|
Match
|
Document |
Document Title |
|
|
5863740 |
Interference eliminating agent for application in immunoassays
The invention concerns interference-eliminating agents for avoiding unspecific interactions in immunoassays in which avidin or streptavidin or a derivative thereof are used as the...
|
|
|
5858803 |
Process and reagent for the determination of a specifically bindable substance
The present invention provides a process for the determination of a specifically bindable substance by incubation of the sample solution with at least three receptors R 1 , R 2 and R 3 , of which...
|
|
|
5856082 |
Devices and methods for characterizing proteins and peptides
The present invention provides analytical devices for the characterization of the primary structure of proteins and peptides, comprising a microenzyme reactor, a separation device, an interface...
|
|
|
5854008 |
Europium and terbium chelators for the time-resolved fluorometric assays
Fluorogenic chelators for Eu 3 + and Tb 3 + are provided, they form highly fluorescent complexes with Eu 3 + and Tb 3 +. In all cases, the fluorescence observed was lanthanide-specific, long-lived...
|
|
|
5851781 |
Reagents and methods for the detection and quantification of testosterone in fluid samples
The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a...
|
|
|
5846737 |
Conjugates of sulforhodamine fluorophores with enhanced fluorescence
The invention describes useful conjugates of sulforhodamine, wherein the conjugated substance and the fluorophore are separated by an alkanoic acid spacer that is attached to the fluorophore via a...
|
|
|
5834197 |
Methods of capturing species from liquids and assay procedures
A species such as a microorganism, e.g. Legionella, Giardia or Cryptosporidium, is captured by first attracting plastic coated magneticbeads or other magnetically attractable particles to a solid...
|
|
|
5830659 |
Active microtubule-based separations by kinesins
A method and system for separating a selected molecule from a heterogeneous mixture of molecules in aqueous solution are described. The method comprises (a) providing a separation device comprising...
|
|
|
5830709 |
Detection method for homologous portions of a class of substances
The invention provides a method of detecting a class of substances, by providing an assay configuration which allows for reaction with a homologous portion common to all members of the class. The...
|
|
|
5827669 |
Sheets, kits and methods for detecting antigens or antibodies
A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the...
|
|
|
5811242 |
Marker and reagent for diabetes mellitus and diabetes mellitus complication
N ε -carboxymethyllysine, a carboxymethylated protein in which at least part of the side-chain amino groups of amino acid residues constituting the protein is carboxymethylated, or a...
|
|
|
5811246 |
Process for immobilization onto the surfaces of ELISA plates of a compound carrier complex and for immunization
The invention relates to a process for immobilization onto the surface of enzyme linked immunosorbent assay (ELISA) plates of a compound or for immunization with a compound, wherein said compound...
|
|
|
5807675 |
Fluorescent oxygen channeling immunoassays
Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such...
|
|
|
5804391 |
Elimination of rheumatoid factor interference using anti-FD antibodies
The invention concerns the use of a composition which is composed of several different antibodies or/and antibody fragments which serves as a reagent to eliminate rheumatoid factor interference in...
|
|
|
5800991 |
Nucleotide or nucleoside photoaffinity compound modified antibodies, methods for their manufacture and use thereof as diagnostics and therapeutics
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. Such photoaffinity sites are contained on a conserved region of...
|
|
|
5798273 |
Direct read lateral flow assay for small analytes
The present invention relates to a method and assay device for detecting small analytes. The results of the assay can be directly read from the device, which is a lateral flow device.
|
|
|
5795725 |
Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
Assays and antibodies are disclosed for the detection and quantitation of cardiac specific troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T...
|
|
|
5792606 |
Nucleic acid hybridization based assay for determining a substance of interest
The application describes homogeneous assays for determining ligands. A sample is contacted with a labeled substance P 2 and receptor R. The receptor R consists of one molecule of P 1 , which...
|
|
|
5792617 |
Cell proliferation-based amplified detection of analytes
A test kit and method for the highly sensitive detection of specific analytes in a sample is provided. The presence of the analyte in the sample results in a decrease in the concentration of a...
|
|
|
5789163 |
Enzyme linked oligonucleotide assays (ELONAS)
This invention discloses novel immunoassay termed an ELONA, employing nucleic acid ligands as capture molecules and/or detector molecules.
|
|
|
5789179 |
Cat assay
A method of assaying for CAT in a fluid involves the use of a complex of chloramphenicol with a member of a specific binding pair such as a hapten or biotin. Biotinylated chloramphenicol is claimed...
|
|
|
5786153 |
Prevention of probe coating on automated analyzers using a non-denaturing surfactant
A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A...
|
|
|
5783398 |
High throughput assay using fusion proteins
This application describes a high throughput assay for screening for compounds capable of binding to a fusion protein which consists of a target protein and an FK506-binding protein. The method for...
|
|
|
5776696 |
High throughput assay using fusion proteins
This application describes a high throughput assay for screening for compounds which are capable of binding to a fusion protein which consists of a target protein and an FKS506-binding protein.
|
|
|
5776702 |
Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor
For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is...
|
|
|
5770460 |
One-step lateral flow nonbibulous assay
A particularly efficient design for a nonbibulous lateral flow one step assay for an analyte in a biological sample is disclosed. In the improved device of the invention, three zones which are in...
|
|
|
5759787 |
Kinase assay
The invention provides novel methods and compositions for detecting kinase activity in solution, without the use of radioactivity. The methods marry the kinetic advantages of solution-based...
|
|
|
5759778 |
Method of nucleic acid sequence selection
The present invention provides a method for the rapid isolation and recovery of a desired target DNA or RNA molecules from a mixture or library containing such molecules. The method involves the...
|
|
|
5759866 |
Device and method for assaying biological components in sample
By using an assay device comprising a sample-receiving port, a pump-connection port, a sample-treating zone which is provided with a labeled substance with a label, a sample-treating and...
|
|
|
5750344 |
Method for selection of biologically active peptide sequences
An improved method for determining binding compounds from a mixture of similar compounds, particularly a phage peptide library, is provided. The method comprises contacting a mixture of candidate...
|
|
|
5747269 |
Determination of peptide motifs on MHC molecules
The present invention concerns a method for the determination of allele-specific peptide motifs on molecules of the major histocompatibility complex (MHC) of classes I and II as well as the peptide...
|
|
|
5741714 |
Detection of bound analyte by magnetic partitioning and masking
A method and apparatus for determining qualitatively or quantitatively the presence of analyte bound to a separation media without doing a bound/free separation. In the method, the bound fraction...
|
|
|
5738984 |
Kits and methods of detection using cellulose binding domain fusion proteins
A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion...
|
|
|
5731158 |
Catalyzed reporter deposition
The present invention concerns a method to catalyze reporter deposition to improve detection or quantitation of an analyte in a sample by amplifying the detector signal which comprises reacting an...
|
|
|
5723344 |
Device for the capture of target molecules, and capturing process using the device
Device for capturing a target molecule for the purpose of detecting it and/or assaying it, including a solid support on which is immobilized a ligand, the ligand being provided in the form of a...
|
|
|
5723303 |
Immunoglobulin a binding protein
The subject invention concerns a novel polynucleotide sequence cloned from emm2.2 gene of a Group A streptococcus, Type II strain which codes for an IgA-binding protein, ML2.2. The subject...
|
|
|
5723304 |
Immunological detection using two detectable labels
The invention relates to a method of detection, a sensor and a test-kit which find application in immunological detection (e.g., immunoassay). The invention provides, inter alia, a method of...
|
|
|
5723306 |
Monoclonal antibodies for the detection of pyrethroids and a process for their production
Highly selective monoclonal antibodies for pyrethrins and pyrethroids which, in their function as pesticides, contain a phenoxybenzyl and/or a cyclopropane component. The number of pyrethroids...
|
|
|
5719031 |
Dye labeled polymers as reagents for measuring polymer degradation
This invention relates to polymers labeled with fluorescent dye to the point that significant fluorescence quenching occurs, such that degradation of the polymer results in fluorescence...
|
|
|
5708154 |
RNA-DNA hybrid molecules of nucleic acid
Molecules having an RNA block linked to a shorter DNA block is described. The RNA and DNA blocks are complementary to accommodate formation of fold-back molecules having a 3' hydroxyl on the DNA...
|
|
|
5705338 |
Reduction of background in noncompetitive binding assays
Novel non-competitive assay techniques have been developed which not only improve sensitivity, but also are convenient and less susceptible to interfering factors. They are compatible with existing...
|
|
|
5700639 |
Method for the detection of metabolically labelled DNA
The invention concerns a method for the non-radioactive detection of metabolically labelled DNA, in one aspect detecting labelled DNA indicative of cell lysis or apoptosis.
|
|
|
5700641 |
Diagnostic method, test kit, drug and therapeutic treatment for autoimmune diseases
Synthesized telomeric sequences bind to and can be used for detecting anti-DNA antibodies in serum. Autoimmune diseases such as Lupus Erythematosus, Rheumatoid Arthritis, and Scleroderma, can be...
|
|
|
5698405 |
Method of reducing immunogenicity
The immunogenicity of avidin, a therapeutic agent moiety of a conjugate, or a targeting composition is reduced by coupling the immunogenic agent with a carbohydrate polymer or polyol groups, such...
|
|
|
5691152 |
Stable avidin composition
Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking...
|
|
|
5690907 |
Avidin-biotin conjugated emulsions as a site specific binding system
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated...
|
|
|
5686257 |
Binding compositions for mammalian T cell antigens and related reagents
T cell surface antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
|
|
|
5679526 |
Threshold ligand-receptor assay
This invention is directed to a ligand-receptor assay for determining the presence of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available...
|
|
|
5674677 |
Immunoassay technique using histidine tags, metals, and chelating agents
Two amino acid sequences are joined together using an electron acceptor moiety and a linking moiety, such as a chelating agent. In particular, an amino acid sequence specific for binding to a...
|
|
|
5665559 |
Production of monoclonal antibodies to bacteroides gingivalis by hybridoma BGII, VF9/2D
A monoclonal antibody is disclosed which is reactive to Bacteroides gingivalis and produced by the hybridoma deposited under ATCC HB 9968. The invention also discloses diagnostic reagents and...
|