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4582789 |
Process for labeling nucleic acids using psoralen derivatives
A labeling reagent of the formula: [A][B]L is prepared where A is an alkylating intercalation moiety, B is a divalent organic spacer arm moiety with a straight chain of at least two carbon atoms,...
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4564597 |
Anti-Sm hybridoma
Anti-Sm antibodies are produced by the hybridoma technique and employed to test for lupus erythematosus in humans.
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4563417 |
Nucleic acid hybridization assay employing antibodies to intercalation complexes
Nucleic acid hybridization assay methods and reagent systems for detecting a particular polynucleotide sequence in a test medium. An aggregate is formed in the assay reaction mixture comprising...
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4550075 |
Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
Methods and compositions are disclosed for the qualitative and quantitative identification of specific ligand in a fluid medium suspected of containing the ligand. The method of the present...
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4535057 |
Immunoassay employing monoclonal herpes simplex antibody and biotin-avidin detection system
An immunoassay and kit for determining a viral antigen, such as herpes simplex. In one embodiment, the antigen is immunocaptured by an insoluble matrix presenting IgG antibody against the viral...
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4530900 |
Soluble insoluble polymers in enzymeimmunoassay
The invention pertains to an improved heterogeneous enzymeimmunoassay involving the use of a reversibly soluble polymeric substance acting as the support for the antibody. In the direct method the...
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4517303 |
Specific binding assays utilizing analyte-cytolysin conjugates
A novel analyte-cytolysin conjugate and its use in a lipid vesicle mediated measurement process is described for a wide variety of analytes present at very low concentration. The method involves...
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4513088 |
Assay for monoclonal antibody against surface Ig of a human B cell tumor
An assay that facilitates screening of hybridoma culture media for monoclonal anti-idiotype antibodies, particularly murine monoclonal antibodies that are useful for treating human B cell tumors is...
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4506009 |
Heterogeneous immunoassay method
A conjugate useful in determining the amount of antigen or antibody in a liquid sample, said conjugate having a marker, an immunoreactive component (i.e. antigen or antibody) bound to the marker...
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4503143 |
Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen
Colorimetric detection of bindable substances such as antibodies and antigens using chromogens of improved sensitivity and stability. The chromogens take the form of activated solutions containing...
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4496654 |
Detection of HCG with solid phase support having avidin coating
Human chorionic gonadotropin (HCG) is detected by enzyme immunoassay by bonding biotinylated antibody to an avidin coupled paper disc, reacting the antibody on the disc with the solution suspected...
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4492751 |
Heterogenous specific binding assay employing an enzyme substrate as label
An improved heterogenous specific binding assay method which employs a substance having reactant activity, i.e., a reactant, as a labeling substance in the detection of a ligand in a liquid medium....
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4489133 |
Two-dimensional crystallization technique
Methods and compositions involving two-dimensional ordering of organic polar solvent soluble organic macromolecules. Lipid monolayer forming molecules are bound covalently or non-covalently to...
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4478914 |
Process for applying multiple layers of a protein and a ligand extender to a surface and to the multiple-layer system
A multiple-layer process for applying, in alternate, successive molecular layers, a protein material, and a ligand extender material to a surface to modify the properties of the surface and to the...
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4467031 |
Enzyme-immunoassay for carcinoembryonic antigen
A solid phase-sandwich enzyme-immunoassay method for the rapid determination of carcinoembryonic antigen (CEA). The sample to be investigated is incubated with a first CEA antibody, which is bound...
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4447545 |
Bladder cancer detection
Disclosed is a technique for screening populations to detect potential bladder cancer patients. The screening test is based on a discovered correlation between the respective ratios of C-reactive...
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4434150 |
Immunological reagents employing polymeric backbone possessing reactive functional groups
An immunological substance detecting reagent is provided which, in the preferred embodiment, employs an immunological homolog specific for the immunological substance to be detected coupled to a...
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4433051 |
Derivatives of α-difluoromethylornithine useful in analysis
There are provided novel labelled derivatives, namely α-difluoromethylornithine tagged with rhodamine or with biotin. These are of value in analysis and in the cytochemical localization of enzymes.
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4395486 |
Method for the direct analysis of sickle cell anemia
A direct diagnosis of sickle cell anemia by a restriction endonuclease assay with an enzyme which recognizes the nucleotide base sequence CTNAG (where N is any base), such as Dde I, for the sickle...
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4383031 |
Homogeneous chemiluminescent specific binding assay
A homogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, in a chemiluminescent reaction as a labeling substance in the detection of a ligand in a...
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4380580 |
Heterogenous chemiluminescent specific binding assay
A heterogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, in a chemiluminescent reaction as a labeling substance in the detection of a ligand in a...
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4340668 |
Heme-labeled specific binding assay
A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme,...
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4318983 |
Fad-labeled specific binding assay monitored with apoglutathione reductase or apolipoamide dehydrogenase
A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme,...
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4312944 |
Carrying out assaying methods involving biospecific reactions
An improvement in carrying out assaying methods involving biospecific affinity reactions in which there are used from two to four reactants, one of which reactants, reactant (I), being labelled...
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4298685 |
Diagnostic reagent
A sample, e.g. serum, containing an antigen, hapten or other biological substance is mixed with antibodies raised against that substance which have been tagged with biotin, and with a known amount...
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4238565 |
Specific binding assay with a prosthetic group as a label component
A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme,...
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4228237 |
Methods for the detection and determination of ligands
A method for determining the presence of a ligand in a liquid medium which utilizes enzyme labeled avidin and biotin labeled reagent in a specific binding process wherein the ligand to be detected...
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4220450 |
Chemically induced fluorescence immunoassay
A competitive protein binding method is provided for the determination of an analyte which is a member of an immunological pair consisting of ligand and receptor for the ligand. A chemiluminescent...
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4134792 |
Specific binding assay with an enzyme modulator as a labeling substance
A specific binding assay method employing, as a labeling substance, a reversibly binding enzyme modulator for the detection of a ligand in a liquid medium. The method follows conventional specific...
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