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6383766 |
Reduced cortisol conjugates
The present invention relates to compositions comprising novel reduced cortisol conjugates, methods for their preparation and use in immunoassays for cortisol. In another aspect, it relates to...
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6372517 |
Magnetic particles with biologically active receptors
Magnetic particles for separating biological mixtures consist of nacreous luster pigments with magnetic properties coated with a biological polymer.
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6372445 |
Chromophores in the preparation of novel tandem conjugates
The inventors herein disclose new heterobifunctional chromophores that are capable of coupling with two distinct moieties. One moiety may be either a signal-enhancing agent or a blocking agent. The...
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6368813 |
Multiflavor streptavidin
Compounds and methods are described for producing streptavidin mutants with changed affinities. In particular, modifications to the sequence of the natural streptavidin gene is described to create...
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6362010 |
Methods and compositions for release of CD3430 cells from affinity matrices
Compounds and methods are provided for use in purification of CD34 + cells and specific surface antigens thereof. The present invention discloses methods for releasing CD34 + cells, as well as...
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6355443 |
4-(4-hydroxystyryl) pyridine-containing substrates for an analyte dependent enzyme activation system
4-(4-hydroxystyryl) pyridine-containing compounds are disclosed as substrates for use in assays. Also, a method for detecting or quantitating an analyte is provided which includes reacting an...
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6355803 |
Near infrared chemiluminescent acridinium compounds and uses thereof
This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional...
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6350579 |
Extended dynamic range assays
A method and compositions for the detection and/or quantification of an analyte through the use of a plurality of labeled probes, with two or more said probes targeted to different regions of said...
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6346196 |
Flow-through, hybrid magnetic field gradient, rotating wall device for enhanced colloidal magnetic affinity separations
A slowly rotating separation chamber with an oscillating axial magnetic field gradient created by an alternating current solenoid superimposed on a steady radial gradient in a horizontal chamber is...
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6342395 |
Compact assay system with digital information
A compact assay system having a solid support has at least one capture binding agent on the support surface. By applying a combination of different binding agents on the support surface, the...
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6342346 |
Method of producing an electrode membrane combination
Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first...
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6340598 |
Apparatus for multichannel fluorescent immunoassays
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity....
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6335205 |
Method and test strip for determining an analyte
The invention concerns a method for the immunological determination of an analyte on a chromatographic test strip containing one or several absorbent matrices on a carrier material which are in...
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6331395 |
Prenatal diagnostic methods
A method of identifying embryonic or fetal red blood cells in a sample containiing maternal blood cells and embryonic or fetal red blood cells or both, the method comprising determining which cell...
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6326157 |
Recombinant fluorescent protein microsphere calibration standard
A method for making recombinant fluorescent protein standard particles for calibration of fluorescence instruments.
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6309825 |
Analytical and therapeutic agents
According to the present invention there is provided an agent and method of detecting 8-oxoquanine, 8-oxodeoxyguanosine, 8-oxoadenine, and 8-oxodeoxyadenosine.
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6309842 |
Use of modified tethers in screening compound libraries
The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The...
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6306665 |
Covalent bonding of molecules to an activated solid phase material
Microporous solid phase materials that are suitable for lateral flow and other assays for detecting the presence of analytes in test samples, that are stable under variations in humidity and, even...
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6306607 |
Heterogeneous assay for pyrophosphate
Nucleotide triphosphate probes containing a fluorophore attached to the γ-phosphate and a quencher moiety sufficiently proximal to the fluorophore moiety for use in pyrophosphate detection assays...
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6303325 |
Method for detecting analytes
The invention relates to methods of determining the presence or amount of an analyte in a sample suspected of containing the analyte, said method comprising the steps of: (a) bringing together in...
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6300141 |
Card-based biosensor device
A diagnostic card device for use in detecting or quantitating an analyte present in a liquid sample, comprising a card substrate having a sample introduction region, a biosensor, and a sample-flow...
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6297062 |
Separation by magnetic particles
The present invention concerns a method for separating at least one species of biological entities from a sample solution, by contacting the sample with a matrix of magnetic particles formed on a...
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6291198 |
Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody
A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the...
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6287792 |
Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
A composition for delivering an agent to cells in vitro or to tissues or organs in vivo. The composition comprises either avidin or an avidin fusion protein bonded to a biotinylated agent to form...
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6277964 |
Anti-PAH monoclonal antibodies and cell lines producing the same
The present invention provides monoclonal antibodies suitable for monitoring polycyclic aromatic hydrocarbons (PAHs) by an immunoasay, hybridoma cell lines producing said antibodies, and an...
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6274325 |
Method for carrying out a homogeneous-immunoassay based on agglutination
The invention concerns a homogeneous immunoassay based on agglutination using an Fab'-biotin material and agglutinatable particles which carry streptavidin or avidin. The invention also concerns...
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6270983 |
Surfaces coated with streptavidin/avidin
The invention relates to surfaces coated with streptavidin and avidin for use in immunoassays, wherein the surfaces comprise a layer of streptavidin and avidin which are bonded on a surface of a...
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6268141 |
Immobilization of unmodified biopolymers to acyl fluoride activated substrates
A method of attaching unmodified biopolymers, particularly, unmodified polynucleotides, directly to a solid support is provided. The method includes the steps of (a) providing unmodified...
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6268123 |
Direct and biochemically functional detection process of retrovirus in biological samples
The present invention relates to processes for the direct detection of biochemically functional retroviruses in biological samples. The processes of the invention are characterized by the...
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6265552 |
Biotinylation of proteins
Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo...
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6258549 |
Elisa screening method for inhibitors of human IgE binding to the high affinity receptor, FcεRIα
The present invention is directed to an Assay for high capacity screening of substances interfering with the attachment of human IgE to its high affinity receptor and/or of substances capable of...
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6251687 |
Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds
The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from...
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6248546 |
Assay of IGFBP complex
A method of assaying the growth hormone status of an individual by immuno-assay for the 150 KDa Insulin-like Growth Factor ternary complex (IGF/IGFBP-3/ALS). Alternatively, a binary complex may be...
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6248544 |
Method of measuring bone resorption rate
Tartrate-resistant acid phosphatase (TRAP) has been used as a marker for bone resorption. However, there are two forms of said enzyme in the body: TRAP 5a and TRAP 5b, of which TRAP 5b is a much...
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6243980 |
Protease inhibitor assay
Heterogenous and homogenous assays are provided for the detection of protease inhibitory activity in a sample or target compound, taking advantage of the chemiluminescent characteristics of...
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6242267 |
Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
An apparatus and method for rapidly analyzing samples for analytes of interest by an homogeneous immunofluorescence assay. The apparatus includes a sample test cartridge having a high control...
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6235488 |
Surface preparation for chemical-specific binding
A mass biosensor uses an intermediate avidin layer to facilitate binding of a biotinylated antibody to a measurement surface of the biosensor. The avidin layer can be added by the manufacturer of...
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6221612 |
Photon reducing agents for use in fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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6214628 |
Method of conducting an assay of a sample containing an analyte of interest
In accordance with the present invention, a method of conducting an assay of a sample containing an analyte of interest includes the step of forming a mixture so as to bring a metal-ligand complex...
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6214568 |
Monoclonal antibodies of isotype IgG which bind specifically to glutamate decarboxylase, and uses thereof
The invention concerns human monoclonal antibodies of the IgG isotype against human pancreatic islet cells which can be obtained by immortalizing human lymphocytes of prediabetics or diabetics,...
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6203974 |
Chemiluminescent immunoassay for detection of antibodies to various viruses
The subject invention relates generally to immunoassays for detection of antibodies by use chemiluminescent compounds. More particularly, the subject invention relates to chemiluminescent...
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6200762 |
Photon reducing agents and compositions for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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6194552 |
Immunosorbents with developed binding efficiency and method of manufacture
The antitope of an antibody is masked with a masking agent, followed by immobilization on a support. The masking agent is then eluted to produce an improved immunosorbent, which is capable of...
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6194225 |
Immunochromatography-assisted device
An immunochromatography-assisted device is disclosed which facilitates accurate and rapid detection of an antigen contained in a fluid sample and from which background coloring and blank coloring...
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6194161 |
Staphylococcus aureus antigen
A negatively-charged S. aureus antigen contains β-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant...
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6183972 |
Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect
Disclosed is a method for determining the concentration of an analyte in a fluid test medium by use of an immunochromatographic test strip through which the test fluid can flow by capillarity. The...
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6174669 |
Method for making full-length cDNA libraries
Disclosed is a method for making full-length CDNA libraries, which is for making libraries of cDNAs having a length corresponding to a full-length of mRNAs and comprises the following steps of;...
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6174688 |
Multiassay method for determining the concentrations of antigens and interferants
A method of determining the concentration of a sample antigen in the presence of an interferant by (1) running two immunoassays on the sample: one assay where the interferant influences the binding...
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6165730 |
Hepatitis C virus peptides obtained from the NS4 coding region and their use in diagnostic assays
The etiological agent responsible for non-A, non-B hepatitis has been identified and termed hepatitis C virus (HCV). The HCV genome is a linear, positive-stranded RNA molecule with a length of...
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6159689 |
Methods of capture and assay procedures
Methods of capturing and labeling a species, include attracting magnetically attractable particles to a solid support by magnetic forces, which particles have an affinity for the species,...
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