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7374902 |
Enzyme cycling based assays for alpha-methylacyl-CoA racemase
The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an...
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7361485 |
Method for the detection of proteolytic enzymes
The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase...
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7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
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7354725 |
Kinase peptides and antibodies
The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and...
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7348147 |
Method and system for nucleic acid detection
The present invention relates to a method of detecting nucleic acids comprising suspending at least one recognizable target nucleic acid in a suspending solution containing polymeric particles...
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7316908 |
Peptides from the E2 proteins of human papillomaviruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of...
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7314709 |
Compositions and methods for detecting and quantifying COX-2 activity by lipoamino acid metabolism
A method of detecting an activity of a COX-2 enzyme in a subject that includes obtaining a sample of the subject; detecting an amino acid eicosanoid metabolite in the sample, wherein the presence...
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7294471 |
Method for purifying cancer-specific proliferating cell nuclear antigen
A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
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7279295 |
Allergen
The present invention relates to a novel allergen from timothy grass ( Phleum pretense ) pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well...
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7279287 |
Analytical method
The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance.
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7276373 |
Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease
The present invention concerns the development of a cell-based assay system having improved sensitivity to HCV NS3 protease activity when compared to known assays, which is useful for screening...
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7267961 |
Peptides from the E7 protein of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papilloma virus associated cancers
An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of...
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7238493 |
Acetylation of pRb by p300 assay method for compounds which modulate this process
The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of...
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7223330 |
Biosensor, biosensor array and method for detecting macromolecular biopolymers with a biosensor
The inventive biosensor has three electrodes, the first electrode having a retaining area for retaining probe molecules which bind with the macromolecular biopolymers. The second electrode and the...
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7198904 |
Immunoassay method employing monoclonal antibody reactive to human iNOS
A panel of monoclonal antibodies recognizing and binding to human inducible nitric oxide synthase (iNOS or type II iNOS) enzyme have been developed. The monoclonal antibodies may also be employed...
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7186502 |
Process for preparing control samples of particles such as microorganisms and cells
Processes for preparing controlled samples of particles, including microorganisms and cells are described. A sample of particles is provided and separated into a predetermined number of desired...
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7183119 |
Method for sensitive detection of multiple biological analytes
The present invention relates to a method of detecting biological analytes comprising suspending a target analyte in a suspending solution containing polymeric particles marked with a probe,...
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7138504 |
Reagents and methods for mycophenolic acid immunoassay
The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic...
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7135304 |
Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis or to diagnose a pancreatitis
Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and the usage thereof to determine the in-vivo activation of hemostasis or...
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7135298 |
Screening assay for agents that alter target of Rapamycin activity
The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate...
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7132245 |
Organ transplant rejection and associated conditions
The application discloses markers associated with organ transplant rejection and associated conditions, and in particular provides materials and methods for the diagnosis, prognosis or treatment of...
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7112408 |
Detection of ovarian cancer based upon alpha-haptoglobin levels
The present invention is directed to a method for determining whether a woman has, or is likely to develop, ovarian cancer based upon assays of the alpha subunit of haptoglobin.
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7105307 |
Compositions and methods for screening for modulators of enzymatic activity
The invention provides a method to screen for a modulator of enzymatic activity comprising the step of monitoring the association or dissociation of a pair of polypeptides which can associate as a...
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7101682 |
Simultaneous screening of multiple analytes
Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the...
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7074622 |
Method and system for sorting and separating particles
The present invention relates to a method of particle separation comprising preparing a suspension of particles containing at least one recognizable target particle in a suspending solution,...
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7053249 |
Metal chelates and methods of using them for time-resolved fluorescence
β-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of...
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7033775 |
Simultaneous screening of multiple analytes
Methods, compositions and kits are disclosed. The methods are directed to determining the presence of one or more analytes in a sample suspected of containing any one of a plurality of the...
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7022493 |
Ubiquitin conjugation assays
The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
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7018523 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7005271 |
Method for the determination of the prethrombotic state
The present invention relates to determining the prethrombotic state, in particular determining an amount or presence of circulating microparticles and/or stimulated procoagulant cells.
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6994980 |
Chemiluminescent compounds and use thereof
A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel...
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6969584 |
Combinatorial enzymatic complexes
The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.
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6964872 |
Immunoassay method
When insoluble magnetic carrier particles are used in immunoassay, a method is provided which is suitable for saving labor and for treating a large number of samples within a short time while...
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6955886 |
Scintillation proximity assay for the detection of peptidoglycan synthesis
The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan...
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6936429 |
Ligand based solution assay for low concentration analytes
The present invention provides an assay for an analyte in solution. The assay relies, in part, on associating two catalytic activities in close proximity to each other (e.g., by conjugating each...
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6933123 |
Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of...
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6913935 |
Multiple assay method
A method for the assay of N samples each containing a compound to be tested, comprises providing N reaction vessels each containing a population of carrier beads and other reagents for performing...
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6913895 |
Methods for assaying transglycosylase reactions, and for identifying inhibitors thereof
This invention relates to the field of bacterial transglycosylase reactions. The invention is directed to methods for assaying for transglycosylase activity, methods of identifying inhibitors of...
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6911316 |
Medical uses of scuPA/suPAR complex
Methods of using a complex (scuPA/suPAR) which has thrombolytic activity under physiological conditions and in the presence of IgG, or of at least one IgG-derived peptide, which complex comprises a...
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6900291 |
Detection and quantitation of 8-OH-adenine using monoclonal antibodies
The present invention relates to methods and materials for the detection and quantitation 8-OH-Ade in biological specimens. Specifically, the present invention is directed to a group of highly...
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6893825 |
Microorganisms for use in the measurement of environmental factors
A microorganism mixture consisting of a first microorganism that secretes a substance upon perception of an environmental factor and a second microorganism that expresses a marker gene upon...
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6887673 |
Humanized antibodies against human 4-1BB
A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for...
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6872543 |
Method for assessing the risk of peptic ulcer, comprising the steps of determining quantitatively the concentrations of pepsinogen I (PGI) and gastrin-17 in a serum sample
The present invention concerns a method for assessing the risk of peptic ulcer by determining the presence and topographic phenotype of gastritis in an individual, by determining quantitatively the...
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6872539 |
Analytical system based upon spore germination
An analytical system for rapid detection and identification of different analytes directly from a test sample by mixing test material with a germinogenic source and enzyme-free spores, allowing the...
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6861232 |
Creatinine biosensor
The present invention generally relates to a method for producing biosensors and a biosensor for determination of creatinine. The biosensor comprises at least two enzymes, for the amperometric...
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6861230 |
Antibiotic sensitivity testing
The use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. Such tests in particular include tests for the...
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6794156 |
Cell growth, induction and lysis in an antibody-coated microplate for use in an ELISA
A competitive assay to determine the presence and concentration of an intracellular analyte (e.g., cAMP) in a sample is provided. All of the steps of the assay can be performed on the same assay...
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6756198 |
Oligonucleotide for highly sensitive detection of hepatitis C virus and method for detection thereof
An oligonucleotide useful for specific amplification of HCV RNA, or highly sensitive detection and identification of HCV RNA, and a combination thereof. A detection method using RNA amplification...
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6740495 |
Ubiquitin ligase assay
The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
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