
Analytical assay device and methods using surfactant treated membranes to increase assay sensitivity
An analytical device comprising a surfactant-treated porous reaction membrane having an exposed sample-contacting surface and at least one receptor area located in a limited region of the exposed...
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6555327 |
Monoclonal antibodies against S100
The present invention relates to novel monoclonal antibodies against the calcium binding protein S100, the use of these antibodies for the development of immunoassays for specific determination of...
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6555388 |
Binding protein capture assay
This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a...
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6551789 |
Process for characterizing a biological sample using patterns of oncogene expression
A method of characterizing a biological sample is provided. The method includes the steps of contacting the sample with at least two receptor molecules to generate a first pattern of reactivity and...
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6551843 |
Methods for enhancing binding interactions between members of specific binding pairs
Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface...
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6551788 |
Particle-based ligand assay with extended dynamic range
This invention relates to methods of assaying one or more analytes simultaneously. The assays of this invention are capable of providing wide dynamic range and rapid processing times. A wide...
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