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5437981 |
Method for the immunological determination of ligands
Method for the immunological determination of a ligand in which the ligand to be determined is reacted with a) at least 2 molecules of a specifically bindable substance P2 of which at least one...
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5429925 |
Method for immunodiagnostic detection of dioxins at low concentrations
A method is described for the use of monoclonal antibodies in a sensitive immunoassay for halogenated dioxins and dibenzofurans in industrial samples which contain impurities. Appropriate sample...
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5424194 |
4-(cyanomethylthio)phenol enhanced peroxidase assays
A chemiluminescent reaction, which may be utilized as an immunoassay, carried out by 2,3-dihydro-1,4-phthalazinedione or its derivative, a peroxidase, and an oxidant, is enhanced by adding a...
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5395938 |
Biotinylated chemiluminescent labels and their conjugates, assays and assay kits
A unique class of chemiluminescent labels containing biotin substitution that are suitable for chemiluminescent assays using inter alia a streptavidin and/or avidin conjugate. The chemiluminescent...
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5391478 |
Assay device and immunoassay
This invention relates to an improved assay device and assay for detecting or quantitating the presence or absence of a substance in a sample. The device has multiple layers comprising a permeable...
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5391483 |
Ligand analogs for immunoassays derived from dicarboxylic acid oxidation products
What is disclosed is a ligand analog comprising a dicarboxylic acid oxidation product of a immunologically reactive mono-or a polysaccharide having vicinal diols, to which a label or a support is...
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5385822 |
Methods for detection and quantification of cell subsets within subpopulations of a mixed cell population
The presence or quantity of a selected subset of cells, which is part of a subpopulation of a mixed cell population, is determined by a method in which a detectable reporter substance is uniformly...
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5384265 |
Biomolecules bound to catalytic inorganic particles, immunoassays using the same
Catalytic colloidal metal particles bound to a biomolecule such as an antibody, avidin, or streptavidin are useful for detecting the presence of the biomolecule in an assay such as an immunoassay.
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5378638 |
Analysis element and process for its manufacture
An analysis element for the determination of an analyte in a liquid sample, especially for medicinal uses. A carrier layer (2) contains, in a reagent domain (4), a reagent applied in a defined...
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5378608 |
Enzyme immunoassay for antigen and solid phase used therefor
An enzyme immunoassay for an antigen using a solid phase, which employs (a) a biotinylated antibody in which a biotin derivative is bound to a thiol group of an Fab' fragment of an antibody, (b) an...
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5376531 |
Method of detecting cancer
The invention provides a method of screening for gastrointestinal cancer in a mammal comprising: (a) contacting a body fluid taken from the mammal with N3; (b) measuring the amount of antibody to...
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5369002 |
Method of detecting injured nuclear DNA
An easy method for detecting injured cell nuclear DNA is provided which does not suffer from "pseudo-positive" staining. The method comprises the steps of subjecting a pathological tissue specimen...
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5366864 |
Buffered wash composition, insolubilizing composition, test kits and method of use
A buffered aqueous composition is useful simultaneously as a wash solution and a dye-providing composition in specific binding assays involving enzyme-labeled specific binding reagents. The wash...
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5366859 |
Radioimmunoassay method
A radioimmunoassay which comprises the steps of reacting a first antibody (A) on an insoluble solid, which is specific for an antigen (B); an antigen (B); and a second antibody (C) derived from an...
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5364591 |
Device for moving a target-bearing solid through a liquid for detection while being contained
There are described a device and method for doing confined reactions such as PCR amplification and detection, wherein solids (e.g., beads) used to obtain separation between bound and "free" label...
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5358846 |
Methods for diagnosing infectous diseases and methods for detecting and identifying microorganisms
The invention provides methods and materials for the detection and identification of biotin-containing bacteria and/or yeast in phagocyte-containing samples obtained from patients.
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5356782 |
Analytical test apparatus with on board negative and positive control
The invention is an apparatus useful in carrying out an analytical assay. The apparatus has a positive and negative control, as well as a site for determining the presence, amount, or lack of an...
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5356779 |
Assay for direct binding of peptides that are T-cell epitopes to MHC gene products on intact antigen-presenting cells and the use thereof for screening susceptibility of autoimmune diseases
As assay for the measurement of direct binding of a peptide that is a T-cell epitope to gene products of the major histocompatibility complex (MHC), classes I and II, on the surface of intact...
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5346670 |
Phthalocyanine and tetrabenztriazaporphyrin reagents
Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1## wherein, M represents either H 2 or is selected from among the following metals:...
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5344760 |
Method of cancer detection
Diagnostic/prognostic methods are provided for detecting and/or quantitating in the body fluids, preferably serum, of mammals carrying a malignant tumor burden, elevated levels of a portion of the...
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5340714 |
Use of nonmetallic tetrapyrrole molecules and novel signal solutions in chemiluminescent reactions and assays
Nonmetallic tetrapyrrole molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution at a pH from about 10.0 to about 14.0, having an...
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5332679 |
Method for specific binding assays using a releasable ligand
Immunoassays and DNA probe assays utilizing a non-immune, reversible binding displacement system are provided. In the assay, a releasable ligand, a binding partner for the releasable ligand, an...
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5330891 |
Method for detection of a nucleic acid using particulate reagent having polyoxyalkylene side chains
Biologically active reagents are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are...
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5300421 |
Method for quantitative measurement of trace enzyme and substrate used therein
A synthetic substrate used for quantitative analysis of a trace enzyme. The substrate has a molecular structure (B)-(A)-(C) comprising at least one structure (A) catalytically affected by the...
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5298395 |
Hyperglycosylated cytokine conjugates
Ligand reagents are disclosed which consist essentially of recombinant hyperglycosylated cytokines, expressed in yeast, which are purified and conjugated to various functional moieties, for...
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5296347 |
Bridge immunoassay
Disclosed is a novel immunoassay methodology, bridge immunoassay, which employs a primary free solution analyte/receptor binding reaction, for example, in a sandwich-type format (two or more...
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5288614 |
Method for the detection of malignant diseases
In order to aid in the detection of malignant diseases the sample of a body fluid is incubated with at least two receptors R 1 and R 2 in which a signal change is produced by binding of at least...
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5281521 |
Modified avidin-biotin technique
A method for preparing an antigen specific probe is provided by incubating a primary antigen specific monoclonal antibody with a biotinylated secondary antibody to produce a complex of the primary...
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5279943 |
Homogeneous process for the detection and/or determination by luminescence of an analyte in a medium in which it may be present
The present invention relates to a homogeneous process for the detection and/or determination of an analyte in a medium in which it may be present, by disclosing the reaction product of the analyte...
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5278081 |
Method for the determination of an immunologically bindable substance
In order to determine an analyte by a heterogeneous immunological test using a first partner of a binding pair which is immobilized on a solid phase in which a sample solution containing the...
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5262334 |
Method for immunoselection of cells using avidin and biotin
The selectivity of immunoselection systems employing insolubilized avidin and biotinylated specific antibody is amplified, and nonspecific recovery is improved, by employing an indirect sandwich...
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5252293 |
Analytical slide with porous filter membrane
This invention encompasses a slide reading assembly, and a slide with a porous filter membrane wherein the slide has a means for aligning the slide within a filter assembly to filter reagents on...
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5246835 |
Method of diagnosing renal diseases
A method of diagnosing renal diseases by detecting fragments of albumin in human urine. The detection of the fragments is carried out by, for example, immunological methods or liquid chromatography...
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5236830 |
Method of assay for antigen
A method of assay for antigen comprising the following sequential steps (A), (B), (C) and (D): (A): the antigen to be assayed in a subject solution is bound with a functional group or marker to...
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5234812 |
Method for sequential determination of an analyte in a fluid sample using a third receptor
The invention relates to an assay for determining an analyte in a fluid sample. Three receptors are used, with formation of a quaternary or four member complex. One of the receptors is bound to a...
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5232832 |
Antibody reactive to hamster immunoglobulins and assay using same
A monoclonal antibody specifically reactive to hamster immunoglobulins, a hybridoma producing said monoclonal antibody, and an immunoassay utilizing said monoclonal antibody are provided. The...
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5230997 |
Methods of detecting the presence of human herpesvirus-7 infection
The present invention relates to a new human herpesvirus-7, proteins encoded in the genome of the virus, and antibodies specific for the virus and proteins. The virus was isolated from human...
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5229266 |
Assay of hair regrowth marker
Terminal hair follicles of the human scalp in the anagen phase of growth are distinguished from non-terminal follicles or from terminal follicles in phases of growth other than anagen by the...
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RE34312 |
Process and reagent for the determination of an antibody
The present invention provides a process for the determination of an antibody by incubation with three different reagents R 1 , R 2 and R 3 , of which R and R 3 are present in liquid phase and...
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5225325 |
Immunohistochemical staining method and reagents therefor
The present invention provides an immunohistochemical staining method using improved reagents. In one aspect, the method uses an evaporation inhibitor liquid to prevent evaporation of reagents...
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5225322 |
Immunoassays for detection of viral subtypes and other antigens
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5221736 |
Sequential peptide and oligonucleotide syntheses using immunoaffinity techniques
The invention is directed to a method of purifying sequentially synthesized peptides and oligonucleotides by affinity techniques. Selected products are capped with and N-terminus capping agent for...
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5219764 |
Hapten-biotin conjugates and their use
Hapten-biotin conjugates in which the hapten is linked with biotin via a spacer, which has 26 to 40 atoms in its chain and contains at least 5 heteroatoms, are novel and are suitable, in particular...
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5212063 |
Ligand trap useful in immunoassays of biotin or free biotin containing samples and improved immunoassays using these ligand traps
The present invention provides a process for the detection of analytes in body fluids containing free biotin by immunoassay with the use of biotin conjugates for the labelling, immobilization or...
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5206136 |
Rapid membrane affinity concentration assays
Rapid assays for analytes of interest in a fluid sample utilize a first conjugate of a labelled reactant that specifically binds to the analyte, and a second conjugate that binds to the analyte...
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5206144 |
Determination of glycated (glycosylated) hemoglobin in blood
The concentration of glycated hemoglobin, HbA 1c , in hemoglobin from diabetic patients is regarded as a useful means of assessing the adequacy of diabetes control. This invention comprises a...
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5200315 |
Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent
Biologically active reactive are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are...
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5190860 |
Differential diagnostic assay for brucellosis
An immunoassay procedure is provided which exhibits increased specificity over current procedures. The procedure allows the differentiation of animals infected with Brucella abortus from animals...
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5188942 |
Method for determining bluetongue virus antibodies in serum
A rapid, competitive enzyme linked immunosorbent assay (cELISA) for the determination of Bluetongue virus antibodies in serum is described. This method utilizes either a biotinylated monoclonal...
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5187060 |
Detection of influenza a virus by polymerase chain reaction (PCR) preceded by reverse transcription of a region of the viral hemagglutinin gene
It was possible to increase substantially the sensitivity of detection of influenza A virus by carrying out a polymerase chain reaction (PCR), using oligonucleotide sequences (amplimers) from the...
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