|
Match
|
Document |
Document Title |
|
|
7635557 |
Enzymatic diagnostic test for SARS and other viral diseases
The present invention is directed towards methods, compositions and kits for testing for a virus in a sample. The methods determine the presence of a viral enzyme by contacting the sample with a...
|
|
|
7635598 |
Inducible fluorescence assay
In one aspect, the invention provides fluorescent probes and assays. The probes include a fluorophore-quencher pair that undergoes a switch from dark to fluorescent in response to a reaction of the...
|
|
|
7618783 |
Anthrax specific antibodies
The present invention is directed to diagnostic tools and therapies using antibodies to Bacillus anthracis. Specifically, the present invention is directed to a B. anthracis -specific monoclonal...
|
|
|
7618784 |
Assay for phospholipid transfer protein (PLTP) activity
Improved methods for assaying the activity of phospholipid transfer protein (PLTP) enhance the signal-to-noise ratio by providing the substrate in donor particles with an aqueous core in the...
|
|
|
7611856 |
Mass spectrometry-based methods for detection and differentiation of botulinum neurotoxins
The present invention is directed to a method for detecting the presence of clostridial neurotoxins in a sample by mixing a sample with a peptide that can serve as a substrate for proteolytic...
|
|
|
7575881 |
Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent...
|
|
|
7569338 |
Diagnostic assays of secreted biological fluids for detection of infection and inflammatory conditions
A rapid and convenient method for detecting inflammatory conditions in breast tissue, such as those associated with mastitis, is described. The method comprises measuring the presence and quantity...
|
|
|
7560287 |
Long wavelength engineered fluorescent proteins
Engineered fluorescent proteins, nucleic acids encoding them and methods of use are provided.
|
|
|
7553630 |
Methods for detecting metalloproteinase inhibitors
A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders...
|
|
|
7553632 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
|
|
|
7541143 |
Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid,...
|
|
|
7534579 |
14273 receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
|
|
|
7527924 |
Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation
A rapid method for the quantitation of various live cell types is described. The method may include a variety of steps including: 1) suspending the cells in a detergent-like compound, 2) isolating...
|
|
|
7527980 |
Indirect detection of cardiac markers for assessing acute myocardial infarction
Assay systems and methods are provided for detecting a target antigen in a physiological fluid (e.g., blood, serum, or urine). The method includes linking via a first antibody a magnetic...
|
|
|
7524639 |
Assay for screening antipsychotic drugs
A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal...
|
|
|
7514228 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
|
|
|
7491381 |
Method of evaluating compound efficacious in treating obesity
Examination of obesity or emaciation is performed based on expression levels of LCE gene or protein in a test tissue or a test cell or a polymorphism of the gene. Evaluation of compounds including...
|
|
|
7482142 |
High-risk human papillomavirus detection
This invention provides compositions and methods for detecting HPV in a sample. This invention also provides related kits, systems, and computers.
|
|
|
7482162 |
Determination of vitamin D metabolite and displacement from plasma or serum binding proteins
We disclose methods for measuring vitamin D metabolite in plasma or serum samples. The methods comprise a step of adding to the plasma or serum samples a non-competitive displacement agent...
|
|
|
7465549 |
Methods for identifying agents that bind a levetiracetam binding site (LBS) or compete with LEV binding to a LBS of a synaptic vesicle protein 2 (SV2)
The present invention is drawn to methods of characterization of the properties and functions of SV2 proteins. The invention further includes methods of identifying compounds or agents which...
|
|
|
7452683 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
|
|
|
7416854 |
Luminogenic and nonluminogenic multiplex assay
A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.
|
|
|
7393698 |
Magnetic fine particles and process for producing the same
The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of...
|
|
|
7374896 |
GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an...
|
|
|
7364843 |
Method of identifying target cell using target cell-specific virus
Provided is a method of identifying a target cell using a virus. The method includes infecting the target cell with the virus by contacting the virus to the target cell and culturing the target...
|
|
|
7358052 |
Catalytic amplification of multiplexed assay signals
Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a...
|
|
|
7354733 |
Method for sorting and separating living cells
We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating...
|
|
|
7348160 |
Phosphoamidase assay
The present invention relates to the use of compounds and to methods for the qualitative and/or quantitative determination of the activity of phosphoamidases or protein phosphoamidases specific for...
|
|
|
7335504 |
Engineered enzymes and uses thereof
The present invention provides engineered enzymes generated from protein scaffolds combined with Specificity Determining Regions, the production thereof and the use of said engineered enzymes for...
|
|
|
7332287 |
Methods and compositions for diagnosing breast cancer
Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights...
|
|
|
7320878 |
Protease assay for therapeutic drug monitoring
The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the...
|
|
|
7314727 |
Methods to facilitate diagnosis of normal pressure hydrocephalus
The present invention relates to methods for differentiating demential diseases comprising measuring the concentration of human lipocalin-type prostaglandin D synthase in a sample of a body fluid...
|
|
|
7312302 |
Compositions for the detection of enzyme activity in biological samples and methods of use thereof
The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated...
|
|
|
7312089 |
Detection of erythropoietin and erythropoietin receptor
The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents...
|
|
|
7306928 |
Homogenous assay for enzymatic activity
An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteases. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a...
|
|
|
7294480 |
High throughput screening assays using fatty acid synthetic enzymes
High throughput screening assays for the identification of potential therapeutic agents able to modulate the activity of enzymes of fatty acid biosynthesis, especially desaturases and/or elongases,...
|
|
|
7291698 |
Synthetic substrate for high specificity enzymatic assays
Novel synthetic enzyme substrates, enhanced to have improved enzymatic specificity, are disclosed. These synthetic enzyme substrates consist of a substrate peptide that has had its specificity...
|
|
|
7291474 |
Hydrolytic substrates for an analyte-dependent enzyme activation system
Disclosed are compounds of the general formulas:
wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is...
|
|
|
7279286 |
High-throughput-assay with high sensitivity for measuring of the activity of β-adrenergic receptor kinase and for determining the impact of test substances on such activity
The present invention relates to an assay for determining the activity of a G-Protein-Coupled Receptor specific protein kinase by means of an amplified luminescent proximity homo homogenous assay.
|
|
|
7276373 |
Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease
The present invention concerns the development of a cell-based assay system having improved sensitivity to HCV NS3 protease activity when compared to known assays, which is useful for screening...
|
|
|
7273713 |
Methods of modulating mitochondrial NAD-dependent deacetylase
The present invention provides methods for identifying agents that modulate a level or an activity of a mitochondrial NAD-dependent deacetylase polypeptide, as well as agents identified by the...
|
|
|
7255999 |
Methods and compositions for analyzing proteins
Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture...
|
|
|
7232663 |
Assays employing novel substrates for measuring P450-mediated N-dealkylation
Methods and compositions for measuring N-dealkylating activity of cytochromes P450 enyzmes are disclosed.
|
|
|
7217527 |
Assay for phosphodiesterase function
The present invention provides filter-based assays for measuring binding of compounds to phosphodiesterases (PDEs). The assay permits stoichiometric binding of compounds to PDEs, thereby providing...
|
|
|
7217523 |
Nucleoside phosphoramidates and nucleoside phosphoramidases
The invention provides isolated nucleic acid sequences encoding polypeptides having nucleoside phosphoramidase activity, and methods of screening for nucleoside phosphoramidate compounds that are...
|
|
|
7205120 |
Substrates and assays for β-secretase activity
The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage...
|
|
|
7195925 |
Polymer having an upper critical solution temperature
The invention relates to a stimulus-responding polymer obtained by polymerizing at least a monomer represented by a general formula (1) and a monomer represented by a general formula (2), and a...
|
|
|
7195885 |
Hepatitis C virus assays
The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high...
|
|
|
7192729 |
Methods for assaying homocysteine
The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay...
|
|
|
7172877 |
Methods and compositions for peptide and protein labeling
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ biotin ligase mutants and biotin analogs...
|