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8182987 |
Probe for visualizing cell-cycle
An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real...
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8180572 |
High-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are...
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8178310 |
Babesia microti genomic clones containing novel antigens useful in the diagnosis of Babesios
Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a...
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8178704 |
Inositol-phosphate derivatives and method of detecting inositol-1-phosphate
The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M,...
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8173383 |
Methods and materials for the detection of Leishmania infection
The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive...
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8163501 |
Methods of assessing Crohn's disease patient phenotype by I2 serologic response
The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA...
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8163511 |
Methods for the identification of LRRK2 interacting molecules
The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with...
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8148110 |
Detection of molecular interactions by β-lactamase reporter fragment complementation
Methods and compositions for detecting molecular interactions, particularly protein-protein interactions, using at least two inactive, weakly-complementing β-lactamase fragments are provided. The ...
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8148095 |
Methods for predicting psychotropic drugs which elicit weight gain
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
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8145433 |
High-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are...
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8133718 |
Analytical strip and detecting method using the same
An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second...
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8128907 |
CSF biomarker dilution factor corrections by MRI imaging and algorithm
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
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8124355 |
Detection and identification of groups of bacteria
The present invention concerns a method for the simultaneous detection of different bacteria, comprising the following steps: coupling one or more species of bacteriophage tail proteins onto a...
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8114620 |
Diagnostic and therapeutic target PRKX proteins for neurodegenerative diseases
The present invention discloses a dysregulation of a PRKX gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease....
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8114624 |
Use of the ornithine transcarbamylase (OTC), as a marker for diagnosing brain damages
The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from...
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8114614 |
Compositions and methods for immunodominant antigens of Mycobacterium tuberculosis
Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In...
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8110663 |
Monoclonal antibodies for cartillage oligomeric matrix protein
The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic...
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8110373 |
Methods and compositions for treating and diagnosing diseases
Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy...
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8084218 |
Method for the diagnosis of cancers by measuring the changes of glycosylation of proteins related to tumorigenesis and metastasis and kit for diagnosis of cancers using the same
The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the...
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8071317 |
Methods for detection of hydrophobic drugs
Methods and reagents are disclosed for pretreating a sample suspected of containing a hydrophobic drug for conducting an assay method for detecting the hydrophobic drug. A combination is provided...
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8067155 |
Receptor tyrosine kinase assays
Methods for detecting phosphorylation of receptor tyrosine kinases (“RTKs”) upon activation are provided. The method employs cells comprising two fusion products: (1) an RTK fused to a small fra...
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8062908 |
Device for collection and assay of oral fluids
A method for rapid collection and assay of oral fluids is disclosed. The method comprising the steps of: (a) placing an assay device into an oral cavity, (b) removing said assay device from said...
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8062900 |
Optically readable microplate
A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based...
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8057797 |
Method of preparing enriched antibodies for detecting mycobacterial infection
The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is...
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8043820 |
Diagnostic methods for the detection of risk of autistic spectrum disorder
The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of...
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8030003 |
Diagnosis of eosinophilic esophagitis based on presence of an elevated level of eotaxin-3
Eotaxin-3, as a marker for eosinophilic esophagitis and methods of assessing, mitigating, and monitoring eosinophilic esophagitis by altering eotaxin-3 and/or CCR3 function, are disclosed.
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8008031 |
Competitive receptor binding assay for detecting beta-glucans
The present invention provides a method for detecting a beta-glucan having immunomodulatory activity in a human cell, which uses a test cell line that stably expresses human dectin-1 molecule on...
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8007998 |
Polymerized conjugates for biological applications
Polymerized conjugates of at least two proteins that have increased sensitivity for detecting proteins in biological assays such as gels and blots, and methods of preparing the conjugates, and a...
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8008025 |
Biomarkers for neurodegenerative disorders
The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene...
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7998691 |
Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a...
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7993868 |
Saposin D and FAM3C are biomarkers for alzheimer's disease
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this...
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7985562 |
Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-lle347 polymorphism
The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying...
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7977110 |
Method for distinguishing between kidney dysfunctions
A method for distinguishing between kidney dysfunctions in a mammal, including pre-renal azotemia, an acute renal injury that may progress to acute renal failure, and chronic kidney disease, using...
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7968349 |
Use of holographic sensor
The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte...
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7968303 |
Diagnostic assay and method of treatment for miscarriage risk or premature birth involving macrophage inhibitory cytokine-1 (MIC-1)
Methods for diagnosing risk of miscarriage and/or premature birth, foetal abnormalities, cancer (e.g. prostate cancer) and inflammatory disease (e.g. rheumatoid arthritis) are disclosed which...
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7964370 |
Analytical strip and detecting method using the same
An analytical strip and a detecting method using the analytical strip are provided. The analytical strip includes a substrate having a channel thereon. The channel has a first region, a second...
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7964369 |
Polypeptide complex that regulates cell cycle and anergy
An active ubiquitin E3 ligase, GRAIL, is crucial in the induction of anergy in cells of the immune system, and in the regulation of cellular proliferation. GRAIL is shown to associate with, and be...
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7947449 |
Methods of diagnosing pre-eclampsia or eclampsia
Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels...
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7932048 |
Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody
The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, ...
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7927827 |
Detection and amplification of ligands
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding...
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7927818 |
Compositions and methods for immunodominant antigens of Mycobacterium tuberculosis
Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In...
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7919248 |
Methods for the modulation of IL-13
The present invention is drawn to methods for modulating IL-13 expression and/or activity in a mammal comprising administering an effective amount of an agent which modulates the expression and/or...
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7910320 |
Methods compositions and compound assays for inhibiting amyloid-beta protein production
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring...
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7901900 |
Assay kit and antibody for human low molecular weight CD14
The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human...
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7897361 |
Methods of diagnosing Alzheimer's disease
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the...
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7897350 |
Immunological assay and antibodies for anti-mullerian hormone
The present invention discloses compositions and methods to measure an amount of Anti-Mullerian Hormone (AMH) in a sample, including a mammalian sample such as a primate, rodent, equine, or bovine...
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7892857 |
Assay by osmotically induced separation and concentration of high-molecular detectable substances and a fluid microsystem for carrying out said assay
The invention relates to an assay method and a fluid microsystem for carrying out said assay method, in particular, for carrying out miniaturized affinity tests in a micro-array format. According...
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7892757 |
Immunochemical determination method and determination reagent for cytochrome c
An immunochemical method for the accurate measurement of the quantity of cytochrome c in a body fluid, in particular, blood, and a kit for the measurement. The quantity of cytochrome c can be...
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7888057 |
Immunological assay for plasmin-digested products of stabilized fibrin
A method of immunologically analyzing plasmin-digested products of stabilized fibrin, characterized by using a combination of a monoclonal antibody (a) which does not react with stabilized fibrin,...
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7868144 |
Method for unspecific enrichment of bacterial cells
The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
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