Patents in Class 435/7.71

Matches 1 - 50 out of 159

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Match	Document	Document Title
1	8148171	Multiplexed analysis of clinical specimens apparatus and methods A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset,...
2	8129589	Protoporphyrinogen oxidase having activity of imparting resistance against acifluorfen and gene thereof Protoporphyrinogen oxidase having an activity of imparting acifluorfen resistance and gene thereof are provided. Cyanobacterium protoporphyrinogen oxidase gene is identified by introducing a...
3	8093044	Methods for identifying inhibitors of botulinum neurotoxins A system and method for identifying a botulinum neurotoxin inhibitor employing a botulinum neurotoxin substrate complex having a peptide substrate, preferably SNAP-25, a reporter domain on one side...
4	8076457	Crystal of a cytochrome-ligand complex and methods of use The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes...
5	7981598	Preventive/remedy for respiratory diseases It is intended to provide a compound inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as one of the amino acid sequences represented by...
6	7977119	Chemical arrays and methods of using the same Methods and compositions for generating mixtures of product molecules from an initial chemical array are provided. In the subject methods, a chemical array of surface immobilized first moieties is...
7	7962290	Identification of pharmacophores from co-crystals of spleen tyrosine kinase (SYK) and SYK ligands The invention comprises for methods of identifying pharmacophores based on the spleen tyrosine kinase (SYK) protein or fragment thereof. The invention further provides methods of identifying SYK...
8	7953557	Crystal of a cytochrome-ligand complex and methods of use The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes...
9	7919267	Method for Identifying an inhibitor of plasmidic classic C beta-lactamase having extended-substrate specifity The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization ...
10	7910698	NPC1L1 orthologues The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
11	7892771	Crystal structure of soluble glutaminyl cyclase A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of...
12	7892833	Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as...
13	7816075	Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, tot...
14	7795399	Stable therapeutic proteins The invention relates to storable medicaments produced from pharmaceutical active ingredient preparations which are virus safe. Said medicaments contain at least one intact therapeutic protein...
15	7790408	Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, tot...
16	7771961	Cytochrome c acetylation Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
17	7696151	Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, tot...
18	7662581	Eg5 co-crystals This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three...
19	7632917	Methods for identifying inhibitors of botulinum neurotoxins A system and method for identifying a botulinum neurotoxin inhibitor employing a botulinum neurotoxin substrate complex having a peptide substrate, preferably SNAP-25, a reporter domain on one side...
20	7632819	Methods and compositions for inhibiting PKC delta cleavage for treatment and prevention of neurodegeneration and apoptosis Methods and compositions are provided which inhibit the apoptotic activity associated with oxidative stress in many disease states. According to the invention, inhibition of chemical cleavage of...
21	7611833	Yeast genes that affect viral replication An antiviral agent comprising an altered MAB1, MAB2, MAB3, or OLE1 gene, gene homologs or related genes is disclosed. In another embodiment, the present invention is a method of creating a virus...
22	7601512	Methods for identifying inhibitors of the 20S and 26S proteasome The present invention relates to methods for identifying fungicides and also inhibitors of the 20S and 26S proteasomes, to methods for isolating 20S proteasomes, to the use of 20S proteasomes for...
23	7588901	Modulation of angiogenesis through targeting of arginyl transferase (ATE1) The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
24	7584087	Structure of protein kinase C theta A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
25	7582443	Method for the detection and measurement of Hapten-conjugated biological binding entities by western and dot-blot using anti-hapten antibodies The invention is a procedure for measuring the binding of an entity (ligand) to a surface by using a hapten-conjugated version of the ligand (hapten-ligand). An excess of the hapten-ligand is...
26	7575881	Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent...
27	7575883	Cytochrome c acetylation Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
28	7575866	Ligand/binding partner bio-labeling systems The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target” mol...
29	7566548	Methods for identifying therapeutic agents and for treating disease Included are methods of identifying compounds that mimic the interaction of Apoptin and APC1, e.g., binding of Apoptin to APC1, e.g., dissociation of APC1 from the APC/C, and compounds identified...
30	7558717	Crystal structure of human JAK3 kinase domain complex and binding pockets thereof The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure...
31	7550436	Compositions containing peptide and electrolyte excretion promoter and foods containing the same A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an...
32	7514228	Detection of analytes using reorganization energy The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
33	7511136	Aminoindazole derivatives active as kinase inhibitors Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or...
34	7504231	Method of alleviating chronic pain via peripheral inhibition of neurotransmitter synthesis A composition having sustained pain-relieving properties such that the composition may be administered to a subject to alleviate chronic pain. The composition includes an effective amount of at...
35	7470519	Methods for detecting TAFIa or TAFIai The invention relates to a diagnostic assay for selectively measuring levels of the 35kD form of thrombin-activatable fibrinolysis inhibitor (TAFIa or TAFIai), or a derivative or variant thereof,...
36	7314726	Beta secretase exosite binding peptides and methods for identifying beta secretase modulators The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The...
37	7251525	Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase...
38	7238779	Acyl CoA:cholesterol acyltransferase (ACAT-2) Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein...
39	7157553	High throughput assays for the proteolytic activities of clostridial neurotoxins In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic...
40	7141385	Microcantilever apparatus and methods for detection of enzymes, enzyme substrates, and enzyme effectors An apparatus and a method are provided for detecting an enzyme, or or for detecting a substrate of an enzyme or for detecting an enzyme effector such as an inhibitor, by measuring a change in...
41	7135298	Screening assay for agents that alter target of Rapamycin activity The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate...
42	7081350	Methods for identifying ecdysteroid synthesis inhibitors using the drosophila P450 enzyme shade The invention relates to methods and materials useful for identifying inhibitors of ecdysteroid biosynthetic enzymes, specifically the Drosophila P450 enzyme, shade. These methods and materials can...
43	7070941	Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
44	7045283	Methods of high-throughput screening for internalizing antibodies This invention provides methods of identifying ligands that are internalized into a cell. The methods typically involve i) contacting the cell with a reporter non-covalently coupled to a ligand;...
45	7018792	Influenza sensor A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also...
46	7008666	Method of inhibiting overactivity of phagocytes or lymphocytes in an individual The invention relates to a method of inhibiting myeloperoxidase activity in neutrophils in an individual by administering to the individual an effective amount of a lignan, where said lignan is...
47	7001737	Urinary trypsin inhibitor assay containing a chelating agent Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include...
48	6951682	Porous coatings bearing ligand arrays and use thereof Articles comprising substantially uniform porous coatings, which may be photopatterned, are provided. The use of such porous coatings increases the surface density of attached compounds within, for...
49	6946547	Ecstasy-class analogs and use of same in detection of ecstasy-class compounds The present invention provides a system for the improved detection of ecstasy-class compounds in biological samples. New ecstasy-class analogs are provided for detection of such ecstasy-class...
50	6916622	Regions of papilloma virus E1 helicase involved in E1 oligomerization There is provided an amino acid sequence comprised within the PV E1 protein region A delineated by amino acids 352 and 439, and any derivative variant or fragment thereof, necessary for the...

Matches 1 - 50 out of 159

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