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7390626 |
Methods and kit for diagnosing tick borne illnesses
ELISA, Western Blot, and a peptide-based ELISA were applied to clinical specimens from patients with clinical symptoms of tick borne diseases, including Lyme disease. Peptides from different...
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7368253 |
Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies
Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the...
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7368251 |
MEGSIN protein
A gene expressed specifically in mesangial cells. A DNA expressed specifically in mesangial cells; a protein encoded by this DNA; an antibody binding to this protein, etc. These substances are...
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7364918 |
Colorimetric sensors constructed of diacetylene materials
Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed....
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7361484 |
GSK3 polypeptides
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also...
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7354728 |
Coactivation of nuclear receptors
The invention provides a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as...
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7354614 |
Diagnostic device
A diagnostic device 1 for performing an immunochromatographic analysis of a sample is disclosed. The diagnostic device 1 comprises a porous substrate 10 for performing the analysis and a...
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7351524 |
Diagnostics and therapeutics for macular degeneration-related disorders
The invention relates to methods for treating, preventing and diagnosing macular degeneration-related disorders.
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7338769 |
Methods for identifying agonists of cypin
Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders.
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7329732 |
HCV RNA-dependent RNA polymerase
The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA...
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7329510 |
Full length human HCN1Ih channel subunit and variants
This invention relates to a DNA sequence encoding a member of the hyperpolarized activated ion channel family (HCN) and variants thereof, and the use of said sequences in assays for the measurement...
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7326776 |
Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises...
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7326540 |
Methods for identifying compounds that modulate stabilization of secretase-associated proteins
The invention relates to methods and products for inhibiting caspase activation-induced Aβ accumulation. The invention is useful for diagnosing, preventing, and treating...
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7326402 |
Method of diagnosing, monitoring, staging, imaging and treating cancer
The present invention provides new methods for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating cancer.
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7314726 |
Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The...
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7285392 |
Methods for identifying active compounds
The present invention relates to methods for identifying agents that modulate the effect of cytokine class I receptor binding compounds, by inhibiting the interaction between the cytokine class I...
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7282347 |
Method for extracting quantitative information relating to interactions between cellular components
A method is described to assay for protein interactions in living cells, e.g. by the introduction of two heterologous conjugates into the cell. The method uses the measurement of cellular...
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7270977 |
Polypeptides for identifying fungicidally active compounds
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
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7269519 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
The present invention provides a method for identifying a member of a mass-coded combinatorial library which is a ligand for biomolecule and assessing the effect of the binding of the ligand to the...
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7262018 |
Agents that bind to and inhibit human cytochrome P450 2C19
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of...
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7256007 |
Methods of regulating cytokine signalling
The present invention relates generally to a method for regulating cytokine signaling and agents useful for same. The method of the present invention is predicated in part on the identification of...
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7252957 |
Identification of etiology of autism
Disclosed herein is a method for following up a prognosis of children with autism before and after treatment with different modalities administered by their clinicians, confirming the involvement...
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7252951 |
Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates...
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7241628 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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7241578 |
Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit
The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an...
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7238491 |
Pregnane X receptor method
The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene...
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7235375 |
Organic anion transport proteins
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with...
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7226747 |
Method of identifying substances which modulate interleukin 4(IL-4) signaling
The present invention relates to a method to identify substances and a use of such substances which can modulate IL-4 dependent signaling involved in tumor diseases, preferably Hodgkin Lymphomas or...
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7226746 |
Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease
In methods for screening treatments for, and treatment of, neurodegenerative diseases, aggregation in neurons of NACP/α-synuclein is measured and expression of a non-amyloidogenic protein is...
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7220552 |
Bifunctional molecules and their use in the disruption of protein-protein interactions
Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target...
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7202046 |
Use of a fluorescent protein for detecting interaction between a target protein and its ligand
The invention relates to the use of a fluorescent protein chosen in particular from autofluorescent proteins,
for the detection of the non-covalent interactions between a target protein...
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7202040 |
Method for screening compounds which change the binding properties of a protein with a ligand
The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the...
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7199219 |
Polypeptides derived from vitamin D nuclear receptor, and their uses in particular for screening vitamin D analogues
Polypeptides derived from vitamin D nuclear receptor, which nuclear receptor comprises a ligand-binding domain, or LBD, which contains a flexible insertion domain. The polypeptides are...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7192729 |
Methods for assaying homocysteine
The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay...
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7192720 |
Array-based epitope-captured antibody display
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is...
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7192698 |
EphA2 as a diagnostic target for metastatic cancer
Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell...
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7186515 |
Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
The present invention relates to the use of alpha (2) macroglobulin (“α2M”) receptor as a heat shock protein receptor, cells that express the α2M receptor bound to an HSP, and antibodies and...
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7169573 |
Method for monitoring coagulability and hypercoagulable states
The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing...
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7169563 |
Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
Methods for identifying a member of a mass-coded molecular library, which is a ligand for a biomolecule and binds to the biomolecule at the binding site of a known second ligand for the biomolecule...
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7166438 |
In Vitro screening for ligands of the estrogen receptor
A method for in vitro screening a group of test substances for a ligand using two assay systems, i.e. a cellular or tissue assay system and an enzymatic assay system, is described. First, those...
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7166423 |
Direct selection of cells by secretion product
Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the...
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7153665 |
Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement
The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.
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7150971 |
Membrane-resident steroid receptors and methods of use thereof
This invention pertains to the discovery that DPR-1 encodes a putative nuclear hormone receptor (NHR) that, based on gene reporter studies, is expressed in the endoderm throughout the life of the...
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7148018 |
Protease-activated receptor (par) modulator assays
There is provided a method of identifying a PAR cleaving molecule comprising the steps of: (a) providing an immobilized PAR cleavage peptide linked to a reporter molecule; (b) contacting the...
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7148017 |
High sensitivity mechanical resonant sensor
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an...
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7147861 |
Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate
A method of designing a new anti-CMV drug is disclosed. In one embodiment, the invention comprises (a) analyzing the binding of glycoprotein O to a glycoprotein O receptor and (b) designing a...
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7129055 |
Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was...
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7125659 |
Method and screening candidate compounds for drug against tumor
Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in...
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