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7384757 |
Scintillation proximity assay method of measuring acetyl CoA carboxylase enzyme activity
The present invention relates generally to enzyme assays and more particularly to a rapid, sensitive, reliable and robust homogeneous assay for acetyl CoA carboxylase activity comprising a coupled...
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7371539 |
Targeted polypeptide degradation
This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical...
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7361485 |
Method for the detection of proteolytic enzymes
The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase...
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7361484 |
GSK3 polypeptides
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also...
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7338769 |
Methods for identifying agonists of cypin
Disclosed are novel materials and screening methods for diagnosing and monitoring cognitive disorders, as well as for identifying compounds for treating such disorders.
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7332292 |
Constitutively translocating cell line
The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which...
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7300761 |
Methods and device for detecting prostate specific antigen (PSA)
An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed...
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7297506 |
Assay for nucleotide triphosphate using a modified nucleoside diphosphate kinase comprising a fluorescent label
Nucleoside diphosphates (NDPs) are detected or measured by following the dephosphorylation of the phosphoenzyme form of nucleoside diphosphate kinase (NDPK), and nucleoside triphosphates (NTPs) are...
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7282347 |
Method for extracting quantitative information relating to interactions between cellular components
A method is described to assay for protein interactions in living cells, e.g. by the introduction of two heterologous conjugates into the cell. The method uses the measurement of cellular...
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7273713 |
Methods of modulating mitochondrial NAD-dependent deacetylase
The present invention provides methods for identifying agents that modulate a level or an activity of a mitochondrial NAD-dependent deacetylase polypeptide, as well as agents identified by the...
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7244391 |
Apparatus and method for the manipulation and testing of molecules, and in particular of DNA
An apparatus for manipulating and testing molecules includes a surface to which the molecule is anchored at multiple points at one end, a paramagnetic bead on which said molecule is anchored at...
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7241583 |
TRL1 as an antifungal target
The present invention relates to a novel antifungal target, tRNA ligase (TRL1), screening methods for TRL1 inhibitors and their use as antifungal compounds, pharmaceutical compositions containing...
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7238493 |
Acetylation of pRb by p300 assay method for compounds which modulate this process
The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of...
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7235369 |
Enzyme-protein complex
A complex of enzyme, protein and carrier comprising two or more molecules of an enzyme conjugated through an amino group or other group to a carrier such as polylysine, and a protein (for example,...
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7226754 |
Kinase Wee1 fusion protein compositions, nucleotide sequences, expression systems, and methods of use
The invention describes recombinant fusion proteins containing Wee1 protein sequences involved in checkpoint regulation of cell cycle, nucleic acid molecules that encode the fusion protein, and...
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7217523 |
Nucleoside phosphoramidates and nucleoside phosphoramidases
The invention provides isolated nucleic acid sequences encoding polypeptides having nucleoside phosphoramidase activity, and methods of screening for nucleoside phosphoramidate compounds that are...
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7202043 |
Detecting cell membrane protein endocytosis
Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label...
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7195923 |
Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the...
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7192729 |
Methods for assaying homocysteine
The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay...
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7172877 |
Methods and compositions for peptide and protein labeling
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ biotin ligase mutants and biotin analogs...
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7166447 |
Probe for analyzing protein—protein interaction and method of analyzing protein—protein interactions with the use of the same
A probe for protein—protein interaction analysis suitable for analyzing protein—protein interactions of various proteins with high accuracy and in a simple manner and a method for analyzing...
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7138266 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
A bacterial strain of Escherichia coli is described which produces L-threonine, and is obtained by a process comprising transduction by bacteriophage P1 which bears a transposon which inactivates...
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7135325 |
Short enzyme donor fragment
Short enzyme donor fragments of β-galactosidase are provided of not more than 40 amino acids, where the short fragments are used as a label and may be substituted with a wide variety of organic...
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7132247 |
Composite devices incorporating biological material and methods
The present invention provides composite biological devices that include biological material as an integral component thereof. The devices can be used for measuring metals, for example,...
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7118877 |
Caspase 9 activation and uses therefor
The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.
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7108994 |
Receptor-type phosphotyrosine phosphatase-alpha
A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7070938 |
Method to detect modulators of VEGF kinase domain
The present invention relates to assays for the detection of compounds with pharmacological activity, particularly for the detection of modulators of rat vascular endothelial growth factor receptor...
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7052843 |
Transcription-based assay for identification of post-translational modification and its application in proteomics
The present invention relates to a method for detecting the post-translational modification of a target protein by a post translational modifier polypeptide molecule; a method for screening a...
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7052650 |
Apparatus and method for the manipulation and testing of molecules, and in particular of DNA
Apparatus for the manipulating and testing of molecules and in particular of DNA comprising a surface on which the molecule is anchored on multiple points at one end and a paramagnetic bead on...
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7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
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7022493 |
Ubiquitin conjugation assays
The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
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6969583 |
Method for detecting variant HBV
The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a...
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6951919 |
Fas ligand derivative
This invention provides a soluble Fas ligand which functions as a Fas antagonist or an apoptosis regulator, a novel Fas ligand derivative which has excellent apoptosis-inducing activity and...
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6913895 |
Methods for assaying transglycosylase reactions, and for identifying inhibitors thereof
This invention relates to the field of bacterial transglycosylase reactions. The invention is directed to methods for assaying for transglycosylase activity, methods of identifying inhibitors of...
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6894022 |
Growth factor modified protein matrices for tissue engineering
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling, and/or drug delivery. The proteins can be incorporated so that they are...
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6893831 |
Immunoassay of PIVKA-II
The present invention provides an immunoassay for specifically measuring with high sensitivity PIVKA-II in serum or plasma through antigen-antibody reaction by adding an animal serum containing...
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6867010 |
Enzyme activity screen with direct substrate reloading
A method for in vitro selection, from a library of catalyst molecules, of a catalyst molecule of interest having a relatively more efficient specific catalytic activity of interest, as compared to...
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6867008 |
Method for assaying compounds affecting cell division using estrogen receptor beta (ERβ) and mitosis arrest deficient 2 (MAD2)
The invention provides a method for assaying compounds that affect cell division by determining the interaction between estrogen receptor ERβ and MAD2, a cell cycle checkpoint protein.
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6861230 |
Antibiotic sensitivity testing
The use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. Such tests in particular include tests for the...
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6855513 |
Quorum sensing signaling in bacteria
The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention...
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6844167 |
Pharmacological targeting of mRNA cap formation for treatment of parasitic infections
This invention provides the genes encoding the RNA triphosphatase and RNA guanylyltransferase of the malaria parasite Plasmodium falciparum and the catalytically active recombinant RNA...
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6787325 |
Complexes containing crosslinked avidin, analytical method with the use of crosslinked avidin and analytical reagents and kits
Provided are novel complexes containing a crosslinked avidin, an analyzing method and analyzing reagents and kits whereby a compound to be analyzed can be quickly, conveniently and accurately...
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6773900 |
End selection in directed evolution
This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution™). A particular advantage...
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6764835 |
Saturation mutageneis in directed evolution
Disclosed is a rapid and facilitated method of producing from a parentlal template polynucleotide, a set of mutagenized progeny polynculeotides whereby at each original codon position there is...
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6753158 |
Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity
A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4,...
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6746849 |
Assay for nucleoside diphosphate using a modified nucleoside diphosphate kinase comprising a fluorescent label
Nucleoside diphosphates (NDPs) are detected or measured by following the dephosphorylation of the phosphoenzyme form of nucleoside diphosphate kinase (NDPK), and nucleoside triphosphates (NTPs) are...
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6740495 |
Ubiquitin ligase assay
The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
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