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Document Title |
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7344849 |
Assay
The present invention relates to assay methods for the determination of cobalamin or vitamin B 12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin,...
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7344847 |
Nanoscale patterning and immobilization of bio-molecules
A support for immobilizing target molecules comprises a substrate having a plurality of binding regions for binding select target molecules, with target-molecule-capturing agent immobilized at the...
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7342091 |
Soluble cyclic analogues of β amyloid peptide
The invention concerns a peptide having the biological activity of an inhibitor of amyloid formation and its diagnostic and medical use.
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7341844 |
Methods for diagnosing autism
The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including...
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7332613 |
Capture and release based isotope tagged peptides and methods for using the same
The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for...
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7332355 |
Method and compositions for the detection of protein glycosylation
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations....
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7332352 |
Separation particles
A composition comprising colloidal Fe 3 O 4 particles coated with streptavidin is disclosed. These particles can be used in a method for separating biotinylated compounds from a solution in which...
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7332351 |
Method of making nanoparticles
Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved...
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7332288 |
Methods and reagents for the rapid and efficient isolation of circulating cancer cells
A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma...
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7329536 |
Piezoimmunosensor
An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real...
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7326578 |
Urine assay for ovarian reserve
It has been found that a urine test for ovarian reserve can be provided which is equivalent in sensitivity to current laboratory methods which determine ovarian reserve based on FSH levels in...
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7314726 |
Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The...
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7300761 |
Methods and device for detecting prostate specific antigen (PSA)
An immunoassay device and assay to detect an antigen, such as PSA, in a biological sample. The device comprises a solid support having multiple reaction zones containing capture antibodies directed...
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7297554 |
Immunoassay system
A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay...
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7294471 |
Method for purifying cancer-specific proliferating cell nuclear antigen
A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
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7282345 |
C-erbB-2 external domain: GP75
Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which...
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7279283 |
Cobalamin assay
The invention provides an assay method for the determination of transcobalamin II (TC II) bound cobalamin in a body sample, comprising contacting a cell free sample of a body fluid with an...
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7273714 |
Alkylguanyltransferase assays
This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional;...
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7267994 |
Element-coded affinity tags
The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a...
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7262019 |
System and methods for detection of Bacillus anthracis related analytes in biological fluids
The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate...
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7256054 |
Core-shell metal particles coated with dextran or aminodextran carrying SH groups, and use thereof
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as...
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7255998 |
High sensitivity immunoassay method
A method for detecting a cytokine in a biological fluid sample with a high sensitivity is provided. A time-resolved fluoroimmunoassay (TR-FIA) method including a step of forming on a solid phase a...
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7252960 |
Test kit for intracellular introduction of protein and/or peptide and method of intracellular introduction
A test kit for intracellular introduction of a protein and/or peptide and a method of such intracellular introduction, make it possible for a protein and/or peptide to be introduced into cells...
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7247709 |
Mitogenic oxygenases
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
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7244580 |
Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies
The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to...
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7244391 |
Apparatus and method for the manipulation and testing of molecules, and in particular of DNA
An apparatus for manipulating and testing molecules includes a surface to which the molecule is anchored at multiple points at one end, a paramagnetic bead on which said molecule is anchored at...
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7241864 |
Recombinant photoproteins and their conjugates
This invention is to provide a photoprotein which binds with a ligand specific for a substance to be detected at a binding ratio of 1:1 such that the luminescence activity is not reduced by binding...
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7241628 |
Method for immobilizing conjugates in diagnostic tests
The invention concerns a method for the detection of an analyte in a sample using analyte-specific conjugates which have at least one heterologous group for an analyte-independent binding to a...
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7235672 |
Probe, assay and kits for detecting 11β-hydroxysteroid dehydrogenase and modulators thereof
A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises:
wherein DM is a detectable marker; and L is a straight or branched chain moiety...
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7229781 |
Diagnostic kit for predicting the onset of menopause
The present invention provides methods to quantitate the hLHβ core fragment in a sample. The present invention now makes it possible to evaluate the metabolism of hLH in premenopausal,...
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7229771 |
Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods
The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.
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7217575 |
Avidin derivatives and uses thereof
A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula:
wherein A is (CH 2 ) n or —CH═CH—, wherein n is an...
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7208322 |
Sensor surfaces for detecting analytes
The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises...
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7208281 |
Ligands used for detecting prions
The invention relates to the use of specific ligand carriers for detecting prions, and to substances that are capable of binding to prions and that are subsequently used to detect prions.
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7208174 |
Liposome compositions
The present invention provides a non-covalent coupling method for the preparation of sterically stabilized lipsomes which may be used for targeted drug delivery, e.g., pegylated liposomes. The...
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7205155 |
Method for the determination of substances using the evanescence field method
This invention relates to a method for the determination of substances using the evanescence field method. A cuvette, a microtiter well, a solution and a kit for application in a method according...
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7202093 |
Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds
Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated...
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7198954 |
Methods for predicting pregnancy outcome in a subject by hCG assay
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
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7195925 |
Polymer having an upper critical solution temperature
The invention relates to a stimulus-responding polymer obtained by polymerizing at least a monomer represented by a general formula (1) and a monomer represented by a general formula (2), and a...
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7193065 |
Protease inhibitor conjugates and antibodies useful in immunoassay
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in...
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7192786 |
Biospecific assay method
This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled...
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7183067 |
Versatile linker compound, ligand, and producing method thereof
A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety...
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7179660 |
Carriers coated with polysaccharides, their preparation and use
A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and,...
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7179659 |
Sensor surfaces for detecting analytes and methods of use
The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free...
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7172907 |
Cyanine dye labelling reagents with meso-substitution
Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1):
in which groups R 3 and R 4 are attached to...
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7172877 |
Methods and compositions for peptide and protein labeling
The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ biotin ligase mutants and biotin analogs...
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7166695 |
Affinity markers for human serum albumin
Methods and compositions are provided for identifying compounds having affinity or complementarity to a target molecule. Compounds according to the invention may be described by the formula E-C a...
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7166425 |
Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells
The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation...
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7166423 |
Direct selection of cells by secretion product
Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the...
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7160733 |
Ligand specific to β2-glycoprotein I and use thereof
The cholesterol derivative, represented by the following formula (1):
wherein R represents a C3–C23 saturated or unsaturated aliphatic hydrocarbon residue having an optional substituent, and,...
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